메뉴 건너뛰기




Volumn 916, Issue , 2016, Pages 87-101

Tumor suppressors in Zebrafish: From TP53 to PTEN and beyond

Author keywords

Apc; Pten; Tp53; Tumor suppressor; Vhl; Zebrafish

Indexed keywords

APC PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE LKB1; PROTEIN P53; RIBOSOME PROTEIN; VON HIPPEL LINDAU PROTEIN;

EID: 84979034967     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-3-319-30654-4_4     Document Type: Chapter
Times cited : (7)

References (77)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0842346437 scopus 로고    scopus 로고
    • Principles of tumor suppression
    • Sherr CJ (2004) Principles of tumor suppression. Cell 116:235–246
    • (2004) Cell , vol.116 , pp. 235-246
    • Sherr, C.J.1
  • 3
    • 34247186766 scopus 로고    scopus 로고
    • Animal models of human disease: Zebrafish swim into view
    • Lieschke GJ, Currie PD (2007) Animal models of human disease: zebrafish swim into view. Nat Rev Genet 8:353–367
    • (2007) Nat Rev Genet , vol.8 , pp. 353-367
    • Lieschke, G.J.1    Currie, P.D.2
  • 4
    • 51049109252 scopus 로고    scopus 로고
    • Zebrafish as a cancer model
    • Feitsma H, Cuppen E (2008) Zebrafish as a cancer model. Mol Cancer Res 6:685–694
    • (2008) Mol Cancer Res , vol.6 , pp. 685-694
    • Feitsma, H.1    Cuppen, E.2
  • 5
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for growth and division
    • Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88:323–331
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 6
    • 0034703742 scopus 로고    scopus 로고
    • P53: Death star
    • Vousden KH (2000) p53: death star. Cell 103:691–694
    • (2000) Cell , vol.103 , pp. 691-694
    • Vousden, K.H.1
  • 8
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: The cell’s response to p53
    • Vousden KH, Lu X (2002) Live or let die: the cell’s response to p53. Nat Rev Cancer 2:594–604
    • (2002) Nat Rev Cancer , vol.2 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 11
    • 0026561121 scopus 로고
    • Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
    • Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA Jr et al (1992) Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356:215–221
    • (1992) Nature , vol.356 , pp. 215-221
    • Donehower, L.A.1    Harvey, M.2    Slagle, B.L.3    McArthur, M.J.4    Montgomery, C.A.5
  • 13
    • 13444258032 scopus 로고    scopus 로고
    • BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma
    • Patton EE, Widlund HR, Kutok JL, Kopani KR, Amatruda JF et al (2005) BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol 15:249–254
    • (2005) Curr Biol , vol.15 , pp. 249-254
    • Patton, E.E.1    Widlund, H.R.2    Kutok, J.L.3    Kopani, K.R.4    Amatruda, J.F.5
  • 14
    • 74049101047 scopus 로고    scopus 로고
    • Oncogenic NRAS cooperates with p53 loss to generate melanoma in zebrafish
    • Dovey M, White RM, Zon LI (2009) Oncogenic NRAS cooperates with p53 loss to generate melanoma in zebrafish. Zebrafish 6:397–404
    • (2009) Zebrafish , vol.6 , pp. 397-404
    • Dovey, M.1    White, R.M.2    Zon, L.I.3
  • 15
    • 0031738326 scopus 로고    scopus 로고
    • N-ras mutations are common in melanomas from sun-exposed skin of humans but rare in mucosal membranes or unexposed skin
    • Jiveskog S, Ragnarsson-Olding B, Platz A, Ringborg U (1998) N-ras mutations are common in melanomas from sun-exposed skin of humans but rare in mucosal membranes or unexposed skin. J Invest Dermatol 111:757–761
    • (1998) J Invest Dermatol , vol.111 , pp. 757-761
    • Jiveskog, S.1    Ragnarsson-Olding, B.2    Platz, A.3    Ringborg, U.4
  • 16
    • 0348223934 scopus 로고    scopus 로고
    • NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression
