Physiological functions of Vitamin D in adipose tissue

Journal of Steroid Biochemistry and Molecular Biology

Volumn 165, Issue , 2017, Pages 369-381

  Abbas, Manal A ^a  

^a AL AHLIYYA AMMAN UNIVERSITY   (Jordan)

Author keywords

Adipogenesis; Adipokines; Adipose tissue; Obesity; VDR

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; CALCITRIOL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEPTIN; VITAMIN D; CALCITRIOL RECEPTOR; UNCOUPLING PROTEIN;

ADIPOGENESIS; ADIPOSE TISSUE; APOPTOSIS; CYTOKINE RELEASE; ENERGY METABOLISM; GENOMICS; INFLAMMATION; NONHUMAN; OBESITY; PROTEIN EXPRESSION; REVIEW; RISK FACTOR; SIGNAL TRANSDUCTION; ADIPOCYTE; ADOLESCENT; ADULT; AGED; ANIMAL; CELL MEMBRANE; CYTOLOGY; FEMALE; GENE EXPRESSION REGULATION; HUMAN; MALE; METABOLISM; MIDDLE AGED; MOUSE; NUCLEOCYTOPLASMIC TRANSPORT; PHYSIOLOGY; YOUNG ADULT;

ACTIVE TRANSPORT, CELL NUCLEUS; ADIPOCYTES; ADIPOGENESIS; ADIPOSE TISSUE; ADOLESCENT; ADULT; AGED; ANIMALS; APOPTOSIS; CALCITRIOL; CELL MEMBRANE; FEMALE; GENE EXPRESSION REGULATION; GENOMICS; HUMANS; INFLAMMATION; LEPTIN; MALE; MICE; MIDDLE AGED; MITOCHONDRIAL UNCOUPLING PROTEINS; OBESITY; RECEPTORS, CALCITRIOL; VITAMIN D; YOUNG ADULT;

EID: 84981717344     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2016.08.004     Document Type: Review

References (152)

1. [1] Human Physiology. Fox, S.I., (eds.), 12th ed., 2011, McGraw-Hill Companies, 687.
2. [2] DeLuca, H.F., Overview of general physiologic features and functions of vitamin D. Am. J. Clin. Nutr. 80:Suppl (2004), 1689S–1696S.
3. [3] Nagpal, S., Na, S., Rathnachalam, R., Noncalcemic actions of vitamin D receptor ligands. Endocr. Rev. 26:5 (2005), 662–687, 10.1210/er.2004-0002.
4. 3 from body fat: evidence for a storage site in the rat. J. Clin. Invest. 50 (1971), 679–687, 10.1172/JCI106538.
5. [5] Ching, S., Kashinkunti, S., Niehaus, M.D., Zinser, G.M., Mammary adipocytes bioactivate 25-hydroxyvitamin D and signal via vitamin D receptor, modulating mammary epithelial cell growth. J. Cell. Biochem. 112 (2011), 3393–3405, 10.1002/jcb.23273.
6. 3 hydroxylase in adipocytes. J. Steroid Biochem. Mol. Biol. 112:1–3 (2008), 122–126, 10.1016/j.jsbmb.2008.09.006.
7. [7] Ryynänen, J., Neme, A., Tuomainen, T.-P., Virtanen, J.K., Voutilainen, S., Nurmi, T., de Mello, V.D.F., Uusitupa, M., Carlberg, C., Changes in vitamin D target gene expression in adipose tissue monitor the vitamin D response of human individuals. Mol. Nutr. Food Res. 58 (2014), 2036–2045, 10.1002/mnfr.201400291.
8. 2) in humans. J. Clin. Endocrinol. Metab. 96 (2011), E447–452, 10.1210/jc.2010-2230.
9. [9] Mawer, E.B., Backhouse, J., Holman, C.A., Lumb, G.A., Stanbury, S.W., The distribution and storage of vitamin D and its metabolites in human tissues. Clin. Sci. 43 (1972), 413–431.
10. [10] Brouwer, D.A., van Beek, J., Ferwerda, H., Brugman, A.M., van der Klis, F.R., van der Heiden, H.J., Muskiet, F.A., Rat adipose tissue rapidly accumulates and slowly releases an orally-administered high vitamin D dose. Br. J. Nutr. 79 (1998), 527–532, 10.1079/BJN19980091.
11. 3 in muscle and adipose tissue of rats and man. Clin. Chim. Acta 157 (1986), 175–181, 10.1016/0009-8981(86)90223-8.
12. 3 in fat tissue. Endocrine 33:1 (2008), 90–94, 10.1007/s12020-008-9051-4.
13. [13] Malmberg, P., Karlsson, T., Svensson, H., Lِnn, M., Carlsson, N.-G., Sandberg, A.-S., Jennische, E., Osmancevic, A., Holmäng, A., A new approach to measuring vitamin D in human adipose tissue using time-of-flight secondary ion mass spectrometry: a pilot study. J. Photochem. Photobiol. B 138 (2014), 295–301, 10.1016/j.jphotobiol.2014.06.008.
14. [14] Wamberg, L., Christiansen, T., Paulsen, S.K., Fisker, S., Rask, P., Rejnmark, L., Richelsen, B., Pedersen, S.B., Expression of vitamin D-metabolizing enzymes in human adipose tissue-the effect of obesity and diet-induced weight loss. Int. J. Obes. 37 (2013), 651–657, 10.1038/ijo.2012.112.
15. 450 in human white adipose tissue: expression and induction. Drug Metab. Dispos. 38 (2010), 679–686, 10.1124/dmd.109.029249.
