PTEN and NEDD4 in Human Breast Carcinoma

Pathology and Oncology Research

Volumn 22, Issue 1, 2016, Pages 41-47

  Chen, Yilun ^a   van de Vijver, Marc J ^b   Hibshoosh, Hanina ^c   Parsons, Ramon ^d   Saal, Lao H ^a  

^a LUND UNIVERSITY   (Sweden)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c Department of Medicine   (United States)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Breast carcinoma; IHC; NEDD4; PTEN

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; UBIQUITIN PROTEIN LIGASE NEDD4; ESCRT PROTEIN; MESSENGER RNA; NEDD4 UBIQUITIN PROTEIN LIGASES; PTEN PROTEIN, HUMAN; TUMOR MARKER; UBIQUITIN PROTEIN LIGASE;

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CANCER GRADING; COHORT ANALYSIS; DISEASE ASSOCIATION; DOWN REGULATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MICROARRAY ANALYSIS; NEDD4 GENE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PTEN GENE; SIGNAL TRANSDUCTION; TUMOR VOLUME; BREAST TUMOR; CANCER STAGING; ENZYME IMMUNOASSAY; FEMALE; FOLLOW UP; GENE EXPRESSION REGULATION; GENETICS; LYMPH NODE METASTASIS; METABOLISM; MIDDLE AGED; PATHOLOGY; PROGNOSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BIOMARKERS, TUMOR; BREAST NEOPLASMS; COHORT STUDIES; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOENZYME TECHNIQUES; LYMPHATIC METASTASIS; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; PTEN PHOSPHOHYDROLASE; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UBIQUITIN-PROTEIN LIGASES;

EID: 84951574068     PISSN: 12194956     EISSN: 15322807     Source Type: Journal    
DOI: 10.1007/s12253-015-9971-2     Document Type: Article

References (30)

1. Maehama T, Dixon JE (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biolumin Chemilumin 273:13375–13378
2. Arch EM, Goodman BK, Van Wesep RA, Liaw D, Clarke K, Parsons R, et al (1997) Deletion of PTEN in a patient with bannayan-riley-ruvalcaba syndrome suggests allelism with cowden disease. Am J Med Genet 71:489–493
3. Liaw D, Marsh DJ, Li J, Dahia PL, Wang SI, Zheng Z, et al (1997) Germline mutations of the PTEN gene in cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet 16:64–67
4. Hobert JA, Eng C (2009) PTEN hamartoma tumor syndrome: an overview. Genitourin Med 11:687–694
5. Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, et al (1997) PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275:1943–1947
6. Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, et al (1997) Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15:356–362
7. Shaw RJ, Cantley LC (2006) Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 441:424–430
8. Forbes SA, Beare D, Gunasekaran P, Leung K, Bindal N, Boutselakis H, et al (2015) COSMIC: exploring the world’s knowledge of somatic mutations in human cancer. Nucleic Acids Res 43:D805–811
9. Saal LH, Holm K, Maurer M, Memeo L, Su T, Wang X, et al (2005) PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res 65:2554–2559
10. The Cancer Genome Atlas Network (2012) Comprehensive molecular portraits of human breast tumours. Nature 490:61–70
11. Simpson L, Parsons R (2001) PTEN: life as a tumor suppressor. Exp Cell Res 264:29–41
12. Wang X, Jiang X (2008) Post-translational regulation of PTEN. Oncogene 27:5454–5463
13. Saal LH, Gruvberger-Saal SK, Persson C, Lovgren K, Jumppanen M, Staaf J, et al (2008) Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair. Nat Genet 40:102–107
14. Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, Gao Z, et al (2007) NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell 128:129–139
15. Drinjakovic J, Jung H, Campbell DS, Strochlic L, Dwivedy A, Holt CE (2010) E3 ligase Nedd4 promotes axon branching by downregulating PTEN. Neuron 65:341–357
16. Goh CP, Low LH, Putz U, Gunnersen J, Hammond V, Howitt J, et al (2013) Ndfip1 expression in developing neurons indicates a role for protein ubiquitination by Nedd4 E3 ligases during cortical development. Neurosci Lett 555:225–230
17. Guo H, Qiao G, Ying H, Li Z, Zhao Y, Liang Y, et al (2012) E3 ubiquitin ligase Cbl-b regulates pten via Nedd4 in T cells independently of its ubiquitin ligase activity. Cell Rep 1:472–482
18. Chung S, Nakashima M, Zembutsu H, Nakamura Y (2011) Possible involvement of NEDD4 in keloid formation; its critical role in fibroblast proliferation and collagen production. Proc Jpn Acad Ser B Phys Biol Sci 87:563–573
19. Shi Y, Wang J, Chandarlapaty S, Cross J, Thompson C, Rosen N, et al (2014) PTEN is a protein tyrosine phosphatase for IRS1. Nat Struct Mol Biol 21:522–527
20. Amodio N, Scrima M, Palaia L, Salman AN, Quintiero A, Franco R, et al (2010) Oncogenic role of the E3 ubiquitin ligase NEDD4-1, a PTEN negative regulator, in non-small-cell lung carcinomas. Am J Pathol 177:2622–2634
21. Hong SW, Moon JH, Kim JS, Shin JS, Jung KA, Lee WK, et al (2014) p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN. Cell Death Differ 21:146–160
22. Trotman LC, Wang X, Alimonti A, Chen Z, Teruya-Feldstein J, Yang H, et al (2007) Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell 128:141–156
23. Fouladkou F, Landry T, Kawabe H, Neeb A, Lu C, Brose N, et al (2008) The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization. Proc Natl Acad Sci U S A 105:8585–8590
24. Maddika S, Kavela S, Rani N, Palicharla VR, Pokorny JL, Sarkaria JN, et al (2011) WWP2 is an E3 ubiquitin ligase for PTEN. Nat Cell Biol 13:728–733
25. Yang Z, Yuan XG, Chen J, Lu NH (2012) Is NEDD4-1 a negative regulator of phosphatase and tensin homolog in gastric carcinogenesis? World J Gastroenterol 18:6345–6348
26. Eide PW, Cekaite L, Danielsen SA, Eilertsen IA, Kjenseth A, Fykerud TA, et al (2013) NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway. Cell Signal 25:12–18
27. Saal LH, Johansson P, Holm K, Gruvberger-Saal SK, She QB, Maurer M, et al (2007) Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity. Proc Natl Acad Sci U S A 104:7564–7569
28. van de Vijver MJ, He YD, van't Veer LJ, Dai H, Hart AA, Voskuil DW, et al (2002) A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 347:1999–2009
29. van 't Veer, LJ, Dai, H, van de Vijver, MJ, He, YD, Hart, AA, Mao, M et al (2002) Gene expression profiling predicts clinical outcome of breast cancer. Nature 415:530–536
30. Ahn Y, Hwang CY, Lee SR, Kwon KS, Lee C (2008) The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4. Biochem J 412:331–338