Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity

European Journal of Immunology

Volumn 46, Issue 8, 2016, Pages 1970-1983

  Gerriets, Valerie A ^a   Danzaki, Keiko ^a   Kishton, Rigel J ^a   Eisner, William ^a   Nichols, Amanda G ^a   Saucillo, Donte C ^a   Shinohara, Mari L ^a   MacIver, Nancie J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

EAE; Glucose metabolism; HIF 1 ; Leptin; Malnutrition; Th17; Treg cells

Indexed keywords

CD4 ANTIGEN; CD69 ANTIGEN; GAMMA INTERFERON; GLUCOSE; GLUTAMINE; GLYCOLYTIC ENZYME; HERMES ANTIGEN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 17; INTERLEUKIN 2 RECEPTOR ALPHA; LEPTIN; LEPTIN RECEPTOR;

ABNORMALLY LOW SUBSTRATE CONCENTRATION IN BLOOD; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CALORIC RESTRICTION; CD4+ T LYMPHOCYTE; CELL METABOLISM; CELL SURVIVAL; CELL VIABILITY; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIET RESTRICTION; DISEASE SEVERITY; EFFECTOR CELL; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOLYSIS; HYPOLEPTINEMIA; IMMUNITY; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MALNUTRITION; MITOCHONDRIAL RESPIRATION; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; NUTRITIONAL STATUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; TH1 CELL; TH17 CELL;

EID: 84982151724     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201545861     Document Type: Article

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