메뉴 건너뛰기




Volumn 6, Issue JUN, 2016, Pages

The quest for targets executing MYC-dependent cell transformation

Author keywords

Carcinogenesis; Genetic; Oncogenes; Signal transduction; Transcription; Tumor suppressor

Indexed keywords

MYC PROTEIN;

EID: 84982812922     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2016.00132     Document Type: Short Survey
Times cited : (33)

References (117)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell (2011) 144:646-74. doi:10.1016/j.cell.2011.02.013
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 84866347303 scopus 로고    scopus 로고
    • Retroviral oncogenes: a historical primer
    • Vogt PK. Retroviral oncogenes: a historical primer. Nat Rev Cancer (2012) 12:639-48. doi:10.1038/nrc3320
    • (2012) Nat Rev Cancer , vol.12 , pp. 639-648
    • Vogt, P.K.1
  • 3
    • 84859171807 scopus 로고    scopus 로고
    • MYC on the path to cancer
    • Dang CV. MYC on the path to cancer. Cell (2012) 149:22-35. doi:10.1016/j.cell.2012.03.003
    • (2012) Cell , vol.149 , pp. 22-35
    • Dang, C.V.1
  • 4
    • 79958026380 scopus 로고    scopus 로고
    • The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
    • Mendoza MC, Er EE, Blenis J. The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation. Trends Biochem Sci (2011) 36:320-8. doi:10.1016/j.tibs.2011.03.006
    • (2011) Trends Biochem Sci , vol.36 , pp. 320-328
    • Mendoza, M.C.1    Er, E.E.2    Blenis, J.3
  • 5
    • 84983758024 scopus 로고    scopus 로고
    • Oncogenes. 2nd ed
    • Maloy S, Hughes K, editors, San Diego: Academic Press
    • Hartl M, Bister K. Oncogenes. 2nd ed. In: Maloy S, Hughes K, editors. Brenner's Encyclopedia of Genetics. (Vol. 5), San Diego: Academic Press (2013). p. 164-6.
    • (2013) Brenner's Encyclopedia of Genetics , vol.5 , pp. 164-166
    • Hartl, M.1    Bister, K.2
  • 6
    • 0017716859 scopus 로고
    • Defectiveness of avian myelocytomatosis virus MC29: isolation of long-term nonproducer cultures and analysis of virus-specific polypeptide synthesis
    • Bister K, Hayman MJ, Vogt PK. Defectiveness of avian myelocytomatosis virus MC29: isolation of long-term nonproducer cultures and analysis of virus-specific polypeptide synthesis. Virology (1977) 82:431-48. doi:10.1016/0042-6822(77)90017-4
    • (1977) Virology , vol.82 , pp. 431-448
    • Bister, K.1    Hayman, M.J.2    Vogt, P.K.3
  • 7
    • 0021176623 scopus 로고
    • Homologous cell-derived oncogenes in avian carcinoma virus MH2 and murine sarcoma virus 3611
    • Jansen HW, Lurz R, Bister K, Bonner TI, Mark GE, Rapp UR. Homologous cell-derived oncogenes in avian carcinoma virus MH2 and murine sarcoma virus 3611. Nature (1984) 307:281-4. doi:10.1038/307281a0
    • (1984) Nature , vol.307 , pp. 281-284
    • Jansen, H.W.1    Lurz, R.2    Bister, K.3    Bonner, T.I.4    Mark, G.E.5    Rapp, U.R.6
  • 8
    • 0022439502 scopus 로고
    • Oncogenes in retroviruses and cells: biochemistry and molecular genetics
    • Bister K, Jansen HW. Oncogenes in retroviruses and cells: biochemistry and molecular genetics. Adv Cancer Res (1986) 47:99-188. doi:10.1016/S0065-230X(08)60199-2
    • (1986) Adv Cancer Res , vol.47 , pp. 99-188
    • Bister, K.1    Jansen, H.W.2
  • 9
    • 33745767294 scopus 로고    scopus 로고
    • Cooperative cell transformation by Myc/Mil(Raf) involves induction of AP-1 and activation of genes implicated in cell motility and metastasis
    • Hartl M, Karagiannidis AI, Bister K. Cooperative cell transformation by Myc/Mil(Raf) involves induction of AP-1 and activation of genes implicated in cell motility and metastasis. Oncogene (2006) 25:4043-55. doi:10.1038/sj.onc.1209441
    • (2006) Oncogene , vol.25 , pp. 4043-4055
    • Hartl, M.1    Karagiannidis, A.I.2    Bister, K.3
  • 10
    • 23144464363 scopus 로고    scopus 로고
    • Transcriptional regulation and transformation by Myc proteins
    • Adhikary S, Eilers M. Transcriptional regulation and transformation by Myc proteins. Nat Rev Mol Cell Biol (2005) 6:635-45. doi:10.1038/nrm1703
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 635-645
    • Adhikary, S.1    Eilers, M.2
  • 12
    • 54349087788 scopus 로고    scopus 로고
    • Myc's broad reach
    • Eilers M, Eisenman RN. Myc's broad reach. Genes Dev (2008) 22:2755-66. doi:10.1101/gad.1712408
    • (2008) Genes Dev , vol.22 , pp. 2755-2766
    • Eilers, M.1    Eisenman, R.N.2
  • 13
    • 0000538165 scopus 로고
    • Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells
    • Dalla-Favera R, Bregni M, Erikson J, Patterson D, Gallo RC, Croce CM. Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci U S A (1982) 79:7824-7. doi:10.1073/pnas.79.24.7824
    • (1982) Proc Natl Acad Sci U S A , vol.79 , pp. 7824-7827
    • Dalla-Favera, R.1    Bregni, M.2    Erikson, J.3    Patterson, D.4    Gallo, R.C.5    Croce, C.M.6
  • 14
    • 84903159476 scopus 로고    scopus 로고
    • Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond
    • Holderfield M, Deuker MM, McCormick F, McMahon M. Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond. Nat Rev Cancer (2014) 14:455-67. doi:10.1038/nrc3760
    • (2014) Nat Rev Cancer , vol.14 , pp. 455-467
    • Holderfield, M.1    Deuker, M.M.2    McCormick, F.3    McMahon, M.4
  • 15
    • 33748757159 scopus 로고    scopus 로고
    • Down-regulation of c-MYC following MEK/ERK inhibition halts the expression of malignant phenotype in rhabdomyosarcoma and in non muscle-derived human tumors
