2016 European Society ofHypertension guidelines for themanagement of high blood pressure in children and adolescents

Journal of Hypertension

Volumn 34, Issue 10, 2016, Pages 1887-1920

  Lurbe, Empar ^a,b   Agabiti Rosei, Enrico ^c   Cruickshank, J Kennedy ^d   Dominiczak, Anna ^e   Erdine, Serap ^f   Hirth, Asle ^g   Invitti, Cecilia ^h   Litwin, Mieczyslaw ⁱ   Mancia, Giuseppe ^h   Pall, Denes ^b,j,k   Rascher, Wolfgang ^a   Redon, Josep ^l   Schaefer, Franz ^m   Seeman, Tomas ⁿ   Sinha, Manish ^o   Stabouli, Stella ^p   Webb, Nicholas J ^q   Wühl, Elke ^m   Zanchetti, Alberto ^h  

^a UNIVERSITY OF VALENCIA   (Spain)

^b Instituto de Salud Carlos III   (Spain)

^c UNIVERSITY OF BRESCIA   (Italy)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF GLASGOW   (United Kingdom)

^f ISTANBUL UNIVERSITY   (Turkey)

^g HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^h ISTITUTO AUXOLOGICO ITALIANO   (Italy)

ⁱ CHILDREN'S MEMORIAL HEALTH INSTITUTE   (Poland)

^j UNIVERSITY OF DEBRECEN   (Hungary)

^k UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^l Instituto Universitario IVI INCLIVA   (Spain)

^m UNIVERSITY OF HEIDELBERG   (Germany)

ⁿ CHARLES UNIVERSITY   (Czech Republic)

^o EVELINA LONDON CHILDREN S HOSPITAL   (United Kingdom)

^p ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^q UNIVERSITY OF MANCHESTER   (United Kingdom)

more..

Author keywords

Adolescents; Central blood pressure; Children; European; Management of high blood pressure; Out of office blood pressure; Recommendations; Society of hypertension

Indexed keywords

ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT; BIOLOGICAL MARKER;

ANTIHYPERTENSIVE THERAPY; AORTA COARCTATION; BLOOD PRESSURE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE MONITORING; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CENTRAL BLOOD PRESSURE; CHRONIC KIDNEY DISEASE; COMORBIDITY; DIABETES MELLITUS; DIASTOLIC BLOOD PRESSURE; DISEASE CLASSIFICATION; EPIDEMIC; ETHNIC GROUP; EXERCISE; FAMILY DECISION MAKING; GENETIC ANALYSIS; GLYCEMIC CONTROL; HEALTH CARE POLICY; HEART FAILURE; HUMAN; HYPERTENSION; INCIDENCE; JUVENILE; KIDNEY DISEASE; KIDNEY FAILURE; KIDNEY FUNCTION; LIFESTYLE MODIFICATION; MALIGNANT HYPERTENSION; MASKED HYPERTENSION; MEAN ARTERIAL PRESSURE; MEDICAL DECISION MAKING; MEDICAL SOCIETY; METABOLIC SYNDROME X; MONOTHERAPY; OBESITY; PHEOCHROMOCYTOMA; PRACTICE GUIDELINE; PREVALENCE; PRIMARY HYPERALDOSTERONISM; PRIORITY JOURNAL; RENOVASCULAR HYPERTENSION; RESISTANT HYPERTENSION; REVIEW; RISK FACTOR; SLEEP DISORDERED BREATHING; SYSTOLIC BLOOD PRESSURE; SYSTOLIC HYPERTENSION; TARGET ORGAN; WHITE COAT HYPERTENSION; ADOLESCENT; CHILD; GENETICS; PROCEDURES;

ADOLESCENT; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; BLOOD PRESSURE DETERMINATION; CHILD; COMORBIDITY; HUMANS; HYPERTENSION; PREVALENCE; RISK FACTORS;

EID: 84980041547     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/HJH.0000000000001039     Document Type: Review

References (284)