    • Omholt K, Platz A, Kanter L, Ringborg U, Hansson J (2003) NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression. Clin Cancer Res 9:6483–6488
    • (2003) Clin Cancer Res , vol.9 , pp. 6483-6488
    • Omholt, K.1    Platz, A.2    Kanter, L.3    Ringborg, U.4    Hansson, J.5
  • 17
    • 78650748163 scopus 로고    scopus 로고
    • Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish
    • Santoriello C, Gennaro E, Anelli V, Distel M, Kelly A et al (2010) Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish. PLoS One 5, e15170
    • (2010) Plos One , vol.5
    • Santoriello, C.1    Gennaro, E.2    Anelli, V.3    Distel, M.4    Kelly, A.5
  • 20
    • 84885123381 scopus 로고    scopus 로고
    • Liver-specific expressions of HBx and src in the p53 mutant trigger hepatocarcinogenesis in zebrafish
    • Lu JW, Yang WY, Tsai SM, Lin YM, Chang PH et al (2013) Liver-specific expressions of HBx and src in the p53 mutant trigger hepatocarcinogenesis in zebrafish. PLoS One 8, e76951
    • (2013) Plos One , vol.8
    • Lu, J.W.1    Yang, W.Y.2    Tsai, S.M.3    Lin, Y.M.4    Chang, P.H.5
  • 21
    • 84893758816 scopus 로고    scopus 로고
    • UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma
    • Mudbhary R, Hoshida Y, Chernyavskaya Y, Jacob V, Villanueva A et al (2014) UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma. Cancer Cell 25:196–209
    • (2014) Cancer Cell , vol.25 , pp. 196-209
    • Mudbhary, R.1    Hoshida, Y.2    Chernyavskaya, Y.3    Jacob, V.4    Villanueva, A.5
  • 24
    • 70350543573 scopus 로고    scopus 로고
    • Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression
    • Rhodes J, Amsterdam A, Sanda T, Moreau LA, McKenna K et al (2009) Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression. Mol Cell Biol 29:5911–5922
    • (2009) Mol Cell Biol , vol.29 , pp. 5911-5922
    • Rhodes, J.1    Amsterdam, A.2    Sanda, T.3    Moreau, L.A.4    McKenna, K.5
  • 25
    • 79952345945 scopus 로고    scopus 로고
    • Zebrafish model of tuberous sclerosis complex reveals cell-autonomous and non-cell-autonomous functions of mutant tuberin
    • Kim SH, Speirs CK, Solnica-Krezel L, Ess KC (2011) Zebrafish model of tuberous sclerosis complex reveals cell-autonomous and non-cell-autonomous functions of mutant tuberin. Dis Model Mech 4:255–267
    • (2011) Dis Model Mech , vol.4 , pp. 255-267
    • Kim, S.H.1    Speirs, C.K.2    Solnica-Krezel, L.3    Ess, K.C.4
  • 26
    • 84880006426 scopus 로고    scopus 로고
    • Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish
    • Kim SH, Kowalski ML, Carson RP, Bridges LR, Ess KC (2013) Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish. Dis Model Mech 6:925–933
    • (2013) Dis Model Mech , vol.6 , pp. 925-933
    • Kim, S.H.1    Kowalski, M.L.2    Carson, R.P.3    Bridges, L.R.4    Ess, K.C.5
  • 27
    • 78650604349 scopus 로고    scopus 로고
    • Brca2 in zebrafish ovarian development, spermatogenesis, and tumorigenesis
    • Shive HR, West RR, Embree LJ, Azuma M, Sood R et al (2010) brca2 in zebrafish ovarian development, spermatogenesis, and tumorigenesis. Proc Natl Acad Sci U S A 107: 19350–19355
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 19350-19355
    • Shive, H.R.1    West, R.R.2    Embree, L.J.3    Azuma, M.4    Sood, R.5
  • 29
    • 84869993353 scopus 로고    scopus 로고
    • Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development
    • Shin J, Padmanabhan A, de Groh ED, Lee JS, Haidar S et al (2012) Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development. Dis Model Mech 5:881–894
    • (2012) Dis Model Mech , vol.5 , pp. 881-894
    • Shin, J.1    Padmanabhan, A.2    De Groh, E.D.3    Lee, J.S.4    Haidar, S.5
