Analysis of the discriminative inhibition of mammalian digestive lipases by 3-phenyl substituted 1,3,4-oxadiazol-2(3H)-ones

European Journal of Medicinal Chemistry

Volumn 58, Issue , 2012, Pages 452-463

  Point, Vanessa ^a   Pavan Kumar, K V P ^b   Marc, Sylvain ^b   Delorme, Vincent ^a,b   Parsiegla, Goetz ^a   Amara, Sawsan ^a   Carrière, Frédéric ^a   Buono, Gérard ^b   Fotiadu, Frédéric ^b   Canaan, Stéphane ^a   Leclaire, Julien ^b   Cavalier, Jean François ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b Ecole Centrale Marseille   (France)

Author keywords

Enzyme; Enzyme inhibition; In silico molecular docking; Lipases; Oxadiazolone

Indexed keywords

1,3,4 OXADIAZOLE DERIVATIVE; 5 METHOXY 3 ( 3 PHENOXYPHENYL) 1,3,4 OXADIAZOL 2 (3H) ONE; 5 METHOXY 3 ( 4 PHENOXYPHENYL) 1,3,4 OXADIAZOL 2 (3H) ONE; 5 METHOXY 3 PHENYL 1,3,4 OXADIAZOL 2 (3H) ONE; DOG GASTRIC LIPASE; ESTERASE; ESTERASE INHIBITOR; GUINEA PIG PANCREATIC LIPASE RELATED PROTEIN 2; HUMAN PANCREATIC CARBOXYL ESTER HYDROLASE; HUMAN PANCREATIC LIPASE; HYDROLASE; PANCREAS EXTRACT; PHENYL GROUP; PORCINE PANCREATIC EXTRACT; PORCINE PANCREATIC LIPASE; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DRUG DISCRIMINATION; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME METABOLISM; FOOD AND DRUG ADMINISTRATION; GUINEA PIG; IN VITRO STUDY; LIPOLYSIS; MOLECULAR DOCKING; MOLECULAR INTERACTION; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GUINEA PIGS; HUMANS; LIPASE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXADIAZOLES; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84868704339     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.10.040     Document Type: Article

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