1. Lurbe E, Cifkova R, Cruickshank JK, Dillon MJ, Ferreira I, Invitti C, et al., European Society of Hypertension. Management of high blood pressure in children and adolescents: Recommendations of the European Society of Hypertension. J Hypertens 2009; 27:1719-1742.
2. Moyer VA, U.S. Preventive Services Task Force. Screening for primary hypertension in children and adolescents: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2013; 159:613-619.
3. Brady TM, Redwine KM, Flynn JT, American Society of Pediatric Nephrology. Screening blood pressure measurement in children: Are we saving lives? Pediatr Nephrol 2014; 29:947-950.
4. Chiolero A, Bovet P, Paradis G. Controversy about hypertension screening in children: A public health perspective. J Hypertens 2015; 33:1352-1355.
5. Bianchetti MG, Bucher BS, Simonetti GD. Controversy about hypertension screening in children: A clinical perspective. J Hypertens 2015; 33:1356-1358.
6. Lurbe E, Ingelfinger JR. Blood pressure in children and adolescents: current insights. J Hypertens 2016; 34:176-183.
7. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004; 114:555-576.
8. Lurbe E, Torro MI, Alvarez-Pitti J, Redon P, Redon J. Central blood pressure and pulse wave amplification across the spectrum of peripheral blood pressure in overweight and obese youth. J Hypertens 2016; 34:1389-1395.
9. Chen X, Wang Y. Tracking of blood pressure from childhood to adulthood: A systematic review and meta-regression analysis. Circulation 2008; 117:3171-3180.
10. Toschke AM, Kohl L, Mansmann U, von Kries R. Meta-Analysis of blood pressure tracking from childhood to adulthood and implications for the design of intervention trials. Acta Paediatr 2010; 99:24-29.
11. Tirosh A, Afek A, Rudich A, Percik R, Gordon B, Ayalon N, et al. Progression of normotensive adolescents to hypertensive adults: A study of 26, 980 teenagers. Hypertension 2010; 56:203-209.
12. Vik KL, Romundstad P, Nilsen TI. Tracking of cardiovascular risk factors across generations: Family linkage within the populationbased HUNT study, Norway. J Epidemiol Community Health 2013; 67:564-570.
13. Carrico RJ, Sun SS, Sima AP, Rosner B. The predictive value of childhood blood pressure values for adult elevated blood pressure. Open J Pediatr 2013; 3:116-126.
14. Campana EM, Brandão AA, Pozzan R, França MdeF, Fonseca FL, Pizzi OL, et al. Blood pressure in young individuals as a cardiovascular risk marker. The Rio de Janeiro study. Arq Bras Cardiol 2009; 93:608-615.
15. Erlingsdottir A, Indridason OS, Thorvaldsson O, Edvardsson VO. Blood pressure in children and target-organ damage later in life. Pediatr Nephrol 2010; 25:323-328.
16. Sundin PO, Udumyan R, Sjöström P, Montgomery S. Predictors in adolescence of ESRD in middle-Aged men. Am J Kidney Dis 2014; 64:723-729.
17. Daniels SR, Loggie JM, Khoury P, Kimball TR. Left ventricular geometry and severe left ventricular hypertrophy in children and adolescentswith essential hypertension. Circulation 1998; 97:1907-1911.
18. Sorof JM, Cardwell G, Franco K, Portman RJ. Ambulatory blood pressure and left ventricular mass in hypertensive children. Hypertension 2002; 39:903-908.
19. Litwin M, Niemirska A, Śladowska J, Antoniewicz J, Daszkowska J, Wierzbicka A, et al. Left ventricular hypertrophy and arterial wall thickening in children with essential hypertension. Pediatr Nephrol 2006; 21:811-819.
20. Assadi F. Relation of left ventricular hypertrophy to microalbuminuria and C-reactive protein in children and adolescents with essential hypertension. Pediatr Cardiol 2008; 29:580-584.
21. Tomczak J, Wasilewska A, Milewski R. Urine NGAL and KIM-1 in children and adolescents with hyperuricemia. Pediatr Nephrol 2013; 28:1863-1869.
22. Litwin M, Niemirska A, Sladowska-Kozlowska J, Wierzbicka A, Janas R, Wawer ZT, et al. Regression of target organ damage in children and adolescents with primary hypertension. Pediatr Nephrol 2010; 25:2489-2499.
23. Seeman T, Gilik J, Vondrak K, Simkova E, Flogelova H, Hladikova M, et al. Regression of left-ventricular hypertrophy in children and adolescents with hypertension during ramipril monotherapy. Am J Hypertens 2007; 20:990-996.
24. Assadi F. Effect of microalbuminuria lowering on regression of left ventricular hypertrophy in children and adolescents with essential hypertension. Pediatr Cardiol 2007; 28:27-33.
25. Wühl E, Trivelli A, Picca S, Litwin M, Peco-Antic A, Zurowska A, et al., ESCAPE Trial Group. Strict blood-pressure control and progression of renal failure in children. N Engl J Med 2009; 361:1639-1650.
26. Aatola H, Magnussen CG, Juonala M, Koivistoinen T, Hutri-Kähönen N, Juonala M, et al. Simplified definitions of elevated pediatric blood pressure and high adult arterial stiffness. Pediatrics 2013; 132:e70-e76.
27. Juonala M, Magnussen CG, Venn A, Dwyer T, Burns TL, Davis PH, et al. Influence of age on associations between childhood risk factors and carotid intima-media thickness in adulthood: The Cardiovascular Risk in Young Finns Study, the Childhood Determinants of Adult Health Study, the Bogalusa Heart Study, and the Muscatine Study for the International Childhood Cardiovascular Cohort (i3C) Consortium. Circulation 2010; 122:2514-2520.
28. Juhola J, Magnussen CG, Berenson GS, Venn A, Burns TL, Sabin MA, et al. Combined effects of child and adult elevated blood pressure on subclinical atherosclerosis: The International Childhood Cardiovascular Cohort Consortium. Circulation 2013; 128:217-224.
29. Kishi S, Teixido-Tura G, Ning H, Venkatesh BS, Wu C, Almeida A, et al. Cumulative blood pressure in early adulthood and cardiac dysfunction in middle age the CARDIA study. J Am Coll Cardiol 2015; 65:2679-2687.
30. Ferreira I, van de Laar RJ, Prins MH, Twisk JW, Stehouwer CD. Carotid stiffness in young adults: A life-course analysis of its early determinants The Amsterdam Growth and Health Longitudinal Study. Hypertension 2012; 59:54-61.
31. Chiolero A, Cachat F, Burnier M, Paccaud F, Bovet P. Prevalence of hypertension in schoolchildren based on repeated measurements and association with overweight. J Hypertens 2007; 25:2209-2217.
32. Katona É, Zrínyi M, Lengyel S, KomonyiÉ, Paragh G, Zatik J, et al. The prevalence of adolescent hypertension in Hungary-The Debrecen hypertension study. Blood Press 2011; 20:134-139.
33. Ostrowska-Nawarycz L, Nawarycz T. Prevalence of excessive body weight and high blood pressure in children and adolescents in the city of Łódź. Kardiol Pol 2007; 65:1079-1087.
34. Akgun C, Dogan M, Akbayram S, Tuncer O, Peker E, Taskin G, et al. The incidence of asymptomatic hypertension in school children. J Nippon Med Sch 2010; 77:160-165.
35. Papandreou D, Stamou M, Malindretos P, Rousso I, Mavromichalis I. Prevalence of hypertension and association of dietary mineral intake with blood pressure in healthy schoolchildren from northern Greece aged 7-15 years. Ann Nutr Metab 2007; 51:471-476.
36. Maldonado J, Pereira T, Fernandes R, Santos R, Carvalho M. An approach of hypertension prevalence in a sample of 5381 Portuguese children and adolescents. The AVELEIRA registry. "Hypertension in children". Blood Press 2011; 20:153-157.
37. Gupta-Malhotra M, Banker A, Shete S, Hashmi SS, Tyson JE, Barratt MS, et al. Essential hypertension vs. secondary hypertension among children. Am J Hypertens 2015; 28:73-80.
38. Rosner B, Cook NR, Daniels S, Falkner B. Childhood blood pressure trends and risk factors for high blood pressure: The NHANES experience 1988-2008. Hypertension 2013; 62:247-254.
39. Genovesi S, Antolini L, Giussani M, Pieruzzi F, Galbiati S, Valsecchi MG, et al. Usefulness of waist circumference for the identification of childhood hypertension. J Hypertens 2008; 26:1563-1570.
40. Sorof JM, Lai D, Turner J, Poffenbarger T, Portman RJ. Overweight, ethnicity, and the prevalence of hypertension in school-Aged children. Pediatrics 2004; 113:475-482.
41. Flechtner-Mors M, Neuhauser H, Reinehr T, Roost HP, Wiegand S, Siegfried W, et al., APV initiative and the BMBF Competence Network Obesity. Blood pressure in 57, 915 pediatric patients who are overweight or obese based on five reference systems. Am J Cardiol 2015; 115:1587-1594.
