메뉴 건너뛰기




Volumn 3, Issue 12, 2014, Pages

Toward prospective prediction of pharmacokinetics in OATP1B1 genetic variant populations

Author keywords

[No Author keywords available]

Indexed keywords

PRAVASTATIN; ROSUVASTATIN; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B1;

EID: 84927701275     PISSN: None     EISSN: 21638306     Source Type: Journal    
DOI: 10.1038/psp.2014.50     Document Type: Article
Times cited : (15)

References (39)
  • 1
    • 77649216536 scopus 로고    scopus 로고
    • The International Transporter Consortium. Membrane transporters in drug development
    • The International Transporter Consortium. Membrane transporters in drug development. Nat. Rev. Drug Discov. 9, 215-36 (2010).
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 215-236
  • 2
    • 70350048926 scopus 로고    scopus 로고
    • Impact of OATP transporters on pharmacokinetics
    • Kalliokoski, A. & Niemi, M. Impact of OATP transporters on pharmacokinetics. Br. J. Pharmacol. 158, 693-705 (2009).
    • (2009) Br. J. Pharmacol. , vol.158 , pp. 693-705
    • Kalliokoski, A.1    Niemi, M.2
  • 3
    • 79953901458 scopus 로고    scopus 로고
    • Organic anion transporting polypeptide 1B1: A genetically polymorphic transporter of major importance for hepatic drug uptake
    • Niemi, M., Pasanen, M.K. & Neuvonen, P.J. Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol. Rev. 63, 157-181 (2011).
    • (2011) Pharmacol. Rev. , vol.63 , pp. 157-181
    • Niemi, M.1    Pasanen, M.K.2    Neuvonen, P.J.3
  • 4
    • 79960148136 scopus 로고    scopus 로고
    • Impact of SLCO1B1 (OATP1B1) and ABCG2 (BCRP) genetic polymorphisms and inhibition on LDL-C lowering and myopathy of statins
    • Generaux, G.T., Bonomo, F.M., Johnson, M. & Doan, K.M. Impact of SLCO1B1 (OATP1B1) and ABCG2 (BCRP) genetic polymorphisms and inhibition on LDL-C lowering and myopathy of statins. Xenobiotica. 41, 639-651 (2011).
    • (2011) Xenobiotica. , vol.41 , pp. 639-651
    • Generaux, G.T.1    Bonomo, F.M.2    Johnson, M.3    Doan, K.M.4
  • 5
    • 84872149285 scopus 로고    scopus 로고
    • Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1
    • Nies, A.T. et al. Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1. Genome Med. 5, 1 (2013).
    • (2013) Genome Med. , vol.5 , pp. 1
    • Nies, A.T.1
  • 6
    • 0025355830 scopus 로고
    • Disposition of pravastatin sodium, a tissue-selective HMG-CoA reductase inhibitor, in healthy subjects
    • Singhvi, S.M., Pan, H.Y., Morrison, R.A. & Willard, D.A. Disposition of pravastatin sodium, a tissue-selective HMG-CoA reductase inhibitor, in healthy subjects. Br. J. Clin. Pharmacol. 29, 239-243 (1990).
    • (1990) Br. J. Clin. Pharmacol. , vol.29 , pp. 239-243
    • Singhvi, S.M.1    Pan, H.Y.2    Morrison, R.A.3    Willard, D.A.4
  • 7
    • 0344664550 scopus 로고    scopus 로고
    • Metabolism, excretion, and pharmacokinetics of rosuvastatin in healthy adult male volunteers
    • Martin, P.D. et al. Metabolism, excretion, and pharmacokinetics of rosuvastatin in healthy adult male volunteers. Clin. Ther. 25, 2822-2835 (2003).
    • (2003) Clin. Ther. , vol.25 , pp. 2822-2835
    • Martin, P.D.1
  • 8
    • 22544454498 scopus 로고    scopus 로고
    • Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1∗5, SLCO1B1∗15 and SLCO1B1∗15+C1007G, by using transient expression systems of HeLa and HEK293 cells
    • Kameyama, Y., Yamashita, K., Kobayashi, K., Hosokawa, M. & Chiba, K. Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1∗5, SLCO1B1∗15 and SLCO1B1∗15+C1007G, by using transient expression systems of HeLa and HEK293 cells. Pharmacogenet. Genomics 15, 513-522 (2005).
