Genetic Polymorphism, Telomere Biology and Non-Small Lung Cancer Risk

Journal of Genetics and Genomics

Volumn 42, Issue 10, 2015, Pages 549-561

  Wei, Rongrong ^a   DeVilbiss, Frank T ^b   Liu, Wanqing ^a  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

Cancer risk; EGFR mutations; Non small cell lung cancer; Polymorphism; Telomere

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; TELOMERASE REVERSE TRANSCRIPTASE;

ALLELE; CANCER RISK; CARCINOGENESIS; DEMOGRAPHY; EAST ASIAN; ENVIRONMENTAL FACTOR; ETHNICITY; GENE MUTATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; HISTOPATHOLOGY; HUMAN; LUNG ADENOCARCINOMA; MEDICAL HISTORY; NON SMALL CELL LUNG CANCER; NONHUMAN; PHYSIOLOGICAL PROCESS; REVIEW; SMOKING; TELOMERE; TELOMERE HOMEOSTASIS; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; LUNG TUMOR; SINGLE NUCLEOTIDE POLYMORPHISM;

GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LUNG NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE; TELOMERE;

EID: 84946714123     PISSN: 16738527     EISSN: 18735533     Source Type: Journal    
DOI: 10.1016/j.jgg.2015.08.005     Document Type: Review

References (117)

1. Ahn M.J., Won H.H., Lee J., Lee S.T., Sun J.M., Park Y.H., Ahn J.S., Kwon O.J., Kim H., Shim Y.M., Kim J., Kim K., Kim Y.H., Park J.Y., Kim J.W., Park K. The 18p11.22 locus is associated with never smoker non-small cell lung cancer susceptibility in Korean populations. Hum. Genet. 2012, 131:365-372.
2. Amos C.I., Wu X., Broderick P., Gorlov I.P., Gu J., Eisen T., Dong Q., Zhang Q., Gu X., Vijayakrishnan J., Sullivan K., Matakidou A., Wang Y., Mills G., Doheny K., Tsai Y.Y., Chen W.V., Shete S., Spitz M.R., Houlston R.S. Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat. Genet. 2008, 40:616-622.
3. Aravindan N., Aravindan S., Herman T.S., Natarajan M. EGFR tyrosine kinase inhibitor pelitinib regulates radiation-induced p65-dependent telomerase activation in squamous cell carcinoma. Radiat. Res. 2013, 179:304-312.
4. Autexier C., Lue N.F. The structure and function of telomerase reverse transcriptase. Annu. Rev. Biochem. 2006, 75:493-517.
5. Bae E.Y., Lee S.Y., Kang B.K., Lee E.J., Choi Y.Y., Kang H.G., Choi J.E., Jeon H.S., Lee W.K., Kam S., Shin K.M., Jin G., Yoo S.S., Lee J., Cha S.I., Kim C.H., Jung T.H., Park J.Y. Replication of results of genome-wide association studies on lung cancer susceptibility loci in a Korean population. Respirology 2012, 17:699-706.
6. Bell D.W., Brannigan B.W., Matsuo K., Finkelstein D.M., Sordella R., Settleman J., Mitsudomi T., Haber D.A. Increased prevalence of EGFR-mutant lung cancer in women and in East Asian populations: analysis of estrogen-related polymorphisms. Clin. Cancer Res. 2008, 14:4079-4084.
7. Bodnar A.G., Ouellette M., Frolkis M., Holt S.E., Chiu C.P., Morin G.B., Harley C.B., Shay J.W., Lichtsteiner S., Wright W.E. Extension of life-span by introduction of telomerase into normal human cells. Science 1998, 279:349-352.
8. Breathnach O.S., Freidlin B., Conley B., Green M.R., Johnson D.H., Gandara D.R., O'Connell M., Shepherd F.A., Johnson B.E. Twenty-two years of phase III trials for patients with advanced non-small-cell lung cancer: sobering results. J. Clin. Oncol. 2001, 19:1734-1742.
9. Brennan P., Hainaut P., Boffetta P. Genetics of lung-cancer susceptibility. Lancet Oncol. 2011, 12:399-408.
10. Broderick P., Wang Y., Vijayakrishnan J., Matakidou A., Spitz M.R., Eisen T., Amos C.I., Houlston R.S. Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. Cancer Res. 2009, 69:6633-6641.
11. Budiyanto A., Bito T., Kunisada M., Ashida M., Ichihashi M., Ueda M. Inhibition of the epidermal growth factor receptor suppresses telomerase activity in HSC-1 human cutaneous squamous cell carcinoma cells. J. Invest. Dermatol. 2003, 121:1088-1094.
12. Campa D., Rizzato C., Stolzenberg-Solomon R., Pacetti P., Vodicka P., Cleary S.P., Capurso G., Bueno-de-Mesquita H.B., Werner J., Gazouli M., Butterbach K., Ivanauskas A., Giese N., Petersen G.M., Fogar P., Wang Z., Bassi C., Ryska M., Theodoropoulos G.E., Kooperberg C., Li D., Greenhalf W., Pasquali C., Hackert T., Fuchs C.S., Mohelnikova-Duchonova B., Sperti C., Funel N., Dieffenbach A.K., Wareham N.J., Buring J., Holcatova I., Costello E., Zambon C.F., Kupcinskas J., Risch H.A., Kraft P., Bracci P.M., Pezzilli R., Olson S.H., Sesso H.D., Hartge P., Strobel O., Malecka-Panas E., Visvanathan K., Arslan A.A., Pedrazzoli S., Soucek P., Gioffreda D., Key T.J., Talar-Wojnarowska R., Scarpa A., Mambrini A., Jacobs E.J., Jamroziak K., Klein A., Tavano F., Bambi F., Landi S., Austin M.A., Vodickova L., Brenner H., Chanock S.J., Delle Fave G., Piepoli A., Cantore M., Zheng W., Wolpin B.M., Amundadottir L.T., Canzian F. TERT gene harbors multiple variants associated with pancreatic cancer susceptibility. Int. J. Cancer 2015, 137:2175-2183.