    • Marampon F, Ciccarelli C, Zani BM. Down-regulation of c-MYC following MEK/ERK inhibition halts the expression of malignant phenotype in rhabdomyosarcoma and in non muscle-derived human tumors. Mol Cancer (2006) 5:31. doi:10.1186/1476-4598-5-31
    • (2006) Mol Cancer , vol.5 , pp. 31
    • Marampon, F.1    Ciccarelli, C.2    Zani, B.M.3
  • 17
    • 84866424540 scopus 로고    scopus 로고
    • B-Raf activation cooperates with PTEN loss to drive c-MYC expression in advanced prostate cancer
    • Wang J, Kobayashi T, Floc'h N, Kinkade CW, Aytes A, Dankort D, et al. B-Raf activation cooperates with PTEN loss to drive c-MYC expression in advanced prostate cancer. Cancer Res (2012) 72:4765-76. doi:10.1158/0008-5472.CAN-12-0820
    • (2012) Cancer Res , vol.72 , pp. 4765-4776
    • Wang, J.1    Kobayashi, T.2    Floc'h, N.3    Kinkade, C.W.4    Aytes, A.5    Dankort, D.6
  • 19
    • 84933576541 scopus 로고    scopus 로고
    • MYC in pancreatic cancer: novel insights and their translation into therapeutic strategies
    • Hessmann E, Schneider G, Ellenrieder V, Siveke JT. MYC in pancreatic cancer: novel insights and their translation into therapeutic strategies. Oncogene (2016) 35:1609-18. doi:10.1038/onc.2015.216
    • (2016) Oncogene , vol.35 , pp. 1609-1618
    • Hessmann, E.1    Schneider, G.2    Ellenrieder, V.3    Siveke, J.T.4
  • 20
    • 84915750036 scopus 로고    scopus 로고
    • Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations
    • Garbe JC, Vrba L, Sputova K, Fuchs L, Novak P, Brothman AR, et al. Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations. Cell Cycle (2014) 13:3423-35. doi:10.4161/15384101.2014.954456
    • (2014) Cell Cycle , vol.13 , pp. 3423-3435
    • Garbe, J.C.1    Vrba, L.2    Sputova, K.3    Fuchs, L.4    Novak, P.5    Brothman, A.R.6
  • 21
    • 84962022244 scopus 로고    scopus 로고
    • A lincRNA connected to cell mortality and epigenetically-silenced in most common human cancers
    • Vrba L, Garbe JC, Stampfer MR, Futscher BW. A lincRNA connected to cell mortality and epigenetically-silenced in most common human cancers. Epigenetics (2015) 10:1074-83. doi:10.1080/15592294.2015.1106673
    • (2015) Epigenetics , vol.10 , pp. 1074-1083
    • Vrba, L.1    Garbe, J.C.2    Stampfer, M.R.3    Futscher, B.W.4
  • 22
    • 0033551374 scopus 로고    scopus 로고
    • MYC oncogenes and human neoplastic disease
    • Nesbit CE, Tersak JM, Prochownik EV. MYC oncogenes and human neoplastic disease. Oncogene (1999) 18:3004-16. doi:10.1038/sj.onc.1202746
    • (1999) Oncogene , vol.18 , pp. 3004-3016
    • Nesbit, C.E.1    Tersak, J.M.2    Prochownik, E.V.3
  • 23
    • 77249119762 scopus 로고    scopus 로고
    • The landscape of somatic copy-number alteration across human cancers
    • Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, et al. The landscape of somatic copy-number alteration across human cancers. Nature (2010) 463:899-905. doi:10.1038/nature08822
    • (2010) Nature , vol.463 , pp. 899-905
    • Beroukhim, R.1    Mermel, C.H.2    Porter, D.3    Wei, G.4    Raychaudhuri, S.5    Donovan, J.6
  • 24
    • 77749233830 scopus 로고    scopus 로고
    • Stem cell-specific activation of an ancestral myc protooncogene with conserved basic functions in the early metazoan Hydra
    • Hartl M, Mitterstiller AM, Valovka T, Breuker K, Hobmayer B, Bister K. Stem cell-specific activation of an ancestral myc protooncogene with conserved basic functions in the early metazoan Hydra. Proc Natl Acad Sci U S A (2010) 107:4051-6. doi:10.1073/pnas.0911060107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 4051-4056
    • Hartl, M.1    Mitterstiller, A.M.2    Valovka, T.3    Breuker, K.4    Hobmayer, B.5    Bister, K.6
  • 25
    • 84979596921 scopus 로고    scopus 로고
    • Hydra myc2, a unique pre-bilaterian member of the myc gene family, is activated in cell proliferation and gametogenesis
    • Hartl M, Glasauer S, Valovka T, Breuker K, Hobmayer B, Bister K. Hydra myc2, a unique pre-bilaterian member of the myc gene family, is activated in cell proliferation and gametogenesis. Biol Open (2014) 3:397-407. doi:10.1242/bio.20147005
    • (2014) Biol Open , vol.3 , pp. 397-407
    • Hartl, M.1    Glasauer, S.2    Valovka, T.3    Breuker, K.4    Hobmayer, B.5    Bister, K.6
  • 27
    • 84934444203 scopus 로고    scopus 로고
    • Genome-wide analysis of c-MYC-regulated mRNAs and miRNAs, and c-MYC DNA binding by next-generation sequencing
    • Jackstadt R, Menssen A, Hermeking H. Genome-wide analysis of c-MYC-regulated mRNAs and miRNAs, and c-MYC DNA binding by next-generation sequencing. Methods Mol Biol (2013) 1012:145-85. doi:10.1007/978-1-62703-429-6_11
    • (2013) Methods Mol Biol , vol.1012 , pp. 145-185
    • Jackstadt, R.1    Menssen, A.2    Hermeking, H.3
  • 28
    • 0033082892 scopus 로고    scopus 로고
    • Ras enhances Myc protein stability
    • Sears R, Leone G, DeGregori J, Nevins JR. Ras enhances Myc protein stability. Mol Cell (1999) 3:169-79. doi:10.1016/S1097-2765(00)80308-1
    • (1999) Mol Cell , vol.3 , pp. 169-179
    • Sears, R.1    Leone, G.2    DeGregori, J.3    Nevins, J.R.4
  • 29
    • 84861154164 scopus 로고    scopus 로고
    • Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells
    • Tsai WB, Aiba I, Long Y, Lin HK, Feun L, Savaraj N, et al. Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells. Cancer Res (2012) 72:2622-33. doi:10.1158/0008-5472.CAN-11-3605
    • (2012) Cancer Res , vol.72 , pp. 2622-2633
    • Tsai, W.B.1    Aiba, I.2    Long, Y.3    Lin, H.K.4    Feun, L.5    Savaraj, N.6
  • 30
    • 67649439003 scopus 로고    scopus 로고
    • Facilitating replication under stress: an oncogenic function of MYC?
