A 12-week double-blind randomized clinical trial of vitamin D3 supplementation on body fat mass in healthy overweight and obese women

Nutrition Journal

Volumn 11, Issue 1, 2012, Pages

  Salehpour, Amin ^a   Hosseinpanah, Farhad ^b   Shidfar, Farzad ^a   Vafa, Mohammadreza ^a   Razaghi, Maryam ^a   Dehghani, Sahar ^a   Hoshiarrad, Anahita ^c   Gohari, Mahmoodreza ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Body fat mass; Obesity; Supplementation; Vitamin d3

Indexed keywords

25 HYDROXYVITAMIN D; COLECALCIFEROL; LACTOSE; PARATHYROID HORMONE; PLACEBO;

ADULT; ANTHROPOMETRY; ARTICLE; BODY FAT; BODY HEIGHT; BODY WEIGHT; CONTROLLED STUDY; DIETARY INTAKE; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; OBESITY; RANDOMIZED CONTROLLED TRIAL; VITAMIN SUPPLEMENTATION; WAIST CIRCUMFERENCE; WAIST HIP RATIO;

25-HYDROXYVITAMIN D 2; ADIPOSITY; ADULT; BODY MASS INDEX; CALCIFEDIOL; CHOLECALCIFEROL; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; IRAN; MIDDLE AGED; OBESITY; OVERWEIGHT; PARATHYROID HORMONE; PATIENT COMPLIANCE; PATIENT DROPOUTS; TIME FACTORS; VITAMIN D DEFICIENCY;

EID: 84866506973     PISSN: None     EISSN: 14752891     Source Type: Journal    
DOI: 10.1186/1475-2891-11-78     Document Type: Article

References (45)

