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Volumn 34, Issue 8, 2016, Pages 845-851

A recellularized human colon model identifies cancer driver genes

(18)  Chen, Huanhuan Joyce a   Wei, Zhubo b   Sun, Jian c   Bhattacharya, Asmita d   Savage, David J e   Serda, Rita e   Mackeyev, Yuri f   Curley, Steven A g   Bu, Pengcheng a   Wang, Lihua h   Chen, Shuibing c   Cohen Gould, Leona c   Huang, Emina i   Shen, Xiling a   Lipkin, Steven M c   Copeland, Neal G b   Jenkins, Nancy A b   Shuler, Michael L a  


Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELL PROLIFERATION; DISEASES; GENES; MUTAGENESIS;

EID: 84981349638     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.3586     Document Type: Article
Times cited : (82)

References (49)
  • 1
    • 79955601786 scopus 로고    scopus 로고
    • Trial watch: Phase II failures: 2008-2010
    • Arrowsmith, J. Trial watch: Phase II failures: 2008-2010. Nat. Rev. Drug Discov. 10, 328-329 (2011).
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 328-329
    • Arrowsmith, J.1
  • 2
    • 58649089340 scopus 로고    scopus 로고
    • Role of cancer microenvironment in metastasis: Focus on colon cancer
    • Gout, S. & Huot, J. Role of cancer microenvironment in metastasis: focus on colon cancer. Cancer Microenviron. 1, 69-83 (2008).
    • (2008) Cancer Microenviron. , vol.1 , pp. 69-83
    • Gout, S.1    Huot, J.2
  • 3
    • 78249261016 scopus 로고    scopus 로고
    • Accumulation of driver and passenger mutations during tumor progression
    • Bozic, I. et al. Accumulation of driver and passenger mutations during tumor progression. Proc. Natl. Acad. Sci. USA 107, 18545-18550 (2010).
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 18545-18550
    • Bozic, I.1
  • 4
    • 41949139438 scopus 로고    scopus 로고
    • Comparative lesion sequencing provides insights into tumor evolution
    • Jones, S. et al. Comparative lesion sequencing provides insights into tumor evolution. Proc. Natl. Acad. Sci. USA 105, 4283-4288 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 4283-4288
    • Jones, S.1
  • 5
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • The Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature 487, 330-337 (2012).
    • (2012) Nature , vol.487 , pp. 330-337
  • 6
    • 70350025459 scopus 로고    scopus 로고
    • Deciphering the genetic landscape of cancer-from genes to pathways
    • Copeland, N.G. & Jenkins, N.A. Deciphering the genetic landscape of cancer-from genes to pathways. Trends Genet. 25, 455-462 (2009).
    • (2009) Trends Genet. , vol.25 , pp. 455-462
    • Copeland, N.G.1    Jenkins, N.A.2
  • 7
    • 84904066077 scopus 로고    scopus 로고
    • Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture
    • Li, X. et al. Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture. Nat. Med. 20, 769-777 (2014).
    • (2014) Nat. Med. , vol.20 , pp. 769-777
    • Li, X.1
  • 8
    • 84924422753 scopus 로고    scopus 로고
    • Modeling colorectal cancer using CRISPR-cas9-mediated engineering of human intestinal organoids
    • Matano, M. et al. Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids. Nat. Med. 21, 256-262 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 256-262
    • Matano, M.1
  • 9
    • 80053978141 scopus 로고    scopus 로고
    • Isolation and in vitro expansion of human colonic stem cells
    • Jung, P. et al. Isolation and in vitro expansion of human colonic stem cells. Nat. Med. 17, 1225-1227 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 1225-1227
    • Jung, P.1
  • 10
    • 33645876484 scopus 로고    scopus 로고
    • Decellularization of tissues and organs
    • Gilbert, T.W., Sellaro, T.L. & Badylak, S.F. Decellularization of tissues and organs. Biomaterials 27, 3675-3683 (2006).
    • (2006) Biomaterials , vol.27 , pp. 3675-3683
    • Gilbert, T.W.1    Sellaro, T.L.2    Badylak, S.F.3
  • 11
    • 77955422758 scopus 로고    scopus 로고
    • Regeneration and orthotopic transplantation of a bioartificial lung
    • Ott, H.C. et al. Regeneration and orthotopic transplantation of a bioartificial lung. Nat. Med. 16, 927-933 (2010).
    • (2010) Nat. Med. , vol.16 , pp. 927-933
    • Ott, H.C.1
  • 12
    • 38949168818 scopus 로고    scopus 로고
    • Perfusion-decellularized matrix: Using nature's platform to engineer a bioartificial heart
    • Ott, H.C. et al. Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart. Nat. Med. 14, 213-221 (2008).