13. Chen X.F., Cai S., Chen Q.G., Ni Z.H., Tang J.H., Xu D.W., Wang X.B. Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma. Genet. Mol. Res. 2012, 11:370-378.
14. Choi J., Southworth L.K., Sarin K.Y., Venteicher A.S., Ma W., Chang W., Cheung P., Jun S., Artandi M.K., Shah N., Kim S.K., Artandi S.E. TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program. PLoS Genet. 2008, 4:e10.
15. Choong N.W., Dietrich S., Seiwert T.Y., Tretiakova M.S., Nallasura V., Davies G.C., Lipkowitz S., Husain A.N., Salgia R., Ma P.C. Gefitinib response of erlotinib-refractory lung cancer involving meninges-role of EGFR mutation. Nat. Clin. Pract. Oncol. 2006, 3:50-57.
16. Clapp R.W., Jacobs M.M., Loechler E.L. Environmental and occupational causes of cancer: new evidence 2005-2007. Rev. Environ. Health 2008, 23:1-37.
17. Codd V., Nelson C.P., Albrecht E., Mangino M., Deelen J., Buxton J.L., Hottenga J.J., Fischer K., Esko T., Surakka I., Broer L., Nyholt D.R., Mateo Leach I., Salo P., Hagg S., Matthews M.K., Palmen J., Norata G.D., O'Reilly P.F., Saleheen D., Amin N., Balmforth A.J., Beekman M., de Boer R.A., Bohringer S., Braund P.S., Burton P.R., de Craen A.J., Denniff M., Dong Y., Douroudis K., Dubinina E., Eriksson J.G., Garlaschelli K., Guo D., Hartikainen A.L., Henders A.K., Houwing-Duistermaat J.J., Kananen L., Karssen L.C., Kettunen J., Klopp N., Lagou V., van Leeuwen E.M., Madden P.A., Magi R., Magnusson P.K., Mannisto S., McCarthy M.I., Medland S.E., Mihailov E., Montgomery G.W., Oostra B.A., Palotie A., Peters A., Pollard H., Pouta A., Prokopenko I., Ripatti S., Salomaa V., Suchiman H.E., Valdes A.M., Verweij N., Vinuela A., Wang X., Wichmann H.E., Widen E., Willemsen G., Wright M.J., Xia K., Xiao X., van Veldhuisen D.J., Catapano A.L., Tobin M.D., Hall A.S., Blakemore A.I., van Gilst W.H., Zhu H., Consortium C., Erdmann J., Reilly M.P., Kathiresan S., Schunkert H., Talmud P.J., Pedersen N.L., Perola M., Ouwehand W., Kaprio J., Martin N.G., van Duijn C.M., Hovatta I., Gieger C., Metspalu A., Boomsma D.I., Jarvelin M.R., Slagboom P.E., Thompson J.R., Spector T.D., van der Harst P., Samani N.J. Identification of seven loci affecting mean telomere length and their association with disease. Nat. Genet. 2013, 45:422-427.
18. Counter C.M., Meyerson M., Eaton E.N., Ellisen L.W., Caddle S.D., Haber D.A., Weinberg R.A. Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase. Oncogene 1998, 16:1217-1222.
19. Daigo Y., Nakamura Y. From cancer genomics to thoracic oncology: discovery of new biomarkers and therapeutic targets for lung and esophageal carcinoma. Gen. Thorac. Cardiovasc. Surg. 2008, 56:43-53.
20. Feng J., Funk W.D., Wang S.S., Weinrich S.L., Avilion A.A., Chiu C.P., Adams R.R., Chang E., Allsopp R.C., Yu J., et al. The RNA component of human telomerase. Science 1995, 269:1236-1241.
21. Ferlay J., Shin H.R., Bray F., Forman D., Mathers C., Parkin D.M. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer 2010, 127:2893-2917.
22. Fu X., Wan S., Hann H.W., Myers R.E., Hann R.S., Au J., Chen B., Xing J., Yang H. Relative telomere length: a novel non-invasive biomarker for the risk of non-cirrhotic hepatocellular carcinoma in patients with chronic hepatitis B infection. Eur. J. Cancer 2012, 48:1014-1022.
23. Gago-Dominguez M., Jiang X., Conti D.V., Castelao J.E., Stern M.C., Cortessis V.K., Pike M.C., Xiang Y.B., Gao Y.T., Yuan J.M., Van Den Berg D.J. Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study. Carcinogenesis 2011, 32:197-202.
24. Gorlova O.Y., Zhang Y., Schabath M.B., Lei L., Zhang Q., Amos C.I., Spitz M.R. Never smokers and lung cancer risk: a case-control study of epidemiological factors. Int. J. Cancer 2006, 118:1798-1804.
25. Greulich H., Chen T.H., Feng W., Janne P.A., Alvarez J.V., Zappaterra M., Bulmer S.E., Frank D.A., Hahn W.C., Sellers W.R., Meyerson M. Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. PLoS Med. 2005, 2:e313.
26. Han J., Qureshi A.A., Prescott J., Guo Q., Ye L., Hunter D.J., De Vivo I. A prospective study of telomere length and the risk of skin cancer. J. Invest. Dermatol. 2009, 129:415-421.
27. Hsiung C.A., Lan Q., Hong Y.C., Chen C.J., Hosgood H.D., Chang I.S., Chatterjee N., Brennan P., Wu C., Zheng W., Chang G.C., Wu T., Park J.Y., Hsiao C.F., Kim Y.H., Shen H., Seow A., Yeager M., Tsai Y.H., Kim Y.T., Chow W.H., Guo H., Wang W.C., Sung S.W., Hu Z., Chen K.Y., Kim J.H., Chen Y., Huang L., Lee K.M., Lo Y.L., Gao Y.T., Liu L., Huang M.S., Jung T.H., Jin G., Caporaso N., Yu D., Kim C.H., Su W.C., Shu X.O., Xu P., Kim I.S., Chen Y.M., Ma H., Shen M., Cha S.I., Tan W., Chang C.H., Sung J.S., Zhang M., Yang T.Y., Park K.H., Yuenger J., Wang C.L., Ryu J.S., Xiang Y., Deng Q., Hutchinson A., Kim J.S., Cai Q., Landi M.T., Yu C.J., Tucker M., Hung J.Y., Lin C.C., Perng R.P., Boffetta P., Chen C.Y., Chen K.C., Yang S.Y., Hu C.Y., Chang C.K., Fraumeni J.F., Chanock S., Yang P.C., Rothman N., Lin D. The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia. PLoS Genet. 2010, 6:e1001051.