16. 2-1 alpha-hydroxylase in human health and disease. J. Steroid Biochem. Mol. Biol. 103 (2007), 316–321, 10.1016/j.jsbmb.2006.12.078.
17. 3 promote the differentiation of human subcutaneous preadipocytes. PLoS One, 7(12), 2012, e52171, 10.1371/journal.pone.0052171.
18. 3-24-hydroxylase, a multicatalytic enzyme. Biochemistry 35:25 (1996), 8465–8472, 10.1021/bi960658i.
19. [19] Jones, G., Prosser, D.E., Kaufmann, M., 25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): its important role in the degradation of vitamin D. Arch. Biochem. Biophys. 523 (2011), 9–18, 10.1016/j.abb.2011.11.003.
20. 3 in 3T3-L1 preadipocytes. Biochem. Biophys. Res. Commun. 193 (1993), 948–955, 10.1006/bbrc.1993.1717.
21. [21] Trayhurn, P., O'Hara, A., Bing, C., Interrogation of microarray datasets indicates that macrophage-secreted factors stimulate the expression of genes associated with vitamin D metabolism (VDR and CYP27B1) in human adipocytes. Adipobiology 3 (2011), 29–34, 10.14748/adipo.v3.269.
22. [22] Ding, C., Gao, D., Wilding, J., Trayhurn, P., Bing, C., Vitamin D signalling in adipose tissue. Br. J. Nutr. 108 (2012), 1915–1923, 10.1017/S0007114512003285.
23. [23] Bouillon, R., Bischoff-Ferrari, H., Willett, W., Vitamin D and health: perspectives from mice and man. J. Bone Miner. Res. 23 (2008), 974–979, 10.1359/JBMR.080420.
24. 3: genomic and non-genomic mechanisms. Best Pract. Res. Clin. Endocrinol. Metab. 25:4 (2011), 543–559, 10.1016/j.beem.2011.05.010.
25. [25] Pike, J.W., Meyer, M.B., Fundamentals of vitamin D hormone regulated gene expression. J. Steroid Biochem. Mol. Biol. 144:Pt. A (2014), 5–11, 10.1016/j.jsbmb.2013.11.004.
26. [26] Dace, A., Martin-El Yazidi, C., Bonne, J., Planells, R., Torresani, J., Calcitriol is a positive effector of adipose differentiation in the OB 17 cell line: relationship with the adipogenic action of triiodothyronine. Biochem. Biophys. Res. Commun. 232 (1997), 771–776, 10.1006/bbrc.1997.6372.
27. 3 inhibits uncoupling protein 2 expression in human adipocytes. FASEB J. 16 (2002), 1808–1810, 10.1096/fj.02-0255fje.
28. [28] Bikle, D.D., Vitamin D metabolism, mechanism of action, and clinical applications. Chem. Biol. 21 (2014), 319–329, 10.1016/j.chembiol.2013.12.016.
29. [29] Rochel, N., Wurtz, J.M., Mitschler, A., Klaholz, B., Moras, D., The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand. Mol. Cell 5 (2000), 173–179, 10.1016/S1097-2765(00)80413-X.
30. [30] Freedman, L.P., Increasing the complexity of coactivation in nuclear receptor signaling. Cell 97 (1999), 5–8, 10.1016/S0092-8674(00)80708-4.
31. 3) is an agonistic vitamin D receptor ligand. J. Steroid Biochem. Mol. Biol. 118 (2010), 162–170, 10.1016/j.jsbmb.2009.11.011.
32. [32] Baran, D.T., Nongenomic rapid effects of Vitamin D. Holick, M.F., (eds.) Vitamin D: Molecular Biology, Physiology, and Clinical Applications, 1999, Humana Press, Totowa, NJ, 195–205, 10.1007/978-1-4757-2861-3_12.
33. [33] Milde, P., Merke, J., Ritz, E., Haussler, M.R., Rauterberg, E.W., Immunohistochemical detection of 1,25-dihydroxyvitamin D3 receptors and estrogen receptors by monoclonal antibodies: comparison of four immunoperoxidase methods. J. Histochem. Cytochem. 37:11 (1989), 1609–1617, 10.1177/37.11.2553800.
34. [34] Barsony, J., Renyi, I., McKoy, W., Subcellular distribution of normal and mutant vitamin D receptors in living cells. J. Biol. Chem. 272 (1997), 5774–5782, 10.1074/jbc.272.9.5774.
35. [35] Michigami, T., Suga, A., Yamazaki, M., Shimizu, C., Cai, G., Okada, S., Ozono, K., Identification of amino acid sequence in the hinge region of human vitamin d receptor that transfers a cytosolic protein to the nucleus. J. Biol. Chem. 274 (1999), 33531–33538, 10.1074/jbc.274.47.33531.
36. [36] Ogawa, H., Inouye, S., Tsuji, F.I., Yasuda, K., Umesono, K., Localization, trafficking, and temperature-dependence of the Aequorea green fluorescent protein in cultured vertebrate cells. Proc. Natl. Acad. Sci. U. S. A. 92 (1995), 11899–11903.
37. [37] Htun, H., Holth, L.T., Walker, D., Davie, J.R., Hager, G.L., Direct visualization of the human estrogen receptor a reveals a role for ligand in the nuclear distribution of the receptor. Mol. Biol. Cell 10:2 (1999), 471–486.
38. [38] Miyauchi, Y., Michigami, T., Sakaguchi, N., Sekimoto, T., Yoneda, Y., Pike_, J.W., Yamagata, M., Ozono, K., Importin 4 is responsible for ligand-independent nuclear translocation of Vitamin D receptor. J. Biol. Chem. 280:49 (2005), 40901–40908, 10.1074/jbc.M509347200.
