Association between Human Telomerase Reverse Transcriptase Gene Variations and Risk of Developing Breast Cancer

Genetic Testing and Molecular Biomarkers

Volumn 20, Issue 8, 2016, Pages 459-464

  Oztas, Ezgi ^a   Kara, Halil ^b   Kara, Zeliha Pala ^a   Aydogan, Manolya Uras ^c   Uras, Cihan ^b   Ozhan, Gul ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b ACIBADEM UNIVERSITY   (Turkey)

^c ISTANBUL UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE REVERSE TRANSCRIPTASE; TELOMERASE; TERT PROTEIN, HUMAN;

ADULT; ARTICLE; BREAST CANCER; CANCER RISK; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; DISEASE COURSE; DNA POLYMORPHISM; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MIDDLE AGED; POPULATION RESEARCH; TURKISH CITIZEN; AGED; ALLELE; BREAST TUMOR; CASE CONTROL STUDY; ENZYMOLOGY; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; METABOLISM; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; TELOMERE; TURKEY;

ADULT; AGED; ALLELES; BREAST NEOPLASMS; CASE-CONTROL STUDIES; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HAPLOTYPES; HUMANS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; TELOMERASE; TELOMERE; TURKEY;

EID: 84981709592     PISSN: 19450265     EISSN: 19450257     Source Type: Journal    
DOI: 10.1089/gtmb.2015.0339     Document Type: Article

References (45)

