Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer

BMC Cancer

Volumn 16, Issue 1, 2016, Pages

  She, Qing Bai ^a,b   Gruvberger Saal, Sofia K ^c,d   Maurer, Matthew ^e   Chen, Yilun ^c   Jumppanen, Mervi ^f   Su, Tao ^e   Dendy, Meaghan ^d   Lau, Ying Ka Ingar ^e   Memeo, Lorenzo ^g   Horlings, Hugo M ^h   van de Vijver, Marc J ⁱ   Isola, Jorma ^j   Hibshoosh, Hanina ^e   Rosen, Neal ^a   Parsons, Ramon ^d,e,k   Saal, Lao H ^c,d  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c LUND UNIVERSITY   (Sweden)

^d NewYork Presbyterian Hospital   (United States)

^e Och Spine at New York Presbyterian Hospitals   (United States)

^f SEINÄJOKI CENTRAL HOSPITAL   (Finland)

^g Mediterranean Institute of Oncology   (Italy)

^h NETHERLANDS CANCER INSTITUTE   (Netherlands)

ⁱ ACADEMIC MEDICAL CENTER   (Netherlands)

^j UNIVERSITY OF TAMPERE   (Finland)

^k MOUNT SINAI SCHOOL OF MEDICINE   (United States)

more..

Author keywords

Basal like; Breast cancer; Combination therapy; EGFR; PTEN

Indexed keywords

17 HYDROXYWORTMANNIN; 2 MORPHOLINO 8 PHENYLCHROMONE; CYTOKERATIN 14; CYTOKERATIN 5; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; GEFITINIB; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; STATHMIN; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; ANDROSTANE DERIVATIVE; CHROMONE DERIVATIVE; EGFR PROTEIN, HUMAN; MACROGOL DERIVATIVE; MORPHOLINE DERIVATIVE; PEGYLATED 17-HYDROXYWORTMANNIN; PHOSPHATASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PHOSPHATIDYLINOSITOL-3,4-BISPHOSPHATE 4-PHOSPHATASE; PIK3CA PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; PTEN PROTEIN, HUMAN; QUINAZOLINE DERIVATIVE;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BASAL LIKE BREAST CANCER; BREAST CANCER CELL LINE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CONTROLLED STUDY; DRUG POTENTIATION; FEMALE; GENE EXPRESSION PROFILING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MAJOR CLINICAL STUDY; MONOTHERAPY; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; TUMOR XENOGRAFT; ANIMAL; BREAST NEOPLASMS; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETICS; MIDDLE AGED; MUTATION; PATHOLOGY; PROCEDURES; SIGNAL TRANSDUCTION; TISSUE MICROARRAY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANDROSTADIENES; ANIMALS; BREAST NEOPLASMS; CHROMONES; CLASS I PHOSPHATIDYLINOSITOL 3-KINASES; DRUG SYNERGISM; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REGULATORY NETWORKS; HUMANS; MICE; MIDDLE AGED; MORPHOLINES; MUTATION; PHOSPHORIC MONOESTER HYDROLASES; POLYETHYLENE GLYCOLS; PROTEIN KINASE INHIBITORS; PTEN PHOSPHOHYDROLASE; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TISSUE ARRAY ANALYSIS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84980343511     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/s12885-016-2609-2     Document Type: Article

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