Serpin polymerization is prevented by a hydrogen bond network that is centered on His-334 and stabilized by glycerol

Journal of Biological Chemistry

Volumn 278, Issue 17, 2003, Pages 15116-15122

  Zhou, Aiwu ^a   Stein, Penelope E ^a   Huntington, James A ^a   Carrell, Robin W ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEXATION; CRYSTALLOGRAPHY; HYDROGEN BONDS; PH EFFECTS;

SERPIN POLYMERIZATION;

POLYMERIZATION;

ALANINE; ALPHA 1 ANTITRYPSIN; ANTITHROMBIN; GLYCEROL; HISTIDINE; SERINE; SERINE PROTEINASE INHIBITOR; THREONINE;

AMINO ACID SUBSTITUTION; ARTICLE; CONCENTRATION RESPONSE; ENZYME STABILITY; GENE MUTATION; GENETIC CONSERVATION; HYDROGEN BOND; PH; POLYMERIZATION; PRIORITY JOURNAL; PROTON TRANSPORT; THERMOSTABILITY; X RAY CRYSTALLOGRAPHY;

ALPHA 1-ANTITRYPSIN; ANTITHROMBINS; CRYSTALLOGRAPHY, X-RAY; GLYCEROL; HISTIDINE; HUMANS; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; POLYMERS; PROTEIN CONFORMATION; PROTEIN DENATURATION; SERPINS; TEMPERATURE;

INSERTION SEQUENCES;

EID: 0038053035     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M211663200     Document Type: Article

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