1. Aloraifi F, Boland M, Green AJ, et al. (2015) Gene analysis techniques and susceptibility gene discovery in non-BRCA1/ BRCA2 familial breast cancer. Surg Oncol 24:100-109
2. Baird DM (2010) Variation at the TERT locus and predisposition for cancer. Expert Rev Mol Med 12:e16
3. Blackburn EH (2001) Switching and signalling at the telomere. Cell 106:661-673
4. Blasco MA (2003) Mammalian telomeres and telomerase: why they matter for cancer and aging. Eur J Cell Biol 82:441-446
5. Bojesen SE, Pooley KA, Johnatty SE, et al. (2013) Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet 45:371-384
6. Callen E, Surralles J (2004) Telomere dysfunction in genome instability syndromes. Mutat Res 567:85-104
7. Choi JE, Kang HG, Jang JS, et al. (2009) Polymorphisms in telomere maintenance genes and risk of lung cancer. Cancer Epidemiol Biomarkers Prev 18:2773-2781
8. Cong YS, Wen J, Bacchetti S (1999) The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter. Hum Mol Genet 8:137-142
9. De Vivo I, Prescott J, Wong JY, et al. (2009) A prospective study of relative telomere length and postmenopausal breast cancer risk. Cancer Epidemiol Biomarkers Prev 18:1152-1156
10. Ding D, Zhou J, Wang M, et al. (2013) Implications of telomere-independent activities of telomerase reverse transcriptase in human cancer. FEBS J 280:3205-3211
11. Feldser DM, Hackett JA, Greider CW (2003) Telomere dysfunction and the initiation of genome instability. Nat Rev Cancer 3:623-627
12. Gao L, Thakur A, Liang Y, et al. (2014) Polymorphisms in the TERT gene are associated with lung cancer risk in the Chinese Han population. Eur J Cancer Prev 23:497-501
13. Gladych M, Wojtyla A, Rubis B (2011) Human telomerase expression regulation. Biochem Cell Biol 89:359-376
14. Goueli BS, Janknecht R (2004) Upregulation of the catalytic telomerase subunit by the transcription factor ER81 and oncogenic HER2/Neu, Ras, or Raf. Mol Cell Biol 24:25-35
15. Haiman CA, Chen GK, Vachon CM, et al. (2012) A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. Nat Genet 43:1210-1214
16. Harley CB (2008) Telomerase and cancer therapeutics. Nat Rev Cancer 8:167-179
17. Hashemi M, Amininia S, Ebrahimi M, et al. (2014) Association between hTERT polymorphisms and the risk of breast cancer in a sample of Southeast Iranian population. BMC Res Notes 7:895
18. Jang JS, Choi YY, Lee WK, et al. (2008) Telomere length and the risk of lung cancer. Cancer Sci 99:1385-1389
19. Kunimura C, Kikuchi K, Ahmed N, et al. (1998) Telomerase activity in a specific cell subset co-expressing integrin beta1/ EGFR but not p75NGFR/bcl2/integrin beta4 in normal human epithelial cells. Oncogene 17:187-197
20. Kyo S, Takakura M, Kanaya T, et al. (1999) Estrogen activates telomerase. Cancer Res 59:5917-5921
21. Ledwon JK, Hennig EE, Maryan N, et al. (2013) Common lowpenetrance risk variants associated with breast cancer in Polish women. BMC Cancer 13:510
22. Li C, Yin Z, Wu W, et al. (2013) Genetic variations in TERTCLPTM1L genes and risk of lung cancer in Chinese women nonsmokers. PLoS One 8:e64988
23. Ma H, Zhou Z, Wei S, et al. (2011) Shortened telomere length is associated with increased risk of cancer: a meta-analysis. PLoS One 6:e20466
24. Machiela MJ, Hsiung CA, Shu X, et al. (2015) Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: A report from the Female Lung Cancer Consortium in Asia. Int J Cancer 137:311-319
25. McGrath M, Wong JYY, Michaud D, et al. (2007) Telomere length, cigarette smoking, and bladder cancer risk in men and women. Cancer Epidemiol Biomarkers Prev 16:815-819
26. Misiti S, Nanni S, Fontemaggi G, et al. (2000) Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells. Mol Cell Biol 20:3764-3771
27. Mocellin S, Pooley KA, Nitti D. (2013) Telomerase and the search for the end of cancer. Trends Mol Med 19:125-133
28. Pellatt AJ, Wolff RK, Herrick J, et al. (2013) TERT's role in colorectal carcinogenesis. Mol Carcinog 52:507-513
29. Qi HY, Zou P, Zhao L, et al. (2012) TERT rs2736098 polymorphism and cancer risk: results of a meta-analysis. Asian Pacific J Cancer Prev 13:3483-3488
30. Rafnar T, Sulem P, Stacey SN, et al. (2009) Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nat Genet 41:221-227
31. Ren H, Zhao T, Wang X, et al. (2010) Leptin upregulates telomerase activity and transcription of human telomerase reverse transcriptase in MCF-7 breast cancer cells. Biochem Biophys Res Commun 394:59-63
32. Savage SA, Chanock SJ, Lissowska J, et al. (2007) Genetic variation in five genes important in telomere biology and risk for breast cancer. Br J Cancer 97:832-836
33. Shadrina AS, Boyarskikh UA, Oskina NA, et al. (2015) TERT polymorphisms rs2853669 and rs7726159 influence on prostate cancer risk in Russian population. Tumor Biol 36:841-847
34. Sheikh A, Hussain SA, Ghori Q, et al. (2015) The spectrum of genetic mutations in breast cancer. Asian Pac J Cancer Prev 16:2177-2185
35. Shen J, Gammon MD, Terry MB, et al. (2009) Telomere length, oxidative damage, antioxidants and breast cancer risk. Int J Cancer 124:1637-1643
36. Shen J, Gammon MD, Terry MB, et al. (2012) Genetic polymorphisms in telomere pathway genes, telomere length, and breast cancer survival. Breast Cancer Res Treat 134:393-400
37. Shen J, Gammon MD, Wu HC, et al. (2010) Multiple genetic variants in telomere pathway genes and breast cancer risk. Cancer Epidemiol Biomarkers Prev 19:219-228
38. Stephens M, Donnelly PA (2003) A comparison of Bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Gen 73:1162-1169
39. Vageli D, Ioannou MG, Koukoulis GK (2009) Transcriptional activation of hTERT in breast carcinomas by the Her2-ER81-related pathway. Oncol Res 17:413-423
40. Valdes AM, Andrew T, Gardner JP, et al. (2005) Obesity, cigarette smoking, and telomere length in women. Lancet 366:662-664
41. Varadi V, Brendle A, Brandt A, et al. (2009a) Polymorphisms in telomere-associated genes, breast cancer susceptibility and prognosis. Eur J Cancer 45:3008-3016
42. Varadi V, Brendle A, Grzybowska E, et al. (2009b) A functional promoter polymorphism in the TERT gene does not affect inherited susceptibility to breast cancer. Cancer Genet Cytogenet 190:71-74
43. Vinagre J, Pinto V, Celestino R, et al. (2014) Telomerase promoter mutations in cancer: an emerging molecular biomarker? Virchows Archiv 465:119-133
44. Wei R, DeVilbiss FT, Liu W (2015) Genetic polymorphism, telomere biology and non-small lung cancer risk. J Genet Genomics 42:549-561
45. Wright WE, Shay JW (2005) Telomere biology in aging and cancer. J Am Geriatr Soc 53:S292-S294