    • Herold S, Herkert B, Eilers M. Facilitating replication under stress: an oncogenic function of MYC? Nat Rev Cancer (2009) 9:441-4. doi:10.1038/nrc2640
    • (2009) Nat Rev Cancer , vol.9 , pp. 441-444
    • Herold, S.1    Herkert, B.2    Eilers, M.3
  • 31
    • 0037197962 scopus 로고    scopus 로고
    • Characterization of the c-MYC-regulated transcriptome by SAGE: identification and analysis of c-MYC target genes
    • Menssen A, Hermeking H. Characterization of the c-MYC-regulated transcriptome by SAGE: identification and analysis of c-MYC target genes. Proc Natl Acad Sci U S A (2002) 99:6274-9. doi:10.1073/pnas.082005599
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 6274-6279
    • Menssen, A.1    Hermeking, H.2
  • 32
    • 0038492517 scopus 로고    scopus 로고
    • A global transcriptional regulatory role for c-MYC in Burkitt's lymphoma cells
    • Li Z, Van Calcar S, Qu C, Cavenee WK, Zhang MQ, Ren B. A global transcriptional regulatory role for c-MYC in Burkitt's lymphoma cells. Proc Natl Acad Sci U S A (2003) 100:8164-9. doi:10.1073/pnas.1332764100
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8164-8169
    • Li, Z.1    Van Calcar, S.2    Qu, C.3    Cavenee, W.K.4    Zhang, M.Q.5    Ren, B.6
  • 33
    • 6044247650 scopus 로고    scopus 로고
    • Identification of novel Myc target genes with a potential role in lymphomagenesis
    • Marinkovic D, Marinkovic T, Kokai E, Barth T, Möller P, Wirth T. Identification of novel Myc target genes with a potential role in lymphomagenesis. Nucleic Acids Res (2004) 32:5368-78. doi:10.1093/nar/gkh877
    • (2004) Nucleic Acids Res , vol.32 , pp. 5368-5378
    • Marinkovic, D.1    Marinkovic, T.2    Kokai, E.3    Barth, T.4    Möller, P.5    Wirth, T.6
  • 34
    • 46349099384 scopus 로고    scopus 로고
    • Global identification of Myc target genes reveals its direct role in mitochondrial biogenesis and its E-box usage in vivo
    • Kim J, Lee JH, Iyer VR. Global identification of Myc target genes reveals its direct role in mitochondrial biogenesis and its E-box usage in vivo. PLoS One (2008) 3:e1798. doi:10.1371/journal.pone.0001798
    • (2008) PLoS One , vol.3
    • Kim, J.1    Lee, J.H.2    Iyer, V.R.3
  • 36
    • 79959943250 scopus 로고    scopus 로고
    • Kinetic profiling of the c-MYC transcriptome and bioinformatic analysis of repressed gene promoters
    • Yap CS, Peterson AL, Castellani G, Sedivy JM, Neretti N. Kinetic profiling of the c-MYC transcriptome and bioinformatic analysis of repressed gene promoters. Cell Cycle (2011) 10:2184-96. doi:10.4161/cc.10.13.16249
    • (2011) Cell Cycle , vol.10 , pp. 2184-2196
    • Yap, C.S.1    Peterson, A.L.2    Castellani, G.3    Sedivy, J.M.4    Neretti, N.5
  • 37
    • 84860389417 scopus 로고    scopus 로고
    • Genome-wide mapping of Myc binding and gene regulation in serum-stimulated fibroblasts
    • Perna D, Fagà G, Verrecchia A, Gorski MM, Barozzi I, Narang V, et al. Genome-wide mapping of Myc binding and gene regulation in serum-stimulated fibroblasts. Oncogene (2012) 31:1695-709. doi:10.1038/onc.2011.359
    • (2012) Oncogene , vol.31 , pp. 1695-1709
    • Perna, D.1    Fagà, G.2    Verrecchia, A.3    Gorski, M.M.4    Barozzi, I.5    Narang, V.6
  • 40
    • 80054789799 scopus 로고    scopus 로고
    • Cell-type independent MYC target genes reveal a primordial signature involved in biomass accumulation
    • Ji H, Wu G, Zhan X, Nolan A, Koh C, De Marzo A, et al. Cell-type independent MYC target genes reveal a primordial signature involved in biomass accumulation. PLoS One (2011) 6:e26057. doi:10.1371/journal.pone.0026057
    • (2011) PLoS One , vol.6
    • Ji, H.1    Wu, G.2    Zhan, X.3    Nolan, A.4    Koh, C.5    De Marzo, A.6
  • 41
    • 84867021989 scopus 로고    scopus 로고
    • Transcriptional amplification in tumor cells with elevated c-Myc
    • Lin CY, Lovén J, Rahl PB, Paranal RM, Burge CB, Bradner JE, et al. Transcriptional amplification in tumor cells with elevated c-Myc. Cell (2012) 151:56-67. doi:10.1016/j.cell.2012.08.026
    • (2012) Cell , vol.151 , pp. 56-67
    • Lin, C.Y.1    Lovén, J.2    Rahl, P.B.3    Paranal, R.M.4    Burge, C.B.5    Bradner, J.E.6
  • 43
    • 84867010006 scopus 로고    scopus 로고
    • c-MYC is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells
    • Nie Z, Hu G, Wei G, Cui K, Yamane A, Resch W, et al. c-MYC is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell (2012) 151:68-79. doi:10.1016/j.cell.2012.08.033
    • (2012) Cell , vol.151 , pp. 68-79
    • Nie, Z.1    Hu, G.2    Wei, G.3    Cui, K.4    Yamane, A.5    Resch, W.6
  • 44
    • 84904785973 scopus 로고    scopus 로고
    • Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis
    • Sabò A, Kress TR, Pelizzola M, de Pretis S, Gorski MM, Tesi A, et al. Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis. Nature (2014) 511:488-92. doi:10.1038/nature13537
    • (2014) Nature , vol.511 , pp. 488-492
    • Sabò, A.1    Kress, T.R.2    Pelizzola, M.3    de Pretis, S.4    Gorski, M.M.5    Tesi, A.6
  • 45
    • 84904823447 scopus 로고    scopus 로고
    • Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles
    • Walz S, Lorenzin F, Morton J, Wiese KE, von Eyss B, Herold S, et al. Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles. Nature (2014) 511:483-7. doi:10.1038/nature13473
    • (2014) Nature , vol.511 , pp. 483-487
    • Walz, S.1    Lorenzin, F.2    Morton, J.3    Wiese, K.E.4    von Eyss, B.5    Herold, S.6
  • 46
    • 84925400202 scopus 로고    scopus 로고
    • Taming of the beast: shaping Myc-dependent amplification
    • Wolf E, Lin CY, Eilers M, Levens DL. Taming of the beast: shaping Myc-dependent amplification. Trends Cell Biol (2015) 25:241-8. doi:10.1016/j.tcb.2014.10.006
    • (2015) Trends Cell Biol , vol.25 , pp. 241-248
    • Wolf, E.1    Lin, C.Y.2    Eilers, M.3    Levens, D.L.4