28. Hsu C.P., Miaw J., Hsia J.Y., Shai S.E., Chen C.Y. Concordant expression of the telomerase-associated genes in non-small cell lung cancer. Eur. J. Surg. Oncol. 2003, 29:594-599.
29. Hu Q.Y., Jin T.B., Wang L., Zhang L., Geng T., Liang G., Kang L.L. Genetic variation in the TP63 gene is associated with lung cancer risk in the Han population. Tumour Biol. 2014, 35:1863-1866.
30. Hu Z., Wu C., Shi Y., Guo H., Zhao X., Yin Z., Yang L., Dai J., Hu L., Tan W., Li Z., Deng Q., Wang J., Wu W., Jin G., Jiang Y., Yu D., Zhou G., Chen H., Guan P., Chen Y., Shu Y., Xu L., Liu X., Liu L., Xu P., Han B., Bai C., Zhao Y., Zhang H., Yan Y., Ma H., Chen J., Chu M., Lu F., Zhang Z., Chen F., Wang X., Jin L., Lu J., Zhou B., Lu D., Wu T., Lin D., Shen H. A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat. Genet. 2011, 43:792-796.
31. Hung R.J., McKay J.D., Gaborieau V., Boffetta P., Hashibe M., Zaridze D., Mukeria A., Szeszenia-Dabrowska N., Lissowska J., Rudnai P., Fabianova E., Mates D., Bencko V., Foretova L., Janout V., Chen C., Goodman G., Field J.K., Liloglou T., Xinarianos G., Cassidy A., McLaughlin J., Liu G., Narod S., Krokan H.E., Skorpen F., Elvestad M.B., Hveem K., Vatten L., Linseisen J., Clavel-Chapelon F., Vineis P., Bueno-de-Mesquita H.B., Lund E., Martinez C., Bingham S., Rasmuson T., Hainaut P., Riboli E., Ahrens W., Benhamou S., Lagiou P., Trichopoulos D., Holcatova I., Merletti F., Kjaerheim K., Agudo A., Macfarlane G., Talamini R., Simonato L., Lowry R., Conway D.I., Znaor A., Healy C., Zelenika D., Boland A., Delepine M., Foglio M., Lechner D., Matsuda F., Blanche H., Gut I., Heath S., Lathrop M., Brennan P. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature 2008, 452:633-637.
32. Janssen-Heijnen M.L., Coebergh J.W. The changing epidemiology of lung cancer in Europe. Lung Cancer 2003, 41:245-258.
33. Jee S.H., Kim I.S., Suh I., Shin D., Appel L.J. Projected mortality from lung cancer in South Korea, 1980-2004. Int. J. Epidemiol. 1998, 27:365-369.
34. Jemal A., Bray F., Center M.M., Ferlay J., Ward E., Forman D. Global cancer statistics. CA Cancer J. Clin. 2011, 61:69-90.
35. Jin G., Xu L., Shu Y., Tian T., Liang J., Xu Y., Wang F., Chen J., Dai J., Hu Z., Shen H. Common genetic variants on 5p15.33 contribute to risk of lung adenocarcinoma in a Chinese population. Carcinogenesis 2009, 30:987-990.
36. Kang J.U., Koo S.H., Kwon K.C., Park J.W., Kim J.M. Gain at chromosomal region 5p15.33, containing TERT, is the most frequent genetic event in early stages of non-small cell lung cancer. Cancer Genet. Cytogenet. 2008, 182:1-11.
37. Kawaguchi T., Matsumura A., Fukai S., Tamura A., Saito R., Zell J.A., Maruyama Y., Ziogas A., Kawahara M., Ignatius Ou S.H. Japanese ethnicity compared with Caucasian ethnicity and never-smoking status are independent favorable prognostic factors for overall survival in non-small cell lung cancer: a collaborative epidemiologic study of the National Hospital Organization Study Group for Lung Cancer (NHSGLC) in Japan and a Southern California Regional Cancer Registry databases. J. Thorac. Oncol. 2010, 5:1001-1010.
38. Ke J., Zhong R., Zhang T., Liu L., Rui R., Shen N., Sun Y., Cheng L., Miao X.P. Replication study in Chinese population and meta-analysis supports association of the 5p15.33 locus with lung cancer. PLoS One 2013, 8:e62485.
39. Kim D.W., Lu B., Hallahan D.E. Receptor tyrosine kinase inhibitors as anti-angiogenic agents. Curr. Opin. Investig. Drugs 2004, 5:597-604.
40. Kim J., Jones-Hall Y.L., Wei R., Myers J., Qi Y., Knipp G.T., Liu W. Association between hTERT rs2736100 polymorphism and sensitivity to anti-cancer agents. Front. Genet. 2013, 4:162.
41. Kinnersley B., Migliorini G., Broderick P., Whiffin N., Dobbins S.E., Casey G., Hopper J., Sieber O., Lipton L., Kerr D.J., Dunlop M.G., Tomlinson I.P., Houlston R.S. The TERT variant rs2736100 is associated with colorectal cancer risk. Br. J. Cancer 2012, 107:1001-1008.
42. Kohno T., Kunitoh H., Shimada Y., Shiraishi K., Ishii Y., Goto K., Ohe Y., Nishiwaki Y., Kuchiba A., Yamamoto S., Hirose H., Oka A., Yanagitani N., Saito R., Inoko H., Yokota J. Individuals susceptible to lung adenocarcinoma defined by combined HLA-DQA1 and TERT genotypes. Carcinogenesis 2010, 31:834-841.
43. Kosaka T., Yatabe Y., Endoh H., Kuwano H., Takahashi T., Mitsudomi T. Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications. Cancer Res. 2004, 64:8919-8923.