    • (2005) Pharmacogenet. Genomics , vol.15 , pp. 513-522
    • Kameyama, Y.1    Yamashita, K.2    Kobayashi, K.3    Hosokawa, M.4    Chiba, K.5
  • 9
    • 84879388463 scopus 로고    scopus 로고
    • Ethnic variability in the plasma exposures of OATP1B1 substrates such as HMG-CoA reductase inhibitors: A kinetic consideration of its mechanism
    • Tomita, Y., Maeda, K. & Sugiyama, Y. Ethnic variability in the plasma exposures of OATP1B1 substrates such as HMG-CoA reductase inhibitors: a kinetic consideration of its mechanism. Clin. Pharmacol. Ther. 94, 37-51 (2013).
    • (2013) Clin. Pharmacol. Ther. , vol.94 , pp. 37-51
    • Tomita, Y.1    Maeda, K.2    Sugiyama, Y.3
  • 10
    • 59649130318 scopus 로고    scopus 로고
    • Physiologically based pharmacokinetic modeling to predict transporter-mediated clearance and distribution of pravastatin in humans
    • Watanabe, T., Kusuhara, H., Maeda, K., Shitara, Y. & Sugiyama, Y. Physiologically based pharmacokinetic modeling to predict transporter-mediated clearance and distribution of pravastatin in humans. J. Pharmacol. Exp. Ther. 328, 652-662 (2009).
    • (2009) J. Pharmacol. Exp. Ther. , vol.328 , pp. 652-662
    • Watanabe, T.1    Kusuhara, H.2    Maeda, K.3    Shitara, Y.4    Sugiyama, Y.5
  • 11
    • 84859910816 scopus 로고    scopus 로고
    • Mechanistic pharmacokinetic modeling for the prediction of transportermediated disposition in humans from sandwich culture human hepatocyte data
    • Jones, H.M. et al. Mechanistic pharmacokinetic modeling for the prediction of transportermediated disposition in humans from sandwich culture human hepatocyte data. Drug Metab. Dispos. 40, 1007-1017 (2012).
    • (2012) Drug Metab. Dispos. , vol.40 , pp. 1007-1017
    • Jones, H.M.1
  • 12
    • 84904201004 scopus 로고    scopus 로고
    • A "middle-out" approach to human pharmacokinetic predictions for OATP substrates using physiologically-based pharmacokinetic modeling
    • Li, R. et al. A "middle-out" approach to human pharmacokinetic predictions for OATP substrates using physiologically-based pharmacokinetic modeling. J. Pharmacokinet. Pharmacodyn. 41, 197-209 (2014).
    • (2014) J. Pharmacokinet. Pharmacodyn. , vol.41 , pp. 197-209
    • Li, R.1
  • 13
    • 0038209381 scopus 로고    scopus 로고
    • Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics
    • Nishizato, Y. et al. Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics. Clin. Pharmacol. Ther. 73, 554-565 (2003).
    • (2003) Clin. Pharmacol. Ther. , vol.73 , pp. 554-565
    • Nishizato, Y.1
  • 14
    • 33646205286 scopus 로고    scopus 로고
    • Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril
    • Maeda, K. et al. Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril. Clin. Pharmacol. Ther. 79, 427-439 (2006).
    • (2006) Clin. Pharmacol. Ther. , vol.79 , pp. 427-439
    • Maeda, K.1
  • 15
    • 34447335619 scopus 로고    scopus 로고
    • Effect of drug transporter genotypes on pravastatin disposition in European- and African-American participants
    • Ho, R.H. et al. Effect of drug transporter genotypes on pravastatin disposition in European- and African-American participants. Pharmacogenet. Genomics 17, 647-656 (2007).
