Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics

Journal of Physiology

Volumn 594, Issue 14, 2016, Pages 3911-3954

  Shivkumar, Kalyanam ^a   Ajijola, Olujimi A ^a   Anand, Inder ^b   Armour, J Andrew ^a   Chen, Peng Sheng ^c   Esler, Murray ^d   De Ferrari, Gaetano M ^e   Fishbein, Michael C ^f   Goldberger, Jeffrey J ^g   Harper, Ronald M ^f   Joyner, Michael J ^h   Khalsa, Sahib S ⁱ   Kumar, Rajesh ^f   Lane, Richard ^j   Mahajan, Aman ^k   Po, Sunny ^l,m   Schwartz, Peter J ⁿ   Somers, Virend K ^h   Valderrabano, Miguel ^o   Vaseghi, Marmar ^a   Zipes, Douglas P ^p   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^e UNIVERSITY OF PAVIA   (Italy)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^h MAYO CLINIC   (United States)

ⁱ LAUREATE INSTITUTE FOR BRAIN RESEARCH   (United States)

^j UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^k UNIVERSITY OF CALIFORNIA   (United States)

^l UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^m UNIVERSITY OF TULSA   (United States)

ⁿ ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^o HOUSTON METHODIST HOSPITAL   (United States)

^p INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC TRANSMISSION; AEROBIC EXERCISE; ARTICLE; ATRIAL FIBRILLATION; CARDIAC RESYNCHRONIZATION THERAPY; CARDIOPULMONARY FUNCTION; CARDIOVASCULAR RISK; CHOLINERGIC TRANSMISSION; FUNCTIONAL ANATOMY; HEART CONDUCTION; HEART DENERVATION; HEART FAILURE; HEART FUNCTION; HOLISTIC CARE; HUMAN; INTEROCEPTION; ISCHEMIC HEART DISEASE; KIDNEY DENERVATION; MEDITATION; MOTONEURON; NERVE CELL NETWORK; NERVE STIMULATION; NEUROANATOMY; NEUROMODULATION; NEUROSCIENCE; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RISK ASSESSMENT; SINUS RHYTHM; SLEEP DISORDERED BREATHING; SPINAL CORD STIMULATION; STELLATE GANGLION BLOCK; THORAX EPIDURAL ANESTHESIA; VAGUS NERVE STIMULATION;

EID: 84978881159     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/JP271870     Document Type: Article

References (438)

1. Ádám G (1998). Visceral Perception: Understanding Internal Cognition. Plenum Press, New York.
2. Ai J, Wurster RD, Harden SW & Cheng ZJ (2009). Vagal afferent innervation and remodeling in the aortic arch of young-adult fischer 344 rats following chronic intermittent hypoxia. Neuroscience 164, 658–666.
3. Ajijola OA, Lellouche N, Bourke T, Tung R, Ahn S, Mahajan A & Shivkumar K (2012a). Bilateral cardiac sympathetic denervation for the management of electrical storm. J Am Coll Cardiol 59, 91–92.
4. Ajijola OA, Wisco JJ, Lambert HW, Mahajan A, Stark E, Fishbein MC & Shivkumar K (2012b). Extracardiac neural remodeling in humans with cardiomyopathy. Circ Arrhythm Electrophysiol 5, 1010–1116.
5. Ajijola OA, Yagishita D, Reddy NK, Yamakawa K, Vaseghi M, Downs AM, Hoover DB, Ardell JL & Shivkumar K (2015). Remodeling of stellate ganglion neurons after spatially targeted myocardial infarction: Neuropeptide and morphologic changes. Heart Rhythm 12, 1027–1035.
6. Albert CM, Chae CU, Grodstein F, Rose LM, Rexrode KM, Ruskin JN, Stampfer MJ & Manson JE (2003). Prospective study of sudden cardiac death among women in the United States. Circulation 107, 2096–2101.
7. Albert CM, Mittleman MA, Chae CU, Lee IM, Hennekens CH & Manson JE (2000). Triggering of sudden death from cardiac causes by vigorous exertion. N Engl J Med 343, 1355–1361.
8. Allessie MA, Bonke FI & Schopman FJ (1977). Circus movement in rabbit atrial muscle as a mechanism of tachycardia. III. The “leading circle” concept: a new model of circus movement in cardiac tissue without the involvement of an anatomical obstacle. Circ Res 41, 9–18.
9. Allessie MA, Lammers WJ, Bonke IM & Hollen J (1984). Intra-atrial reentry as a mechanism for atrial flutter induced by acetylcholine and rapid pacing in the dog. Circulation 70, 123–135.