  • 47
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 126:663-76. doi:10.1016/j.cell.2006.07.024
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 48
    • 84890470353 scopus 로고    scopus 로고
    • HER2/Neu tumorigenesis and metastasis is regulated by E2F activator transcription factors
    • Andrechek ER. HER2/Neu tumorigenesis and metastasis is regulated by E2F activator transcription factors. Oncogene (2015) 34:217-25. doi:10.1038/onc.2013.540
    • (2015) Oncogene , vol.34 , pp. 217-225
    • Andrechek, E.R.1
  • 50
    • 65249109840 scopus 로고    scopus 로고
    • Inhibition of Myc-induced cell transformation by brain acid-soluble protein 1 (BASP1)
    • Hartl M, Nist A, Khan MI, Valovka T, Bister K. Inhibition of Myc-induced cell transformation by brain acid-soluble protein 1 (BASP1). Proc Natl Acad Sci U S A (2009) 106:5604-9. doi:10.1073/pnas.0812101106
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 5604-5609
    • Hartl, M.1    Nist, A.2    Khan, M.I.3    Valovka, T.4    Bister, K.5
  • 51
    • 84907482159 scopus 로고    scopus 로고
    • AP4 is required for mitogen-and c-MYC-induced cell cycle progression
    • Jackstadt R, Hermeking H. AP4 is required for mitogen-and c-MYC-induced cell cycle progression. Oncotarget (2014) 5:7316-27. doi:10.18632/oncotarget.2348
    • (2014) Oncotarget , vol.5 , pp. 7316-7327
    • Jackstadt, R.1    Hermeking, H.2
  • 52
    • 79959663967 scopus 로고    scopus 로고
    • Bone morphogenetic protein-7 is a MYC target with prosurvival functions in childhood medulloblastoma
    • Fiaschetti G, Castelletti D, Zoller S, Schramm A, Schroeder C, Nagaishi M, et al. Bone morphogenetic protein-7 is a MYC target with prosurvival functions in childhood medulloblastoma. Oncogene (2011) 30:2823-35. doi:10.1038/onc.2011.10
    • (2011) Oncogene , vol.30 , pp. 2823-2835
    • Fiaschetti, G.1    Castelletti, D.2    Zoller, S.3    Schramm, A.4    Schroeder, C.5    Nagaishi, M.6
  • 53
    • 0035418188 scopus 로고    scopus 로고
    • Inverse regulation of cyclin B1 by c-MYC and p53 and induction of tetraploidy by cyclin B1 overexpression
    • Yin XY, Grove L, Datta NS, Katula K, Long MW, Prochownik EV. Inverse regulation of cyclin B1 by c-MYC and p53 and induction of tetraploidy by cyclin B1 overexpression. Cancer Res (2001) 61:6487-93.
    • (2001) Cancer Res , vol.61 , pp. 6487-6493
    • Yin, X.Y.1    Grove, L.2    Datta, N.S.3    Katula, K.4    Long, M.W.5    Prochownik, E.V.6
  • 54
    • 4444307411 scopus 로고    scopus 로고
    • Mouse development and cell proliferation in the absence of D-cyclins
    • Kozar K, Ciemerych MA, Rebel VI, Shigematsu H, Zagozdzon A, Sicinska E, et al. Mouse development and cell proliferation in the absence of D-cyclins. Cell (2004) 118:477-91. doi:10.1016/j.cell.2004.07.025
    • (2004) Cell , vol.118 , pp. 477-491
    • Kozar, K.1    Ciemerych, M.A.2    Rebel, V.I.3    Shigematsu, H.4    Zagozdzon, A.5    Sicinska, E.6
  • 55
    • 0030995824 scopus 로고    scopus 로고
    • Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F
    • Leone G, DeGregori J, Sears R, Jakoi L, Nevins JR. Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature (1997) 387:422-6. doi:10.1038/387422a0
    • (1997) Nature , vol.387 , pp. 422-426
    • Leone, G.1    DeGregori, J.2    Sears, R.3    Jakoi, L.4    Nevins, J.R.5
  • 56
    • 0029779280 scopus 로고    scopus 로고
    • Cdc25 cell-cycle phosphatase as a target of c-myc
    • Galaktionov K, Chen X, Beach D. Cdc25 cell-cycle phosphatase as a target of c-myc. Nature (1996) 382:511-7. doi:10.1038/382511a0
    • (1996) Nature , vol.382 , pp. 511-517
    • Galaktionov, K.1    Chen, X.2    Beach, D.3
  • 57
    • 4344631708 scopus 로고    scopus 로고
    • Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues
    • Miliani de Marval PL, Macias E, Rounbehler R, Sicinski P, Kiyokawa H, Johnson DG, et al. Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues. Mol Cell Biol (2004) 24:7538-47. doi:10.1128/MCB.24.17.7538-7547.2004
    • (2004) Mol Cell Biol , vol.24 , pp. 7538-7547
    • Miliani de Marval, P.L.1    Macias, E.2    Rounbehler, R.3    Sicinski, P.4    Kiyokawa, H.5    Johnson, D.G.6
  • 60
    • 2442477691 scopus 로고    scopus 로고
    • Direct activation of HSP90A transcription by c-MYC contributes to c-MYC-induced transformation
    • Teng SC, Chen YY, Su YN, Chou PC, Chiang YC, Tseng SF, et al. Direct activation of HSP90A transcription by c-MYC contributes to c-MYC-induced transformation. J Biol Chem (2004) 279:14649-55. doi:10.1074/jbc.M308842200
    • (2004) J Biol Chem , vol.279 , pp. 14649-14655
    • Teng, S.C.1    Chen, Y.Y.2    Su, Y.N.3    Chou, P.C.4    Chiang, Y.C.5    Tseng, S.F.6
  • 61
    • 77649253330 scopus 로고    scopus 로고
    • Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model
    • Yustein JT, Liu YC, Gao P, Jie C, Le A, Vuica-Ross M, et al. Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model. Proc Natl Acad Sci U S A (2010) 107:3534-9. doi:10.1073/pnas.0901230107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 3534-3539
    • Yustein, J.T.1    Liu, Y.C.2    Gao, P.3    Jie, C.4    Le, A.5    Vuica-Ross, M.6
  • 62
    • 21344455515 scopus 로고    scopus 로고
    • The Myc target gene JPO1/CDCA7 is frequently overexpressed in human tumors and has limited transforming activity in vivo
    • Osthus RC, Karim B, Prescott JE, Smith BD, McDevitt M, Huso DL, et al. The Myc target gene JPO1/CDCA7 is frequently overexpressed in human tumors and has limited transforming activity in vivo. Cancer Res (2005) 65:5620-7. doi:10.1158/0008-5472.CAN-05-0536
    • (2005) Cancer Res , vol.65 , pp. 5620-5627
    • Osthus, R.C.1    Karim, B.2    Prescott, J.E.3    Smith, B.D.4    McDevitt, M.5    Huso, D.L.6
  • 64
    • 84960364267 scopus 로고    scopus 로고
