Molecular mechanism of Z α1-antitrypsin deficiency

Journal of Biological Chemistry

Volumn 291, Issue 30, 2016, Pages 15674-15686

  Huang, Xin ^a,b   Zheng, Ying ^c   Zhang, Fei ^c   Wei, Zhenquan ^c   Wang, Yugang ^c   Carrell, Robin W ^d   Read, Randy J ^d   Chen, Guo Qiang ^a,b,c   Zhou, Aiwu ^c  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c Shanghai Jiao Tong University School of Medicine   (China)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINS; CRYSTAL STRUCTURE; ENZYME ACTIVITY; MONOMERS; POLYMERIZATION;

ALPHA 1-ANTITRYPSIN; BETA-SHEET; HEPATOCYTES; IT SUPPORTS; LIVER CIRRHOSIS; MOLECULAR MECHANISM; SIDE-CHAINS; SMALL MOLECULES;

CONFORMATIONS;

ALPHA 1 ANTITRYPSIN;

ALPHA 1 ANTITRYPSIN DEFICIENCY; ARTICLE; BETA SHEET; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; GENE MUTATION; MOLECULAR INTERACTION; MOLECULAR PATHOLOGY; PRIORITY JOURNAL; PROTEIN POLYMERIZATION; AMINO ACID SUBSTITUTION; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MISSENSE MUTATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; X RAY CRYSTALLOGRAPHY;

ALPHA 1-ANTITRYPSIN; ALPHA 1-ANTITRYPSIN DEFICIENCY; AMINO ACID SUBSTITUTION; CRYSTALLOGRAPHY, X-RAY; HUMANS; MUTATION, MISSENSE; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY;

EID: 84979074257     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.727826     Document Type: Article

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