10. Allessie MA, Lammers WJEP, Bonke FIM & Hollen J (1985). Experimental evaluation of Moe's multiple wavelet hypothesis of atrial fibrillation. In Cardiac Electrophysiology and Arrhythmias, ed. Zipes DP & Jalife J, pp. 265–275. Grune and Straton, Inc., Orlando.
11. Andersen K, Farahmand B, Ahlbom A, Held C, Ljunghall S, Michaelsson K & Sundstrom J (2013). Risk of arrhythmias in 52 755 long-distance cross-country skiers: a cohort study. Eur Heart J 34, 3624–3631.
12. Antiel RM, Bos JM, Joyce DD, Owen HJ, Roskos PL, Moir C & Ackerman MJ (2015). Quality of life after videoscopic left cardiac sympathetic denervation in patients with potentially life-threatening cardiac channelopathies/cardiomyopathies. Heart Rhythm 13, 62–69.
13. Arch JJ, Brown KW, Dean DJ, Landy LN, Brown KD & Laudenslager ML (2014). Self-compassion training modulates alpha-amylase, heart rate variability, and subjective responses to social evaluative threat in women. Psychoneuroendocrinology 42, 49–58.
14. Ardell JL, Butler CK, Smith FM, Hopkins DA & Armour JA (1991). Activity of in vivo atrial and ventricular neurons in chronically decentralized canine hearts. Am J Physiol 260, H713–H721.
15. Ardell JL, Rajendran PS, Nier HA, KenKnight BH & Armour JA (2015). Central-peripheral neural network interactions evoked by vagus nerve stimulation: functional consequences on control of cardiac function. Am J Physiol Heart Circ Physiol 309, H1740–H1752.
16. Armour JA (1985). Activity of in situ middle cervical ganglion neurons in dogs, using extracellular recording techniques. Can J Physiol Pharmacol 63, 704–716.
17. Armour JA (2004). Cardiac neuronal hierarchy in health and disease. Am J Physiol Regul Integr Comp Physiol 287, R262–R271.
18. Armour JA (2008). Potential clinical relevance of the ‘little brain’ on the mammalian heart. Exp Physiol 93, 165–176.
19. Armour JA & Ardell JL (2004). Basic and Clinical Neurocardiology. Oxford University Press, New York.
20. Armour JA, Huang MH, Pelleg A & Sylven C (1994). Responsiveness of in situ canine nodose ganglion afferent neurones to epicardial mechanical or chemical stimuli. Cardiovasc Res 28, 1218–1225.
21. Armour JA, Murphy DA, Yuan BX, Macdonald S & Hopkins DA (1997). Gross and microscopic anatomy of the human intrinsic cardiac nervous system. Anat Rec 247, 289–298.
22. Arora R, Ng J, Ulphani J, Mylonas I, Subacius H, Shade G, Gordon D, Morris A, He X, Lu Y, Belin R, Goldberger JJ & Kadish AH (2007). Unique autonomic profile of the pulmonary veins and posterior left atrium. J Am Coll Cardiol 49, 1340–1348.
23. Arora RC, Ardell JL & Armour JA (2000). Cardiac denervation and cardiac function. Curr Interv Cardiol Rep 2, 188–195.
24. AVID Investigators (1997). A comparison of antiarrhythmic-drug therapy with implantable defibrillators in patients resuscitated from near-fatal ventricular arrhythmias. The Antiarrhythmics versus Implantable Defibrillators (AVID) Investigators. N Engl J Med 337, 1576–1583.
25. Baez-Escudero JL, Keida T, Dave AS, Okishige K & Valderrabano M (2014). Ethanol infusion in the vein of Marshall leads to parasympathetic denervation of the human left atrium: implications for atrial fibrillation. J Am Coll Cardiol 63, 1892–1901.
26. Barajas L (1964). The innervation of the juxtaglomerular apparatus. An electron microscopic study of the innervation of the glomerular arterioles. Lab Invest 13, 916–929.
27. Barajas L & Muller J (1973). The innervation of the juxtaglomerular apparatus and surrounding tubules: a quantitative analysis by serial section electron microscopy. J Ultrastruct Res 43, 107–132.
28. Barnes PM, Powell-Griner E, McFann K & Nahin RL (2004). Complementary and alternative medicine use among adults: United States, 2002. Adv Data 343, 1–19.