    • Loss of a single Mcl-1 allele inhibits MYC-driven lymphomagenesis by sensitizing pro-B cells to apoptosis
    • Grabow S, Delbridge AR, Aubrey BJ, Vandenberg CJ, Strasser A. Loss of a single Mcl-1 allele inhibits MYC-driven lymphomagenesis by sensitizing pro-B cells to apoptosis. Cell Rep (2016) 14:2337-47. doi:10.1016/j.celrep.2016.02.039
    • (2016) Cell Rep , vol.14 , pp. 2337-2347
    • Grabow, S.1    Delbridge, A.R.2    Aubrey, B.J.3    Vandenberg, C.J.4    Strasser, A.5
  • 65
    • 21244446630 scopus 로고    scopus 로고
    • A novel Myc-target gene, mimitin, that is involved in cell proliferation of esophageal squamous cell carcinoma
    • Tsuneoka M, Teye K, Arima N, Soejima M, Otera H, Ohashi K, et al. A novel Myc-target gene, mimitin, that is involved in cell proliferation of esophageal squamous cell carcinoma. J Biol Chem (2005) 280:19977-85. doi:10.1074/jbc.M501231200
    • (2005) J Biol Chem , vol.280 , pp. 19977-19985
    • Tsuneoka, M.1    Teye, K.2    Arima, N.3    Soejima, M.4    Otera, H.5    Ohashi, K.6
  • 66
    • 25444508476 scopus 로고    scopus 로고
    • Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein
    • Zhang XY, DeSalle LM, Patel JH, Capobianco AJ, Yu D, Thomas-Tikhonenko A, et al. Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein. Proc Natl Acad Sci U S A (2005) 102:13968-73. doi:10.1073/pnas.0502330102
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 13968-13973
    • Zhang, X.Y.1    DeSalle, L.M.2    Patel, J.H.3    Capobianco, A.J.4    Yu, D.5    Thomas-Tikhonenko, A.6
  • 68
    • 57749116048 scopus 로고    scopus 로고
    • Nucleophosmin interacts directly with c-MYC and controls c-MYC-induced hyperproliferation and transformation
    • Li Z, Boone D, Hann SR. Nucleophosmin interacts directly with c-MYC and controls c-MYC-induced hyperproliferation and transformation. Proc Natl Acad Sci U S A (2008) 105:18794-9. doi:10.1073/pnas.0806879105
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 18794-18799
    • Li, Z.1    Boone, D.2    Hann, S.R.3
  • 69
    • 21144448938 scopus 로고    scopus 로고
    • Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation
    • Nilsson JA, Keller UB, Baudino TA, Yang C, Norton S, Old JA, et al. Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation. Cancer Cell (2005) 7:433-44. doi:10.1016/j.ccr.2005.03.036
    • (2005) Cancer Cell , vol.7 , pp. 433-444
    • Nilsson, J.A.1    Keller, U.B.2    Baudino, T.A.3    Yang, C.4    Norton, S.5    Old, J.A.6
  • 70
    • 84965049886 scopus 로고    scopus 로고
    • Pin1 is required for sustained B cell proliferation upon oncogenic activation of Myc
    • D'Artista L, Bisso A, Piontini A, Doni M, Verrecchia A, Kress TR, et al. Pin1 is required for sustained B cell proliferation upon oncogenic activation of Myc. Oncotarget (2016). doi:10.18632/oncotarget.7846
    • (2016) Oncotarget
    • D'Artista, L.1    Bisso, A.2    Piontini, A.3    Doni, M.4    Verrecchia, A.5    Kress, T.R.6
  • 71
    • 0035910515 scopus 로고    scopus 로고
    • Prothymosin alpha functions as a cellular oncoprotein by inducing transformation of rodent fibroblasts in vitro
    • Orre RS, Cotter MA II, Subramanian C, Robertson ES. Prothymosin alpha functions as a cellular oncoprotein by inducing transformation of rodent fibroblasts in vitro. J Biol Chem (2001) 276:1794-9. doi:10.1074/jbc.M008560200
    • (2001) J Biol Chem , vol.276 , pp. 1794-1799
    • Orre, R.S.1    Cotter, M.A.2    Subramanian, C.3    Robertson, E.S.4
  • 72
    • 0037076433 scopus 로고    scopus 로고
    • The c-MYC target gene PRDX3 is required for mitochondrial homeostasis and neoplastic transformation
    • Wonsey DR, Zeller KI, Dang CV. The c-MYC target gene PRDX3 is required for mitochondrial homeostasis and neoplastic transformation. Proc Natl Acad Sci U S A (2002) 99:6649-54. doi:10.1073/pnas.102523299
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 6649-6654
    • Wonsey, D.R.1    Zeller, K.I.2    Dang, C.V.3
  • 73
    • 84933282444 scopus 로고    scopus 로고
    • MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis
    • Koh CM, Bezzi M, Low DH, Ang WX, Teo SX, Gay FP, et al. MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis. Nature (2015) 523:96-100. doi:10.1038/nature14351
    • (2015) Nature , vol.523 , pp. 96-100
    • Koh, C.M.1    Bezzi, M.2    Low, D.H.3    Ang, W.X.4    Teo, S.X.5    Gay, F.P.6
  • 74
    • 33644770587 scopus 로고    scopus 로고
    • Activation of transferrin receptor 1 by c-MYC enhances cellular proliferation and tumorigenesis
    • O'Donnell KA, Yu D, Zeller KI, Kim JW, Racke F, Thomas-Tikhonenko A, et al. Activation of transferrin receptor 1 by c-MYC enhances cellular proliferation and tumorigenesis. Mol Cell Biol (2006) 26:2373-86. doi:10.1128/MCB.26.6.2373-2386.2006
    • (2006) Mol Cell Biol , vol.26 , pp. 2373-2386
    • O'Donnell, K.A.1    Yu, D.2    Zeller, K.I.3    Kim, J.W.4    Racke, F.5    Thomas-Tikhonenko, A.6
  • 75
    • 0032954035 scopus 로고    scopus 로고
    • The tmp gene, encoding a membrane protein, is a c-MYC target with a tumorigenic activity
    • Ben-Porath I, Yanuka O, Benvenisty N. The tmp gene, encoding a membrane protein, is a c-MYC target with a tumorigenic activity. Mol Cell Biol (1999) 19:3529-39. doi:10.1128/MCB.19.5.3529
    • (1999) Mol Cell Biol , vol.19 , pp. 3529-3539
    • Ben-Porath, I.1    Yanuka, O.2    Benvenisty, N.3
  • 76
    • 33947257902 scopus 로고    scopus 로고
    • WS5, a direct target of oncogenic transcription factor Myc, is related to human melanoma glycoprotein genes and has oncogenic potential
    • Reiter F, Hartl M, Karagiannidis AI, Bister K. WS5, a direct target of oncogenic transcription factor Myc, is related to human melanoma glycoprotein genes and has oncogenic potential. Oncogene (2007) 26:1769-79. doi:10.1038/sj.onc.1209975
    • (2007) Oncogene , vol.26 , pp. 1769-1779