1. Waist-hip ratio is the dominant risk factor predicting cardiovascular death in australia. Welborn TA, Dhaliwal SS, Bennett SA, Med J Aust 2003 179 580 585 14636121 (Pubitemid 37536577)
2. Preferred clinical measures of central obesity for predicting mortality. Welborn TA, Dhaliwal SS, Eur J Clin Nutr 2007 61 1373 1379 10.1038/sj.ejcn. 1602656 17299478 (Pubitemid 350245910)
3. Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. Marieke B, Snijder MB, van Dam RM, Visser M, Deeg DJH, Dekker JM, Bouter LM, Seidell JC, Lips P, J Clin Endocrinol Metab 2005 90 4119 4123 10.1210/jc.2005-0216 15855256 (Pubitemid 41058184)
4. Diabetes mellitus: a thrifty genotype rendered detrimental by progress? Neel JV, Am J Hum Genet 1962 14 353 362 13937884
5. Physical activity and obesity prevention. Wareham N, Obes Rev 2007 8 Suppl 109 114 17371314
6. Vitamin D deficiency in morbidly obese. Buffington C, Walker B, Cowan GS, Scruggs D, Obes Surg 1993 3 421 424 10.1381/096089293765559142 10757956 (Pubitemid 24014299)
7. Mineral metabolism in obese children. Zamboni G, Soffiati M, Giavarina D, Tato L, Acta Paediatr Scand 1988 77 741 746 10.1111/j.1651-2227.1988.tb10740.x 2849283
8. The prevalence of hypovitaminosis d and secondary hyperparathyroidism in obese black americans. Yanoff LB, Parikh SJ, Spitalnik A, Denkinger B, Sebring NG, Slaughter P, McHugh T, Remaley AT, Yanovski JA, Clin Endocrinol 2006 64 23 s29
9. Low circulating vitamin d in obesity. Liel Y, Ulmer E, Shary J, Hollis BW, Bell NH, Calcif Tissue Int 1988 43 199 201 10.1007/BF02555135 3145124
10. Vitamin d and diabetes mellitus. Danescu LG, Levy S, Levy J, Endocrine 2009 35 11 7 10.1007/s12020-008-9115-5 18979202
11. Evidence for alteration of the vitamin d endocrine system in obese subjects. Bell NH, Epstein S, Greene A, Shary J, Oexmann MJ, Shaw S, J Clin Invest 1985 76 370 373 10.1172/JCI111971 2991340 (Pubitemid 15243466)
12. Vitamin d levels, lung function, and steroid response in adult asthma. Sutherland ER, Goleva E, Jackson LP, Stevens AD, Leung DY, Am J Respir Crit Care Med 2010 181 699 704 10.1164/rccm.200911-1710OC 20075384
13. Integration of npy, agrp, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Cowley MA, Pronchuk N, Fan W, Dinulescu DM, Colmers WF, Cone RD, Neuron 1999 24 Suppl 1 155 163 10677034 (Pubitemid 29466155)
14. Pathogenic potential of adipose tissue and metabolic consequences of adipocyte hypertrophy and increased visceral adiposity. Bays HE, Gonzalez-Campoy JM, Bray GA, Kitabchi AE, Bergman DA, Schorr AB, Rodbard HW, Henry RR, Expert Rev Cardio Ther 2008 6 343 368 10.1586/14779072.6.3.343
15. Adiposity signaling and biological defense against weight gain: absence of protection or central hormone resistance? Schwartz MW, Niswender KD, J Clin Endocrinol Metab 2004 89 Suppl 12 5889 5897 15579732 (Pubitemid 39628388)
16. Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. Posey KA, Clegg DJ, Printz RL, Byun J, Morton GJ, Vivekanandan-Giri A, Pennathur S, Baskin DG, Heinecke JW, Woods SC, Schwartz MW, Niswender KD, Am J Physiol Endocrinol Metab 2009 296 1003 E1012 10.1152/ajpendo.90377.2008 19116375
17. Decreased bioavailability of vitamin d in obesity. Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF, Am J Clin Nutr 2000 72 690 693 10966885 (Pubitemid 30667088)
18. Regulation of adiposity by dietary calcium. Zemel MB, Shi H, Greer B, Dirienzo D, Zemel PC, FASEB J 2000 14 1132 1138 10834935 (Pubitemid 30350395)
19. Calcium intake and reduction of fat mass. Teegarden D, J Nutr 2003 133 249S 251S 12514302 (Pubitemid 36070611)
20. Proposed role of calcium and dairy food components in weight management and metabolic health. Zemel MB, Physician Sport Med 2009 37 29 39
21. The role of dairy products in healthy weight and body composition in children and adolescents. Spence LA, Cifelli CJ, Miller GD, Curr Nutr Food Sci 2011 7 Suppl 1 40 49(10) 22299005
22. Vitamin d receptor gene polymorphisms are associated with adiposity phenotypes. Ochs-Balcom HM, Chennamaneni R, Millen AE, Shields PG, Marian C, Trevisan M, Freudenheim JL, Am J Clin Nutr 2011 93 5 10 10.3945/ajcn.2010.29986 21048058
23. Vitamin d and adipogenesis: new molecular insights. Wood RJ, Nutr Rev 2008 66 40 46 10.1111/j.1753-4887.2007.00004.x 18254883 (Pubitemid 351666660)
24. Molecular mechanism of 1,25-dihydroxyvitamin d3 inhibition of adipogenesis in 3T3-L1 cells. Kong J, Li YC, Am J Physiol Endocrinol Metab 2006 290 916 E924 10.1152/ajpendo.00410.2005 16368784