39. [39] Li, Y.C., Amling, M., Pirro, A.E., Priemel, M., Meuse, J., Baron, R., Delling, G., Demay, M.B., Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice. Endocrinology 139 (1998), 4391–4396, 10.1210/endo.139.10.6262.
40. [40] Bouillon, R., Carmeliet, G., Verlinden, L., van Etten, E., Verstuyf, A., Luderer, H.F., Lieben, L., Mathieu, C., Demay, M., Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr. Rev. 29 (2008), 726–776, 10.1210/er.2008-0004.
41. 3 receptor-corepressor partnership. FASEB J. 14 (2000), 1455–1463, 10.1096/fj.14.10.1455.
42. [42] Seuter, S., Heikkinen, S., Carlberg, C., Chromatin acetylation at transcription start sites and vitamin D receptor binding regions relates to effects of 1a, 25-dihydroxyvitamin D3 and histone deacetylase inhibitors on gene expression. Nucleic Acids Res. 41 (2013), 110–124, 10.1093/nar/gks959.
43. [43] Malloy, P.J., Feldman, B.J., Cell-autonomous regulation of brown fat identity gene UCP1 by unliganded vitamin D receptor. Mol. Endocrinol. 27 (2013), 1632–1642, 10.1210/me.2013-1037.
44. [44] Honeka, J., Lima, S., Fischera, C., Iwamoto, H., Seki, T., Cao, Y., Brown adipose tissue, thermogenesis, angiogenesis: pathophysiological aspects. Horm. Mol. Biol. Clin. Invest. 19:1 (2014), 5–11, 10.1515/hmbci-2014-0014.
45. [45] Cypess, A.M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A.B., Kuo, F.C., Palmer, E.L., Tseng, Y.-H., Doria, A., Kolodny, G.M., Kahn, C.R., Identification and importance of brown adipose tissue in adult humans. N. Engl. J. Med. 360:15 (2009), 1509–1517, 10.1056/NEJMoa0810780.
46. [46] Park, A., Kim, W.K., Bae, K.H., Distinction of white, beige and brown adipocytes derived from mesenchymal stem cells. World J. Stem Cells 6 (2014), 33–42, 10.4252/wjsc.v6.i1.33.
47. [47] Cronin, C.G., Prakash, P., Daniels, G.H., Boland, G.W., Kalra, M.K., Halpern, E.F., Palmer, E.L., Blake, M.A., Brown fat at PET/CT: correlation with patient characteristics. Radiology 263:3 (2012), 336–842, 10.1148/radiol.12100683.
48. [48] Kajimura, S., Saito, M., A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis. Annu. Rev. Physiol. 76 (2014), 225–249, 10.1146/annurev-physiol-021113-170252.
49. [49] Cinti, S., Between brown and white: novel aspects of adipocyte differentiation. Ann. Med. 43 (2011), 104–115, 10.3109/07853890.2010.535557.
50. [50] Thoonen, R., Hindle, A.G., Scherrer-Crosbie, M., Brown adipose tissue: the heat is on the heart. Am. J. Physiol. Heart Circ. Physiol. 310 (2016), H1592–H1605, 10.1152/ajpheart.00698.2015.
51. [51] Mizwicki, M.T., Norman, A.W., The vitamin D sterol-vitamin D receptor ensemble model offers unique insights into both genomic and rapid-response signaling. Sci. Signal., 2, 2009, re4, 10.1126/scisignal.275re4.
52. 3 modulates human adipocyte metabolism via nongenomic action. FASEB J. 15 (2001), 2751–2753, 10.1096/fj.01-0584fje.
53. 3 in vivo and in vitro. Mol. Endocrinol. 18 (2004), 2660–2671, 10.1210/me.2004-0116.
54. [54] Hii, C.S., Ferrante, A., The non-genomic actions of vitamin D. Nutrients, 8, 2016, 135, 10.3390/nu8030135.
55. [55] Norman, A.W., From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am. J. Clin. Nutr. 88:Suppl (2008), 491S–499S.
56. 3 requires the presence of a functional vitamin D nuclear receptor. Proc. Natl. Acad. Sci. U. S. A. 101 (2004), 1589–1594, 10.1073/pnas.0305802101.
57. [57] Chen, J., Doroudi, M., Cheung, J., Grozier, A.L., Schwartz, Z., Boyan, B.D., Plasma membrane Pdia3 and VDR interact to elicit rapid responses 2 to 1α,25(OH)2D3. Cell. Signal. 25:12 (2013), 2362–2373, 10.1016/j.cellsig.2013.07.020.
58. [58] Gustavsson, J., Parpal, S., Karlsson, M., Ramsing, C., Thorn, H., Borg, M., Lindroth, M., Peterson, K.H., Magnusson, K.E., Strâlfors, P., Localization of the insulin receptor in caveolae of adipocyte plasma membrane. FASEB J. 13:14 (1999), 1961–1971.
59. [59] Wood, R.J., Vitamin, D., and adipogenesis: new molecular insights. Nutr. Rev. 66:1 (2008), 40–46, 10.1111/j.1753-4887.2007.00004.x.
60. [60] Lee, M.-J., Fried, S.K., Optimal protocol for the differentiation and metabolic analysis of human adipose stromal cells. Methods Enzymol. 538 (2014), 49–65, 10.1016/B978-0-12-800280-3.00004-9.