    • Reiter, F.1    Hartl, M.2    Karagiannidis, A.I.3    Bister, K.4
  • 77
    • 84921804444 scopus 로고    scopus 로고
    • Mitochondrial p32 is upregulated in Myc expressing brain cancers and mediates glutamine addiction
    • Fogal V, Babic I, Chao Y, Pastorino S, Mukthavaram R, Jiang P, et al. Mitochondrial p32 is upregulated in Myc expressing brain cancers and mediates glutamine addiction. Oncotarget (2015) 6:1157-70. doi:10.18632/oncotarget.2708
    • (2015) Oncotarget , vol.6 , pp. 1157-1170
    • Fogal, V.1    Babic, I.2    Chao, Y.3    Pastorino, S.4    Mukthavaram, R.5    Jiang, P.6
  • 78
    • 33744912772 scopus 로고    scopus 로고
    • The c-MYC oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis
    • Barsyte-Lovejoy D, Lau SK, Boutros PC, Khosravi F, Jurisica I, Andrulis IL, et al. The c-MYC oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis. Cancer Res (2006) 66:5330-7. doi:10.1158/0008-5472.CAN-06-0037
    • (2006) Cancer Res , vol.66 , pp. 5330-5337
    • Barsyte-Lovejoy, D.1    Lau, S.K.2    Boutros, P.C.3    Khosravi, F.4    Jurisica, I.5    Andrulis, I.L.6
  • 79
    • 0033613854 scopus 로고    scopus 로고
    • Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC
    • Wu KJ, Polack A, Dalla-Favera R. Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC. Science (1999) 283:676-9. doi:10.1126/science.283.5402.676
    • (1999) Science , vol.283 , pp. 676-679
    • Wu, K.J.1    Polack, A.2    Dalla-Favera, R.3
  • 80
    • 0041884865 scopus 로고    scopus 로고
    • The growth-inhibitory Ndrg1 gene is a Myc negative target in human neuroblastomas and other cell types with overexpressed N-or c-myc
    • Li J, Kretzner L. The growth-inhibitory Ndrg1 gene is a Myc negative target in human neuroblastomas and other cell types with overexpressed N-or c-myc. Mol Cell Biochem (2003) 250:91-105. doi:10.1023/A:1024918328162
    • (2003) Mol Cell Biochem , vol.250 , pp. 91-105
    • Li, J.1    Kretzner, L.2
  • 81
    • 84923365961 scopus 로고    scopus 로고
    • Loss of PRDM11 promotes MYC-driven lymphomagenesis
    • Fog CK, Asmar F, Côme C, Jensen KT, Johansen JV, Kheir TB, et al. Loss of PRDM11 promotes MYC-driven lymphomagenesis. Blood (2015) 125:1272-81. doi:10.1182/blood-2014-03-560805
    • (2015) Blood , vol.125 , pp. 1272-1281
    • Fog, C.K.1    Asmar, F.2    Côme, C.3    Jensen, K.T.4    Johansen, J.V.5    Kheir, T.B.6
  • 82
    • 27844605411 scopus 로고    scopus 로고
    • Onzin, a c-MYC-repressed target, promotes survival and transformation by modulating the Akt-Mdm2-p53 pathway
    • Rogulski K, Li Y, Rothermund K, Pu L, Watkins S, Yi F, et al. Onzin, a c-MYC-repressed target, promotes survival and transformation by modulating the Akt-Mdm2-p53 pathway. Oncogene (2005) 24:7524-41. doi:10.1038/sj.onc.1208897
    • (2005) Oncogene , vol.24 , pp. 7524-7541
    • Rogulski, K.1    Li, Y.2    Rothermund, K.3    Pu, L.4    Watkins, S.5    Yi, F.6
  • 83
    • 84930083608 scopus 로고    scopus 로고
    • Thrombospondin-1 repression is mediated via distinct mechanisms in fibroblasts and epithelial cells
    • Watnick RS, Rodriguez RK, Wang S, Blois AL, Rangarajan A, Ince T, et al. Thrombospondin-1 repression is mediated via distinct mechanisms in fibroblasts and epithelial cells. Oncogene (2015) 34:2823-35. doi:10.1038/onc.2014.228
    • (2015) Oncogene , vol.34 , pp. 2823-2835
    • Watnick, R.S.1    Rodriguez, R.K.2    Wang, S.3    Blois, A.L.4    Rangarajan, A.5    Ince, T.6
  • 84
    • 84928544717 scopus 로고    scopus 로고
    • Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP
    • Shen L, O'Shea JM, Kaadige MR, Cunha S, Wilde BR, Cohen AL, et al. Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP. Proc Natl Acad Sci U S A (2015) 112:5425-30. doi:10.1073/pnas.1501555112
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 5425-5430
    • Shen, L.1    O'Shea, J.M.2    Kaadige, M.R.3    Cunha, S.4    Wilde, B.R.5    Cohen, A.L.6
  • 85
    • 84938847446 scopus 로고    scopus 로고
    • MYC-repressed long noncoding RNAs antagonize MYC-induced cell proliferation and cell cycle progression
    • Kim T, Cui R, Jeon YJ, Fadda P, Alder H, Croce CM. MYC-repressed long noncoding RNAs antagonize MYC-induced cell proliferation and cell cycle progression. Oncotarget (2015) 6:18780-9. doi:10.18632/oncotarget.3909
    • (2015) Oncotarget , vol.6 , pp. 18780-18789
    • Kim, T.1    Cui, R.2    Jeon, Y.J.3    Fadda, P.4    Alder, H.5    Croce, C.M.6
  • 86
    • 84896508973 scopus 로고    scopus 로고
    • Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5
    • Kim T, Cui R, Jeon YJ, Lee JH, Lee JH, Sim H, et al. Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5. Proc Natl Acad Sci U S A (2014) 111:4173-8. doi:10.1073/pnas.1400350111
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 4173-4178
    • Kim, T.1    Cui, R.2    Jeon, Y.J.3    Lee, J.H.4    Lee, J.H.5    Sim, H.6
  • 88
    • 79952822367 scopus 로고    scopus 로고
    • Targeting MYC-regulated miRNAs to combat cancer
    • Frenzel A, Lovén J, Henriksson MA. Targeting MYC-regulated miRNAs to combat cancer. Genes Cancer (2010) 1:660-7. doi:10.1177/1947601910377488
    • (2010) Genes Cancer , vol.1 , pp. 660-667
    • Frenzel, A.1    Lovén, J.2    Henriksson, M.A.3
  • 89
    • 79952694643 scopus 로고    scopus 로고
    • Myc: maestro of microRNAs
    • Bui TV, Mendell JT. Myc: maestro of microRNAs. Genes Cancer (2010) 1:568-75. doi:10.1177/1947601910377491
    • (2010) Genes Cancer , vol.1 , pp. 568-575
    • Bui, T.V.1    Mendell, J.T.2
  • 90
    • 84934434980 scopus 로고    scopus 로고
    • Methods to quantify microRNAs in the Myc gene network for posttranscriptional gene repression
    • Song R, Sponer N, He L. Methods to quantify microRNAs in the Myc gene network for posttranscriptional gene repression. Methods Mol Biol (2013) 1012:135-44. doi:10.1007/978-1-62703-429-6_10
