Transporter-Enzyme Interplay: Deconvoluting Effects of Hepatic Transporters and Enzymes on Drug Disposition Using Static and Dynamic Mechanistic Models

Journal of Clinical Pharmacology

Volumn , Issue , 2016, Pages S99-S109

  Varma, Manthena V ^a   El Kattan, Ayman F ^a  

^a PFIZER INC   (United States)

Author keywords

cytochrome P 450; drug transporters; drug drug interactions; extended clearance classification system; organic anion transporting polypeptides; physiologically based pharmacokinetic model; transporter enzyme interplay

Indexed keywords

CARRIER PROTEIN; ENZYME; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B1;

ARTICLE; DRUG CLEARANCE; DRUG DISPOSITION; DRUG UPTAKE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HEPATIC CLEARANCE; HUMAN; PHARMACODYNAMICS; PREDICTION; PROTEIN DENATURATION;

EID: 84979010312     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1002/jcph.695     Document Type: Article

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