    • (2008) Nat. Med. , vol.14 , pp. 213-221
    • Ott, H.C.1
  • 13
    • 78650012935 scopus 로고    scopus 로고
    • Invasive three-dimensional organotypic neoplasia from multiple normal human epithelia
    • Ridky, T.W., Chow, J.M., Wong, D.J. & Khavari, P.A. Invasive three-dimensional organotypic neoplasia from multiple normal human epithelia. Nat. Med. 16, 1450-1455 (2010).
    • (2010) Nat. Med. , vol.16 , pp. 1450-1455
    • Ridky, T.W.1    Chow, J.M.2    Wong, D.J.3    Khavari, P.A.4
  • 14
    • 11144356354 scopus 로고    scopus 로고
    • G12D stimulates proliferation and widespread neoplastic and developmental defects
    • G12D stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell 5, 375-387 (2004).
    • (2004) Cancer Cell , vol.5 , pp. 375-387
    • Tuveson, D.A.1
  • 15
    • 3142664714 scopus 로고    scopus 로고
    • Transforming growth factor-β receptor type II inactivation promotes the establishment and progression of colon cancer
    • Biswas, S. et al. Transforming growth factor-β receptor type II inactivation promotes the establishment and progression of colon cancer. Cancer Res. 64, 4687-4692 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 4687-4692
    • Biswas, S.1
  • 16
    • 65249153611 scopus 로고    scopus 로고
    • TGF-β receptor inactivation and mutant kras induce intestinal neoplasms in mice via a β-catenin-independent pathway
    • Trobridge, P. et al. TGF-β receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a β-catenin-independent pathway. Gastroenterology 136, 1680-1688.e7 (2009).
    • (2009) Gastroenterology , vol.136 , pp. 1680-1688
    • Trobridge, P.1
  • 17
    • 0029742814 scopus 로고    scopus 로고
    • Laminins, tenascin and type VII collagen in colorectal mucosa
    • Lohi, J. et al. Laminins, tenascin and type VII collagen in colorectal mucosa. Histochem. J. 28, 431-440 (1996).
    • (1996) Histochem. J. , vol.28 , pp. 431-440
    • Lohi, J.1
  • 18
    • 51649111430 scopus 로고    scopus 로고
    • Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity
    • Vermeulen, L. et al. Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity. Proc. Natl. Acad. Sci. USA 105, 13427-13432 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 13427-13432
    • Vermeulen, L.1
  • 19
    • 0021714105 scopus 로고
    • Tumor invasion and metastases: Role of the basement membrane. Warner-lambert parke-davis award lecture
    • Liotta, L.A. Tumor invasion and metastases: role of the basement membrane. Warner-Lambert Parke-Davis Award lecture. Am. J. Pathol. 117, 339-348 (1984).
    • (1984) Am. J. Pathol. , vol.117 , pp. 339-348
    • Liotta, L.A.1
  • 20
    • 33847755702 scopus 로고    scopus 로고
    • WNT signaling in the normal intestine and colorectal cancer
    • Lau, W., Barker, N. & Clevers, H. WNT signaling in the normal intestine and colorectal cancer. Front. Biosci. 12, 471-491 (2007).
    • (2007) Front. Biosci. , vol.12 , pp. 471-491
    • Lau, W.1    Barker, N.2    Clevers, H.3
  • 21
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon, E.R. & Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell 61, 759-767 (1990).
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 22
    • 36248962105 scopus 로고    scopus 로고
    • The genomic landscapes of human breast and colorectal cancers
    • Wood, L.D. et al. The genomic landscapes of human breast and colorectal cancers. Science 318, 1108-1113 (2007).
    • (2007) Science , vol.318 , pp. 1108-1113
    • Wood, L.D.1
  • 23
    • 84923172083 scopus 로고    scopus 로고
    • Suppressing TGFβ signaling in regenerating epithelia in an inflammatory microenvironment is sufficient to cause invasive intestinal cancer
    • Oshima, H. et al. Suppressing TGFβ signaling in regenerating epithelia in an inflammatory microenvironment is sufficient to cause invasive intestinal cancer. Cancer Res. 75, 766-776 (2015).
    • (2015) Cancer Res. , vol.75 , pp. 766-776
    • Oshima, H.1
  • 24
    • 77957132245 scopus 로고    scopus 로고
    • Harnessing transposons for cancer gene discovery
    • Copeland, N.G. & Jenkins, N.A. Harnessing transposons for cancer gene discovery. Nat. Rev. Cancer 10, 696-706 (2010).