42. Redwine KM, Acosta AA, Poffenbarger T, Portman RJ, Samuels J. Development of hypertension in adolescents with Ppe-hypertension. J Pediatr 2012; 160:98-103.
43. Lurbe E, Thijs L, Torro MI, Alvarez J, Staessen JA, Redon J. Sexual dimorphism in the transition from masked to sustained hypertension in healthy youths. Hypertension 2013; 62:410-414.
44. TODAY Study Group. Rapid rise in hypertension and nephropathy in youth with type 2 diabetes. Diabetes Care 2013; 36:1735-1741.
45. Parker ED, Sinaiko AR, Kharbanda EO, Margolis KL, Daley MF, Trower NK, et al. Change in weight status and development of hypertension. Pediatrics 2016; 137:1-9.
46. Bocelli A, Favilli S, Pollini I, Bini RM, Ballo P, Chiappa E, Zuppirol A. Prevalence and long-Term predictors of left ventricular hypertrophy, late hypertension, and hypertensive response to exercise after successful aortic coarctation repair. Pediatr Cardiol 2013; 34:620-629.
47. Havlik RJ, Garrison RJ, Feinleib M, Kannel WB, Castelli WP, McNamara PM. Blood pressure aggregation in families. AM J Epidemiol 1979; 110:304-312.
48. Bochud M, Bovet P, Elston RC, Paccaud F, Falconnet C, Maillard M, et al. High heritability of ambulatory blood pressure in families of East African descent. Hypertension 2005; 45:445-450.
49. Bonati MT, Graziano F, Monti MC, Crocamo C, Terradura-Vagnarelli O, Cirillo M, et al. Heritability of blood pressure through latent curve trajectories in families from the Gubbio population study. J Hypertens 2014; 32:2179-2187.
50. Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension. Cell 2001; 104:545-556.
51. Padmanabhan S, Caulfield M, Dominiczak AF. Blood pressure genomics. Circ Res 2015; 116:937-959.
52. Harding S, Whitrow M, Lenguerrand E, Maynard M, Teyhan A, Cruickshank JK, et al. Emergence of ethnic differences in blood pressure in adolescence: The determinants of adolescent social well being and health study. Hypertension 2010; 55:1063-1069.
53. O'Brien E, O'Malley K. Evaluation of blood pressure measuring devices with special reference to ambulatory systems. J Hypertens Suppl 1990; 8:S133-S139.
54. Association for the Advancement of Medical Instrumentation. American National Standard. Electronic or automated sphygmomanometers ANSI/AAMI SP10-1992. Arlington, VA, USA: AAMI; 1993.
55. O'Brien E, Pickering T, Asmar R, Myers M, Parati G, Staessen J, et al., On behalf of the Working Group on Blood Pressure Monitoring of the European Society of Hypertension. International protocol for validation of blood pressure measuring devices in adults. Blood Press Monit 2002; 7:3-17.
56. Neuhauser HK, Thamm M, Ellert U, Hense HW, Rosario AS. Blood pressure percentiles by age and height from nonoverweight children and adolescents in Germany. Pediatrics 2011; 127:e978-e988.
57. Kułaga Z, Litwin M, Grajda A, Kułaga K, Gurzkowska B, Góźdź M, et al., OLAF Study Group. Oscillometric blood pressure percentiles for Polish normal-weight school-Aged children and adolescents. J Hypertens 2012; 30:1942-1954.
58. Barba G, Buck C, Bammann K, Hadjigeorgiou C, Hebestreit A, Ma rild S, et al., IDEFICS Consortium. Blood pressure reference values for European nonoverweight school children: The IDEFICS study. Int J Obes 2014; 38:S48-S56.
59. O'Brien E, Parati G, Stergiou G, Asmar R, Beilin L, Bilo G, et al., European Society of Hypertension Working Group on Blood Pressure Monitoring. European Society of Hypertension position paper on ambulatory blood pressure monitoring. J Hypertens 2013; 31:1731-1768.
60. Parati G, Stergiou G, O'Brien E, Asmar R, Beilin L, Bilo G, et al., European Society of Hypertension Working Group on Blood Pressure Monitoring and Cardiovascular Variability. European Society of Hypertension practice guidelines for ambulatory blood pressure monitoring. J Hypertens 2014; 32:1359-1366.
61. Salice P, Ardissino G, Barbier P, Bacà L, Vecchi DL, Ghiglia S, et al. Differences between office and ambulatory blood pressures in children and adolescents attending a hospital hypertension clinic. J Hypertens 2013; 31:2165-2175.
62. Sega R, Facchetti R, Bombelli M, Cesana G, Corrao G, Grassi G, et al. Prognostic value of ambulatory and home blood pressures compared with office blood pressure in the general population: Follow-up results from the Pressioni Arteriose Monitorate e Loro Associazioni (PAMELA) study. Circulation 2005; 111:1777-1783.
63. Lurbe E. Ambulatory blood pressure in children: confidence and wisdom. J Hypertens 2013; 31:2125-2127.
64. Stergiou GS, Yiannes NG, Rarra VC, Panagiotakos DB. Home blood pressure normalcy in children and adolescents: The Arsakeion School study. J Hypertens 2007; 25:1375-1379.
65. Salgado CM, Jardim PC, Viana JK, Jardim TdeS, Velasquez PP. Home blood pressure in children and adolescents: A comparison with office and ambulatory blood pressure measurements. Acta Paediatr 2011; 100:163-168.
66. Asayama K, Staessen JA, Hayashi K, Hosaka M, Tatsuta N, Kurokawa N, et al. Mother-offspring aggregation in home versus conventional blood pressure in the Tohoku Study of Child Development (TSCD). Acta Cardiol 2012; 67:449-456.
67. Stergiou GS, Nasothimiou EG, Giovas PP, Rarra VC. Long-Term reproducibility of home vs. office blood pressure in children and adolescents: The Arsakeion school study. Hypertens Res 2009; 32:311-315.
68. Wühl E, Hadtstein C, Mehls O, Schaefer F, Escape Trial Group. Home, clinic, and ambulatory blood pressure monitoring in children with chronic renal failure. Pediatr Res 2004; 55:492-497.
69. Furusawa É A, Filho UD, Junior DM, Koch VH. Home and ambulatory blood pressure to identify white coat and masked hypertension in the pediatric patient. Am J Hypertens 2011; 24:893-897.
70. Stergiou GS, Ntineri A, Kollias A, Destounis A, Nasothimiou E, Roussias L. Changing relationship among clinic, home, and ambulatory blood pressure with increasing age. J Am Soc Hypertens 2015; 9:544-552.
71. Kollias A, Dafni M, Poulidakis E, Ntineri A, Stergiou GS. Out-of-office blood pressure and target organ damage in children and adolescents: A systematic review and meta-Analysis. J Hypertens 2014; 32:2315-2331.
72. Karatzi K, Protogerou A, Rarra V, Stergiou GS. Home and office blood pressure in children and adolescents: The role of obesity. The Arsakeion School Study. J Hum Hypertens 2009; 23:512-520.
73. Stergiou GS, Giovas PP, Kollias A, Rarra VC, Papagiannis J, Georgakopoulos D, et al. Relationship of home blood pressure with targetorgan damage in children and adolescents. Hypertens Res 2011; 35:640-644.
74. Stergiou G, Nasothimiou E, Giovas P, Kapoyiannis A, Vazeou A. Diagnosis of hypertension in children and adolescents based on home versus ambulatory blood pressure monitoring. J Hypertens 2008; 26:1556-1562.
75. Stergiou GS, Christodoulakis G, Giovas P, Lourida P, Alamara C, Roussias LG. Home blood pressure monitoring in children: how many measurements are needed? Am J Hypertens 2008; 21:633-638.
76. Lurbe E, Torro MI, Alvarez J. Ambulatory blood pressure monitoring in children and adolescents: coming of age? Curr Hypertens Rep 2013; 15:143-149.
77. Matsuoka S, Awazu M. Masked hypertension in children and young adults. Pediatr Nephrol 2004; 19:651-654.
78. Stabouli S, Kotsis V, Toumanidis S, Papamichael C, Constantopoulos A, Zakopoulos N. White-coat and masked hypertension in children: Association with target organ damage. Pediatr Nephrol 2005; 20:1151-1155.
79. Lurbe E, Torro I, Alvarez V, Nawrot T, Paya R, Redon J, et al. Prevalence, persistence, and clinical significance of masked hypertension in youth. Hypertension 2005; 45:493-498.
80. Di Salvo G, Castaldi B, Baldini L, Gala S, del Gaizo F, D'Andrea A, et al. Masked hypertension in young patients after successful aortic coarctation repair: impact on left ventricular geometry and function. J Hum Hypertens 2011; 25:739-745.
81. Pauca AL, Wallenhaupt SL, Kon ND, Tucker WY. Does radial artery pressure accurately reflect aortic pressure? Chest 1992; 102:1193-1198.
82. Milne L, Keehn L, Guilcher A, Reidy JF, Karunanithy N, Rosenthal E, et al. Central aortic blood pressure from ultrasound wall-Tracking of the carotid artery in children: comparison with invasive measurements and radial tonometry. Hypertension 2015; 65:1141-1146.