29. Barrett LF & Simmons WK (2015). Interoceptive predictions in the brain. Nat Rev Neurosci 16, 419–429.
30. Barsky AJ, Ahern DK, Brener J, Surman OS, Ring C & Dec GW (1998). Palpitations and cardiac awareness after heart transplantation. Psychosom Med 60, 557–562.
31. Barsky AJ, Cleary PD, Brener J & Ruskin JN (1993). The perception of cardiac activity in medical outpatients. Cardiology 83, 304–315.
32. Bauer A, Barthel P, Schneider R, Ulm K, Muller A, Joeinig A, Stich R, Kiviniemi A, Hnatkova K, Huikuri H, Schomig A, Malik M & Schmidt G (2009). Improved Stratification of Autonomic Regulation for risk prediction in post-infarction patients with preserved left ventricular function (ISAR-Risk). Eur Heart J 30, 576–583.
33. Bauer A, Kantelhardt JW, Barthel P, Schneider R, Makikallio T, Ulm K, Hnatkova K, Schomig A, Huikuri H, Bunde A, Malik M & Schmidt G (2006). Deceleration capacity of heart rate as a predictor of mortality after myocardial infarction: cohort study. Lancet 367, 1674–1681.
34. Beaumont E, Salavatian S, Southerland EM, Vinet A, Jacquemet V, Armour JA & Ardell JL (2013). Network interactions within the canine intrinsic cardiac nervous system: implications for reflex control of regional cardiac function. J Physiol 591, 4515–4533.
35. Beaumont E, Southerland EM, Hardwick JC, Wright GL, Ryan S, Li Y, KenKnight BH, Armour JA & Ardell JL (2015). Vagus nerve stimulation mitigates intrinsic cardiac neuronal and adverse myocyte remodeling postmyocardial infarction. Am J Physiol Heart Circ Physiol 309, H1198–H1206.
36. Ben-Menachem E (2001). Vagus nerve stimulation, side effects, and long-term safety. J Clin Neurophysiol 18, 415–418.
37. Ben-Menachem E (2002). Vagus-nerve stimulation for the treatment of epilepsy. Lancet Neurol 1, 477–482.
38. Bengel FM, Ueberfuhr P, Schiepel N, Nekolla SG, Reichart B & Schwaiger M (2001). Myocardial efficiency and sympathetic reinnervation after orthotopic heart transplantation: a noninvasive study with positron emission tomography. Circulation 103, 1881–1886.
39. Bercovitz A, Sengupta M, Jones A & Harris-Kojetin LD (2011). Complementary and alternative therapies in hospice: The national home and hospice care survey: United States, 2007. Natl Health Stat Report 33, 1–20.
40. Bhatt DL, Kandzari DE, O'Neill WW, D'Agostino R, Flack JM, Katzen BT, Leon MB, Liu M, Mauri L, Negoita M, Cohen SA, Oparil S, Rocha-Singh K, Townsend RR & Bakris GL (2014). A controlled trial of renal denervation for resistant hypertension. N Engl J Med 370, 1393–1401.
41. Billman GE, Cagnoli KL, Csepe T, Li N, Wright P, Mohler PJ & Fedorov VV (2015). Exercise training-induced bradycardia: evidence for enhanced parasympathetic regulation without changes in intrinsic sinoatrial node function. J Appl Physiol 118, 1344–1355.
42. Billman GE, Schwartz PJ & Stone HL (1984). The effects of daily exercise on susceptibility to sudden cardiac death. Circulation 69, 1182–1189.
43. Black LI, Clarke TC, Barnes PM, Stussman BJ & Nahin RL (2015). Use of complementary health approaches among children aged 4-17 years in the United States: National Health Interview Survey, 2007-2012. Natl Health Stat Report 78, 1–19.
44. Boon P, Vonck K, De Reuck J & Caemaert J (2001). Vagus nerve stimulation for refractory epilepsy. Seizure 10, 456–458; quiz 458–460.
45. Booth LC, Nishi EE, Yao ST, Ramchandra R, Lambert GW, Schlaich MP & May CN (2015). Reinnervation following catheter-based radio-frequency renal denervation. Exp Physiol 100, 485–490.
46. Borges DG, Monteiro RA, Schmidt A & Pazin-Filho A (2013). World soccer cup as a trigger of cardiovascular events. Arq Bras Cardiol 100, 546–552.
47. Bosnjak ZJ & Kampine JP (1989). Cardiac sympathetic afferent cell bodies are located in the peripheral nervous system of the cat. Circ Res 64, 554–562.