44. Lam W.K. Lung cancer in Asian women-the environment and genes. Respirology 2005, 10:408-417.
45. Lan Q., Cawthon R., Gao Y., Hu W., Hosgood H.D., Barone-Adesi F., Ji B.T., Bassig B., Chow W.H., Shu X., Cai Q., Xiang Y., Berndt S., Kim C., Chanock S., Zheng W., Rothman N. Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China. PLoS One 2013, 8:e59230.
46. Lan Q., Cawthon R., Shen M., Weinstein S.J., Virtamo J., Lim U., Hosgood H.D., Albanes D., Rothman N. A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of non-Hodgkin lymphoma. Clin. Cancer Res. 2009, 15:7429-7433.
47. Lan Q., Hsiung C.A., Matsuo K., Hong Y.C., Seow A., Wang Z., Hosgood H.D., Chen K., Wang J.C., Chatterjee N., Hu W., Wong M.P., Zheng W., Caporaso N., Park J.Y., Chen C.J., Kim Y.H., Kim Y.T., Landi M.T., Shen H., Lawrence C., Burdett L., Yeager M., Yuenger J., Jacobs K.B., Chang I.S., Mitsudomi T., Kim H.N., Chang G.C., Bassig B.A., Tucker M., Wei F., Yin Z., Wu C., An S.J., Qian B., Lee V.H., Lu D., Liu J., Jeon H.S., Hsiao C.F., Sung J.S., Kim J.H., Gao Y.T., Tsai Y.H., Jung Y.J., Guo H., Hu Z., Hutchinson A., Wang W.C., Klein R., Chung C.C., Oh I.J., Chen K.Y., Berndt S.I., He X., Wu W., Chang J., Zhang X.C., Huang M.S., Zheng H., Wang J., Zhao X., Li Y., Choi J.E., Su W.C., Park K.H., Sung S.W., Shu X.O., Chen Y.M., Liu L., Kang C.H., Hu L., Chen C.H., Pao W., Kim Y.C., Yang T.Y., Xu J., Guan P., Tan W., Su J., Wang C.L., Li H., Sihoe A.D., Zhao Z., Chen Y., Choi Y.Y., Hung J.Y., Kim J.S., Yoon H.I., Cai Q., Lin C.C., Park I.K., Xu P., Dong J., Kim C., He Q., Perng R.P., Kohno T., Kweon S.S., Chen C.Y., Vermeulen R., Wu J., Lim W.Y., Chen K.C., Chow W.H., Ji B.T., Chan J.K., Chu M., Li Y.J., Yokota J., Li J., Chen H., Xiang Y.B., Yu C.J., Kunitoh H., Wu G., Jin L., Lo Y.L., Shiraishi K., Chen Y.H., Lin H.C., Wu T., Wu Y.L., Yang P.C., Zhou B., Shin M.H., Fraumeni J.F., Lin D., Chanock S.J., Rothman N. Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nat. Genet. 2012, 44:1330-1335.
48. Landi M.T., Chatterjee N., Yu K., Goldin L.R., Goldstein A.M., Rotunno M., Mirabello L., Jacobs K., Wheeler W., Yeager M., Bergen A.W., Li Q., Consonni D., Pesatori A.C., Wacholder S., Thun M., Diver R., Oken M., Virtamo J., Albanes D., Wang Z., Burdette L., Doheny K.F., Pugh E.W., Laurie C., Brennan P., Hung R., Gaborieau V., McKay J.D., Lathrop M., McLaughlin J., Wang Y., Tsao M.S., Spitz M.R., Krokan H., Vatten L., Skorpen F., Arnesen E., Benhamou S., Bouchard C., Metspalu A., Vooder T., Nelis M., Valk K., Field J.K., Chen C., Goodman G., Sulem P., Thorleifsson G., Rafnar T., Eisen T., Sauter W., Rosenberger A., Bickeboller H., Risch A., Chang-Claude J., Wichmann H.E., Stefansson K., Houlston R., Amos C.I., Fraumeni J.F., Savage S.A., Bertazzi P.A., Tucker M.A., Chanock S., Caporaso N.E. A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Am. J. Hum. Genet. 2009, 85:679-691.
49. Lantuejoul S., Salon C., Soria J.C., Brambilla E. Telomerase expression in lung preneoplasia and neoplasia. Int. J. Cancer 2007, 120:1835-1841.
50. Liam C.K., Pang Y.K., Leow C.H., Poosparajah S., Menon A. Changes in the distribution of lung cancer cell types and patient demography in a developing multiracial Asian country: experience of a university teaching hospital. Lung Cancer 2006, 53:23-30.
51. Lichtenstein P., Holm N.V., Verkasalo P.K., Iliadou A., Kaprio J., Koskenvuo M., Pukkala E., Skytthe A., Hemminki K. Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland. N. Engl. J. Med. 2000, 343:78-85.
52. Longo D., Fauci A., Kasper D., Hauser S., Jameson J., Loscalzo J. Harrison's Principles of Internal Medicine 2011, McGraw Hill Education, (Chapter 89). eighteenth ed.
53. Lortet-Tieulent J., Soerjomataram I., Ferlay J., Rutherford M., Weiderpass E., Bray F. International trends in lung cancer incidence by histological subtype: adenocarcinoma stabilizing in men but still increasing in women. Lung Cancer 2014, 84:13-22.
54. Lu X., Ke J., Luo X., Zhu Y., Zou L., Li H., Zhu B., Xiong Z., Chen W., Deng L., Lou J., Wang X., Zhang Y., Wang Z., Miao X., Cheng L. The SNP rs402710 in 5p15.33 is associated with lung cancer risk: a replication study in Chinese population and a meta-analysis. PLoS One 2013, 8:e76252.
55. Lundberg A.S., Randell S.H., Stewart S.A., Elenbaas B., Hartwell K.A., Brooks M.W., Fleming M.D., Olsen J.C., Miller S.W., Weinberg R.A., Hahn W.C. Immortalization and transformation of primary human airway epithelial cells by gene transfer. Oncogene 2002, 21:4577-4586.