61. [61] Fu, M., Sun, T., Bookout, A.L., Downes, M., Yu, R.T., Evans, R.M., Mangelsdorf, D.J., A nuclear receptor atlas: 3T3-L1 adipogenesis. Mol. Endocrinol. 19:10 (2005), 2437–2450, 10.1210/me.2004-0539.
62. [62] Blumberg, J.M., Tzameli, I., Astapova, I., Lam, F.S., Flier, J.S., Hollenberg, A.N., Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells. J. Biol. Chem. 281:16 (2006), 11205–11213, 10.1074/jbc.M510343200.
63. 3 inhibition of adipogenesis in 3T3-L1 cells. Am. J. Physiol. Endocrinol. Metab. 290 (2006), E916–E924, 10.1152/ajpendo.00410.2005.
64. 3/vitamin D receptor suppresses brown adipocyte differentiation and mitochondrial respiration. Eur. J. Nutr. 54:6 (2015), 1001–1012, 10.1007/s00394-014-0778-9.
65. 3 inhibits adipocyte differentiation and gene expression in murine bone marrow stromal cell clones and primary cultures. Endocrinology 139:5 (1998), 2622–2628, 10.1210/endo.139.5.5970.
66. [66] Cianferotti, L., Demay, M.B., VDR-mediated inhibition of DKK1 and SFRP2 suppresses adipogenic differentiation of murine bone marrow stromal cells. J. Cell. Biochem. 101 (2007), 80–88, 10.1002/jcb.21151.
67. [67] Sakuma, S., Fujisawa, J., Sumida, M., Tanigawa, M., Inoda, R., Sujihera, T., Kohda, T., Fujimoto, Y., The involvement of mitogen-activated protein kinases in the 1α,25-dihydroxy-cholecalciferol-induced inhibition of adipocyte differentiation in vitro. J. Nutr. Sci. Vitaminol. (Tokyo) 58:1 (2012), 1–8.
68. 3 are mediated by the maintenance of the wingless-type MMTV integration site/ß-catenin pathway. Int. J. Mol. Med. 30 (2012), 1219–1224, 10.3892/ijmm.2012.1101.
69. 3 stimulation of adipogenesis in mesenchymal progenitor cells derived from human adipose tissue. J. Cell. Physiol. 228:10 (2013), 2024–2036, 10.1002/jcp.2437.
70. [70] Ross, S.E., Hemati, N., Longo, K.A., Bennett, C.N., Lucas, P.C., Erickson, R.L., MacDougald, O.A., Inhibition of adipogenesis by Wnt signaling. Science 289 (2000), 950–953, 10.1126/science.289.5481.950.
71. [71] De Girolamo, L., Stanco, D., Salvatori, L., Coroniti, G., Arrigoni, E., Silecchia, G., Russo, M.A., Niada, S., Petrangeli, E., Brini, A.T., Stemness and osteogenic and adipogenic potential are differently impaired in subcutaneous and visceral adipose derived stem cells (ASCs) isolated from obese donors. Int. J. Immunopathol. Pharmacol. 26 (2013), 11–21.
72. [72] Wong, K.E., Szeto, F.L., Zhang, W., Ye, H., Kong, J., Zhang, Z., Sun, X.J., Li, Y.C., Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins. Am. J. Physiol. Endocrinol. Metab. 296 (2009), E820–E828, 10.1152/ajpendo.90763.2008.
73. [73] Sun, X., Morris, K.L., Zemel, M.B., Role of calcitriol and cortisol on human adipocyte proliferation and oxidative and inflammatory stress: a microarray study. J. Nutrigenet. Nutrigenomics 1:1–2 (2008), 30–48, 10.1159/000109873.
74. [74] Sergeev, I.N., Song, Q., High vitamin D and calcium intakes reduce diet-induced obesity in mice by increasing adipose tissue apoptosis. Mol. Nutr. Food Res. 58 (2014), 1342–1348, 10.1002/mnfr.201300503.
75. 3 in modulating adipocyte apoptosis. FASEB J. 18 (2004), 1430–1432, 10.1096/fj.04-1971fje.
76. [76] Zemel, M.B., Sun, X., Calcitriol and energy metabolism. Nutr. Rev. 66 (2008), S139–S146, 10.1111/j.1753-4887.2008.00099.x.
77. 2+-mediated apoptosis in adipocytes via activation of calpain and caspase-12. Biochem. Biophys. Res. Commun. 384 (2009), 18–21, 10.1016/j.bbrc.2009.04.078.
78. 3-induced apoptosis. J. Steroid Biochem. Mol. Biol. 89–90 (2004), 419–425, 10.1016/j.jsbmb.2004.03.010.
79. [79] Shi, Y., Burn, P., Lipid metabolic enzymes: emerging drug targets for the treatment of obesity. Nat. Rev. Drug Disc. 3 (2004), 695–710, 10.1038/nrd1469.
80. 3 upregulates leptin expression in mouse adipose tissue. J. Endocrinol. 216 (2013), 265–271, 10.1530/JOE-12-0344.
81. [81] Roy, P., Nadeau, M., Valle, Marion, Bellmann, K., Marette, A., Tchernof, A., Gagnon, C., Vitamin D reduces LPS-induced cytokine release in omental adipose tissue of women but not men. Steroids 104 (2015), 65–71, 10.1016/j.steroids.2015.08.014.
82. [82] Walker, G.E., Ricotti, R., Roccio, M., Moia, S., Bellone, S., Prodam, F., Bona, G., Pediatric obesity and vitamin D deficiency: a proteomic approach identifies multimeric adiponectin as a key link between these conditions. PLoS One, 9(1), 2014, e83685, 10.1371/journal.pone.0083685.