48. Bourke T, Vaseghi M, Michowitz Y, Sankhla V, Shah M, Swapna N, Boyle NG, Mahajan A, Narasimhan C, Lokhandwala Y & Shivkumar K (2010). Neuraxial modulation for refractory ventricular arrhythmias: value of thoracic epidural anesthesia and surgical left cardiac sympathetic denervation. Circulation 121, 2255–2262.
49. Brener J & Kluvitse C (1988). Heartbeat detection: judgments of the simultaneity of external stimuli and heartbeats. Psychophysiology 25, 554–561.
50. Buckley U, Yamakawa K, Takamiya T, Andrew Armour J, Shivkumar K & Ardell JL (2016). Targeted stellate decentralization: Implications for sympathetic control of ventricular electrophysiology. Heart Rhythm 13, 282–288.
51. Bultz BD, Cummings GG, Grassi L, Travado L, Hoekstra-Weebers J & Watson M (2014). 2013 President's Plenary International Psycho-oncology Society: embracing the IPOS standards as a means of enhancing comprehensive cancer care. Psychooncology 23, 1073–1078.
52. Burn JH, Williams EM & Walker JM (1955). The effects of acetylcholine in the heart-lung preparation including the production of auricular fibrillation. J Physiol 128, 277–293.
53. Callister R, Suwarno NO & Seals DR (1992). Sympathetic activity is influenced by task difficulty and stress perception during mental challenge in humans. J Physiol 454, 373–387.
54. Cameron OG (2002). Visceral Sensory Neuroscience: Interoception. Oxford University Press, New York.
55. Cameron OG & Minoshima S (2002). Regional brain activation due to pharmacologically induced adrenergic interoceptive stimulation in humans. Psychosom Med 64, 851–861.
56. Campese VM & Kogosov E (1995). Renal afferent denervation prevents hypertension in rats with chronic renal failure. Hypertension 25, 878–882.
57. Canales-Johnson A, Silva C, Huepe D, Rivera-Rei A, Noreika V, Garcia Mdel C, Silva W, Ciraolo C, Vaucheret E, Sedeno L, Couto B, Kargieman L, Baglivo F, Sigman M, Chennu S, Ibanez A, Rodriguez E & Bekinschtein TA (2015). Auditory feedback differentially modulates behavioral and neural markers of objective and subjective performance when tapping to your heartbeat. Cereb Cortex 25, 4490–4503.
58. Cao JM, Chen LS, KenKnight BH, Ohara T, Lee MH, Tsai J, Lai WW, Karagueuzian HS, Wolf PL, Fishbein MC & Chen PS (2000a). Nerve sprouting and sudden cardiac death. Circ Res 86, 816–821.
59. Cao JM, Fishbein MC, Han JB, Lai WW, Lai AC, Wu TJ, Czer L, Wolf PL, Denton TA, Shintaku IP, Chen PS & Chen LS (2000b). Relationship between regional cardiac hyperinnervation and ventricular arrhythmia. Circulation 101, 1960–1969.
60. Cardinal R, Page P, Vermeulen M, Ardell JL & Armour JA (2009). Spatially divergent cardiac responses to nicotinic stimulation of ganglionated plexus neurons in the canine heart. Auton Neurosci 145, 55–62.
61. Carlson MD, Geha AS, Hsu J, Martin PJ, Levy MN, Jacobs G & Waldo AL (1992). Selective stimulation of parasympathetic nerve fibers to the human sinoatrial node. Circulation 85, 1311–1317.
62. Carter JR & Ray CA (2009). Sympathetic neural responses to mental stress: responders, nonresponders and sex differences. Am J Physiol Heart Circ Physiol 296, H847–853.
63. Cha YM, Oh J, Miyazaki C, Hayes DL, Rea RF, Shen WK, Asirvatham SJ, Kemp BJ, Hodge DO, Chen PS & Chareonthaitawee P (2008). Cardiac resynchronization therapy upregulates cardiac autonomic control. J Cardiovasc Electrophysiol 10, 1045–1052.
64. Chang CM, Wu TJ, Zhou SM, Doshi RN, Lee MH, Ohara T, Fishbein MC, Karagueuzian HS, Chen PS & Chen LS (2001). Nerve sprouting and sympathetic hyperinnervation in a canine model of atrial fibrillation produced by prolonged right atrial pacing. Circulation 103, 22–25.
65. Charney DS, Heninger GR & Jatlow PI (1985). Increased anxiogenic effects of caffeine in panic disorders. Arch General Psychiatry 42, 233–243.
66. Chaya MS, Kurpad AV, Nagendra HR & Nagarathna R (2006). The effect of long term combined yoga practice on the basal metabolic rate of healthy adults. BMC Complement Altern Med 6, 28.