56. Lynch T.J., Bell D.W., Sordella R., Gurubhagavatula S., Okimoto R.A., Brannigan B.W., Harris P.L., Haserlat S.M., Supko J.G., Haluska F.G., Louis D.N., Christiani D.C., Settleman J., Haber D.A. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 2004, 350:2129-2139.
57. Machiela M.J., Hsiung C.A., Shu X.O., Seow W.J., Wang Z., Matsuo K., Hong Y.C., Seow A., Wu C., Hosgood H.D., Chen K., Wang J.C., Wen W., Cawthon R., Chatterjee N., Hu W., Caporaso N.E., Park J.Y., Chen C.J., Kim Y.H., Kim Y.T., Landi M.T., Shen H., Lawrence C., Burdett L., Yeager M., Chang I.S., Mitsudomi T., Kim H.N., Chang G.C., Bassig B.A., Tucker M., Wei F., Yin Z., An S.J., Qian B., Lee V.H., Lu D., Liu J., Jeon H.S., Hsiao C.F., Sung J.S., Kim J.H., Gao Y.T., Tsai Y.H., Jung Y.J., Guo H., Hu Z., Hutchinson A., Wang W.C., Klein R.J., Chung C.C., Oh I.J., Chen K.Y., Berndt S.I., Wu W., Chang J., Zhang X.C., Huang M.S., Zheng H., Wang J., Zhao X., Li Y., Choi J.E., Su W.C., Park K.H., Sung S.W., Chen Y.M., Liu L., Kang C.H., Hu L., Chen C.H., Pao W., Kim Y.C., Yang T.Y., Xu J., Guan P., Tan W., Su J., Wang C.L., Li H., Sihoe A.D., Zhao Z., Chen Y., Choi Y.Y., Hung J.Y., Kim J.S., Yoon H.I., Cai Q., Lin C.C., Park I.K., Xu P., Dong J., Kim C., He Q., Perng R.P., Kohno T., Kweon S.S., Chen C.Y., Vermeulen R.C., Wu J., Lim W.Y., Chen K.C., Chow W.H., Ji B.T., Chan J.K., Chu M., Li Y.J., Yokota J., Li J., Chen H., Xiang Y.B., Yu C.J., Kunitoh H., Wu G., Jin L., Lo Y.L., Shiraishi K., Chen Y.H., Lin H.C., Wu T., Wong M.P., Wu Y.L., Yang P.C., Zhou B., Shin M.H., Fraumeni J.F., Zheng W., Lin D., Chanock S.J., Rothman N., Lan Q. Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia. Int. J. Cancer 2015, 137:311-319.
58. Maida Y., Kyo S., Kanaya T., Wang Z., Yatabe N., Tanaka M., Nakamura M., Ohmichi M., Gotoh N., Murakami S., Inoue M. Direct activation of telomerase by EGF through Ets-mediated transactivation of TERT via MAP kinase signaling pathway. Oncogene 2002, 21:4071-4079.
59. Mason R.J., Broaddus V.C., Marin T., King T.E., Schraufnagel D., Murray J.E., Nadel J.A. Murray & Nadel's Textbook of Respiratory Medicine 2010, Elsevier, Saunders, Philadelphia, (Chapter 46). fifth ed.
60. McCracken M., Olsen M., Chen M.S., Jemal A., Thun M., Cokkinides V., Deapen D., Ward E. Cancer incidence, mortality, and associated risk factors among Asian Americans of Chinese, Filipino, Vietnamese, Korean, and Japanese ethnicities. CA Cancer J. Clin. 2007, 57:190-205.
61. McCredie M., Williams S., Coates M. Cancer mortality in East and Southeast Asian migrants to New South Wales, Australia, 1975-1995. Br. J. Cancer 1999, 79:1277-1282.
62. McKay J.D., Hung R.J., Gaborieau V., Boffetta P., Chabrier A., Byrnes G., Zaridze D., Mukeria A., Szeszenia-Dabrowska N., Lissowska J., Rudnai P., Fabianova E., Mates D., Bencko V., Foretova L., Janout V., McLaughlin J., Shepherd F., Montpetit A., Narod S., Krokan H.E., Skorpen F., Elvestad M.B., Vatten L., Njolstad I., Axelsson T., Chen C., Goodman G., Barnett M., Loomis M.M., Lubinski J., Matyjasik J., Lener M., Oszutowska D., Field J., Liloglou T., Xinarianos G., Cassidy A., Vineis P., Clavel-Chapelon F., Palli D., Tumino R., Krogh V., Panico S., Gonzalez C.A., Ramon Quiros J., Martinez C., Navarro C., Ardanaz E., Larranaga N., Kham K.T., Key T., Bueno-de-Mesquita H.B., Peeters P.H., Trichopoulou A., Linseisen J., Boeing H., Hallmans G., Overvad K., Tjonneland A., Kumle M., Riboli E., Zelenika D., Boland A., Delepine M., Foglio M., Lechner D., Matsuda F., Blanche H., Gut I., Heath S., Lathrop M., Brennan P. Lung cancer susceptibility locus at 5p15.33. Nat. Genet. 2008, 40:1404-1406.
63. Melin B.S., Nordfjall K., Andersson U., Roos G. hTERT cancer risk genotypes are associated with telomere length. Genet. Epidemiol. 2012, 36:368-372.
64. Miki D., Kubo M., Takahashi A., Yoon K.A., Kim J., Lee G.K., Zo J.I., Lee J.S., Hosono N., Morizono T., Tsunoda T., Kamatani N., Chayama K., Takahashi T., Inazawa J., Nakamura Y., Daigo Y. Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. Nat. Genet. 2010, 42:893-896.
65. Needham B.L., Diez Roux A.V., Bird C.E., Bradley R., Fitzpatrick A.L., Jacobs D.R., Ouyang P., Seeman T.E., Thurston R.C., Vaidya D., Wang S. A test of biological and behavioral explanations for gender differences in telomere length: the multi-ethnic study of atherosclerosis. Biodemography Soc. Biol. 2014, 60:156-173.
