A functional promoter polymorphism in the TERT gene does not affect inherited susceptibility to breast cancer

Cancer Genetics and Cytogenetics

Volumn 190, Issue 2, 2009, Pages 71-74

  Varadi, Verena ^a   Brendle, Annika ^a   Grzybowska, Ewa ^b   Johansson, Robert ^c   Enquist, Kerstin ^d   Butkiewicz, Dorota ^b   Pamula Pilat, Jolanta ^b   Pekala, Wioletta ^b   Hemminki, Kari ^a,e   Lenner, Per ^c   Försti, Asta ^a,e  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b INSTITUTE OF ONCOLOGY   (Poland)

^c UMEÅ UNIVERSITY HOSPITAL   (Sweden)

^d UMEÅ UNIVERSITY   (Sweden)

^e KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

ADOLESCENT; ADULT; AGED; ARTICLE; BREAST CANCER; CANCER RISK; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; FEMALE; GENE SEQUENCE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; TELOMERASE;

EID: 64549147054     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2008.12.006     Document Type: Article

References (14)

1. Savage S.A., Chanock S.J., Lissowska J., Brinton L.A., Richesson D., Peplonska B., Bardin-Mikolajczak A., Zatonski W., Szeszenia-Dabrowska N., and Garcia-Closas M. Genetic variation in five genes important in telomere biology and risk for breast cancer. Br J Cancer 97 (2007) 832-836
2. Meyerson M., Counter C.M., Eaton E.N., Ellisen L.W., Steiner P., Caddle S.D., Ziaugra L., Beijersbergen R.L., Davidoff M.J., Liu Q., Bacchetti S., Haber D.A., and Weinberg R.A. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 90 (1997) 785-795
3. Hsu C.-P., Hsu N.-Y., Lee L.-W., and Ko J.-L. Ets2 binding site single nucleotide polymorphism at the hTERT gene promoter: effect on telomerase expression and telomere length maintenance in non-small cell lung cancer. Eur J Cancer 42 (2006) 1466-1474
4. Cong Y.S., Wen J., and Bacchetti S. The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter. Hum Mol Genet 8 (1999) 137-142
5. Cheung A.L., and Deng W. Telomere dysfunction, genome instability and cancer. Front Biosci 13 (2008) 2075-2090
6. Jefford C.E., and Irminger-Finger I. Mechanisms of chromosome instability in cancers. Crit Rev Oncol Hematol 59 (2006) 1-14
7. Savage S.A., Stewart B.J., Eckert A., Kiley M., Liao J.S., and Chanock S.J. Genetic variation, nucleotide diversity, and linkage disequilibrium in seven telomere stability genes suggest that these genes may be under constraint. Hum Mutat 26 (2005) 343-350
8. Jin Q., Hemminki K., Grzybowska E., Klaes R., Söderberg M., Zientek H., Rogozinska-Szczepka J., Utracka-Hutka B., Pamula J., Pekala W., and Försti A. Polymorphisms and haplotype structures in genes for transforming growth factor β1 and its receptors in familial and unselected breast cancers. Int J Cancer 112 (2004) 94-99
9. Kaaks R., Lundin E., Rinaldi S., Manjer J., Biessy C., Söderberg S., Lenner P., Janzon L., Riboli E., Berglund G., and Hallmans G. Prospective study of IGF-I, IGF-binding proteins, and breast cancer risk, in northern and southern Sweden. Cancer Causes Control 13 (2002) 307-316
10. Brendle A., Lei H., Brandt A., Johansson R., Enquist K., Henriksson R., Hemminki K., Lenner P., and Försti A. Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker. Carcinogenesis 29 (2008) 1394-1399
11. Vaclavicek A., Hemminki K., Bartram C.R., Wagner K., Wappenschmidt B., Meindl A., Schmutzler R.K., Klaes R., Untch M., Burwinkel B., and Försti A. Association of prolactin and its receptor gene regions with familial breast cancer. J Clin Endocrinol Metab 91 (2006) 1513-1519
12. Barrett J.C., Fry B., Maller J., and Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21 (2005) 263-265
13. Houlston R.S., and Peto J. The future of association studies of common cancers. Hum Genet 112 (2003) 434-435
14. Salhab M., Jiang W.G., Newbold R.F., and Mokbel K. The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome. Breast Cancer Res Treat 109 (2008) 35-46