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 696-706
    • Copeland, N.G.1    Jenkins, N.A.2
  • 25
    • 22444431606 scopus 로고    scopus 로고
    • Mammalian mutagenesis using a highly mobile somatic sleeping beauty transposon system
    • Dupuy, A.J., Akagi, K., Largaespada, D.A., Copeland, N.G. & Jenkins, N.A. Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. Nature 436, 221-226 (2005).
    • (2005) Nature , vol.436 , pp. 221-226
    • Dupuy, A.J.1    Akagi, K.2    Largaespada, D.A.3    Copeland, N.G.4    Jenkins, N.A.5
  • 26
    • 82255179056 scopus 로고    scopus 로고
    • Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis
    • March, H.N. et al. Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis. Nat. Genet. 43, 1202-1209 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 1202-1209
    • March, H.N.1
  • 27
    • 84926170118 scopus 로고    scopus 로고
    • Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression
    • Takeda, H. et al. Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression. Nat. Genet. 47, 142-150 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 142-150
    • Takeda, H.1
  • 28
    • 77953132759 scopus 로고    scopus 로고
    • Comparative analysis of transposable element vector systems in human cells
    • Grabundzija, I. et al. Comparative analysis of transposable element vector systems in human cells. Mol. Ther. 18, 1200-1209 (2010).
    • (2010) Mol. Ther. , vol.18 , pp. 1200-1209
    • Grabundzija, I.1
  • 29
    • 80052765869 scopus 로고    scopus 로고
    • Novel molecular and computational methods improve the accuracy of insertion site analysis in sleeping beauty-induced tumors
    • Brett, B.T. et al. Novel molecular and computational methods improve the accuracy of insertion site analysis in Sleeping Beauty-induced tumors. PLoS One 6, e24668 (2011).
    • (2011) PLoS One , vol.6 , pp. e24668
    • Brett, B.T.1
  • 30
    • 79953215305 scopus 로고    scopus 로고
    • T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis
    • Angus-Hill, M.L., Elbert, K.M., Hidalgo, J. & Capecchi, M.R. T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis. Proc. Natl. Acad. Sci. USA 108, 4914-4919 (2011).
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 4914-4919
    • Angus-Hill, M.L.1    Elbert, K.M.2    Hidalgo, J.3    Capecchi, M.R.4
  • 31
    • 0032562603 scopus 로고    scopus 로고
    • Functional interaction of an axin homolog, conductin, with β-catenin, APC, and GSK3β
    • Behrens, J. et al. Functional interaction of an axin homolog, conductin, with β-catenin, APC, and GSK3β. Science 280, 596-599 (1998).
    • (1998) Science , vol.280 , pp. 596-599
    • Behrens, J.1
  • 32
    • 84876531308 scopus 로고    scopus 로고
    • Twist2 is a valuable prognostic biomarker for colorectal cancer
    • Yu, H. et al. Twist2 is a valuable prognostic biomarker for colorectal cancer. World J. Gastroenterol. 19, 2404-2411 (2013).
    • (2013) World J. Gastroenterol. , vol.19 , pp. 2404-2411
    • Yu, H.1
  • 33
    • 40149094813 scopus 로고    scopus 로고
    • Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells
    • Xiong, H. et al. Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells. Neoplasia 10, 287-297 (2008).
    • (2008) Neoplasia , vol.10 , pp. 287-297
    • Xiong, H.1
  • 34
    • 0035853158 scopus 로고    scopus 로고
    • The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation
    • Forcet, C. et al. The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation. Proc. Natl. Acad. Sci. USA 98, 3416-3421 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 3416-3421
    • Forcet, C.1
  • 35
    • 33749334018 scopus 로고    scopus 로고
    • A positive feedback loop between the p53 and lats2 tumor suppressors prevents tetraploidization
    • Aylon, Y. et al. A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. Genes Dev. 20, 2687-2700 (2006).
    • (2006) Genes Dev. , vol.20 , pp. 2687-2700
    • Aylon, Y.1
  • 36
    • 0034094293 scopus 로고    scopus 로고
    • Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the drosophila tumor suppressor gene lats/warts
    • Yabuta, N. et al. Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts. Genomics 63, 263-270 (2000).
    • (2000) Genomics , vol.63 , pp. 263-270
    • Yabuta, N.1
  • 37
    • 79953284982 scopus 로고    scopus 로고
    • Tyrosine phosphatase PTPRD suppresses colon cancer cell migration in coordination with CD44
    • Funato, K., Yamazumi, Y., Oda, T. & Akiyama, T. Tyrosine phosphatase PTPRD suppresses colon cancer cell migration in coordination with CD44. Exp. Ther. Med. 2, 457-463 (2011).