83. Roman MJ, Devereux RB. Association of central and peripheral blood pressures with intermediate cardiovascular phenotypes. Hypertension 2014; 63:1148-1153.
84. Elmenhorst J, Hulpke-Wette M, Barta C, Dalla Pozza R, Springer S, Oberhoffer R. Percentiles for central blood pressure and pulse wave velocity in children and adolescents recorded with an oscillometric device. Atherosclerosis 2015; 238:9-16.
85. Mahoney LT, Schieken RM, Clarke WR, Lauer RM. Left ventricular mass and exercise responses predict future blood pressure. The Muscatine Study. Hypertension 1988; 12:206-213.
86. Grøntved A, Brage S, Møller NC, Kristensen PL, Wedderkopp N, Froberg K, et al. Hemodynamic variables during exercise in childhood and resting systolic blood pressure levels 6 years later in adolescence: The European Youth Heart Study. J Hum Hypertens 2011; 25:608-614.
87. Kavey RE, Kveselis DA, Atallah N, Smith FC. White coat hypertension in childhood: Evidence for end-organ effect. J Pediatr 2007; 150:491-497.
88. Kavey RE, Kveselis DA, Gaum WE. Exaggerated blood pressure response to exercise in children with increased low-density lipoprotein cholesterol. Am Heart J 1997; 133:162-168.
89. Møller NC, Grøntved A, Wedderkopp N, Ried-Larsen M, Kristensen PL, Andersen LB, et al. Cardiovascular disease risk factors and blood pressure response during exercise in healthy children and adolescents: The European Youth Heart Study. J Appl Physiol 2010; 109:1125-1132.
90. Garg R, Malhotra V, Dhar U, Tripathi Y. The isometric handgrip exercise as a test for unmasking hypertension in the offsprings of hypertensive parents. J Clin Diagn Res 2013; 7:996-999.
91. Hacke C, Weisser B. Reference values for exercise systolic blood pressure in 12-To 17-year-old adolescents. Am J Hypertens 2016; 29:747-753.
92. Mancia G, Fagard R, Narkiewicz K, Redón J, Zanchetti A, Böhm M, et al., Task Force Members. 2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2013; 31:1281-1357.
93. Alpay H, Ozdemir N, Wühl E, Topuzoǧlu A. Ambulatory blood pressure monitoring in healthy children with parental hypertension. Pediatr Nephrol 2009; 24:155-161.
94. Gopinath B, Baur LA, Hardy LL, Wang JJ, Teber E, Wong TY, et al. Parental history of hypertension is associated with narrower retinal arteriolar caliber in young girls. Hypertension 2011; 58:425-430.
95. Othman AS, Othman NI, Rosman A, Nudin SS, Rahman AR Central and peripheral blood pressure profile of young offspring with hypertensive and normotensive parents. J Hypertens 2012; 30:1552-1555.
96. Eriksson JG, Forsén T, Tuomilehto J, Winter PD, Osmond C, Barker DJ. Catch-up growth in childhood and death from coronary heart disease: longitudinal study. BMJ 1999; 318:427-431.
97. Barker DJ, Osmond C, Forsén TJ, Kajantie E, Eriksson JG. Trajectories of growth among children who have coronary events as adults. N Engl J Med 2005; 353:1802-1809.
98. Gluckman PD, Hanson MA, Cooper C, Thornburg KL. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med 2008; 359:61-73.
99. Fabricius-Bjerre S, Jensen RB, Færch K, Larsen T, Mølgaard C, Michaelsen KF, et al. Impact of birth weight and early infant weight gain on insulin resistance and associated cardiovascular risk factors in adolescence. Plos One 2011; 6:e20595.
100. Skilton MR, Marks GB, Ayer JG, Garden FL, Garnett SP, Harmer JA, et al. Weight gain in infancy and vascular risk factors in later childhood. Pediatrics 2013; 131:e1821-e1828.
101. Lurbe E, Garcia-Vicent C, Torro MI, Aguilar F, Redon J. Associations of birth weight and postnatal weight gain with cardiometabolic risk parameters at 5 years of age. Hypertension 2014; 63:1326-1332.
102. Falkner B, Ingelfinger J. Understanding the power of perinatal events and metabolic status in childhood. Hypertension 2014; 63:1166-1167.
103. Meng L, Hou D, Zhao X, Hu Y, Liang Y, Liu J, et al. Cardiovascular target organ damage could have been detected in sustained pediatric hypertension. Blood Press 2015; 24:284-292.
104. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al. Recommendations for chamber quantification. Eur J Echocardiogr 2006; 7:79-108.
105. Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I, et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol 1986; 57:450-458.
106. de Simone G, Devereux RB, Daniels SR, Koren MJ, Meyer RA, Laragh JH. Effect of growth on variability of left ventricular mass: Assessment of allometric signals in adults and children and their capacity to predict cardiovascular risk. J Am Coll Cardiol 1995; 25:1056-1062.
107. de Simone G, Daniels SR, Kimball TR, Roman MJ, Romano C, Chinali M, et al. Evaluation of concentric left ventricular geometry in humans: Evidence for age-related systematic underestimation. Hypertension 2005; 45:64-68.
108. Khoury PR, Mitsnefes M, Daniels SR, Kimball TR. Age-specific reference intervals for indexed left ventricular mass in children. J Am Soc Echocardiogr 2009; 22:709-714.
109. Chinali M, Emma F, Esposito C, Rinelli G, Franceschini A, Doyon A, et al. Left ventricular mass indexing in infants, children, and adolescents: A simplified approach for the identification of left ventricular hypertrophy in clinical practice. J Pediatr 2016; 170:193-198.
110. Sharp AS, Tapp RJ, Thom SA, Francis DP, Hughes AD, Stanton AV, et al. Tissue Doppler E/E0 ratio is a powerful predictor of primary cardiac events in a hypertensive population: An ASCOT substudy. Eur Heart J 2010; 31:747-752.
111. Killian L, Simpson JM, Savis A, Rawlins D, Sinha MD. Electrocardiography is a poor screening test to detect left ventricular hypertrophy in children. Arch Dis Child 2010; 95:832-836.
112. Bratincsak A, Williams M, Kimata C, Perry JC. The electrocardiogram is a poor diagnostic tool to detect left ventricular hypertrophy in children: A comparison with echocardiographic assessment of left ventricular mass. Congenit Heart Dis 2015; 10:E164-E171.
113. Doyon A, Kracht D, Bayazit AK, Deveci M, Duzova A, Krmar RT, et al., For the 4C Study Consortium. Carotid artery intima-media thickness and distensibility in children and adolescents: Reference values and role of body dimensions. Hypertension 2013; 62:550-556.
114. Calabro MP, Carerj S, Russo MS, De Luca FL, Onofrio MTN, Antonini-Canterin F, et al. Carotid artery intima-media thickness and stiffness index b changes in normal children: Role of age, height and sex. J Cardiovasc Med 2015; Epub ahead of print.
115. Järvisalo MJ, Jartti L, Näntö-Salonen K, Irjala K, Rönnemaa T, Hartiala JJ, et al. Increased aortic intima-media thickness: A marker of preclinical atherosclerosis in high-risk children. Circulation 2001; 104:2943-2947.
116. Wiegman A, de Groot E, Hutten BA, Rodenburg J, Gort J, Bakker HD, et al. Arterial intima-media thickness in children heterozygous for familial hypercholesterolaemia. Lancet 2004; 363:369-370.
117. Zhu W, Huang X, He J, Li M, Neubauer H. Arterial intima-media thickening and endothelial dysfunction in obese Chinese children. Eur J Pediatr 2005; 164:337-344.
118. Meyer AA, Kundt G, Steiner M, Schuff-Werner P, Kienast W. Impaired flow-mediated vasodilation, carotid artery intima-media thickening, and elevated endothelial plasma markers in obese children: The impact of cardiovascular risk factors. Pediatrics 2006; 117:1560-1567.
119. Sorof JM, Alexandrov AV, Cardwell G, Portman RJ. Carotid artery intimal-medial thickness and left ventricular hypertrophy in children with elevated blood pressure. Pediatrics 2003; 111:61-66.
120. Lande MB, Carson NL, Roy J, Meagher CC. Effects of childhood primary hypertension on carotid intima media thickness: A matched controlled study. Hypertension 2006; 48:40-44.
121. Järvisalo MJ, Raitakari M, Toikka JO, Putto-Laurila A, Rontu R, Laine S, et al. Endothelial dysfunction and increased arterial intima-media thickness in children with type 1 diabetes. Circulation 2004; 109:1750-1755.
122. Ben-Shlomo Y, Spears M, Boustred C, May M, Anderson SG, Benjamin EJ, et al. Aortic pulse wave velocity improves cardiovascular event prediction: An individual participant meta-Analysis of prospective data from 17, 635 subjects. J Am Coll Cardiol 2014; 63:636-646.
123. Reusz GS, Cseprekal O, Temmar M, Kis E, Cherif AB, Thaleb A, et al. Reference values of pulse wave velocity in healthy children and teenagers. Hypertension 2010; 56:217-224.
