Angiotensin(1–7) attenuated Angiotensin II-induced hepatocyte EMT by inhibiting NOX-derived H2O2-activated NLRP3 inflammasome/IL-1β/Smad circuit

Free Radical Biology and Medicine

Volumn 97, Issue , 2016, Pages 531-543

  Zhang, Li Li ^a   Huang, Shan ^a   Ma, Xiao Xin ^a   Zhang, Wen Yong ^a   Wang, Dan ^a   Jin, Si Yi ^a   Zhang, Yan Ping ^a   Li, Yang ^a   Li, Xu ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Angiotensin II; Angiotensin (1 7); Epithelial mesenchymal transition; Hepatocyte; Liver fibrosis; NADPH oxidase; NLRP3 inflammasome; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; ALBUMIN; ANGIOTENSIN II; ANGIOTENSIN[1-7]; ANGIOTENSIN[1-7][7 DEXTRO ALANINE]; COLLAGEN TYPE 1; CRYOPYRIN; DIPHENYLIODONIUM SALT; HYDROGEN PEROXIDE; HYDROXYPROLINE; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MOESIN; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SMAD PROTEIN; SMALL INTERFERING RNA; UVOMORULIN; VIMENTIN; ANGIOTENSIN I; ANGIOTENSIN I (1-7); COLLAGEN TYPE I, ALPHA 1 CHAIN; NLRP3 PROTEIN, HUMAN; PEPTIDE FRAGMENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; EPITHELIAL MESENCHYMAL TRANSITION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; LIVER FIBROSIS; MALE; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RAT; RETROSPECTIVE STUDY; UPREGULATION; WESTERN BLOTTING; ANIMAL; CELL CULTURE; GENE EXPRESSION; GENETICS; LIVER CELL; LIVER CIRRHOSIS; METABOLISM; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; WISTAR RAT;

ANGIOTENSIN I; ANGIOTENSIN II; ANIMALS; CELLS, CULTURED; COLLAGEN TYPE I; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION; HEPATOCYTES; HUMANS; HYDROGEN PEROXIDE; INFLAMMASOMES; INTERLEUKIN-1BETA; LIVER CIRRHOSIS; MALE; MICE; NADPH OXIDASE 4; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PEPTIDE FRAGMENTS; RATS, WISTAR; SIGNAL TRANSDUCTION; SMAD PROTEINS;

EID: 84979223426     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2016.07.014     Document Type: Article

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