66. Ng M., Freeman M.K., Fleming T.D., Robinson M., Dwyer-Lindgren L., Thomson B., Wollum A., Sanman E., Wulf S., Lopez A.D., Murray C.J., Gakidou E. Smoking prevalence and cigarette consumption in 187 countries, 1980-2012. JAMA 2014, 311:183-192.
67. Nishii T., Yokose T., Miyagi Y., Daigo Y., Ito H., Isaka T., Imai K., Murakami S., Kondo T., Saito H., Oshita F., Yamada K., Matsukuma S., Tsuboi M., Nakayama H., Masuda M. Clinicopathological features and EGFR gene mutation status in elderly patients with resected non-small-cell lung cancer. BMC Cancer 2014, 14:610.
68. O'Reilly K.M., McLaughlin A.M., Beckett W.S., Sime P.J. Asbestos-related lung disease. Am. Fam. Physician 2007, 75:683-688.
69. Paez J.G., Janne P.A., Lee J.C., Tracy S., Greulich H., Gabriel S., Herman P., Kaye F.J., Lindeman N., Boggon T.J., Naoki K., Sasaki H., Fujii Y., Eck M.J., Sellers W.R., Johnson B.E., Meyerson M. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004, 304:1497-1500.
70. Parkin D.M., Bray F., Ferlay J., Pisani P. Global cancer statistics, 2002. CA Cancer J. Clin. 2005, 55:74-108.
71. Piao C.Q., Liu L., Zhao Y.L., Balajee A.S., Suzuki M., Hei T.K. Immortalization of human small airway epithelial cells by ectopic expression of telomerase. Carcinogenesis 2005, 26:725-731.
72. Poole J.C., Andrews L.G., Tollefsbol T.O. Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT). Gene 2001, 269:1-12.
73. Rafnar T., Sulem P., Stacey S.N., Geller F., Gudmundsson J., Sigurdsson A., Jakobsdottir M., Helgadottir H., Thorlacius S., Aben K.K., Blondal T., Thorgeirsson T.E., Thorleifsson G., Kristjansson K., Thorisdottir K., Ragnarsson R., Sigurgeirsson B., Skuladottir H., Gudbjartsson T., Isaksson H.J., Einarsson G.V., Benediktsdottir K.R., Agnarsson B.A., Olafsson K., Salvarsdottir A., Bjarnason H., Asgeirsdottir M., Kristinsson K.T., Matthiasdottir S., Sveinsdottir S.G., Polidoro S., Hoiom V., Botella-Estrada R., Hemminki K., Rudnai P., Bishop D.T., Campagna M., Kellen E., Zeegers M.P., de Verdier P., Ferrer A., Isla D., Vidal M.J., Andres R., Saez B., Juberias P., Banzo J., Navarrete S., Tres A., Kan D., Lindblom A., Gurzau E., Koppova K., de Vegt F., Schalken J.A., van der Heijden H.F., Smit H.J., Termeer R.A., Oosterwijk E., van Hooij O., Nagore E., Porru S., Steineck G., Hansson J., Buntinx F., Catalona W.J., Matullo G., Vineis P., Kiltie A.E., Mayordomo J.I., Kumar R., Kiemeney L.A., Frigge M.L., Jonsson T., Saemundsson H., Barkardottir R.B., Jonsson E., Jonsson S., Olafsson J.H., Gulcher J.R., Masson G., Gudbjartsson D.F., Kong A., Thorsteinsdottir U., Stefansson K. Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nat. Genet. 2009, 41:221-227.
74. Sakurada A., Shepherd F.A., Tsao M.S. Epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer: impact of primary or secondary mutations. Clin. Lung Cancer 2006, 7(Suppl. 4):S138-144.
75. Sato M., Larsen J.E., Lee W., Sun H., Shames D.S., Dalvi M.P., Ramirez R.D., Tang H., DiMaio J.M., Gao B., Xie Y., Wistuba, Gazdar A.F., Shay J.W., Minna J.D. Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations. Mol. Cancer Res. 2013, 11:638-650.
76. Sharma S.V., Bell D.W., Settleman J., Haber D.A. Epidermal growth factor receptor mutations in lung cancer. Nat. Rev. Cancer 2007, 7:169-181.
77. Shen M., Cawthon R., Rothman N., Weinstein S.J., Virtamo J., Hosgood H.D., Hu W., Lim U., Albanes D., Lan Q. A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of lung cancer. Lung Cancer 2011, 73:133-137.
78. Shete S., Hosking F.J., Robertson L.B., Dobbins S.E., Sanson M., Malmer B., Simon M., Marie Y., Boisselier B., Delattre J.Y., Hoang-Xuan K., El Hallani S., Idbaih A., Zelenika D., Andersson U., Henriksson R., Bergenheim A.T., Feychting M., Lonn S., Ahlbom A., Schramm J., Linnebank M., Hemminki K., Kumar R., Hepworth S.J., Price A., Armstrong G., Liu Y., Gu X., Yu R., Lau C., Schoemaker M., Muir K., Swerdlow A., Lathrop M., Bondy M., Houlston R.S. Genome-wide association study identifies five susceptibility loci for glioma. Nat. Genet. 2009, 41:899-904.
79. Shigematsu H., Lin L., Takahashi T., Nomura M., Suzuki M., Wistuba, Fong K.M., Lee H., Toyooka S., Shimizu N., Fujisawa T., Feng Z., Roth J.A., Herz J., Minna J.D., Gazdar A.F. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J. Natl. Cancer Inst. 2005, 97:339-346.
80. Shiraishi K., Kohno T., Kunitoh H., Watanabe S., Goto K., Nishiwaki Y., Shimada Y., Hirose H., Saito I., Kuchiba A., Yamamoto S., Yokota J. Contribution of nicotine acetylcholine receptor polymorphisms to lung cancer risk in a smoking-independent manner in the Japanese. Carcinogenesis 2009, 30:65-70.
81. Shiraishi K., Kunitoh H., Daigo Y., Takahashi A., Goto K., Sakamoto H., Ohnami S., Shimada Y., Ashikawa K., Saito A., Watanabe S., Tsuta K., Kamatani N., Yoshida T., Nakamura Y., Yokota J., Kubo M., Kohno T. A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. Nat. Genet. 2012, 44:900-903.