83. [83] Scherer, P.E., Williams, S., Fogliano, M., Baldini, G., Lodish, H.F., A novel serum protein similar to C1q, produced exclusively in adipocytes. J. Biol. Chem. 270:45 (1995), 26746–26749, 10.1074/jbc.270.45.26746.
84. [84] Chandran, M., Phillips, S.A., Ciaraldi, T., Henry, R.R., Adiponectin more than just another fat cell hormone?. Diabetes Care 26 (2003), 2442–2450, 10.2337/diacare.26.8.2442.
85. [85] Neyestani, T.R., Nikooyeh, B., Alavi-Majd, H., Shariatzadeh, N., Kalayi, A., Tayebinejad, N., Heravifard, S., Salekzamani, S., Zahedirad, M., Improvement of vitamin D status via daily intake of fortified yogurt drink either with or without extra calcium ameliorates systemic inflammatory biomarkers, including adipokines, in the subjects with type 2 diabetes. J. Clin. Endocrinol. Metab. 97 (2012), 2005–2011, 10.1210/jc.2011-3465.
86. 3 regulation of adipokine expression. Obesity 15:2 (2007), 340–348, 10.1038/oby.2007.540.
87. [87] Mantzoros, C.S., The role of leptin in human obesity and disease: a review of current evidence. Ann. Intern. Med. 130 (1999), 671–680.
88. [88] Schwartz, M.W., Woods, S.C., DJr, Porte, Seeley, R.J., Baskin, D.G., Central nervous system control of food intake. Nature 404 (2000), 661–671, 10.1038/nature05026.
89. [89] Frühbeck, G., Aguado, M., Martínez, J.A., In vitro lipolytic effect of leptin on mouse adipocytes: evidence for a possible autocrine/paracrine role of leptin. Biochem. Biophys. Res. Commun. 240 (1997), 590–594.
90. [90] Frühbeck, G., Aguado, M., Gómez-Ambrosi, J., Martínez, J.A., Lipolytic effect of in vivo leptin administration on adipocytes of lean and ob/ob mice, but not db/db mice. Biochem. Biophys. Res. Commun. 250 (1998), 99–102.
91. [91] Narvaez, C.J., Matthews, D., Broun, E., Chan, M., Welsh, J., Lean phenotype and resistance to diet-induced obesity in vitamin D receptor knockout mice correlates with induction of uncoupling protein-1 in white adipose tissue. Endocrinology 150 (2009), 651–661, 10.1210/en.2008-1118.
92. [92] Kaneko, I., Sabir, M.S., Dussik, C.M., Whitfield, G.K., Karrys, A., Hsieh, J.-C., Haussler, M.R., Meyer, M.B., Pike, J.W., urutka, P.W., 1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D. FASEB J. 29:9 (2015), 4023–4035, 10.1096/fj.14-269811.
93. [93] Bouillon, R., Carmeliet, G., Lieben, L., Watanabe, M., Perino, A., Auwerx, J., Schoonjans, K., Verstuyf, A., Vitamin D and energy homeostasis: of mice and men. Nat. Rev. Endocrinol. 10:2 (2014), 79–87, 10.1038/nrendo.2013.226.
94. [94] Haussler, M.R., Whitfield, G.K., Kaneko, I., Forster, R., Saini, R., Hsieh, J.-C., Haussler, C.A., Jurutka, P.W., The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis. Rev. Endocr. Metab. Disord. 13:1 (2012), 57–69, 10.1007/s11154-011-9199-8.
95. 3 synthesis in leptin-deficient mice. J. Bone Miner. Res. 25:8 (2010), 1711–1723, 10.1002/jbmr.65.
96. [96] Lynch, L., Adipose invariant natural killer T cells. Immunology 142:3 (2014), 337–346, 10.1111/imm.12269.
97. 3 protects against macrophage-induced activation of NFkB and MAPK signalling and chemokine release in human adipocytes. PLoS One, 8(4), 2013, e61707, 10.1371/journal.pone.0061707.
98. [98] Gao, D., Trayhurn, P., Bing, C., 1,25-Dihydroxyvitamin D3 inhibits the cytokine-induced secretion of MCP-1 and reduces monocyte recruitment by human preadipocytes. Int. J. Obes. (Lond.) 37:3 (2013), 357–365, 10.1038/ijo.2012.53.
99. [99] Lorente-Cebrián, S., Eriksson, A., Dunlop, T., Mejhert, N., Dahlman, I., Aström, G., Sjölin, E., Wåhlén, K., Carlberg, C., Laurencikiene, J., Hedén, P., Arner, P., Rydén, M., Differential effects of 1a, 25-dihydroxycholecalciferol on MCP-1 and adiponectin production in human white adipocytes. Eur. J. Nutr. 51 (2012), 335–342, 10.1007/s00394-011-0218-z.
100. [100] Marcotorchino, J., Gouranton, E., Romier, B., Tourniaire, F., Astier, J., Malezet, C., Amiot, M.-J., Landrier, J.-F., Vitamin D reduces the inflammatory response and restores glucose uptake in adipocytes. Mol. Nutr. Food Res. 56 (2012), 1771–1782, 10.1002/mnfr.201200383.
101. [101] Karkeni, E., Marcotorchino, J., Tourniaire, F., Astier, J., Peiretti, F., Darmon, P., Landrier, J.-F., Vitamin D limits chemokine expression in adipocytes and macrophage migration in vitro and in male mice. Endocrinology 156:5 (2015), 1782–1793, 10.1210/en.2014-1647.