    • (2013) Methods Mol Biol , vol.1012 , pp. 135-144
    • Song, R.1    Sponer, N.2    He, L.3
  • 91
    • 84892615509 scopus 로고    scopus 로고
    • c-MYC-miRNA circuitry: a central regulator of aggressive B-cell malignancies
    • Tao J, Zhao X, Tao J. c-MYC-miRNA circuitry: a central regulator of aggressive B-cell malignancies. Cell Cycle (2014) 13:191-8. doi:10.4161/cc.27646
    • (2014) Cell Cycle , vol.13 , pp. 191-198
    • Tao, J.1    Zhao, X.2    Tao, J.3
  • 92
    • 48249098902 scopus 로고    scopus 로고
    • Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM
    • Fontana L, Fiori ME, Albini S, Cifaldi L, Giovinazzi S, Forloni M, et al. Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM. PLoS One (2008) 3:e2236. doi:10.1371/journal.pone.0002236
    • (2008) PLoS One , vol.3
    • Fontana, L.1    Fiori, M.E.2    Albini, S.3    Cifaldi, L.4    Giovinazzi, S.5    Forloni, M.6
  • 93
    • 70349320158 scopus 로고    scopus 로고
    • Causes and consequences of microRNA dysregulation in cancer
    • Croce CM. Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet (2009) 10:704-14. doi:10.1038/nrg2634
    • (2009) Nat Rev Genet , vol.10 , pp. 704-714
    • Croce, C.M.1
  • 94
    • 84875211731 scopus 로고    scopus 로고
    • Cancer heterogeneity: implications for targeted therapeutics
    • Fisher R, Pusztai L, Swanton C. Cancer heterogeneity: implications for targeted therapeutics. Br J Cancer (2013) 108:479-85. doi:10.1038/bjc.2012.581
    • (2013) Br J Cancer , vol.108 , pp. 479-485
    • Fisher, R.1    Pusztai, L.2    Swanton, C.3
  • 95
    • 85027932352 scopus 로고    scopus 로고
    • Distinct metabolic responses of an ovarian cancer stem cell line
    • Vermeersch KA, Wang L, McDonald JF, Styczynski MP. Distinct metabolic responses of an ovarian cancer stem cell line. BMC Syst Biol (2014) 8:134. doi:10.1186/s12918-014-0134-y
    • (2014) BMC Syst Biol , vol.8 , pp. 134
    • Vermeersch, K.A.1    Wang, L.2    McDonald, J.F.3    Styczynski, M.P.4
  • 96
    • 84921810171 scopus 로고    scopus 로고
    • The butterfly effect in cancer: a single base mutation can remodel the cell
    • Hart JR, Zhang Y, Liao L, Ueno L, Du L, Jonkers M, et al. The butterfly effect in cancer: a single base mutation can remodel the cell. Proc Natl Acad Sci U S A (2015) 112:1131-6. doi:10.1073/pnas.1424012112
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 1131-1136
    • Hart, J.R.1    Zhang, Y.2    Liao, L.3    Ueno, L.4    Du, L.5    Jonkers, M.6
  • 97
    • 0033057439 scopus 로고    scopus 로고
    • Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: transformation of a host with epithelial features by c-MYC and the zinc finger protein GKLF1
    • Foster KW, Ren S, Louro ID, Lobo-Ruppert SM, McKie-Bell P, Grizzle W, et al. Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: transformation of a host with epithelial features by c-MYC and the zinc finger protein GKLF1. Cell Growth Differ (1999) 10:423-34.
    • (1999) Cell Growth Differ , vol.10 , pp. 423-434
    • Foster, K.W.1    Ren, S.2    Louro, I.D.3    Lobo-Ruppert, S.M.4    McKie-Bell, P.5    Grizzle, W.6
  • 98
    • 0036742061 scopus 로고    scopus 로고
    • Functional cloning using pFB retroviral cDNA expression libraries
    • Felts KA, Chen K, Zaharee K, Sundar L, Limjoco J, Miller A, et al. Functional cloning using pFB retroviral cDNA expression libraries. Mol Biotechnol (2002) 22:25-32. doi:10.1385/MB:22:1:025
    • (2002) Mol Biotechnol , vol.22 , pp. 25-32
    • Felts, K.A.1    Chen, K.2    Zaharee, K.3    Sundar, L.4    Limjoco, J.5    Miller, A.6
  • 99
    • 34547638047 scopus 로고    scopus 로고
    • Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
    • Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature (2007) 448:561-6. doi:10.1038/nature05945
    • (2007) Nature , vol.448 , pp. 561-566
    • Soda, M.1    Choi, Y.L.2    Enomoto, M.3    Takada, S.4    Yamashita, Y.5    Ishikawa, S.6
  • 100
  • 101
    • 0035980805 scopus 로고    scopus 로고
    • Generation of RCAS vectors useful for functional genomic analyses
    • Loftus SK, Larson DM, Watkins-Chow D, Church DM, Pavan WJ. Generation of RCAS vectors useful for functional genomic analyses. DNA Res (2001) 8:216-21. doi:10.1093/dnares/8.5.221
    • (2001) DNA Res , vol.8 , pp. 216-221
    • Loftus, S.K.1    Larson, D.M.2    Watkins-Chow, D.3    Church, D.M.4    Pavan, W.J.5
  • 102
    • 84876438259 scopus 로고    scopus 로고
    • Towards optimising the production of and expression from polycistronic vectors in embryonic stem cells
    • Gao SY, Jack MM, O'Neill C. Towards optimising the production of and expression from polycistronic vectors in embryonic stem cells. PLoS One (2012) 7:e48668. doi:10.1371/journal.pone.0048668
    • (2012) PLoS One , vol.7
    • Gao, S.Y.1    Jack, M.M.2    O'Neill, C.3
  • 103
    • 84904468142 scopus 로고    scopus 로고
    • Harnessing CRISPR-Cas9 immunity for genetic engineering
    • Charpentier E, Marraffini LA. Harnessing CRISPR-Cas9 immunity for genetic engineering. Curr Opin Microbiol (2014) 19C:114-9. doi:10.1016/j.mib.2014.07.001
    • (2014) Curr Opin Microbiol , vol.19C , pp. 114-119
    • Charpentier, E.1    Marraffini, L.A.2
  • 104
    • 84913594397 scopus 로고    scopus 로고
    • Genome editing. The new frontier of genome engineering with CRISPR-Cas9
    • Doudna JA, Charpentier E. Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Science (2014) 346:6213. doi:10.1126/science.1258096
    • (2014) Science , vol.346 , pp. 6213
    • Doudna, J.A.1    Charpentier, E.2
  • 105
    • 79959712087 scopus 로고    scopus 로고
    • Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health
    • Chappell WH, Steelman LS, Long JM, Kempf RC, Abrams SL, Franklin RA, et al. Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health. Oncotarget (2011) 2:135-64. doi:10.18632/oncotarget.240