124. Thurn D, Doyon A, Sözeri B, Bayazit AK, Canpolat N, Duzova A, et al., 4C Study Consortium. Aortic pulse wave velocity in healthy children and adolescents: Reference values for the Vicorder device and modifying factors. Am J Hypertens 2015; 28:1480-1488.
125. Aggoun Y, Bonnet D, Sidi D, Girardet JP, Brucker E, Polak M, et al. Arterial mechanical changes in children with familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 2000; 20:2070-2075.
126. Oren A, Vos LE, Uiterwaal CSPM, Gorissen WHM, Grobbee DE, Bots ML. Adolescent blood pressure does not predict aortic stiffness in healthy young adults. The Atherosclerosis Risk in Young Adults (ARYA) study. J Hypertens 2003; 21:321-326.
127. Juonala M, Järvisalo MJ, Mäki-Torkko N, Kähönen M, Viikari JSA, Raitakari OT. Risk factors identified in childhood and decreased carotid artery elasticity in adulthood: The Cardiovascular Risk in Young Finns Study. Circulation 2005; 112:1486-1493.
128. Riggio S, Mandraffino G, Sardo MA, Iudicello R, Camarda N, Imbalzano E, et al. Pulse wave velocity and augmentation index, but not intima-media thickness, are early indicators of vascular damage in hypercholesterolemic children. Eur J Clin Invest 2010; 40:250-257.
129. Sinha MD, Keehn L, Milne L, Sofocleous P, Chowienczyk PJ. Decreased arterial elasticity in children with nondialysis chronic kidney disease is related to blood pressure and not to glomerular filtration rate. Hypertension 2015; 66:809-815.
130. Lubrano R, Travasso E, Raggi C, Guido G, Masciangelo R, Elli M. Blood pressure load, proteinuria and renal function in prehypertensive children. Pediatr Nephrol 2009; 24:823-831.
131. Tullus K, Roebuck DJ, McLaren CA, Marks SD. Imaging in the evaluation of renovascular disease. Pediatr Nephrol 2010; 25:1049-1056.
132. Mitchell P, Cheung N, de Haseth K, Taylor B, Rochtchina E, Islam FM, et al. Blood pressure and retinal arteriolar narrowing in children. Hypertension 2007; 49:1156-1162.
133. Daniels SR, Lipman MJ, Burke MJ, Loggie JM. The prevalence of retinal vascular abnormalities in children and adolescents with essential hypertension. Am J Ophthalmol 1991; 111:205-258.
134. Foster BJ, Ali H, Mamber S, Polomeno RC, Mackie AS. Prevalence and severity of hypertensive retinopathy in children. Clin Pediatr 2009; 48:926-930.
135. Williams KM, Shah AN, Morrison D, Sinha MD. Hypertensive retinopathy in severely hypertensive children: demographic, clinical, and ophthalmoscopic findings from a 30-year British cohort. J Pediatr Ophthalmol Strabismus 2013; 50:222-228.
136. Sharma M, Kupferman JC, Brosgol Y, Paterno K, Goodman S, Prohovnik I, et al. The effects of hypertension on the paediatric bra: A justifiable concern. Lancet Neurol 2010; 9:933-940.
137. Agarwal A, Kapur G, Altinok D. Childhood posterior reversible encephalopathy syndrome: magnetic resonance imaging findings with emphasis on increased leptomeningeal FLAIR signal. Neuroradiol J 2015; 28:638-643.
138. Vkachopoulos C, Xaplanteris P, Aboyans V, Brodmann M, Cifkova R, Cosentino F, et al. The role of vascular biomarkers for primary and secondary prevention. Atherosclerosis 2015; 241:507-532.
139. Hlatky MA, Greenland P, Arnett DK, Ballantyne CM, Criqui MH, Elkind MS, et al., American Heart Association Expert Panel on Subclinical Atherosclerotic Diseases and Emerging Risk Factors and the Stroke Council. Criteria for evaluation of novel markers of cardiovascular risk: A scientific statement from the American Heart Association. Circulation 2009; 119:2408-2416.
140. Jameson JL, Longo DL. Precision medicine-personalized, problematic and promising. New Eng J Med 2015; 372:2229-2234.
141. Nguyen S, McCulloch C, Brakeman P, Portale A, Hsu CY. Being overweight modifies the association between cardiovascular risk factors and microalbuminuria in adolescents. Pediatrics 2008; 121:37-45.
142. Reilly JJ, Kelly J. Long-Term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: Systematic review. Int J Obes 2011; 35:891-898.
143. Park MH, Falconer C, Viner RM, Kinra S. The impact of childhood obesity on morbidity and mortality in adulthood: A systematic review. Obes Rev 2012; 13:985-1000.
144. World Health Organization. Obesity and overweight 2015. Available at: http://www.who.int/mediacentre/factsheets/fs311/en/[last accessed 13 April 2016].
145. Wright CM, Parker L, Lamont D, Craft AW. Implications of childhood obesity for adult health: Findings from thousand families cohort study. BMJ 2001; 323:1280-1284.
146. Juonala M, Magnussen CG, Berenson GS, Venn A, Burns TL, Sabin MA, et al. Childhood adiposity, adult adiposity, and cardiovascular risk factors. N Engl J Med 2011; 365:1876-1885.
147. Steinberger J, Daniels SR, Eckel RH, Hayman L, Lustig RH, McCrindle B, et al., American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; and Council on Nutrition, Physical Activity, and Metabolism. Progress and challenges in metabolic syndrome in children and adolescents: A scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; and Council on Nutrition, Physical Activity, and Metabolism. Circulation 2009; 119:628-647.
148. Cameron FJ, Wherrett DK. Care of diabetes in children and adolescents: controversies, changes, and consensus. Lancet 2015; 385:2096-2106.
149. Zeitler P, Fu J, Tandon N, Nadeau K, Urakami T, Bartlett T, et al. ISPAD Clinical Practice Consensus Guidelines 2014 Compendium Type 2 diabetes in the child and adolescent. Pediatr Diabetes 2014; 15:26-46.
150. Rodriguez BL, Dabelea D, Liese AD, Fujimoto W, Waitzfelder B, Liu L, et al., SEARCH Study Group. Prevalence and correlates of elevated blood pressure in youth with diabetes mellitus: The search for diabetes in youth study. J Pediatr 2010; 157:245-251.
151. American Diabetes Association. Children and adolescents. Sec. 11. In standards of medical care in diabetes 2015. Diabetes Care 2015; 38:S70-S76.
152. Maahs DM, Daniels SR, de Ferranti SD, Dichek HL, Flynn J, Goldstein BI, et al., American Heart Association Atherosclerosis, Hypertension and Obesity in Youth Committee of the Council on Cardiovascular Disease in the Young, Council on Clinical Cardiology, Council on Cardiovascular and Stroke Nursing, Council for High Blood Pressure Research, and Council on Lifestyle and Cardiometabolic Health. Cardiovascular disease risk factors in youth with diabetes mellitus: A scientific statement from the American Heart Association. Circulation 2014; 130:1532-1558.
153. Nambam B, DuBose SN, Nathan BM, Beck RW, Maahs DM, Wadwa RP, et al., T1D Exchange Clinic Network. Therapeutic inertia: underdiagnosed and undertreated hypertension in children participating in the T1D Exchange Clinic Registry. Pediatr Diabetes 2016; 17:15-20.
154. Lingens N, Dobos E, Witte K, Busch C, Lemmer B, Klaus G, et al. Twenty-four-hour ambulatory blood pressure profiles in pediatric patients after renal transplantation. Pediatr Nephrol 1997; 11:23-26.
155. Mitsnefes M, Stablein D. Hypertension in pediatric patients on longterm dialysis: A report of the North American Pediatric Renal Transplant Cooperataive Study (NAPRTCS). Am J Kidney Dis 2005; 45:309-315.
156. Seeman T, Simková E, Kreisinger J, Vondrák K, Dusek J, Gilík J, et al. Control of hypertension in children after renal transplantation. Pediatr Transplant 2006; 10:316-322.
157. Flynn JT, Mitsnefes M, Pierce C, Cole SR, Parekh RS, Furth SL, et al., Chronic Kidney Disease in Children Study Group. Blood pressure in children with chronic kidney disease: A report from the Chronic Kidney Disease in Children Study. Hypertension 2008; 52:631-637.
158. Schaefer F, Mehls O. Hypertension in chronic kidney disease. In: Portman RJ, Sorof JM, Ingelfinger JR, editors. Pediatric hypertension. Totowa, NJ: Humana Press; 2004. pp. 371-387.
159. Klag MJ, Whelton PK, Randall BL, Neaton JD, Brancati FL, Ford CE, et al. Blood pressure and end-stage renal disease in men. N Engl J Med 1996; 334:13-18.
160. Locatelli F, Marcelli D, Comelli M, Alberti D, Graziani G, Buccianti G, et al. Proteinuria and blood pressure as causal components of progression to end-stage renal failure. Northern Italian Cooperative Study Group. Nephrol Dial Transplant 1996; 11:461-467.