67. Chiou CW, Eble JN & Zipes DP (1997). Efferent vagal innervation of the canine atria and sinus and atrioventricular nodes. The third fat pad. Circulation 95, 2573–2584.
68. Chou CC, Nihei M, Zhou S, Tan AY, Kawase A, Macias ES, Fishbein MC, Lin SF & Chen PS (2005). Intracellular calcium dynamics and anisotropic reentry in isolated canine pulmonary veins and left atrium. Circulation 111, 2889–2297.
69. Chugh SS, Reinier K, Teodorescu C, Evanado A, Kehr E, Al Samara M, Mariani R, Gunson K & Jui J (2008). Epidemiology of sudden cardiac death: clinical and research implications. Prog Cardiovasc Dis 51, 213–228.
70. Clancy JA, Mary DA, Witte KK, Greenwood JP, Deuchars SA & Deuchars J (2014). Non-invasive vagus nerve stimulation in healthy humans reduces sympathetic nerve activity. Brain Stimul 7, 871–877.
71. Clarke TC, Black LI, Stussman BJ, Barnes PM & Nahin RL (2015). Trends in the use of complementary health approaches among adults: United States, 2002–2012. Natl Health Stat Report 79, 1–16.
72. Cohen MA & Taylor JA (2002). Short-term cardiovascular oscillations in man: measuring and modeling the physiologies. J Physiol 542, 669–683.
73. Collura CA, Johnson JN, Moir C & Ackerman MJ (2009). Left cardiac sympathetic denervation for the treatment of long QT syndrome and catecholaminergic polymorphic ventricular tachycardia using video-assisted thoracic surgery. Heart Rhythm 6, 752–759.
74. Converse RL Jr, Jacobsen TN, Toto RD, Jost CM, Cosentino F, Fouad-Tarazi F & Victor RG (1992). Sympathetic overactivity in patients with chronic renal failure. N Engl J Med 327, 1912–1918.
75. Cooke WH, Ryan KL & Convertino VA (2004). Lower body negative pressure as a model to study progression to acute hemorrhagic shock in humans. J Appl Physiol 96, 1249–1261.
76. Coumel P, Krikler D, Rosen MR, Wellens HJ & Zipes DP (1978). Newer antiarrhythmic drugs. Pacing Clin Electrophysiol 1, 521–528.
77. Couto B, Salles A, Sedeno L, Peradejordi M, Barttfeld P, Canales-Johnson A, Dos Santos YV, Huepe D, Bekinschtein T, Sigman M, Favaloro R, Manes F & Ibanez A (2013). The man who feels two hearts: the different pathways of interoception. Soc Cogn Affect Neurosci 9, 1253–1260.
78. Cowie MR, Woehrle H, Wegscheider K, Angermann C, d'Ortho MP, Erdmann E, Levy P, Simonds AK, Somers VK, Zannad F & Teschler H (2015). Adaptive servo-ventilation for central sleep apnea in systolic heart failure. N Engl J Med 373, 1095–1105.
79. Critchley HD, Wiens S, Rotshtein P, Ohman A & Dolan RJ (2004). Neural systems supporting interoceptive awareness. Nat Neurosci 7, 189–195.
80. Cysarz D & Bussing A (2005). Cardiorespiratory synchronization during Zen meditation. Eur J Appl Physiol 95, 88–95.
81. Daly MD, Angell-James JE & Elsner R (1979). Role of carotid-body chemoreceptors and their reflex interactions in bradycardia and cardiac arrest. Lancet 1, 764–767.
82. Davidson RJ, Horowitz ME, Schwartz GE & Goodman DM (1981). Lateral differences in the latency between finger tapping and the heart beat. Psychophysiology 18, 36–41.
83. De Ferrari GM (2014). Vagal stimulation in heart failure. J Cardiovasc Transl Res 7, 310–320.
84. De Ferrari GM, Crijns HJ, Borggrefe M, Milasinovic G, Smid J, Zabel M, Gavazzi A, Sanzo A, Dennert R, Kuschyk J, Raspopovic S, Klein H, Swedberg K & Schwartz PJ (2011). Chronic vagus nerve stimulation: a new and promising therapeutic approach for chronic heart failure. Eur Heart J 32, 847–855.
85. De Ferrari GM & Dusi V (2015). [Vagus nerve stimulation for the treatment of heart failure]. G Ital Cardiol 16, 147–154.