    • (2007) Pharmacogenet. Genomics , vol.17 , pp. 647-656
    • Ho, R.H.1
  • 16
    • 3242808852 scopus 로고    scopus 로고
    • High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)
    • Niemi, M. et al. High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1). Pharmacogenetics 14, 429-440 (2004).
    • (2004) Pharmacogenetics , vol.14 , pp. 429-440
    • Niemi, M.1
  • 17
    • 33749049136 scopus 로고    scopus 로고
    • SLCO1B1 polymorphism and sex affect the pharmacokinetics of pravastatin but not fluvastatin
    • Niemi, M., Pasanen, M.K. & Neuvonen, P.J. SLCO1B1 polymorphism and sex affect the pharmacokinetics of pravastatin but not fluvastatin. Clin. Pharmacol. Ther. 80, 356-366 (2006).
    • (2006) Clin. Pharmacol. Ther. , vol.80 , pp. 356-366
    • Niemi, M.1    Pasanen, M.K.2    Neuvonen, P.J.3
  • 18
    • 36148953896 scopus 로고    scopus 로고
    • Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin
    • Pasanen, M.K., Fredrikson, H., Neuvonen, P.J. & Niemi, M. Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin. Clin. Pharmacol. Ther. 82, 726-733 (2007).
    • (2007) Clin. Pharmacol. Ther. , vol.82 , pp. 726-733
    • Pasanen, M.K.1    Fredrikson, H.2    Neuvonen, P.J.3    Niemi, M.4
  • 19
    • 84879168884 scopus 로고    scopus 로고
    • OATP1B1-related drug-drug and drug-gene interactions as potential risk factors for cerivastatin-induced rhabdomyolysis
    • Tamraz, B. et al. OATP1B1-related drug-drug and drug-gene interactions as potential risk factors for cerivastatin-induced rhabdomyolysis. Pharmacogenet. Genomics 23, 355-364 (2013).
    • (2013) Pharmacogenet. Genomics , vol.23 , pp. 355-364
    • Tamraz, B.1
  • 20
    • 2042469487 scopus 로고    scopus 로고
    • Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics
    • Mwinyi, J., Johne, A., Bauer, S., Roots, I. & Gerloff, T. Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics. Clin. Pharmacol. Ther. 75, 415-421 (2004).
    • (2004) Clin. Pharmacol. Ther. , vol.75 , pp. 415-421
    • Mwinyi, J.1    Johne, A.2    Bauer, S.3    Roots, I.4    Gerloff, T.5
  • 21
    • 38549159477 scopus 로고    scopus 로고
    • Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans
    • Choi, J.H., Lee, M.G., Cho, J.Y., Lee, J.E., Kim, K.H. & Park, K. Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans. Clin. Pharmacol. Ther. 83, 251-257 (2008).
    • (2008) Clin. Pharmacol. Ther. , vol.83 , pp. 251-257
    • Choi, J.H.1    Lee, M.G.2    Cho, J.Y.3    Lee, J.E.4    Kim, K.H.5    Park, K.6
  • 22
    • 25844458977 scopus 로고    scopus 로고
    • Rosuvastatin pharmacokinetics and pharmacogenetics in white and Asian subjects residing in the same environment
    • Lee, E. et al. Rosuvastatin pharmacokinetics and pharmacogenetics in white and Asian subjects residing in the same environment. Clin. Pharmacol. Ther. 78, 330-341 (2005).
    • (2005) Clin. Pharmacol. Ther. , vol.78 , pp. 330-341
    • Lee, E.1
  • 23
    • 84872229531 scopus 로고    scopus 로고
    • Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: Their roles in hepatic clearance and intestinal absorption
    • Shitara, Y., Maeda, K., Ikejiri, K., Yoshida, K., Horie, T. & Sugiyama, Y. Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption. Biopharm. Drug Dispos. 34, 45-78 (2013).
