Hydrolysis of dietary fat by pancreatic lipase stimulates cholecystokinin release

Gastroenterology

Volumn 114, Issue 1, 1998, Pages 123-129

  Hildebrand, P ^a   Petrig, C ^a   Burckhardt, B ^a   Ketterer, S ^a   Lengsfeld, H ^a   Fleury, A ^a   Hadvary, P ^a   Beglinger, C ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLASE; CHOLECYSTOKININ RECEPTOR; ENZYME INHIBITOR; LIPASE INHIBITOR; TETRAHYDROLIPSTATIN; TRYPSIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; ENZYME ACTIVATION; FAT INTAKE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; HYDROLYSIS; HYPOTHESIS; LIPID METABOLISM; MALE; NEGATIVE FEEDBACK; NORMAL HUMAN; PANCREAS SECRETION; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

EID: 0031982587     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-5085(98)70640-7     Document Type: Article

References (34)

1. TE Solomon Control of exocrine pancreatic secretion 3rd ed LR Johnson Physiology of the gastrointestinal tract Volume 2 1994 Raven New York 1499 1529
2. AC Ivy The physiology of gall bladder Physiol Rev 14 1934 1 102
3. AA Harper HS Raper Pancreozymin, stimulant of secretion of pancreatic enzymes in extracts of small intestine J Physiol (Lond) 102 1943 115 125
4. RA Liddle IR Goldfine MS Rosen RA Taplitz JA Williams Cholecystokinin bioactivity in human plasma. Molecular forms, responses to feeding, and relationship to gallbladder contraction J Clin Invest 75 1985 1144 1152
5. JH Meyer RS Jones Canine pancreatic responses to intestinally perfused fat and products of fat digestion Am J Physiol 226 1974 1178 1187
6. A Tonkich Zur Physiologie des Pankreas Pflugers Arch Gesamte Physiol Menschen Tiere 206 1924 525 553
7. OB Schaffalitzky de Muckadell O Olsen P Cantor E Magid Concentrations of secretin and CCK in plasma and pancreaticobiliary secretion in response to intraduodenal acid and fat Pancreas 1 1986 536 543
8. AS Fink JH Meyer Intraduodenal emulsions of oleic acid augment acid-induced canine pancreatic secretion Am J Physiol 245 1983 G85 G891
9. S Watanabe KY Lee TM Chang L Berger-Ornstein WY Chey Role of pancreatic enzymes on release of cholecystokinin-pancreozymin in response to fat Am J Physiol 254 1988 G837 G842
10. P Hadváry H Lengsfeld H Wolfer Inhibition of pancreatic lipase in vitro by the covalent inhibitor tetrahydrolipstatin Biochem J 256 1988 357 361
11. B Borgström Mode of action of tetrahydrolipstatin: a derivative of the naturally occurring lipase inhibitor lipstatin Biochim Biophys Acta 962 1988 308 316
12. C Güzelhan HJMJ Crijns PAM Peters JHG Jonkman D Hartmann Pharmacological activity (inhibition of fat absorption) and tolerability in healthy volunteers of tetrahydrolipstatin (THL)—a specific lipase inhibitor (abstr) Int J Obesity 15 Suppl 1 1991 29
13. S Hydén A turbidimetric method for the determination of higher polyethylene glycols in biological materials Kungliga Lantbruk-shögskolans Annaler 22 1955 139 145
14. S Imamura T Hirayama T Arai K Takao H Misaki An enzymatic method using 1,2-diglyceride for pancreatic lipase test in serum (abstr) Clin Chem 35 1989 1126
15. W Rick H Stegbauer Zur Bestimmung der Amylaseaktivität im Harn Fresenius Z Anal Chem 243 1968 415 416
16. HS Wiggins Simple method for estimating trypsin Gut 8 1967 415 416
17. G Schellong U Wende A technic for standardization of methods in serum bilirubin determination Klin Wochenschr 38 1960 703 707
18. E Hashimura F Shimizu T Nishino K Imagawa K Tateishi T Hamaoka Production of rabbit antibody specific for aminoterminal residues of cholecystokinin octapeptide (CCK-8) by selective suppression of cross-reactive antibody response J Immunol Methods 55 1982 375 387
19. C Beglinger P Hildebrand R Meier P Bauerfeind H Hasslocher N Urscheler F Delco A Eberle K Gyr A physiological role for cholecystokinin as a regulator of gastrin secretion Gastroenterology 103 1992 490 495
20. IL Dolinsky Thesis 1928 in St. Petersburg 2nd ed BP Babkin Die äussere Sekretion der Verdauungsdrüsen 1984 Springer Berlin Cited in
21. AC Ivy E Oldberg A hormone mechanism for gallbladder contraction and evacuation Am J Physiol 86 1928 599 613
22. P Hildebrand C Beglinger K Gyr JBMJ Jansen LC Rovati M Zuercher CBHW Lamers I Setnikar GA Stalder Effects of a cholecystokinin receptor antagonist on intestinal phase of pancreatic and biliary responses in man J Clin Invest 85 1990 640 646
23. P Cantor PE Mortensen J Myhre I Gjorup H Worning E Stahl TT Survill The effect of the cholecystokinin receptor antagonist MK-329 on meal-stimulated pancreaticobiliary output in humans Gastroenterology 102 1992 1742 1751
24. BM Meyer BA Werth C Beglinger P Hildebrand JBMJ Jansen D Zach LC Rovati GA Stalder Role of cholecystokinin in regulation of gastrointestinal motor functions Lancet 2 1989 12 15
25. RA Liddle BJ Gertz S Kanayama L Beccaria LD Coker TT Turnbull ET Morita Effects of a novel cholecystokinin (CCK) receptor antagonist, MK 329, on gallbladder contraction and gastric emptying in humans. Implications for the physiology of CCK J Clin Invest 84 1989 1220 1225
26. RA Liddle Regulation of cholecystokinin secretion by intraluminal releasing factors Am J Physiol 269 1995 G319 G327
27. GM Green Feedback inhibition of cholecystokinin secretion by bile acids and pancreatic proteases Ann NY Acad Sci 713 1994 167 179
28. C Owyang D May DS Louie Trypsin suppression of pancreatic enzyme secretion. Differential effect on cholecystokinin release and the enteropancreatic reflex Gastroenterology 91 1986 637 643
29. HO Jin CW Song TM Chang WY Chey Roles of gut hormones in negative-feedback regulation of pancreatic exocrine secretion in humans Gastroenterology 107 1994 1828 1834
30. G Adler C Beglinger U Braun M Reinshagen I Koop A Schafmayer L Rovati R Arnold Interaction of the cholinergic system and cholecystokinin in the regulation of endogenous and exogenous stimulation of pancreatic secretion in humans Gastroenterology 100 1991 537 543
31. J Hotz SB Ho VLW Go EP DiMagno Short-term inhibition of duodenal tryptic activity does not affect human pancreatic, biliary, or gastric function J Lab Clin Med 101 1983 488 495
32. PWL Thimister WPM Hopman CEJ Sloots G Rosenbusch HL Willems FJM Trijbels JBMJ Jansen Role of intraduodenal proteases in plasma cholecystokinin and pancreaticobiliary responses to protein and amino acids Gastroenterology 110 1996 567 575
33. JR Malagelada EP DiMagno WHJ Summerskill VLW Go Regulation of pancreatic and gallbladder functions by intraluminal fatty acids and bile acids in man J Clin Invest 58 1976 493 499
34. G Gomez F Lluis YS Guo GH Greeley Jr CM Townsend Jr JC Thompson Bile inhibits release of cholecystokinin and neurotensin Surgery 100 1986 363 368