86. De Ferrari GM, Dusi V, Spazzolini C, Bos JM, Abrams DJ, Berul CI, Crotti L, Davis AM, Eldar M, Kharlap M, Khoury A, Krahn AD, Leenhardt A, Moir CR, Odero A, Olde Nordkamp L, Paul T, Roses INF, Shkolnikova M, Till J, Wilde AA, Ackerman MJ & Schwartz PJ (2015). Clinical management of catecholaminergic polymorphic ventricular tachycardia: the role of left cardiac sympathetic denervation. Circulation 131, 2185–2193.
87. De Ferrari GM, Tuinenburg AE, Ruble S, Brugada J, Klein H, Butter C, Wright DJ, Schubert B, Solomon S, Meyer S, Stein K, Ramuzat A & Zannad F (2014). Rationale and study design of the NEuroCardiac TherApy foR Heart Failure Study: NECTAR-HF. Eur J Heart Fail 16, 692–699.
88. Denq JC, O'Brien PC & Low PA (1998). Normative data on phases of the Valsalva maneuver. J Clin Neurophysiol 15, 535–540.
89. DeSilva RA & Lown B (1978). Ventricular premature beats, stress, and sudden death. Psychosomatics 19, 649–653, 656–661.
90. Diaz T & Taylor JA (2006). Probing the arterial baroreflex: is there a ‘spontaneous’ baroreflex? Clin Auton Res 16, 256–261.
91. DiBona GF & Esler M (2010). Translational medicine: the antihypertensive effect of renal denervation. Am J Physiol Regul Integr Comp Physiol 298, R245–R253.
92. DiBona GF & Kopp UC (1997). Neural control of renal function. Physiol Rev 77, 75–197.
93. Dietz NM, Rivera JM, Eggener SE, Fix RT, Warner DO & Joyner MJ (1994). Nitric oxide contributes to the rise in forearm blood flow during mental stress in humans. J Physiol 480, 361–368.
94. Dillon DJ, Gorman JM, Liebowitz MR, Fyer AJ & Klein DF (1987). Measurement of lactate-induced panic and anxiety. Psychiatry Res 20, 97–105.
95. Dimsdale JE & Mills PJ (2002). An unanticipated effect of meditation on cardiovascular pharmacology and physiology. Am J Cardiol 90, 908–909.
96. Docimo S, Piccolo C, Van Arsdale D & Elkowitz DE (2008). Pathology-dependent histological changes of the left stellate Ganglia: a cadaveric study. Clin Med Pathol 1, 105–113.
97. Domschke K, Stevens S, Pfleiderer B & Gerlach AL (2010). Interoceptive sensitivity in anxiety and anxiety disorders: an overview and integration of neurobiological findings. Clin Psychol Rev 30, 1–11.
98. Donald DE & Shepherd JT (1980). Autonomic regulation of the peripheral circulation. Annu Rev Physiol 42, 429–439.
99. Drapeau J, El Helou V, Clement R, Bel-Hadj S, Gosselin H, Trudeau LE, Villeneuve L & Calderone A (2004). Nestin-expressing neural stem cells identified in the scar following myocardial infarction. J Cell Physiol 204, 51–62.
100. Dutoit AP, Hart EC, Charkoudian N, Wallin BG, Curry TB & Joyner MJ (2010). Cardiac baroreflex sensitivity is not correlated to sympathetic baroreflex sensitivity within healthy, young humans. Hypertension 56, 1118–1123.
101. Dworkin BR (2007). Interoception. In Handbook of Psychophysiology, 3rd edn, ed. Cacciopo JT, Tassinary LG, Bernston GG, pp. 482–506. Cambridge University Press.
102. Dworkin BR, Dworkin S & Tang X (2000). Carotid and aortic baroreflexes of the rat: I. Open-loop steady-state properties and blood pressure variability. Am J Physiol Regul Integr Comp Physiol 279, R1910–R1921.
103. Edgerton JR, Brinkman WT, Weaver T, Prince SL, Culica D, Herbert MA & Mack MJ (2010). Pulmonary vein isolation and autonomic denervation for the management of paroxysmal atrial fibrillation by a minimally invasive surgical approach. J Thorac Cardiovasc Surg 140, 823–828.
104. Ehlers A & Breuer P (1996). How good are patients with panic disorder at perceiving their heartbeats? Biol Psychol 42, 165–182.
105. Ehlers A, Mayou RA, Sprigings DC & Birkhead J (2000). Psychological and perceptual factors associated with arrhythmias and benign palpitations. Psychosom Med 62, 693–702.