102. [102] de Souza, W.N., Norde, M.M., Oki, É., Rogero, M.M., Marchioni, D.M.L., Fisberg, R.M., Martini, L.A., Association between 25-hydroxyvitamin D and inflammatory biomarker levels in a cross-sectional population-based study, São Paulo. Brazil. Nutr. Res. 36 (2016), 1–6, 10.1016/j.nutres.2015.10.006.
103. [103] Wamberg, L., Cullberg, K.B., Rejnmark, L., Richelsen, B., Pedersen, S.B., Investigations of the anti-inflammatory effects of vitamin D in adipose tissue: results from an in vitro study and a randomized controlled trial. Horm. Metab. Res. 45 (2013), 456–462, 10.1055/s-0032-1331746.
104. [104] Morin, S.O., Poggi, M., Alessi, M.C., Landrier, J.F., Nunès, J.A., Modulation of T cell activation in obesity. Antioxid. Redox Signal., 2016, 10.1089/ars.2016.6746 (in press).
105. [105] Zeng, H., Chi, H., Metabolic control of regulatory T cell development and function. Trends Immunol. 36 (2015), 3–12.
106. [106] Olefsky, J.M., Glass, C.K., Macrophages, inflammation, and insulin resistance. Annu. Rev. Physiol. 72 (2010), 219–246, 10.1146/annurev-physiol-021909-135846.
107. [107] Bapat, S.P., Myoung Suh, J., Fang, S., Liu, S., Zhang, Y., Cheng, A., Zhou, C., Liang, Y., LeBlanc, M., Liddle, C., Atkins, A.R., Yu, R.T., Downes, M., Evans, R.M., Zheng, Y., Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature 3528:7580 (2015), 137–141, 10.1038/nature16151.
108. [108] Mocanu, V., Oboroceanu, T., Zugun-Eloae, F., Current status in vitamin D and regulatory T cells-immunological implications. Rev. Med. Chir. Soc. Med. Nat. Iasi 117:4 (2013), 965–973, 10.1007/s12026-014-8499-y.
109. [109] Calton, E.K., Keane, K.N., Newsholme, P., Soares, M.J., The impact of vitamin D levels on inflammatory status: a systematic review of immune cell studies. PLoS One, 10(11), 2015, e0141770, 10.1371/journal.pone.0141770.
110. [110] Ahmad, R., Al-Mass, A., Atizado, V., Al-Hubail, A., Al-Ghimlas, F., Al-Arouj, M., Bennakhi, A., Dermime, S., Behbehani, K., Elevated expression of the toll like receptors 2 and 4 in obese individuals: its significance for obesity-induced inflammation. J. Inflamm. (Lond.) 9:1 (2012), 48–58, 10.1186/1476-9255-9-48.
111. [111] Vitseva, O.I., Tanriverdi, K., Tchkonia, T.T., Kirkland, J.L., McDonnell, M.E., Apovian, C.M., et al. Inducible toll-like receptor and NF-κB regulatory pathway expression in human adipose tissue. Obesity 16:5 (2008), 932–937, 10.1038/oby.2008.25.
112. [112] Weber, K., Erben, R.G., Differences in triglyceride and cholesterol metabolism and resistance to obesity in male and female vitamin D receptor knockout mice. J. Anim. Physiol. Anim. Nutr. 97:4 (2013), 675–683, 10.1111/j.1439-0396.2012.01308.x.
113. [113] Wong, K.E., Kong, J., Zhang, W., Szeto, F.L., Ye, H., Deb, D.K., Brady, M.J., Li, Y.C., Targeted expression of human vitamin D receptor in adipocytes decreases energy expenditure and induces obesity in mice. J. Biol. Chem. 286 (2011), 33804–33810, 10.1074/jbc.M111.257568.
114. [114] Walder, K., Norman, R.A., Hanson, R.L., Schrauwen, P., Neverova, M., Jenkinson, C.P., Easlick, J., Warden, C.H., Pecqueur, C., Raimbault, S., Ricquier, D., Silver, M.H., Shuldiner, A.R., Solanes, G., Lowell, B.B., Chung, W.K., Leibel, R.L., Pratley, R., Ravussin, E., Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima Indians. Hum. Mol. Genet. 7 (1998), 1431–1435, 10.1093/hmg/7.9.1431.
115. [115] Matthews, D.G., D'Angelo, J., Drelich, J., Welsh, J., Adipose-specific Vdr deletion alters body fat and enhances mammary epithelial density. J. Steroid Biochem. Mol. Biol., 2015, 10.1016/j.jsbmb.2015.09.035.
116. [116] Ji, L., Gupta, M., Feldman, B.J., Vitamin, D., regulates fatty acid composition in subcutaneous adipose tissue through Elovl3. Endocrinology 157:1 (2016), 91–97, 10.1210/en.2015-1674.
117. [117] Bhat, M., Noolu, B., Qadri, S., Ismail, A., Vitamin D deficiency decreases adiposity in rats and causes altered 2 expression of uncoupling proteins and steroid receptor coactivator. J. Steroid Biochem. Mol. Biol. 144:part B (2014), 304–312, 10.1016/j.jsbmb.2014.08.005.
118. [118] Mukherjee, R., Choi, J.-W., Choi, D.K., Oh, T.S., Liu, H., Yun, J.W., Gender-dependent protein expression in white adipose tissues of lean and obese rats fed a high fat diet. Cell. Physiol. Biochem. 29 (2012), 617–634, 10.1159/000338515.
119. [119] Choi, D.K., Oh, T.S., Choi, J.-W., Mukherjee, R., Wang, X., Liu, H., Yun, J.W., Gender difference in proteome of brown adipose tissues between male and female rats exposed to a high fat diet. Cell. Physiol. Biochem. 28 (2011), 933–948, 10.1002/pmic.201100271.