    • (2013) Biopharm. Drug Dispos. , vol.34 , pp. 45-78
    • Shitara, Y.1    Maeda, K.2    Ikejiri, K.3    Yoshida, K.4    Horie, T.5    Sugiyama, Y.6
  • 24
    • 84867873811 scopus 로고    scopus 로고
    • Understanding the critical disposition pathways of statins to assess drug-drug interaction risk during drug development: It's not just about OATP1B1
    • Elsby, R., Hilgendorf, C. & Fenner, K. Understanding the critical disposition pathways of statins to assess drug-drug interaction risk during drug development: it's not just about OATP1B1. Clin. Pharmacol. Ther. 92, 584-598 (2012).
    • (2012) Clin. Pharmacol. Ther. , vol.92 , pp. 584-598
    • Elsby, R.1    Hilgendorf, C.2    Fenner, K.3
  • 25
    • 34547178337 scopus 로고    scopus 로고
    • Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3
    • Noé, J., Portmann, R., Brun, M.E. & Funk, C. Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3. Drug Metab. Dispos. 35, 1308-1314 (2007).
    • (2007) Drug Metab. Dispos. , vol.35 , pp. 1308-1314
    • Noé, J.1    Portmann, R.2    Brun, M.E.3    Funk, C.4
  • 26
    • 78650183300 scopus 로고    scopus 로고
    • Differential effect of genetic variants of Na(+)-taurocholate co-transporting polypeptide (NTCP) and organic anion-transporting polypeptide 1B1 (OATP1B1) on the uptake of HMG-CoA reductase inhibitors
    • Choi, M.K., Shin, H.J., Choi, Y.L., Deng, J.W., Shin, J.G. & Song, I.S. Differential effect of genetic variants of Na(+)-taurocholate co-transporting polypeptide (NTCP) and organic anion-transporting polypeptide 1B1 (OATP1B1) on the uptake of HMG-CoA reductase inhibitors. Xenobiotica. 41, 24-34 (2011).
    • (2011) Xenobiotica. , vol.41 , pp. 24-34
    • Choi, M.K.1    Shin, H.J.2    Choi, Y.L.3    Deng, J.W.4    Shin, J.G.5    Song, I.S.6
  • 27
    • 42149127614 scopus 로고    scopus 로고
    • The effect of SLCO1B1∗15 on the disposition of pravastatin and pitavastatin is substrate dependent: The contribution of transporting activity changes by SLCO1B1∗15
    • Deng, J.W. et al. The effect of SLCO1B1∗ 15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1∗15. Pharmacogenet. Genomics 18, 424-433 (2008).
    • (2008) Pharmacogenet. Genomics , vol.18 , pp. 424-433
    • Deng, J.W.1
  • 28
    • 0030953045 scopus 로고    scopus 로고
    • Pharmacodynamics and pharmacokinetics of the HMGCoA reductase inhibitors. Similarities and differences
    • Lennernäs, H. & Fager, G. Pharmacodynamics and pharmacokinetics of the HMGCoA reductase inhibitors. Similarities and differences. Clin. Pharmacokinet. 32, 403-425 (1997).
    • (1997) Clin. Pharmacokinet. , vol.32 , pp. 403-425
    • Lennernäs, H.1    Fager, G.2
  • 29
    • 84905370710 scopus 로고    scopus 로고
    • Application of a Physiologically Based Pharmacokinetic Model to Predict OATP1B1- Related Variability in Pharmacodynamics of Rosuvastatin
    • Rose, R.H., Neuhoff, S., Abduljalil, K., Chetty, M., Rostami-Hodjegan, A. & Jamei, M. Application of a Physiologically Based Pharmacokinetic Model to Predict OATP1B1- Related Variability in Pharmacodynamics of Rosuvastatin. CPT. Pharmacometrics Syst. Pharmacol. 3, e124 (2014).
    • (2014) CPT. Pharmacometrics Syst. Pharmacol. , vol.3 , pp. e124
    • Rose, R.H.1    Neuhoff, S.2    Abduljalil, K.3    Chetty, M.4    Rostami-Hodjegan, A.5    Jamei, M.6
  • 30
    • 70349088094 scopus 로고    scopus 로고
    • Liver toxicity: The Achilles' heel of endothelin receptor antagonist therapy?
    • Hoeper, M.M. Liver toxicity: the Achilles' heel of endothelin receptor antagonist therapy? Eur. Respir. J. 34, 529-530 (2009).