106. Eisenberg DM, Kessler RC, Foster C, Norlock FE, Calkins DR & Delbanco TL (1993). Unconventional medicine in the United States. Prevalence, costs, and patterns of use. N Engl J Med 328, 246–252.
107. El Mhandi L, Pichot V, Calmels P, Gautheron V, Roche F & Feasson L (2011). Exercise training improves autonomic profiles in patients with Charcot-Marie-Tooth disease. Muscle Nerve 44, 732–736.
108. Esler M (2014). Illusions of truths in the Symplicity HTN-3 trial: generic design strengths but neuroscience failings. J Am Soc Hypertens 8, 593–598.
109. Esler M, Lambert G & Jennings G (1990). Increased regional sympathetic nervous activity in human hypertension: causes and consequences. J Hypertens Suppl. 8, S53–S57.
110. Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE & Bohm M (2010). Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet 376, 1903–1909.
111. Estes EH Jr & Izlar HL Jr (1961). Recurrent ventricular tachycardia. A case successfully treated by bilateral cardiac sympathectomy. Am J Med 31, 493–497.
112. Exner DV, Kavanagh KM, Slawnych MP, Mitchell LB, Ramadan D, Aggarwal SG, Noullett C, Van Schaik A, Mitchell RT, Shibata MA, Gulamhussein S, McMeekin J, Tymchak W, Schnell G, Gillis AM, Sheldon RS, Fick GH & Duff HJ (2007). Noninvasive risk assessment early after a myocardial infarction the REFINE study. J Am Coll Cardiol 50, 2275–2284.
113. Fadel PJ, Ogoh S, Keller DM & Raven PB (2003). Recent insights into carotid baroreflex function in humans using the variable pressure neck chamber. Exp Physiol 88, 671–680.
114. Fallavollita JA, Heavey BM, Luisi AJ Jr, Michalek SM, Baldwa S, Mashtare TL Jr, Hutson AD, Dekemp RA, Haka MS, Sajjad M, Cimato TR, Curtis AB, Cain ME & Canty JM Jr (2014). Regional myocardial sympathetic denervation predicts the risk of sudden cardiac arrest in ischemic cardiomyopathy. J Am Coll Cardiol 63, 141–149.
115. Fallgatter AJ, Neuhauser B, Herrmann MJ, Ehlis AC, Wagener A, Scheuerpflug P, Reiners K & Riederer P (2003). Far field potentials from the brain stem after transcutaneous vagus nerve stimulation. J Neural Transm 110, 1437–1443.
116. Fatouleh RH, Hammam E, Lundblad LC, Macey PM, McKenzie DK, Henderson LA & Macefield VG (2014). Functional and structural changes in the brain associated with the increase in muscle sympathetic nerve activity in obstructive sleep apnoea. Neuroimage Clin 6, 275–283.
117. Fedorowski A, Stavenow L, Hedblad B, Berglund G, Nilsson PM & Melander O (2010). Orthostatic hypotension predicts all-cause mortality and coronary events in middle-aged individuals (The Malmo Preventive Project). Eur Heart J 31, 85–91.
118. Feldman JL, Del Negro CA & Gray PA (2013). Understanding the rhythm of breathing: so near, yet so far. Annu Rev Physiol 75, 423–452.
119. Fitzpatrick AP, Banner N, Cheng A, Yacoub M & Sutton R (1993). Vasovagal reactions may occur after orthotopic heart transplantation. J Am Coll Cardiol 21, 1132–1137.
120. Flaker GC, Belew K, Beckman K, Vidaillet H, Kron J, Safford R, Mickel M & Barrell P (2005). Asymptomatic atrial fibrillation: demographic features and prognostic information from the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study. Am Heart J 149, 657–663.
121. Florea VG & Cohn JN (2014). The autonomic nervous system and heart failure. Circ Res 114, 1815–1826.
122. Frangos E, Ellrich J & Komisaruk BR (2015). Non-invasive access to the vagus nerve central projections via electrical stimulation of the external ear: fMRI evidence in humans. Brain Stimul 8, 624–636.
123. Frasure-Smith N & Lesperance F (2003). Depression and other psychological risks following myocardial infarction. Arch Gen Psychiatry 60, 627–636.
124. Frasure-Smith N, Lesperance F & Talajic M (1993). Depression following myocardial infarction. Impact on 6-month survival. JAMA 270, 1819–1825.
125. Frasure-Smith N, Lesperance F & Talajic M (1995). Depression and 18-month prognosis after myocardial infarction. Circulation 91, 999–1005.