  • 31
    • 79953038262 scopus 로고    scopus 로고
    • PTEN loss in the continuum of common cancers, rare syndromes and mouse models
    • Hollander MC, Blumenthal GM, Dennis PA (2011) PTEN loss in the continuum of common cancers, rare syndromes and mouse models. Nat Rev Cancer 11:289–301
    • (2011) Nat Rev Cancer , vol.11 , pp. 289-301
    • Hollander, M.C.1    Blumenthal, G.M.2    Dennis, P.A.3
  • 32
    • 0031001041 scopus 로고    scopus 로고
    • TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta
    • Li DM, Sun H (1997) TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res 57:2124–2129
    • (1997) Cancer Res , vol.57 , pp. 2124-2129
    • Li, D.M.1    Sun, H.2
  • 33
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li J, Yen C, Liaw D, Podsypanina K, Bose S et al (1997) PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275:1943–1947
    • (1997) Science , vol.275 , pp. 1943-1947
    • Li, J.1    Yen, C.2    Liaw, D.3    Podsypanina, K.4    Bose, S.5
  • 34
    • 0033579163 scopus 로고    scopus 로고
    • Mutational spectra of PTEN/MMAC1 gene: A tumor suppressor with lipid phosphatase activity
    • Ali IU, Schriml LM, Dean M (1999) Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity. J Natl Cancer Inst 91:1922–1932
    • (1999) J Natl Cancer Inst , vol.91 , pp. 1922-1932
    • Ali, I.U.1    Schriml, L.M.2    Dean, M.3
  • 35
    • 0031203265 scopus 로고    scopus 로고
    • Germline mutations in PTEN are present in Bannayan-Zonana syndrome
    • Marsh DJ, Dahia PL, Zheng Z, Liaw D, Parsons R et al (1997) Germline mutations in PTEN are present in Bannayan-Zonana syndrome. Nat Genet 16:333–334
    • (1997) Nat Genet , vol.16 , pp. 333-334
    • Marsh, D.J.1    Dahia, P.L.2    Zheng, Z.3    Liaw, D.4    Parsons, R.5
  • 36
    • 0031004088 scopus 로고    scopus 로고
    • Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
    • Liaw D, Marsh DJ, Li J, Dahia PL, Wang SI et al (1997) Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet 16:64–67
    • (1997) Nat Genet , vol.16 , pp. 64-67
    • Liaw, D.1    Marsh, D.J.2    Li, J.3    Dahia, P.L.4    Wang, S.I.5
  • 37
    • 0041742215 scopus 로고    scopus 로고
    • Germline PTEN promoter mutations and deletions in Cowden/Bannayan-Riley-Ruvalcaba syndrome result in aberrant PTEN protein and dysregulation of the phosphoinositol-3-kinase/Akt pathway
    • Zhou XP, Waite KA, Pilarski R, Hampel H, Fernandez MJ et al (2003) Germline PTEN promoter mutations and deletions in Cowden/Bannayan-Riley-Ruvalcaba syndrome result in aberrant PTEN protein and dysregulation of the phosphoinositol-3-kinase/Akt pathway. Am J Hum Genet 73:404–411
    • (2003) Am J Hum Genet , vol.73 , pp. 404-411
    • Zhou, X.P.1    Waite, K.A.2    Pilarski, R.3    Hampel, H.4    Fernandez, M.J.5
  • 38
    • 0031870959 scopus 로고    scopus 로고
    • Pten is essential for embryonic development and tumour suppression
    • Di Cristofano A, Pesce B, Cordon-Cardo C, PandolfiPP (1998) Pten is essential for embryonic development and tumour suppression. Nat Genet 19:348–355
    • (1998) Nat Genet , vol.19 , pp. 348-355
    • Di Cristofano, A.1    Pesce, B.2    Cordon-Cardo, C.3    Pandolfi, P.P.4
  • 40
    • 13144249184 scopus 로고    scopus 로고
    • High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
    • Suzuki A, de la Pompa JL, Stambolic V, Elia AJ, Sasaki T et al (1998) High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol 8:1169–1178
    • (1998) Curr Biol , vol.8 , pp. 1169-1178
    • Suzuki, A.1    De La Pompa, J.L.2    Stambolic, V.3    Elia, A.J.4    Sasaki, T.5
  • 42
    • 77956236877 scopus 로고    scopus 로고
    • PI(3)king apart PTEN’s role in cancer