    • (2009) Eur. Respir. J. , vol.34 , pp. 529-530
    • Hoeper, M.M.1
  • 31
    • 84875160515 scopus 로고    scopus 로고
    • Model-based approaches to predict drug-drug interactions associated with hepatic uptake transporters: Preclinical, clinical and beyond
    • Barton, H.A. et al. Model-based approaches to predict drug-drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond. Expert Opin. Drug Metab. Toxicol. 9, 459-472 (2013).
    • (2013) Expert Opin. Drug Metab. Toxicol. , vol.9 , pp. 459-472
    • Barton, H.A.1
  • 32
    • 0028294020 scopus 로고
    • Quantitative analysis of intrahepatic bile duct component in normal adult human liver and in primary biliary cirrhosis
    • Casali, A.M., Siringo, S., Sofia, S., Bolondi, L., Di Febo, G. & Cavalli, G. Quantitative analysis of intrahepatic bile duct component in normal adult human liver and in primary biliary cirrhosis. Pathol. Res. Pract. 190, 201-206 (1994).
    • (1994) Pathol. Res. Pract. , vol.190 , pp. 201-206
    • Casali, A.M.1    Siringo, S.2    Sofia, S.3    Bolondi, L.4    Di Febo, G.5    Cavalli, G.6
  • 33
    • 0027275566 scopus 로고
    • Physiological parameters in laboratory animals and humans
    • Davies, B. & Morris, T. Physiological parameters in laboratory animals and humans. Pharm. Res. 10, 1093-1095 (1993).
    • (1993) Pharm. Res. , vol.10 , pp. 1093-1095
    • Davies, B.1    Morris, T.2
  • 35
    • 77249122159 scopus 로고    scopus 로고
    • Physicochemical space for optimum oral bioavailability: Contribution of human intestinal absorption and first-pass elimination
    • Varma, M.V. et al. Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. J. Med. Chem. 53, 1098-1108 (2010).
    • (2010) J. Med. Chem. , vol.53 , pp. 1098-1108
    • Varma, M.V.1
  • 36
    • 33646536542 scopus 로고    scopus 로고
    • Drug and bile acid transporters in rosuvastatin hepatic uptake: Function, expression, and pharmacogenetics
    • Ho, R.H. et al. Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Gastroenterology 130, 1793-1806 (2006).
    • (2006) Gastroenterology , vol.130 , pp. 1793-1806
    • Ho, R.H.1
  • 37
    • 52949104006 scopus 로고    scopus 로고
    • Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin
    • Kitamura, S., Maeda, K., Wang, Y. & Sugiyama, Y. Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin. Drug Metab. Dispos. 36, 2014-2023 (2008).
    • (2008) Drug Metab. Dispos. , vol.36 , pp. 2014-2023
    • Kitamura, S.1    Maeda, K.2    Wang, Y.3    Sugiyama, Y.4
  • 38
    • 40949126593 scopus 로고    scopus 로고
    • Global analysis of genetic variation in SLCO1B1
    • Pasanen, M.K., Neuvonen, P.J. & Niemi, M. Global analysis of genetic variation in SLCO1B1. Pharmacogenomics 9, 19-33 (2008).
    • (2008) Pharmacogenomics , vol.9 , pp. 19-33
    • Pasanen, M.K.1    Neuvonen, P.J.2    Niemi, M.3
  • 39
    • 84888592045 scopus 로고    scopus 로고
    • Differences in cytochrome p450-mediated pharmacokinetics between chinese and caucasian populations predicted by mechanistic physiologically based pharmacokinetic modelling
    • Barter, Z.E., Tucker, G.T. & Rowland-Yeo, K. Differences in cytochrome p450-mediated pharmacokinetics between chinese and caucasian populations predicted by mechanistic physiologically based pharmacokinetic modelling. Clin. Pharmacokinet. 52, 1085-1100 (2013).
    • (2013) Clin. Pharmacokinet. , vol.52 , pp. 1085-1100
    • Barter, Z.E.1    Tucker, G.T.2    Rowland-Yeo, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.