82. Song Z., Zhu H., Guo Z., Wu W., Sun W., Zhang Y. Correlation of EGFR mutation and predominant histologic subtype according to the new lung adenocarcinoma classification in Chinese patients. Med. Oncol. 2013, 30:645.
83. Stewart B.W., Kleihues P. World Cancer Report 2003, World Health Organization, IARC Press, Lyon.
84. Stewart B.W., Wild C.P. World Cancer Report 2014, World Health Organization, (Chapter 5.1).
85. Subramanian J., Govindan R. Lung cancer in never smokers: a review. J. Clin. Oncol. 2007, 25:561-570.
86. Sweet-Cordero A., Tseng G.C., You H., Douglass M., Huey B., Albertson D., Jacks T. Comparison of gene expression and DNA copy number changes in a murine model of lung cancer. Genes Chromosomes Cancer 2006, 45:338-348.
87. Thatcher N., Chang A., Parikh P., Rodrigues Pereira J., Ciuleanu T., von Pawel J., Thongprasert S., Tan E.H., Pemberton K., Archer V., Carroll K. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 2005, 366:1527-1537.
88. Thorgeirsson T.E., Geller F., Sulem P., Rafnar T., Wiste A., Magnusson K.P., Manolescu A., Thorleifsson G., Stefansson H., Ingason A., Stacey S.N., Bergthorsson J.T., Thorlacius S., Gudmundsson J., Jonsson T., Jakobsdottir M., Saemundsdottir J., Olafsdottir O., Gudmundsson L.J., Bjornsdottir G., Kristjansson K., Skuladottir H., Isaksson H.J., Gudbjartsson T., Jones G.T., Mueller T., Gottsater A., Flex A., Aben K.K., de Vegt F., Mulders P.F., Isla D., Vidal M.J., Asin L., Saez B., Murillo L., Blondal T., Kolbeinsson H., Stefansson J.G., Hansdottir I., Runarsdottir V., Pola R., Lindblad B., van Rij A.M., Dieplinger B., Haltmayer M., Mayordomo J.I., Kiemeney L.A., Matthiasson S.E., Oskarsson H., Tyrfingsson T., Gudbjartsson D.F., Gulcher J.R., Jonsson S., Thorsteinsdottir U., Kong A., Stefansson K. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature 2008, 452:638-642.
89. Thun M.J., Hannan L.M., Adams-Campbell L.L., Boffetta P., Buring J.E., Feskanich D., Flanders W.D., Jee S.H., Katanoda K., Kolonel L.N., Lee I.M., Marugame T., Palmer J.R., Riboli E., Sobue T., Avila-Tang E., Wilkens L.R., Samet J.M. Lung cancer occurrence in never-smokers: an analysis of 13 cohorts and 22 cancer registry studies. PLoS Med. 2008, 5:e185.
90. Tokumo M., Toyooka S., Kiura K., Shigematsu H., Tomii K., Aoe M., Ichimura K., Tsuda T., Yano M., Tsukuda K. The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non-small cell lung cancers. Clin. Cancer Res. 2005, 11:1167-1173.
91. Torre L.A., Bray F., Siegel R.L., Ferlay J., Lortet-Tieulent J., Jemal A. Global cancer statistics, 2012. CA Cancer J. Clin. 2015, 65:87-108.
92. Toyoda Y., Nakayama T., Ioka A., Tsukuma H. Trends in lung cancer incidence by histological type in Osaka, Japan. Jpn. J. Clin. Oncol. 2008, 38:534-539.
93. Truong T., Hung R.J., Amos C.I., Wu X., Bickeboller H., Rosenberger A., Sauter W., Illig T., Wichmann H.E., Risch A., Dienemann H., Kaaks R., Yang P., Jiang R., Wiencke J.K., Wrensch M., Hansen H., Kelsey K.T., Matsuo K., Tajima K., Schwartz A.G., Wenzlaff A., Seow A., Ying C., Staratschek-Jox A., Nurnberg P., Stoelben E., Wolf J., Lazarus P., Muscat J.E., Gallagher C.J., Zienolddiny S., Haugen A., van der Heijden H.F., Kiemeney L.A., Isla D., Mayordomo J.I., Rafnar T., Stefansson K., Zhang Z.F., Chang S.C., Kim J.H., Hong Y.C., Duell E.J., Andrew A.S., Lejbkowicz F., Rennert G., Muller H., Brenner H., Le Marchand L., Benhamou S., Bouchardy C., Teare M.D., Xue X., McLaughlin J., Liu G., McKay J.D., Brennan P., Spitz M.R. Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium. J. Natl. Cancer Inst. 2010, 102:959-971.
94. Tsao Anne Lung Carcinoma: Tumors of the Lungs 2007, Merck Manual Professional Edition, Online edition. http://www.merckmanuals.com/professional/pulmonary-disorders/tumors-of-the-lungs.
95. U.S.Department of Health and Human Services The health consequences of involuntary exposure to tobacco smoke: a report of the surgeon general. Centers for Disease Control and Prevention, Coordinating Center for Health Promotion, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health 2006, U.S. Department of Health and Human Services, Atlanta, GA.
96. Verde Z., Reinoso-Barbero L., Chicharro L., Garatachea N., Resano P., Sanchez-Hernandez I., Rodriguez Gonzalez-Moro J.M., Bandres F., Santiago C., Gomez-Gallego F. Effects of cigarette smoking and nicotine metabolite ratio on leukocyte telomere length. Environ. Res. 2015, 140:488-494.
97. Villa C., Cagle P.T., Johnson M., Patel J.D., Yeldandi A.V., Raj R., DeCamp M.M., Raparia K. Correlation of EGFR mutation status with predominant histologic subtype of adenocarcinoma according to the new lung adenocarcinoma classification of the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society. Arch. Pathol. Lab. Med. 2014, 138:1353-1357.