120. [120] Zhang, X.-Q., Pan, Y., Yu, C.-H., Xu, C.-F., Xu, L., Li, Y.-M., Chen, W., PDI knockdown exacerbates free fatty acid-induced hepatocyte steatosis and apoptosis. PLoS One, 10(7), 2015, e0133882, 10.1371/journal.pone.0133882.
121. [121] Al-Daghri, N.M., Guerini, F.R., Al-Attas, O.S., Alokail, M.S., Alkharfy, K.M., Draz, H.M., Agliardi, C., Costa, A.S., Saulle, I., Mohammed, A.K., Biasin, M., Clerici, M., Vitamin D receptor gene polymorphisms are associated with obesity and inflammosome activity. PLoS One, 9(7), 2014, e102141, 10.1371/journal.pone.0102141.
122. [122] Ye, W.Z., Reis, A.F., Dubois-Laforgue, D., Bellanne-Chantelot, C., Timsit, J., Velho, G., Vitamin D receptor gene polymorphisms are associated with obesity in type 2 diabetic subjects with early age of onset. Eur. J. Endocrinol. 145 (2001), 181–186.
123. [123] Vimaleswaran, K.S., Berry, D.J., Lu, C., Tikkanen, E., Pilz, S., Hiraki, L.T., Cooper, J.D., Dastani, Z., Li, R., Houston, D.K., Wood, A.R., Michaëlsson, K., Vandenput, L., Zgaga, L., Yerges-Armstrong, L.M., McCarthy, M.I., Dupuis, J., Kaakinen, M., Kleber, M.E., Jameson, K., Arden, N., Raitakari, O., Viikari, J., Lohman, K.K., Ferrucci, L., Melhus, H., Ingelsson, E., Byberg, L., Lind, L., Lorentzon, M., Salomaa, V., Campbell, H., Dunlop, M., Mitchell, B.D., Herzig, K.-H., Pouta, A., Hartikainen, A.L., the Genetic Investigation of Anthropometric Traits (GIANT) consortium, Streeten, E.A., Theodoratou, E., Jula, A., Wareham, N.J., Ohlsson, C., Frayling, T.M., Kritchevsky, S.B., Spector, T.D., Richards, B.J., Lehtimäki, T., Ouwehand, W.H., Kraft, P., Cooper, C., März, W., Power, C., Loos, R.J.F., Wang, T.J., Järvelin, M.-R., Whittaker, J.C., Hingorani, A.D., Hyppӧnen, E., Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med., 10(2), 2013, e1001383, 10.1371/journal.pmed.1001383.
124. [124] Looker, A.C., Body fat and vitamin D status in black versus white women. J. Clin. Endocrinol. Metab. 90 (2005), 635–640, 10.1210/jc.2004-1765.
125. [125] Gangloff, A., Bergeron, J., Pelletier-Beaumont, E., Nazare, J.A., Smith, J., Borel, A.L., Lemieux, I., Tremblay, A., Poirier, P., Alméras, N., Després, J.-P., Effect of adipose tissue volume loss on circulating 25-hydroxyvitamin D levels: results from a 1-year lifestyle intervention in viscerally obese men. Int. J. Obes. (Lond.) 39 (2015), 1638–1643, 10.1038/ijo.2015.118.
126. [126] Holecki, M., Zahorska-Markiewicz, B., Wiecek, A., Mizia-Stecc, K., Nieszporek, T., Zak-Gołąb, A., Influence of calcium and vitamin D supplementation on weight and fat loss in obese women. Obes. Facts 1 (2008), 274–279, 10.1159/000169831.
127. [127] Parikh, S.J., Edelman, M., Uwaifo, G.I., Freedman, R.J., Semega-Janneh, M., Reynolds, J., Yanovski, J.A., The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults. J. Clin. Endocrinol. Metab. 89 (2004), 1196–1199, 10.1210/jc.2003-031398.
128. 3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity. Nutr. J. 7 (2008), 4–8, 10.1186/1475-2891-7-4.
129. [129] Muscogiuri, G., Sorice, G.P., Prioletta, A., Policola, C., Della Casa, S., Pontecorvi, A., Giaccari, A., 25-Hydroxyvitamin D concentration correlates with insulin-sensitivity and BMI in obesity. Obesity 18 (2010), 1906–1910, 10.1038/oby.2010.11.
130. [130] Snijder, M.B., van Dam, R.M., Visser, M., Deeg, D.J.H., Dekker, J.M., Bouter, L.M., Seidell, J.C., Lips, P., Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. J. Clin. Endocrinol. Metab. 90 (2005), 4119–4123, 10.1210/jc.2005-0216.
131. [131] Arunabh, S., Pollack, S., Yeh, J., Aloia, J.F., Body fat content and 25-hydroxyvitamin D levels in healthy women. J. Clin. Endocrinol. Metab. 88:1 (2003), 157–161, 10.1210/jc.2002-020978.
132. 3 in obese vs non-obese african american children. Obesity 16 (2008), 90–95, 10.1038/oby.2007.23.
133. [133] Gilbert-Diamond, D., Baylin, A., Mora-Plazas, M., Marin, C., Arsenault, J.E., Hughes, M.D., Willett, W.C., Villamor, E., Vitamin D deficiency and anthropometric indicators of adiposity in school-age children: a prospective study. Am. J. Clin. Nutr. 92 (2010), 1446–1451, 10.3945/ajcn.2010.29746.