    • (2011) Oncotarget , vol.2 , pp. 135-164
    • Chappell, W.H.1    Steelman, L.S.2    Long, J.M.3    Kempf, R.C.4    Abrams, S.L.5    Franklin, R.A.6
  • 106
    • 84955287687 scopus 로고    scopus 로고
    • PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: structural and pharmacological perspectives
    • Asati V, Mahapatra DK, Bharti SK. PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: structural and pharmacological perspectives. Eur J Med Chem (2016) 109:314-41. doi:10.1016/j.ejmech.2016.01.012
    • (2016) Eur J Med Chem , vol.109 , pp. 314-341
    • Asati, V.1    Mahapatra, D.K.2    Bharti, S.K.3
  • 107
    • 84920423504 scopus 로고    scopus 로고
    • An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma
    • Baratta MG, Schinzel AC, Zwang Y, Bandopadhayay P, Bowman-Colin C, Kutt J, et al. An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma. Proc Natl Acad Sci U S A (2015) 112:232-7. doi:10.1073/pnas.1422165112
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 232-237
    • Baratta, M.G.1    Schinzel, A.C.2    Zwang, Y.3    Bandopadhayay, P.4    Bowman-Colin, C.5    Kutt, J.6
  • 108
    • 84940890937 scopus 로고    scopus 로고
    • Ectopic expression of miR-494 inhibited the proliferation, invasion and chemoresistance of pancreatic cancer by regulating SIRT1 and c-Myc
    • Liu Y, Li X, Zhu S, Zhang JG, Yang M, Qin Q, et al. Ectopic expression of miR-494 inhibited the proliferation, invasion and chemoresistance of pancreatic cancer by regulating SIRT1 and c-Myc. Gene Ther (2015) 22:729-38. doi:10.1038/gt.2015.39
    • (2015) Gene Ther , vol.22 , pp. 729-738
    • Liu, Y.1    Li, X.2    Zhu, S.3    Zhang, J.G.4    Yang, M.5    Qin, Q.6
  • 109
    • 84907303705 scopus 로고    scopus 로고
    • Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis
    • Annibali D, Whitfield JR, Favuzzi E, Jauset T, Serrano E, Cuartas I, et al. Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis. Nat Commun (2014) 5:4632. doi:10.1038/ncomms5632
    • (2014) Nat Commun , vol.5 , pp. 4632
    • Annibali, D.1    Whitfield, J.R.2    Favuzzi, E.3    Jauset, T.4    Serrano, E.5    Cuartas, I.6
  • 110
    • 84927582243 scopus 로고    scopus 로고
    • Perturbation of the c-MYC-Max protein-protein interaction via synthetic α-helix mimetics
    • Jung KY, Wang H, Teriete P, Yap JL, Chen L, Lanning ME, et al. Perturbation of the c-MYC-Max protein-protein interaction via synthetic α-helix mimetics. J Med Chem (2015) 58:3002-24. doi:10.1021/jm501440q
    • (2015) J Med Chem , vol.58 , pp. 3002-3024
    • Jung, K.Y.1    Wang, H.2    Teriete, P.3    Yap, J.L.4    Chen, L.5    Lanning, M.E.6
  • 111
    • 84930536733 scopus 로고    scopus 로고
    • Growth-promoting and tumourigenic activity of c-MYC is suppressed by Hhex
    • Marfil V, Blazquez M, Serrano F, Castell JV, Bort R. Growth-promoting and tumourigenic activity of c-MYC is suppressed by Hhex. Oncogene (2015) 34:3011-22. doi:10.1038/onc.2014.240
    • (2015) Oncogene , vol.34 , pp. 3011-3022
    • Marfil, V.1    Blazquez, M.2    Serrano, F.3    Castell, J.V.4    Bort, R.5
  • 112
    • 84906674331 scopus 로고    scopus 로고
    • Inhibitor of MYC identified in a Kröhnke pyridine library
    • Hart JR, Garner AL, Yu J, Ito Y, Sun M, Ueno L, et al. Inhibitor of MYC identified in a Kröhnke pyridine library. Proc Natl Acad Sci U S A (2014) 111:12556-61. doi:10.1073/pnas.1319488111
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 12556-12561
    • Hart, J.R.1    Garner, A.L.2    Yu, J.3    Ito, Y.4    Sun, M.5    Ueno, L.6
  • 113
    • 84910070397 scopus 로고    scopus 로고
    • In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential
    • Raffeiner P, Röck R, Schraffl A, Hartl M, Hart JR, Janda KD, et al. In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential. Oncotarget (2014) 5:8869-78. doi:10.18632/oncotarget.2588
    • (2014) Oncotarget , vol.5 , pp. 8869-8878
    • Raffeiner, P.1    Röck, R.2    Schraffl, A.3    Hartl, M.4    Hart, J.R.5    Janda, K.D.6
  • 114
    • 79955592811 scopus 로고    scopus 로고
    • Harnessing synthetic lethal interactions in anticancer drug discovery
    • Chan DA, Giaccia AJ. Harnessing synthetic lethal interactions in anticancer drug discovery. Nat Rev Drug Discov (2011) 10:351-64. doi:10.1038/nrd3374
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 351-364
    • Chan, D.A.1    Giaccia, A.J.2
  • 115
    • 84861171712 scopus 로고    scopus 로고
    • Targeting synthetic lethal interactions between Myc and the eIF4F complex impedes tumorigenesis
    • Lin CJ, Nasr Z, Premsrirut PK, Porco JA Jr, Hippo Y, Lowe SW, et al. Targeting synthetic lethal interactions between Myc and the eIF4F complex impedes tumorigenesis. Cell Rep (2012) 1:325-33. doi:10.1016/j.celrep.2012.02.010
    • (2012) Cell Rep , vol.1 , pp. 325-333
    • Lin, C.J.1    Nasr, Z.2    Premsrirut, P.K.3    Porco, J.A.4    Hippo, Y.5    Lowe, S.W.6
  • 116
    • 84892448216 scopus 로고    scopus 로고
    • Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells
    • Kang J, Sergio CM, Sutherland RL, Musgrove EA. Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells. BMC Cancer (2014) 14:32. doi:10.1186/1471-2407-14-32
    • (2014) BMC Cancer , vol.14 , pp. 32
    • Kang, J.1    Sergio, C.M.2    Sutherland, R.L.3    Musgrove, E.A.4
  • 117
    • 84924360464 scopus 로고    scopus 로고
    • Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening
    • Zhou Z, Patel M, Ng N, Hsieh MH, Orth AP, Walker JR, et al. Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening. BMC Cancer (2014) 14:944. doi:10.1186/1471-2407-14-944
    • (2014) BMC Cancer , vol.14 , pp. 944
    • Zhou, Z.1    Patel, M.2    Ng, N.3    Hsieh, M.H.4    Orth, A.P.5    Walker, J.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.