25. Regulation of adiposity and obesity risk by dietary calcium: mechanisms and implications. Zemel MB, J Am Coll Nutr 2002 21 146S 151S 11999543 (Pubitemid 38622950)
26. Reproducibility and relative validity of food group intake in a food frequency questionnaire developed for the tehran lipid and glucose study. Hosseini Esfahani F, Asghari G, Mirmiran P, Azizi F, J Epidemiol 2010 20 150 158 10.2188/jea.JE20090083 20154450
27. Azar M, Sarkisian E, Food Composition Table of Iran National Nutrition and Food Research Institute, Shaheed Beheshti University, Tehran 1980
28. Ars.usda.gov. http://www.nal.usda.gov/fnic/foodcomp/
29. International physical activity questionnaire: 12-country reliability and validity. Craig CL, Marshall AL, Sjostrom M, Bauman AE, Booth ML, Ainsworth BE, Med Sci Sports Exercise 2003 35 1381 1395 10.1249/01.MSS.0000078924.61453.FB (Pubitemid 36936159)
30. World Health Organization Physical Status, The Use 478 and Interpretation of Anthropometry. Technical Report 479 Series no. 854 WHO, Geneva 1995
31. Dietary intervention with vitamin d, calcium, and whey protein reduced fat mass and increased lean mass in rats. Siddiqui SM, Chang E, Li J, Burlage C, Zou M, Buhman KK, Koser S, Donkin SS, Teegarden D, Nutr Res 2008 28 783 790 10.1016/j.nutres.2008.08.004 19083488
32. Calcium and vitamin d supplementation is associated with decreased abdominal visceral adipose tissue in overweight and obese adults. Rosenblum JL, Castro VM, Moore CE, Kaplan LM, Am J Clin Nutr 2012 95 Suppl 1 101 108 22170363
33. Update in vitamin d. Adams JS, Hewison M, J Clin Endocrinol Metab 2010 95 471 478 10.1210/jc.2009-1773 20133466
34. Relationships between fat and bone. Reid IR, Osteoporos Int 2008 19 595 606 10.1007/s00198-007-0492-z 17965817 (Pubitemid 351642171)
35. Vitamin d status and muscle function in post-menarchal adolescent girls. Ward KA, Das G, Berry JL, Roberts SA, Rawer R, Adams JE, Mughal Z, J Clin Endocrinol Metab 2009 9 559 563
36. A 16-week randomized clinical trial of 2000 international units daily vitamin d3 supplementation in black youth: 25-hydroxyvitamin d, adiposity, and arterial stiffness. Dong Y, Stallmann-Jorgensen IS, Pollock NK, Harris RA, Keeton D, Huang Y, Li K, Bassali R, Guo D, Thomas J, Pierce GL, White J, Holick MF, Zhu H, J Clin Endocrinol Metab 2010 95 4584 4591 10.1210/jc.2010-0606 20660028
37. The effect of calcium and vitamin d supplementation on obesity in postmenopausal women: secondary analysis for a large-scale, placebo controlled, double-blind, 4-year longitudinal clinical trial. Zhou J, Zhao LJ, Watson P, Zhang Q, Lappe JM, Nutr Metab 2010 7 62 70 10.1186/1743-7075-7-62
38. Calcium plus vitamin d supplementation and fat mass loss in female very low-calcium consumers: potential link with a calcium-specific appetite control. Major GC, Alarie FP, Dore J, Tremblay A, Brit J Nutr 2009 101 659 663 10.1017/S0007114508030808 19263591
39. Vitamin d supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. Zittermann A, Frisch S, Berthold HK, Götting C, Kuhn J, Kleesiek K, Stehle P, Koertke H, Koerfer R, Am J Clin Nutr 2009 89 1321 1327 10.3945/ajcn.2008.27004 19321573
40. Calcium-induced inhibition of phosphoserine phosphatase in insulin target cells is mediated by the phosphorylation and activation of inhibitor 1. Begum N, Sussman KE, Draznin B, J Biol Chem 1992 267 5959 5963 1313423
41. Effects of parathyroid hormone on cytosolic calcium of rat adipocytes. Ni Z, Smogorzewski M, Massry SG, Endocrinology 1994 135 1837 1844 10.1210/en.135.5.1837 7525254 (Pubitemid 24363874)
42. Mechanism of intracellular calcium ([ca2+]i) inhibition of lipolysis in human adipocytes. Xue B, Greenberg AG, Kraemer FB, Zemel MB, FASEB J 2001 15 2527 2529 11641262
43. The effects of calcium channel blockade on agouti-induced obesity. Kim JH, Mynatt RL, Moore JW, Woychik RP, Moustaid N, Zemel MB, FASEB J 1996 10 1646 1652 9002558 (Pubitemid 27043783)
44. The carbon pathway for lipogenesis in isolated adipocytes from rat, guinea pig, and human adipose tissue. Shrago E, Spennetta T, Am J Clin Nutr 1976 29 540 545 1266795
45. De novo lipogenesis in adipose tissue of lean and obese women: application of deuterated water and isotope ratio mass spectrometry. Guo ZK, Cella LK, Baum C, Ravussin E, Schoeller DA, Int J Obes Relat Metab Disord 2000 24 932 937 10.1038/sj.ijo.0801256 10918543 (Pubitemid 30449932)