    • Zhang S, Yu D (2010) PI(3)king apart PTEN’s role in cancer. Clin Cancer Res 16:4325–4330
    • (2010) Clin Cancer Res , vol.16 , pp. 4325-4330
    • Zhang, S.1    Yu, D.2
  • 43
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
    • Maehama T, Dixon JE (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273:13375–13378
    • (1998) J Biol Chem , vol.273 , pp. 13375-13378
    • Maehama, T.1    Dixon, J.E.2
  • 45
    • 0032475861 scopus 로고    scopus 로고
    • Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
    • Stambolic V, Suzuki A, de la Pompa JL, Brothers GM, Mirtsos C et al (1998) Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95:29–39
    • (1998) Cell , vol.95 , pp. 29-39
    • Stambolic, V.1    Suzuki, A.2    De La Pompa, J.L.3    Brothers, G.M.4    Mirtsos, C.5
  • 46
    • 84860217431 scopus 로고    scopus 로고
    • The functions and regulation of the PTEN tumour suppressor
    • Song MS, Salmena L, PandolfiPP (2012) The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol 13:283–296
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 283-296
    • Song, M.S.1    Salmena, L.2    Pandolfi, P.P.3
  • 47
    • 28444492622 scopus 로고    scopus 로고
    • Ptena and ptenb genes play distinct roles in zebrafish embryogenesis
    • Croushore JA, Blasiole B, Riddle RC, Thisse C, Thisse B et al (2005) Ptena and ptenb genes play distinct roles in zebrafish embryogenesis. Dev Dyn 234:911–921
    • (2005) Dev Dyn , vol.234 , pp. 911-921
    • Croushore, J.A.1    Blasiole, B.2    Riddle, R.C.3    Thisse, C.4    Thisse, B.5
  • 48
    • 39149134579 scopus 로고    scopus 로고
    • Zebrafish pten genes have overlapping and non-redundant functions in tumorigenesis and embryonic development
    • Faucherre A, Taylor GS, Overvoorde J, Dixon JE, Hertog J (2008) Zebrafish pten genes have overlapping and non-redundant functions in tumorigenesis and embryonic development. Oncogene 27:1079–1086
    • (2008) Oncogene , vol.27 , pp. 1079-1086
    • Faucherre, A.1    Taylor, G.S.2    Overvoorde, J.3    Dixon, J.E.4    Hertog, J.5
  • 49
    • 84858060772 scopus 로고    scopus 로고
    • Haploinsufficiency of the genes encoding the tumor suppressor Pten predisposes zebrafish to hemangiosarcoma
    • Choorapoikayil S, Kuiper RV, de Bruin A, den Hertog J (2012) Haploinsufficiency of the genes encoding the tumor suppressor Pten predisposes zebrafish to hemangiosarcoma. Dis Model Mech 5:241–247
    • (2012) Dis Model Mech , vol.5 , pp. 241-247
    • Choorapoikayil, S.1    Kuiper, R.V.2    De Bruin, A.3    Den Hertog, J.4
  • 50
    • 79961133165 scopus 로고    scopus 로고
    • Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia
    • Gutierrez A, Grebliunaite R, Feng H, Kozakewich E, Zhu S et al (2011) Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia. J Exp Med 208:1595–1603
    • (2011) J Exp Med , vol.208 , pp. 1595-1603
    • Gutierrez, A.1    Grebliunaite, R.2    Feng, H.3    Kozakewich, E.4    Zhu, S.5
  • 51
  • 52
    • 84892629097 scopus 로고    scopus 로고
    • Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish
    • Choorapoikayil S, Kers R, Herbomel P, Kissa K, den Hertog J (2014) Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish. Blood 123:184–190
    • (2014) Blood , vol.123 , pp. 184-190
    • Choorapoikayil, S.1    Kers, R.2    Herbomel, P.3    Kissa, K.4    Den Hertog, J.5
  • 53
    • 84898036350 scopus 로고    scopus 로고
    • Pten regulates homeostasis and inflammation- induced migration of myelocytes in zebrafish
    • Dong ZW, Ren CG, Xia Y, Su D, Du TT et al (2014) Pten regulates homeostasis and inflammation- induced migration of myelocytes in zebrafish. J Hematol Oncol 7:17
    • (2014) J Hematol Oncol , vol.7 , pp. 17
    • Dong, Z.W.1    Ren, C.G.2    Xia, Y.3    Su, D.4    Du, T.T.5