    • (2011) Exp. Ther. Med. , vol.2 , pp. 457-463
    • Funato, K.1    Yamazumi, Y.2    Oda, T.3    Akiyama, T.4
  • 38
    • 84930934091 scopus 로고    scopus 로고
    • Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting
    • Chen, H.J. et al. Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting. Nat. Biotechnol. 33, 656-660 (2015).
    • (2015) Nat. Biotechnol. , vol.33 , pp. 656-660
    • Chen, H.J.1
  • 39
    • 84881108886 scopus 로고    scopus 로고
    • Functional and cancer genomics of ASXL family members
    • Katoh, M. Functional and cancer genomics of ASXL family members. Br. J. Cancer 109, 299-306 (2013).
    • (2013) Br. J. Cancer , vol.109 , pp. 299-306
    • Katoh, M.1
  • 40
    • 79251475891 scopus 로고    scopus 로고
    • Nonsense mediated decay resistant mutations are a source of expressed mutant proteins in colon cancer cell lines with microsatellite instability
    • Williams, D.S. et al. Nonsense mediated decay resistant mutations are a source of expressed mutant proteins in colon cancer cell lines with microsatellite instability. PLoS One 5, e16012 (2010).
    • (2010) PLoS One , vol.5 , pp. e16012
    • Williams, D.S.1
  • 41
    • 79954611862 scopus 로고    scopus 로고
    • CAMTA1, a 1p36 tumor suppressor candidate, inhibits growth and activates differentiation programs in neuroblastoma cells
    • Henrich, K.O. et al. CAMTA1, a 1p36 tumor suppressor candidate, inhibits growth and activates differentiation programs in neuroblastoma cells. Cancer Res. 71, 3142-3151 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 3142-3151
    • Henrich, K.O.1
  • 42
    • 33845649043 scopus 로고    scopus 로고
    • Recurrent genomic alterations with impact on survival in colorectal cancer identified by genome-wide array comparative genomic hybridization
    • Kim, M.Y. et al. Recurrent genomic alterations with impact on survival in colorectal cancer identified by genome-wide array comparative genomic hybridization. Gastroenterology 131, 1913-1924 (2006).
    • (2006) Gastroenterology , vol.131 , pp. 1913-1924
    • Kim, M.Y.1
  • 43
    • 77249105997 scopus 로고    scopus 로고
    • Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro
    • Roig, A.I. et al. Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro. Gastroenterology 138, 1012-1021 (2010).
    • (2010) Gastroenterology , vol.138 , pp. 1012-1021
    • Roig, A.I.1
  • 44
    • 84864070178 scopus 로고    scopus 로고
    • Assessment of TP53 mutations in benign and malignant salivary gland neoplasms
    • Gomes, C.C. et al. Assessment of TP53 mutations in benign and malignant salivary gland neoplasms. PLoS One 7, e41261 (2012).
    • (2012) PLoS One , vol.7 , pp. e41261
    • Gomes, C.C.1
  • 45
    • 0025938038 scopus 로고
    • Identification and characterization of the familial adenomatous polyposis coli gene
    • Groden, J. et al. Identification and characterization of the familial adenomatous polyposis coli gene. Cell 66, 589-600 (1991).
    • (1991) Cell , vol.66 , pp. 589-600
    • Groden, J.1
  • 46
    • 33646228635 scopus 로고    scopus 로고
    • KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
    • Lièvre, A. et al. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res. 66, 3992-3995 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 3992-3995
    • Lièvre, A.1
  • 47
    • 0035487662 scopus 로고    scopus 로고
    • Mutation analysis of the adenomatous polyposis coli (APC) gene in northwest Spanish patients with familial adenomatous polyposis (FAP) and sporadic colorectal cancer
    • Ruiz-Ponte, C., Vega, A., Carracedo, A. & Barros, F. Mutation analysis of the adenomatous polyposis coli (APC) gene in northwest Spanish patients with familial adenomatous polyposis (FAP) and sporadic colorectal cancer. Hum. Mutat. 18, 355 (2001).
    • (2001) Hum. Mutat. , vol.18 , pp. 355
    • Ruiz-Ponte, C.1    Vega, A.2    Carracedo, A.3    Barros, F.4
  • 49
    • 84865965653 scopus 로고    scopus 로고
    • Chemokine 25-induced signaling suppresses colon cancer invasion and metastasis
    • Chen, H.J. et al. Chemokine 25-induced signaling suppresses colon cancer invasion and metastasis. J. Clin. Invest. 122, 3184-3196 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 3184-3196
    • Chen, H.J.1


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