161. Iseki K, Ikemiya Y, Iseki C, Takishita S. Proteinuria and the risk of developing end-stage renal disease. Kidney Int 2003; 63:1468-1474.
162. Wingen AM, Fabian-Bach C, Schaefer F, Mehls O. Randomised multicentre study of a low-protein diet on the progression of chronic renal failure in children. European Study Group of Nutritional Treatment of Chronic Renal Failure in Childhood. Lancet 1997; 349:1117-1123.
163. Ohkubo T, Hozawa A, Yamaguchi J, Kikuya M, Ohmori K, Michimata M, et al. Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure: The Ohasama study. J Hypertens 2002; 20:2183-2189.
164. Jacob P, Hartung R, Bohlender J, Stein G. Utility of 24-h ambulatory blood pressure measurement in a routine clinical setting of patients with chronic renal disease. J Hum Hypertens 2004; 18:745-751.
165. Timio M, Venanzi S. "Nondipper" hypertensive patients and progressive renal insufficiency: A 3-year longitudinal study. Clin Nephrol 1995; 43:382-387.
166. Cifkova R, Skodova Z, Bruthans J, Holub J, Adamkova V, Jozifova M, et al. Longitudinal trends in cardiovascular mortality and blood pressure levels, prevalence, awareness, treatment, and control of hypertension in the Czech population from 1985 to 2007/2008. J Hypertens 2010; 28:2196-2203.
167. Banach M, Bromfield S, Howard G, Howard VJ, Zanchetti A, Aronow WS, et al. Association of systolic blood pressure levels with cardiovascular events and all-cause mortality among older adults taking antihypertensive medication. Int J Cardiol 2014; 176:219-226.
168. Thomopoulos C, Parati G, Zanchetti A. Effects of blood pressure lowering on outcome incidence in hypertension. 1. Overview, metaanalyses, and meta-regression analyses of randomized trials. J Hypertens 2014; 32:2285-2295.
169. Emdin CA, Rahimi K, Neal B, Callender T, Perkovic V, Patel A. Blood pressure lowering in type 2 diabetes: A systematic review and metaanalysis. JAMA 2015; 313:603-615.
170. Thomopoulos C, Parati G, Zanchetti A. Effects of blood pressure lowering on outcome incidence in hypertension: 7. Effects of more vs. less intensive blood pressure lowering and different achieved blood pressure levels-updated overview and meta-Analyses of randomized trials. J Hypertens 2016; 34:613-622.
171. Devereux RB, Wachtell K, Gerdts E, Boman K, Nieminen MS, Papademetriou V, et al. Prognostic significance of left ventricular mass change during treatment of hypertension. JAMA 2004; 292:2350-2356.
172. Devereux RB, Dahlöf B, Gerdts E, Boman K, Nieminen MS, Papademetriou V, et al. Regression of hypertensive left ventricular hypertrophy by losartan compared with atenolol: The Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) trial. Circulation 2004; 110:1456-1462.
173. Fagard RH, Celis H, Thijs L, Wouters S. Regression of left ventricular mass by antihypertensive treatment: A meta-Analysis of randomized comparative studies. Hypertension 2009; 54:1084-1091.
174. Seeman T, Dostalek L, Gilik J. Control of hypertension in treated children and its association with target organ damage. Am J Hypertens 2012; 25:389-395.
175. Matteucci MC, Chinali M, Rinelli G, Wühl E, Zurowska A, Charbit M, et al., ESCAPE Trial Group. Change in cardiac geometry and function in CKD children during strict BP control: A randomized study. Clin J Am Soc Nephrol 2013; 8:203-210.
176. Kupferman JC, Aronson Friedman L, Cox C, Flynn J, Furth S, Warady B, et al., CKiD Study Group. BP control and left ventricular hypertrophy regression in children with CKD. J Am Soc Nephrol 2014; 25:167-174.
177. Ettehad D, Emdin CA, Kiran A, Anderson SG, Callender T, Emberson J, et al. Blood pressure lowering for prevention of cardiovascular disease and death: A systematic review and meta-Analysis. Lancet 2016; 387:957-967.
178. Heerspink HJ, Kröpelin TF, Hoekman J, de Zeeuw D, Reducing Albuminuria as Surrogate Endpoint (REASSURE) Consortium. Druginduced reduction in albuminuria is associated with subsequent renoprotection: A meta-Analysis. J Am Soc Nephrol 2015; 26:2055-2064.
179. Ferguson MA, Flynn JT. Pharmacologic treatment of childhood hypertension. In: Flynn JT, Ingelfinger JR, Portman RJ, editors. Pediatric hypertension. New York: Humana Press; 2013. pp. 539-555.
180. Stabouli S, Kotsis V, Rizos Z. Left ventricular mass in normotensive prehypertensive and hypertensive children and adolescents. Pediatr Nephrol 2009; 24:1545-1551.
181. Urbina EM, Khoury PR, McCoy C, Daniels SR, Kimball TR, Dolan LM. Cardiac and vascular consequences of prehypertension in youth. J Clin Hypertens 2011; 13:332-342.
182. Gimpel C, Wühl E, Arbeiter K, Drozdz D, Trivelli A, Charbit M, et al., ESCAPE Trial Group. Superior consistency of ambulatory blood pressure monitoring in children: implications for clinical trials. J Hypertens 2009; 27:1568-1574.
183. Wühl E, Witte K, Soergel M, Mehls O, Schaefer F, German Working Group on Pediatric Hypertension. Distribution of 24-h ambulatory blood pressure in children: normalized reference values and role of body dimensions. J Hypertens 2002; 20:1995-2007.
184. James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 2014; 311:507-520.
185. Wright JT Jr, Williamson JD, Whelton PK, Snyder JK, Sink KM, Rocco MV, et al., SPRINT Research Group. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med 2015; 373:2103-2116.
186. Falkner B, Gidding SS. Is the SPRINT blood pressure treatment target of 120/80mmHg relevant for children? Hypertension 2016; 67:826-828.
187. Furth S, Flynn J, Pierce C, Mitsnefes M, Wong C, Saland J, et al. Lower systolic BP associated with slower CKD progression in the CKiD study. J Am Soc Nephrol 2010;551A.
188. Arguedas JA, Perez MI, Wright JM. Treatment blood pressure targets for hypertension. Cochrane Database Syst Rev 2009;CD004349.
189. Upadhyay A, Earley A, Haynes SM, Uhlig K. Systematic review: blood pressure target in chronic kidney disease and proteinuria as an effect modifier. Ann Intern Med 2011; 154:541-548.
190. Raile K, Galler A, Hofer S, Herbst A, Dunstheimer D, Busch P, et al. Diabetic nephropathy in 27, 805 children, adolescents and adults with type 1 diabetes. Effect of diabetes duration, A1C, hypertension, dyslipidemia, diabetes onset, and sex. Diabetes Care 2007; 30:2523-2528.
191. Lurbe E, Redon J, Kesani A, Pascual JM, Tacons J, Alvarez V, et al. Increase in nocturnal blood pressure and progression to microalbuminuria in type 1 diabetes. N Engl J Med 2002; 347:797-805.
192. Ettinger LM, Freeman K, DiMartino-Nardi JR, Flynn JT. Microalbuminuria and abnormal ambulatory blood pressure in adolescents with type 2 diabetes mellitus. J Pediatr 2005; 147:67-73.
193. Ho M, Garnett SP, Baur L, Burrows T, Stewart L, Neve M, Collins C. Effectiveness of lifestyle interventions in child obesity: Systematic review with meta-Analysis. Pediatrics 2012; 130:e1647-e1671.
194. Rocchini AP, Katch V, Anderson J, Hinderliter J, Becque D, Martin M, et al. Blood pressure in obese adolescents: Effect of weight loss. Pediatrics 1988; 82:16-23.
195. Holm JC, Gamborg M, Neland M, Ward L, Gammeltoft S, Heitmann BL, et al. Longitudinal changes in blood pressure during weight loss and regain of weight in obese boys and girls. J Hypertens 2012; 30:368-374.
196. Hvidt KN, Olsen MH, Ibsen H, Holm JC. Effect of changes in BMI and waist circumference on ambulatory blood pressure in obese children and adolescents. J Hypertens 2014; 32:1470-1477.
197. Kelley GA, Kelley KS, Tran ZV. The effects of exercise on resting blood pressure in children and adolescents: A meta-Analysis of randomized controlled trials. Prev Cardiol 2003; 6:8-16.
198. Farpour-Lambert NJ, Aggoun Y, Marchand LM, Martin XE, Herrmann FR, Beghetti M. Physical activity reduces systemic blood pressure and improves early markers of atherosclerosis in prepubertal obese children. J Am Coll Cardiol 2009; 54:2396-2406.
199. Leary SD, Ness AR, Smith GD, Mattocks C, Deere K, Blair SN, et al. Physical activity and blood pressure in childhood: Findings from a population-based study. Hypertension 2008; 51:92-98.
200. World Health Organization. Physical activity and young people. Recommended levels of physical activity for children aged 5-17 years. 2010. Available at: http://www.who.int/dietphysicalactivity/factsheet-young-people/en/[last accessed 13th April 2016].