  • 54
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler KW, Vogelstein B (1996) Lessons from hereditary colorectal cancer. Cell 87:159–170
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 55
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • Clevers H (2006) Wnt/beta-catenin signaling in development and disease. Cell 127:469–480
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 56
    • 0028567875 scopus 로고
    • A targeted chaintermination mutation in the mouse Apc gene results in multiple intestinal tumors
    • Fodde R, Edelmann W, Yang K, van Leeuwen C, Carlson C et al (1994) A targeted chaintermination mutation in the mouse Apc gene results in multiple intestinal tumors. Proc Natl Acad Sci U S A 91:8969–8973
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 8969-8973
    • Fodde, R.1    Edelmann, W.2    Yang, K.3    Van Leeuwen, C.4    Carlson, C.5
  • 58
    • 67549150437 scopus 로고    scopus 로고
    • Apc1 is required for maintenance of local brain organizers and dorsal midbrain survival
    • Paridaen JT, Danesin C, Elas AT, van de Water S, Houart C et al (2009) Apc1 is required for maintenance of local brain organizers and dorsal midbrain survival. Dev Biol 331:101–112
    • (2009) Dev Biol , vol.331 , pp. 101-112
    • Paridaen, J.T.1    Danesin, C.2    Elas, A.T.3    Van De Water, S.4    Houart, C.5
  • 59
    • 33645508586 scopus 로고    scopus 로고
    • Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia
    • Haramis AP, Hurlstone A, van der Velden Y, Begthel H, van den Born M et al (2006) Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia. EMBO Rep 7:444–449
    • (2006) EMBO Rep , vol.7 , pp. 444-449
    • Haramis, A.P.1    Hurlstone, A.2    Van Der Velden, Y.3    Begthel, H.4    Van Den Born, M.5
  • 60
    • 65549159598 scopus 로고    scopus 로고
    • A two-step model for colon adenoma initiation and progression caused by APC loss
    • Phelps RA, Chidester S, Dehghanizadeh S, Phelps J, Sandoval IT et al (2009) A two-step model for colon adenoma initiation and progression caused by APC loss. Cell 137:623–634
    • (2009) Cell , vol.137 , pp. 623-634
    • Phelps, R.A.1    Chidester, S.2    Dehghanizadeh, S.3    Phelps, J.4    Sandoval, I.T.5
  • 61
    • 84892429398 scopus 로고    scopus 로고
    • Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish
    • Valvezan AJ, Huang J, Lengner CJ, Pack M, Klein PS (2014) Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish. Dis Model Mech 7:63–71
    • (2014) Dis Model Mech , vol.7 , pp. 63-71
    • Valvezan, A.J.1    Huang, J.2    Lengner, C.J.3    Pack, M.4    Klein, P.S.5
  • 62
    • 33746427905 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor protein: Roles in cancer and oxygen sensing
    • Kaelin WG (2005) The von Hippel-Lindau tumor suppressor protein: roles in cancer and oxygen sensing. Cold Spring Harb Symp Quant Biol 70:159–166
    • (2005) Cold Spring Harb Symp Quant Biol , vol.70 , pp. 159-166
    • Kaelin, W.G.1
  • 63
    • 24344452947 scopus 로고    scopus 로고
    • The VHL tumor suppressor in development and disease: Functional studies in mice by conditional gene targeting
    • Haase VH (2005) The VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targeting. Semin Cell Dev Biol 16:564–574
    • (2005) Semin Cell Dev Biol , vol.16 , pp. 564-574
    • Haase, V.H.1
  • 64
    • 67650634987 scopus 로고    scopus 로고
    • Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia
    • van Rooijen E, Voest EE, Logister I, Korving J, Schwerte T et al (2009) Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia. Blood 113:6449–6460
    • (2009) Blood , vol.113 , pp. 6449-6460