98. Vineis P., Airoldi L., Veglia F., Olgiati L., Pastorelli R., Autrup H., Dunning A., Garte S., Gormally E., Hainaut P., Malaveille C., Matullo G., Peluso M., Overvad K., Tjonneland A., Clavel-Chapelon F., Boeing H., Krogh V., Palli D., Panico S., Tumino R., Bueno-De-Mesquita B., Peeters P., Berglund G., Hallmans G., Saracci R., Riboli E. Environmental tobacco smoke and risk of respiratory cancer and chronic obstructive pulmonary disease in former smokers and never smokers in the EPIC prospective study. BMJ 2005, 330:277.
99. Wakelee H.A., Chang E.T., Gomez S.L., Keegan T.H., Feskanich D., Clarke C.A., Holmberg L., Yong L.C., Kolonel L.N., Gould M.K., West D.W. Lung cancer incidence in never smokers. J. Clin. Oncol. 2007, 25:472-478.
100. Walters M.S., De B.P., Salit J., Buro-Auriemma L.J., Wilson T., Rogalski A.M., Lief L., Hackett N.R., Staudt M.R., Tilley A.E., Harvey B.G., Kaner R.J., Mezey J.G., Ashbridge B., Moore M.A., Crystal R.G. Smoking accelerates aging of the small airway epithelium. Respir. Res. 2014, 15:94.
101. Wang F., Fu P., Pang Y., Liu C., Shao Z., Zhu J., Li J., Wang T., Zhang X., Liu J. TERT rs2736100T/G polymorphism upregulates interleukin 6 expression in non-small cell lung cancer especially in adenocarcinoma. Tumour Biol. 2014, 35:4667-4672.
102. Wang Y., Broderick P., Matakidou A., Eisen T., Houlston R.S. Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers. Carcinogenesis 2010, 31:234-238.
103. Wang Y., Broderick P., Webb E., Wu X., Vijayakrishnan J., Matakidou A., Qureshi M., Dong Q., Gu X., Chen W.V., Spitz M.R., Eisen T., Amos C.I., Houlston R.S. Common 5p15.33 and 6p21.33 variants influence lung cancer risk. Nat. Genet. 2008, 40:1407-1409.
104. Wei R., Cao L., Pu H., Wang H.W., Zheng Y., Niu X., Weng X., Zhang H., Favus M., Zhang L.J., Jia W., Zeng Y.X., Amos C.I., Lu S., Wang H.Y., Liu Y., Liu W. TERT polymorphism rs2736100-C is associated with EGFR mutation-positive non-small cell lung cancer. Clin. Cancer Res. 2015, 10.1158/1078-0432.CCR-15-0009.
105. Weinrich S.L., Pruzan R., Ma L., Ouellette M., Tesmer V.M., Holt S.E., Bodnar A.G., Lichtsteiner S., Kim N.W., Trager J.B., Taylor R.D., Carlos R., Andrews W.H., Wright W.E., Shay J.W., Harley C.B., Morin G.B. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat. Genet. 1997, 17:498-502.
106. Wentzensen I.M., Mirabello L., Pfeiffer R.M., Savage S.A. The association of telomere length and cancer: a meta-analysis. Cancer Epidemiol. Biomarkers Prev. 2011, 20:1238-1250.
107. Wu C., Hu Z., Yu D., Huang L., Jin G., Liang J., Guo H., Tan W., Zhang M., Qian J., Lu D., Wu T., Lin D., Shen H. Genetic variants on chromosome 15q25 associated with lung cancer risk in Chinese populations. Cancer Res. 2009, 69:5065-5072.
108. Wu T.C., Lin P., Hsu C.P., Huang Y.J., Chen C.Y., Chung W.C., Lee H., Ko J.L. Loss of telomerase activity may be a potential favorable prognostic marker in lung carcinomas. Lung Cancer 2003, 41:163-169.
109. Xie M., Chen Q., He S., Li B., Hu C. Silencing of the human TERT gene by RNAi inhibits A549 lung adenocarcinoma cell growth in vitro and in vivo. Oncol. Rep. 2011, 26:1019-1027.
110. Yang J., Chang E., Cherry A.M., Bangs C.D., Oei Y., Bodnar A., Bronstein A., Chiu C.P., Herron G.S. Human endothelial cell life extension by telomerase expression. J. Biol. Chem. 1999, 274:26141-26148.
111. Yin Z., Cui Z., Ren Y., Zhang H., Yan Y., Zhao Y., Ma R., Wang Q., He Q., Zhou B. Genetic polymorphisms of TERT and CLPTM1L, cooking oil fume exposure, and risk of lung cancer: a case-control study in a Chinese non-smoking female population. Med. Oncol. 2014, 31:114.
112. Yoon K.A., Park J.H., Han J., Park S., Lee G.K., Han J.Y., Zo J.I., Kim J., Lee J.E., Takahashi A., Kubo M., Nakamura Y., Lee J.S. A genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population. Hum. Mol. Genet. 2010, 19:4948-4954.
113. Yuan Y., Lu C., Xue L., Ge D. Association between TERT rs2736100 polymorphism and lung cancer susceptibility: evidence from 22 case-control studies. Tumour Biol. 2014, 35:4435-4442.
114. Zhao D.P., Yang C.L., Zhou X., Ding J.A., Jiang G.N. Association between CLPTM1L polymorphisms (rs402710 and rs401681) and lung cancer susceptibility: evidence from 27 case-control studies. Mol. Genet. Genomics 2014, 289:1001-1012.
115. Zhao Z., Li C., Yang L., Zhang X., Zhao X., Song X., Li X., Wang J., Qian J., Yang Y., Jin L., Chen H., Lu D. Significant association of 5p15.33 (TERT-CLPTM1L genes) with lung cancer in Chinese Han population. Exp. Lung Res. 2013, 39:91-98.
116. Zienolddiny S., Skaug V., Landvik N.E., Ryberg D., Phillips D.H., Houlston R., Haugen A. The TERT-CLPTM1L lung cancer susceptibility variant associates with higher DNA adduct formation in the lung. Carcinogenesis 2009, 30:1368-1371.
117. Zou P., Gu A., Ji G., Zhao L., Zhao P., Lu A. The TERT rs2736100 polymorphism and cancer risk: a meta-analysis based on 25 case-control studies. BMC Cancer 2012, 12:7.