201. Shi L, Krupp D, Remer T. Salt, fruit and vegetable consumption and blood pressure development: A longitudinal investigation in healthy children. Br J Nutr 2014; 111:662-671.
202. Moore LL, Bradlee ML, Singer MR, Qureshi MM, Buendia JR, Daniels SR. Dietary Approaches to Stop Hypertension (DASH) eating pattern and risk of elevated blood pressure in adolescent girls. Br J Nutr 2012; 108:1678-1685.
203. Niinikoski H, Jula A, Viikari J, Rönnemaa T, Heino P, Lagström H, et al. Blood pressure is lower in children and adolescents with a lowsaturated-fat diet since infancy: The special Turku coronary risk factor intervention project. Hypertension 2009; 53:918-924.
204. Nguyen S, Choi HK, Lustig RH, Hsu CY. Sugar-sweetened beverages, serum uric acid, and blood pressure in adolescents. J Pediatr 2009; 154:807-813.
205. Yang Q, Zhang Z, Kuklina EV, Fang J, Ayala C, Hong Y, et al. Sodium intake and blood pressure among US children and adolescents. Pediatrics 2012; 130:611-619.
206. He FJ, MacGregor GA. Importance of salt in determining blood pressure in children: meta-Analysis of controlled trials. Hypertension 2006; 48:861-869.
207. Geleijnse JM, Hofman A, Witteman JC, Hazebroek AA, Valkenburg HA, Grobbee DE. Long-Term effects of neonatal sodium restriction on blood pressure. Hypertension 1997; 29:913-917.
208. Boegehold MA. The effect of high salt intake on endothelial function: Reduced vascular nitric oxide in the absence of hypertension. J Vasc Res 2013; 50:458-467.
209. Simonetti GD, Schwertz R, Klett M, Hoffmann GF, Schaefer F, Wühl E. Determinants of blood pressure in preschool children: The role of parental smoking. Circulation 2011; 123:292-298.
210. Thomopoulos C, Parati G, Zanchetti A. Effects of blood pressurelowering on outcome incidence in hypertension: 5. Head-To-head comparisons of various classes of antihypertensive drugs-overview and meta-Analyses. J Hypertens 2015; 33:1321-1341.
211. Schaefer F, Litwin M, Zachwieja J, Zurowska A, Turi S, Grosso A, et al. Efficacy and safety of valsartan when compared to enalapril in hypertensive children: A 12 week, randomised, double-blind, parallelgroup study. J Hypertens 2011; 29:2484-2490.
212. Chaturvedi S, Lipszyc DH, Licht C, Craig JC, Parekh R. Pharmacological interventions for hypertension in children. Cochrane Database Syst Rev 2014; 2:CD008117.
213. Thomopoulos C, Parati G, Zanchetti A. Effects of blood pressure lowering on outcome incidence in hypertension: 4. Effects of various classes of antihypertensive drugs-overview and meta-Analyses. J Hypertens 2015; 33:195-211.
214. Claxton AJ, Cramer J, Pierce C. A systematic review of the associations between dose regimens and medication compliance. Clin Ther 2001; 23:1296-1310.
215. Ferguson MA, Flynn JT. Rational use of anthypertensive medications in children. Pediatr Nephrol 2013; 29:979-988.
216. Elliott WJ1, Meyer PM. Incident diabetes in clinical trials of antihypertensive drugs: A network meta-Analysis. Lancet 2007; 369:201-207.
217. Mancia G, Grassi G, Zanchetti A. New-onset diabetes and antihypertensive drugs. J Hypertens 2006; 24:3-10..
218. Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents. National Heart, Lung, and Blood Institute. Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: Summary report. Pediatrics 2011; 128:S213-S256.
219. Yusuf S, Teo KK, Pogue J, Dyal L, Copland I, Schumacher H, et al., ONTARGET Investigators. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med 2008; 358:1547-1559.
220. Parving HH, Brenner BM, McMurray JJ, de Zeeuw D, Haffner SM, Solomon SD, et al., ALTITUDE Investigators. Cardiorenal end points in a trial of aliskiren for type 2 diabetes. N Engl J Med 2012; 367:2204-2213.
221. Fried LF, Emanuele N, Zhang JH, Brophy M, Conner TA, Duckworth W, et al., VA NEPHRON-D Investigators. Combined angiotensin inhibition for the treatment of diabetic nephropathy. N Engl J Med 2013; 369:1892-1903.
222. Sorof JM, Cargo P, Graepel J, Humphrey D, King E, Rolf C, et al. Betablocker/thiazide combination for treatment of hypertensive children: A randomised double-blind, placebo-controlled trial. Pediatr Nephrol 2002; 17:345-350.
223. de Boer IH, Rue TC, Cleary PA, Lachin JM, Molitch ME, Steffes MW, et al., Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group. Long-Term renal outcomes of patients with type 1 diabetes mellitus and microalbuminuria: An analysis of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications cohort. Arch Intern Med 2011; 171:412-420.
224. Giunti S, Barit D, Cooper ME. Diabetic nephropathy: From mechanisms to rational therapies. Minerva Med 2006; 97:241-262.
225. American Diabetes Association. Cardiovascular disease and risk management. Sec. 8. In standards of medical care in diabetes 2016. Diabetes Care 2016; 39:60-71.
226. Rad EM, Assadi F. Management of hypertension in children with cardiovascular disease and heart failure. Int J Prev Med 2014; 5:10-16.
227. Flynn JT, Tullus K. Severe hypertension in children and adolescents: pathophysiology and treatment. Pediatr Nephrol 2009; 24:1101-1112.
228. Simonetti GD, Rizzi M, Donadini R, Bianchetti MG. Effects of antihypertensive drugs on blood pressure and proteinuria in childhood. J Hypertens 2007; 25:2370-2376.
229. Von Vigier RO, Franscini LMD, Bianda ND, Pfister R, Casaulta-Aebischer C, Bianchetti MG. Antihypertensive efficacy of amlodipine in children with chronic kidney diseases. J Hum Hypertens 2001; 15:387-391.
230. Ellis D, Vats A, Moritz ML, Reitz S, Grosso MJ, Janosky JE. Long-Term antiproteinuric and renoprotective efficacy and safety of losartan in children with proteinuria. J Pediatr 2003; 143:89-97.
231. Schaefer F, van de Walle J, Zurowska A, Gimpel C, van Hoeck K, Drozdz D, et al., Candesartan in Children with Hypertension Investigators. Efficacy, safety and pharmacokinetics of candesartan cilexetil in hypertensive children from 1 to less than 6 years of age. J Hypertens 2010; 28:1083-1090.
232. Flynn JT, Meyers KE, Neto JP, de Paula Meneses R, Zurowska A, Bagga A, et al. Efficacy and safety of the angiotensin receptor blocker valsartan in children with hypertension aged 1 to 5 years. Hypertension 2008; 52:222-228.
233. MacKinnon M, Shurraw S, Akbari A, Knoll GA, Jaffey J, Clark HD. Combination therapy with an angiotensin receptor blocker and an ACE inhibitor in proteinuric renal disease: A systematic review of the efficacy and safety data. Am J Kidney Dis 2006; 48:8-20.
234. Lubrano R, Soscia F, Elli M, Ventriglia F, Raggi C, Travasso E, et al. Renal and cardiovascular effects of angiotensin-converting enzyme inhibitor plus angiotensin II receptor antagonist therapy in children with proteinuria. Pediatrics 2006; 118:e833-e838.
235. Pulgaron ER, Delamater AM. Obesity and type 2 diabetes in children: Epidemiology and treatment. Curr Diab Rep 2014; 14:508.
236. Viner RM, Hsia Y, Tomsic T, Wong IC. Efficacy and safety of antiobesity drugs in children and adolescents: Systematic review and meta-Analysis. Obes Rev 2010; 11:593-602.
237. Matson KL, Fallon RM. Treatment of obesity in children and adolescents. J Pediatr Pharmacol Ther 2012; 17:45-57.
238. Redon J, Cifkova R, Laurent S, Nilsson P, Narkiewicz K, Erdine S, et al., Scientific Council of the European Society of Hypertension. The metabolic syndrome in hypertension: European society of hypertension position statement. J Hypertens 2008; 26:1891-1900.
239. Wu HP, Yang WC, Wu YK, Zhao LL, Chan CY, Fu YC. Clinical significance of blood pressure ratios in hypertensive crisis in children. Arch Dis Child 2012; 97:200-205.
240. Deal JE, Barrat TM, Dillon MJ. Management of hypertensive emergencies. Arch Dis Child 1992; 67:1089-1092.
241. Adelman RD, Coppo R, Dillon MJ. The emergency management of severe hypertension. Pediatr Nephrol 2000; 14:422-427.
242. Patel HP, Mitsnefes M. Advances in the pathogenesis and management of hypertensive crisis. Curr Opin Pediatr 2005; 17:210-214.
243. Chandar J, Zilleruelo G. Hypertensive crisis in children. Pediatr Nephrol 2012; 27:741-751.