    • Van Rooijen, E.1    Voest, E.E.2    Logister, I.3    Korving, J.4    Schwerte, T.5
  • 65
    • 77952183381 scopus 로고    scopus 로고
    • Von Hippel-Lindau tumor suppressor mutants faithfully model pathological hypoxia-driven angiogenesis and vascular retinopathies in zebrafish
    • van Rooijen E, Voest EE, Logister I, Bussmann J, Korving J et al (2010) von Hippel-Lindau tumor suppressor mutants faithfully model pathological hypoxia-driven angiogenesis and vascular retinopathies in zebrafish. Dis Model Mech 3:343–353
    • (2010) Dis Model Mech , vol.3 , pp. 343-353
    • Van Rooijen, E.1    Voest, E.E.2    Logister, I.3    Bussmann, J.4    Korving, J.5
  • 66
    • 84865137450 scopus 로고    scopus 로고
    • A zebrafish model to study and therapeutically manipulate hypoxia signaling in tumorigenesis
    • Santhakumar K, Judson EC, Elks PM, McKee S, Elworthy S et al (2012) A zebrafish model to study and therapeutically manipulate hypoxia signaling in tumorigenesis. Cancer Res 72:4017–4027
    • (2012) Cancer Res , vol.72 , pp. 4017-4027
    • Santhakumar, K.1    Judson, E.C.2    Elks, P.M.3    McKee, S.4    Elworthy, S.5
  • 69
    • 84915804410 scopus 로고    scopus 로고
    • The tumor suppressor rpl36 restrains KRAS(G12V)-induced pancreatic cancer
    • Provost E, Bailey JM, Aldrugh S, Liu S, Iacobuzio-Donahue C et al (2014) The tumor suppressor rpl36 restrains KRAS(G12V)-induced pancreatic cancer. Zebrafish 11:551–559
    • (2014) Zebrafish , vol.11 , pp. 551-559
    • Provost, E.1    Bailey, J.M.2    Aldrugh, S.3    Liu, S.4    Iacobuzio-Donahue, C.5
  • 70
    • 84856966440 scopus 로고    scopus 로고
    • Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation
    • Taylor AM, Humphries JM, White RM, Murphey RD, Burns CE et al (2012) Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation. Exp Hematol 40:228–237.e5
    • (2012) Exp Hematol , vol.40 , pp. 228-237
    • Taylor, A.M.1    Humphries, J.M.2    White, R.M.3    Murphey, R.D.4    Burns, C.E.5
  • 72
    • 84961291997 scopus 로고    scopus 로고
    • A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing
    • Gjini E, Mansour MR, Sander JD, Moritz N, Nguyen AT et al (2015) A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing. Mol Cell Biol 35:789–804
    • (2015) Mol Cell Biol , vol.35 , pp. 789-804
    • Gjini, E.1    Mansour, M.R.2    Sander, J.D.3    Moritz, N.4    Nguyen, A.T.5
  • 73
    • 73649126176 scopus 로고    scopus 로고
    • Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermis
    • Reischauer S, Levesque MP, Nusslein-Volhard C, Sonawane M (2009) Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermis. PLoS Genet 5, e1000720
    • (2009) Plos Genet , vol.5
    • Reischauer, S.1    Levesque, M.P.2    Nusslein-Volhard, C.3    Sonawane, M.4
  • 74
    • 84870660793 scopus 로고    scopus 로고
    • The tumor suppressor gene retinoblastoma- 1 is required for retinotectal development and visual function in zebrafish
    • Gyda M, Wolman M, Lorent K, Granato M (2012) The tumor suppressor gene retinoblastoma- 1 is required for retinotectal development and visual function in zebrafish. PLoS Genet 8, e1003106
    • (2012) Plos Genet , vol.8
    • Gyda, M.1    Wolman, M.2    Lorent, K.3    Granato, M.4
  • 77
    • 84877949521 scopus 로고    scopus 로고
    • The histone methyltransferase SUV39H1 suppresses embryonal rhabdomyosarcoma formation in zebrafish
    • Albacker CE, Storer NY, Langdon EM, Dibiase A, Zhou Y et al (2013) The histone methyltransferase SUV39H1 suppresses embryonal rhabdomyosarcoma formation in zebrafish. PLoS One 8, e64969
    • (2013) Plos One , vol.8
    • Albacker, C.E.1    Storer, N.Y.2    Langdon, E.M.3    Dibiase, A.4    Zhou, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.