134. [134] Cheng, S., Massaro, J.M., Fox, C.S., Larson, M.G., Keyes, M.J., McCabe, E.L., Robins, S.J., O'Donnell, C.J., Hoffmann, U., Jacques, P.F., Booth, S.L., Vasan, R.S., Wolf, M., Wang, T.J., Adiposity, cardiometabolic risk, and vitamin D status: the Framingham heart study. Diabetes 59 (2010), 242–248, 10.2337/db09-1011.
135. [135] Rajakumar, K., de las Heras, J., Chen, T.C., Lee, S., Holick, M.F., Arslanian, S.A., Vitamin D status, adiposity, and lipids in black American and caucasian children. J. Clin. Endocrinol. Metab. 96 (2011), 1560–1567, 10.1210/jc. 2010–2388.
136. [136] Young, K.A., Engelman, C.D., Langefeld, C.D., Hairston, K.G., Haffner, S.M., Bryer-Ash, M., Norris, J.M., Association of plasma Vitamin D levels with adiposity in hispanic and african americans. J. Clin. Endocrinol. Metab. 94 (2009), 3306–3313, 10.1210/jc.2009-0079.
137. [137] Lagunova, Z., Porojnicu, A.C., Lindberg, F., Hexeberg, S., Moan, J., The dependency of vitamin D status on body mass index, gender, age and season. Anticancer Res. 29 (2009), 3713–3720.
138. [138] Kremer, R., Campbell, P.P., Reinhardt, T., Gilsanz, V., Vitamin D status and its relationship to body fat, final height, and peak bone mass in young women. J. Clin. Endocrinol. Metab. 94 (2009), 67–73, 10.1210/jc.2008-1575.
139. [139] Lenders, C.M., Feldman, H.A., Von Scheven, E., Merewood, A., Sweeney, C., Wilson, D.M., Lee, P.D.K., Abrams, S.H., Gitelman, S.E., Wertz, M.S., Klish, W.J., Taylor, G.A., Chen, T.C., Holick, M.F., Relation of body fat indexes to vitamin D status and deficiency among obese adolescents. Am. J. Clin. Nutr. 90 (2009), 459–467, 10.3945/ajcn.2008.27275.
140. [140] Grethen, E., McClintock, R., Gupta, C.E., Jones, R., Cacucci, B.M., Diaz, D., Fulford, A.D., Perkins, S.M., Considine, R.V., Peacock, M., Vitamin D and hyperparathyroidism in obesity. J. Clin. Endocrinol. Metab. 96 (2011), 1320–1326, 10.1210/jc.2010-2202.
141. [141] Drincic, A.T., Armas, L.A., Van Diest, E.E., Heaney, R.P., Volumetric dilution, rather than sequestration best explains the low vitamin D status of obesity. Obesity 20 (2012), 1444–1448, 10.1038/oby.2011.404.
142. [142] Wortsman, J., Matsuoka, L.Y., Chen, T.C., Lu, Z., Holick, M.F., Decreased bioavailability of vitamin D in obesity. Am. J. Clin. Nutr. 72 (2000), 690–693.
143. [143] Foss, Y.J., Vitamin, D., deficiency is the cause of common obesity. Med. Hypotheses 72 (2009), 314–321, 10.1016/j.mehy.2008.10.005.
144. [144] Cherniack, E.P., Seldeen, K., Troen, B.R., Vitamin D: a regulator of metabolism and inflammation. Curr. Nutr. Food Sci. 10 (2014), 3–11, 10.2174/15734013113096660008.
145. [145] Vanlint, S., Vitamin D and obesity. Nutrients 5 (2013), 949–956, 10.3390/nu5030949.
146. [146] McCarty, M.F., Thomas, C.A., PTH excess may promote weight gain by impeding catecholamine-induced lipolysis-implications for the impact of calcium, vitamin D, and alcohol on body weight. Med. Hypotheses 61 (2003), 535–542, 10.1016/S0306-9877(03)00227-5.
147. [147] Dorjgochoo, T., Shi, J., Gao, Y.T., Long, J., Delahanty, R., Xiang, Y.-B., Cai, Q., Shu, X.O., Genetic variants in vitamin D metabolism-related genes and body mass index: analysis of genome-wide scan data of approximately 7000 Chinese women. Int. J. Obes. (Lond.) 36 (2012), 1252–1255, 10.1038/ijo.2011.246.
148. 3) supplementation on body fat mass in healthy overweight and obese women. Nutr. J. 11 (2012), 78–85, 10.1186/1475-2891-11-78.
149. [149] Sneve, M., Figenschau, Y., Jorde, R., Supplementation with cholecalciferol does not result in weight reduction in overweight and obese subjects. Eur. J. Endocrinol. 159 (2008), 675–684, 10.1530/EJE-08-0339.
150. [150] Zittermann, A., Frisch, S., Berthold, H.K., Gotting, C., Kuhn, J., Kleesiek, K., Stehle, P., Koertke, H., Koerfer, R., Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. Am. J. Clin. Nutr. 89 (2009), 1321–1327, 10.3945/ajcn.2008.27004.
151. [151] Marcotorchino, J., Tourniaire, F., Astier, J., Karkeni, E., Canault, M., Marie-Josèphe, A., David, B., Monique, B., Jean-Charles, M., Benoit, G., Jean-François, L., Vitamin D protects against diet-induced obesity by enhancing fatty acid oxidation. J. Nutr. Biochem. 25 (2014), 1077–1083, 10.1016/j.jnutbio.2014.05.010.
152. 3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients. Int. J. Clin. Pract. 57:4 (2003), 258–261.