244. Yang WC, Zhao LL, Chen CY, Wu YK, Chang YJ, Wu HP. First-Attack pediatric hypertensive crisis presenting to the pediatric emergency department. BMC Pediatrics 2012; 12:200.
245. Cremer A, Amraoui F, Lip GY, Morales E, Rubin S, Segura J, et al. From malignant hypertension to hypertension-MOD: A modern definition for an old but still dangerous emergency. J Hum Hypertens 2015; doi:10.1038/jhh.2015.112.
246. Stone NJ, Robinson JG, Lichtenstein AH, Bairey Metz CN, Eckel RH, Blum CB, et al., American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2014; 129 (Suppl 2):1-45.
247. Vuorio A, Kuoppala J, Kovanen PT, Humphries SE, Tonstad S, Wiegman A, et al. Statins for children with familial hypercholesterolemia. Cochrane Database Syst Rev 2014; 7:CD006401.
248. Gooding HC, Rodday AE, Wong JB, Gillman MW, Lloyd-Jones DM, Leslie LK, et al. Application of pediatric and adult guidelines for treatment of lipid levels among US adolescents transitioning to young adulthood. JAMA Pediatr 2015; 169:569-574.
249. Hirst K, Pyle L, Linder B, Copeland K, Arslanian S, Cuttler L, et al. A clinical trial to maintain glycemic control in youth with type 2 diabetes. N Engl J Med 2012; 366:2247-2256.
250. Amar MY, Hogg RJ, Arant BS. Etiology of sustained hypertension in children in the southwestern United States. Pediatr Nephrol 1994; 8:186-189.
251. Gomes RS, Quirino IG, Pereira RM. Primary versus secondary hypertension in children followed up at an outpatient tertiary unit. Pediatr Nephrol 2011; 26:441-447.
252. Flynn J, Zhang Y, Solar-Yohay S, Shi V. Clinical and demographic characteristics of children with hypertension. Hypertension 2012; 60:1047-1054.
253. Vogt BA. Hypertension in children and adolescents: definition, pathophysiology, risk-factors and long-Term sequelae. Curr Ther Res 2001; 62:283-297.
254. Olin JW, Gornik HL, Bacharach JM, Biller J, Fine LJ, Gray BH, et al., American Heart Association Council on Peripheral Vascular Disease. American Heart Association Council on Clinical Cardiology. American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation. American Heart Association Council on Cardiovascular Disease in the Young. American Heart Association Council on Cardiovascular Radiology and Intervention. American Heart Association Council on Epidemiology and Prevention. American Heart Association Council on Functional Genomics and Translational Biology. American Heart Association Council for High Blood Pressure Research. American Heart Association Council on the Kidney in Cardiovascular Disease. American Heart Association Stroke Council. Fibromuscular dysplasia: State of the science and critical unanswered questions: A scientific statement from the American Heart Association. Circulation 2014; 129:1048-1078.
255. Tullus K, Brennan E, Hamilton G, Lord R, McLaren CA, Marks SD, et al. Renovascular hypertension in children. Lancet 2008; 371:1453-1463.
256. Kari JA, Roebuck DJ, McLaren CA, Davis M, Dillon MJ, Hamilton G, et al. Angioplasty for renovascular hypertension in 78 children. Arch Dis Child 2015; 100:474-478.
257. Eliason JL, Coleman DM, Criado E, Kershaw DB, Blatt NB, Williams DM, et al. Operations for failed endovascular therapy of 32 renal artery stenoses in 24 children. Pediatr Nephrol 2016; 31:809-817.
258. Waguespack SG, Rich T, Grubbs E, Ying AK, Perrier ND, Ayala-Ramirez M, et al. A current review of the etiology, diagnosis, and treatment of pediatric pheochromocytoma and paraganglioma. J Clin Endocrinol Metab 2010; 95:2023-2037.
259. Garnier S, Réguerre Y, Orbach D, Brugières L, Kalfa N. Pediatric pheochromocytoma and paraganglioma: An update. Bull Cancer 2014; 101:966-975.
260. Zennaro MC, Boulkroun S, Fernandes-Rosa F. An update on novel mechanisms of primary aldosteronism. J Endocrinol 2015; 224:R63-R77.
261. Stratakis CA. Cushing syndrome in paediatrics. Endocrinol Metab Clin North Am 2012; 41:793-803.
262. Magiakou MA, Mastorakos G, Zachman K, Chrousos GP. Blood pressure in children and adolescents with Cushing's syndrome before and after surgical care. J Clin Endocrinol Metab 1997; 82:1734-1738.
263. Sinaii N, Patronas N, Batista DL, Keil M, Samuel J, Moran J, et al. Blood pressure in pediatric patients with Cushing syndrome. J Clin Endocrinol Metab 2009; 94:2002-2082.
264. Su MS, Zhang HL, Cai XH, Lin Y, Liu PN, Zhang Y, et al. Obesity in children with different risk factors for obstructive sleep apnea: A community based study. Eur J Pediatr 2016; 175:211-220.
265. Silvestre JM, Jesé-Mayer DE, Bass MT. Polisomnography in obese children with a history of sleep-Associated breathing disorders. Pediatr Pulmonol 1993; 16:124-129.
266. Marcus CL, Curtis S, Koerner CB. Evaluation of pulmonary function and polisomnography in obese children and adolescents. Pediatr Pulmonol 1996; 21:176-183.
267. Chay OM, Goh A, Abisheganaden J. Obstructive sleep apnea syndrome in obese Singapore children. Pediatr Pulmonol 2000; 29:284-290.
268. Wing YK, Hui SH, Pak WM. A controlled study of sleep related disordered breathing in obese children. Arch Dis Child 2003; 88:1043-1047.
269. Dayyat ED, Kheirandish-Gozal L, Gozal D. Childhood obstructive sleep apnea: one or two distinct disease entities? Sleep Med Clin 2007; 2:433-444.
270. Levy P, Bonsignore MR, Eckel J. Sleep, sleep-disordered breathing and metabolic consequences. Eur Respir J 2009; 34:243-260.
271. Fletcher S, Miller J, Schaaf JW, Fletcher JG. Urinary catecholamines before and after tracheostomy in patients with obstructive sleep apnea and hypertension. Sleep 1987; 10:35-44.
272. Strohl KP, Novak RD, Singer W, Cahan C, Boehm KD, Denko CW, Hoffstem VS. Insulin levels, blood pressure, and sleep apnea. Sleep 1994; 17:614-618.
273. Vgontzas AN. Does obesity plays a major role in the pathogenesis of sleep apnea and its associated manifestations via inflammation, visceral adiposity and insulin resistance? Arch Physiol Biochem 2008; 114:211-223.
274. Torok RD, Campbell MJ, Fleming GA, Hill KD. Coarctation of the aorta: management from infancy to adulthood. World J Cardiol 2015; 7:765-775.
275. Morgan GJ, Lee KJ, Chaturvedi R, Bradley TJ, Mertens L, Benson L. Systemic blood pressure after stent management for arch coarctation implications for clinical care. JACC Cardiovasc Interv 2013; 6:192-201.
276. O'Sullivan JJ, Derrick G, Darnell R. Prevalence of hypertension in children after early repair of coarctation of the aorta: A cohort study using casual and 24 h blood pressure measurement. Heart 2002; 88:163-166.
277. Hager A, Kanz S, Kaemmerer H, Schreiber C, Hess J. Coarctation Longterm Assessment (COALA): Significance of arterial hypertension in a cohort of 404 patients up to 27 years after surgical repair of isolated coarctation of the aorta, even in the absence of restenosis and prosthetic material. J Thorac Cardiovasc Surg 2007; 134:738-745.
278. Grontved A, Brage S, Moller NC, Kristensen PL, Wedderkopp N, Froberg K, et al. Hemodynamic variables during exercise in childhood and resting systolic blood pressure levels 6 years later in adolescence: The European Youth Heart Study. J Hum Hypertens 2011; 25:608-614.
279. Luijendijk P, Bouma BJ, Vriend JW, Vliegen HW, Groenink M, Mulder BJ. Usefulness of exercise-induced hypertension as predictor of chronic hypertension in adults after operative therapy for aortic isthmic coarctation in childhood. Am J Cardiol 2011; 108:435-439.
280. Giordano U, Cifra B, Giannico S, Turchetta A, Calzolari A. Mid-Term results, and therapeutic management, for patients suffering hypertension after surgical repair of aortic coarctation. Cardiol Young 2009; 19:451-455.
281. Moltzer E, Mattace Raso FU, Karamermer Y, Boersma E, Webb GD, Simoons ML, et al. Comparison of candesartan versus metoprolol for treatment of systemic hypertension after repaired aortic coarctation. Am J Cardiol 2010; 105:217-222.
282. Grossman A, Messerli FH, Grossman E. Drug-induced hypertension-An unappreciated cause of secondary hypertension. Eur J Pharmacol 2015; 763:15-22.
283. Kassel LE, Odum LE. Our own worst enemy: pharmacologic mechanisms of hypertension. Adv Chr Kid Dis 2015; 22:245-252.
284. Maass PG, Aydin A, Luft FC, Schächterle C, Weise A, Stricker S, et al. PDE3A mutations cause autosomal dominant hypertension with brachydactyly. Nat Genet 2015; 47:647-653.