Slowing down fat digestion and absorption by an oxadiazolone inhibitor targeting selectively gastric lipolysis

European Journal of Medicinal Chemistry

Volumn 123, Issue , 2016, Pages 834-848

  Point, Vanessa ^a   Bénarouche, Anais ^a   Zarrillo, Julie ^a   Guy, Alexandre ^a   Magnez, Romain ^c   Fonseca, Laurence ^c   Raux, Brigitt ^a   Leclaire, Julien ^b,d   Buono, Gérard ^b   Fotiadu, Frédéric ^b   Durand, Thierry ^a   Carrière, Frédéric ^a   Vaysse, Carole ^c   Couëdelo, Leslie ^c   Cavalier, Jean François ^a  

^a CNRS   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

^c UNIVERSITÉ DE BORDEAUX   (France)

^d UNIVERSITÉ LYON 1   (France)

Author keywords

Digestive enzyme; Enzyme inhibition; Gastrointestinal digestion; Intestinal absorption; Lipases; Lymphatic lipids; Oxadiazolone

Indexed keywords

5 (2 ETHYLHEXYLOXY) 3 (3 PHENOXYPHENYL) 1,3,4 OXADIAZOL 2(3H)ONE; 5 (2 METHOXYETHOXY) 3 (3 PHENOXYPHENYL) 1,3,4 OXADIAZOL 2(3H)ONE; 5 ALKOXY N 3 (3 PHENOXY PHENYL) 1,3,4 OXADIAZOL 2(3H)ONE DERIVATIVE; 5 BUTYLOXY 3 (3 PHENOXYPHENYL) 1,3,4 OXADIAZOL 2(3H)ONE; 5 DECYLOXY 3 (3 PHENOXYPHENYL) 1,3,4 OXADIAZOL 2(3H)ONE; 5 DODECYLOXY 3 (3 PHENOXYPHENYL) 1,3,4 OXADIAZOL 2(3H)ONE; 5 ETHOXY 3 (3 PHENOXYPHENYL) 1,3,4 OXADIAZOL 2(3H)ONE; 5 HEXYLOXY 3 (3 PHENOXYPHENYL) 1,3,4 OXADIAZOL 2(3H)ONE; 5 ISOBUTOXY 3 (3 PHENOXYPHENYL) 1,3,4 OXADIAZOL 2(3H)ONE; 5 OCTYLOXY 3 (3 PHENOXYPHENYL) 1,3,4 OXADIAZOL 2(3H)ONE; 5 [2 (BENZYLOXY)ETHOXY] 3 (3 PHENOXYPHENYL) 1,3,4 OXADIAZOL 2(3H)ONE; ESTERASE INHIBITOR; FAT; FATTY ACID; PANCREAS EXTRACT; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; 1,3,4-OXADIAZOL-2(3H)-ONE; ENZYME INHIBITOR; OXADIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; LIPID ABSORPTION; LIPOLYSIS; MAXIMUM PLASMA CONCENTRATION; MOLECULAR DOCKING; MOLECULE; NONHUMAN; PANCREAS JUICE; RAT; STRUCTURE ACTIVITY RELATION; TEST MEAL; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DIGESTION; DOG; DRUG EFFECTS; GUINEA PIG; KINETICS; MALE; METABOLISM; PROTEIN CONFORMATION; STOMACH;

ANIMALS; DIGESTION; DOGS; ENZYME INHIBITORS; GUINEA PIGS; HUMANS; INTESTINAL ABSORPTION; KINETICS; LIPASE; LIPOLYSIS; MALE; MOLECULAR DOCKING SIMULATION; OXADIAZOLES; PROTEIN CONFORMATION; RATS; STOMACH;

EID: 84982094995     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2016.08.009     Document Type: Article

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