126. Freedenberg VA, Thomas SA & Friedmann E (2015). A pilot study of a mindfulness based stress reduction program in adolescents with implantable cardioverter defibrillators or pacemakers. Pediatr Cardiol 36, 786–795.
127. Freedland KE (2013). Demanding attention: reconsidering the role of attention control groups in behavioral intervention research. Psychosom Med 75, 100–102.
128. Freedland KE, Mohr DC, Davidson KW & Schwartz JE (2011). Usual and unusual care: existing practice control groups in randomized controlled trials of behavioral interventions. Psychosom Med 73, 323–335.
129. Fukuda K, Kanazawa H, Aizawa Y, Ardell JL & Shivkumar K (2015). Cardiac innervation and sudden cardiac death. Circ Res 116, 2005–2019.
130. Garcia-Moran E, Sandin-Fuentes MG, Alvarez Lopez JC, Duro-Aguado I, Uruena-Martinez N & Hernandez-Luis C (2013). Electrical storm secondary to acute myocardial infarction and heart failure treated with left stellate ganglion block. Rev Esp Cardiol 66, 595–597.
131. Garimella RS, Chung EH, Mounsey JP, Schwartz JD, Pursell I & Gehi AK (2015). Accuracy of patient perception of their prevailing rhythm: A comparative analysis of monitor data and questionnaire responses in patients with atrial fibrillation. Heart Rhythm 12, 658–665.
132. Garrey WE (1924). Auricular fibrillation. Physiol Rev 4, 215–250.
133. Gherghiceanu M, Hinescu ME, Andrei F, Mandache E, Macarie CE, Faussone-Pellegrini MS & Popescu LM (2008). Interstitial Cajal-like cells (ICLC) in myocardial sleeves of human pulmonary veins. J Cell Mol Med 12, 1777–1781.
134. Ghuran A, Reid F, La Rovere MT, Schmidt G, Bigger JT Jr, Camm AJ, Schwartz PJ & Malik M (2002). Heart rate turbulence-based predictors of fatal and nonfatal cardiac arrest (The Autonomic Tone and Reflexes After Myocardial Infarction substudy). Am J Cardiol 89, 184–190.
135. Golbidi S, Frisbee JC & Laher I (2015). Chronic stress impacts the cardiovascular system: animal models and clinical outcomes. Am J Physiol Heart Circ Physiol 308, H1476–H1498.
136. Goldberger JJ, Subacius H, Patel T, Cunnane R & Kadish AH (2014). Sudden cardiac death risk stratification in patients with nonischemic dilated cardiomyopathy. J Am Coll Cardiol 63, 1879–1889.
137. Gordon A, Tyni-Lenne R, Jansson E, Kaijser L, Theodorsson-Norheim E & Sylven C (1997). Improved ventilation and decreased sympathetic stress in chronic heart failure patients following local endurance training with leg muscles. J Card Fail 3, 3–12.
138. Goyal M, Singh S, Sibinga EM, Gould NF, Rowland-Seymour A, Sharma R, Berger Z, Sleicher D, Maron DD, Shihab HM, Ranasinghe PD, Linn S, Saha S, Bass EB & Haythornthwaite JA (2014). Meditation programs for psychological stress and well-being: a systematic review and meta-analysis. JAMA Intern Med 174, 357–368.
139. Gray AL, Johnson TA, Ardell JL & Massari VJ (2004). Parasympathetic control of the heart. II. A novel interganglionic intrinsic cardiac circuit mediates neural control of heart rate. J Appl Physiol 96, 2273–2278.
140. Gray MA, Taggart P, Sutton PM, Groves D, Holdright DR, Bradbury D, Brull D & Critchley HD (2007). A cortical potential reflecting cardiac function. Proc Natl Acad Sci 104, 6818–6823.
141. Groehs RV, Toschi-Dias E, Antunes-Correa LM, Trevizan PF, Rondon MU, Oliveira P, Alves MJ, Almeida DR, Middlekauff HR & Negrao CE (2015). Exercise training prevents the deterioration in the arterial baroreflex control of sympathetic nerve activity in chronic heart failure patients. Am J Physiol Heart Circ Physiol 308, H1096–H1102.
142. Gunda S, Kanmanthareddy A, Atkins D, Bommana S, Pimentel R, Drisko J, Dibiase L, Beheiry S, Hao S, Natale A & Lakkireddy D (2015). Role of yoga as an adjunctive therapy in patients with neurocardiogenic syncope: a pilot study. J Interv Card Electrophysiol 43, 105–110.
143. Gurguis GN, Vitton BJ & Uhde TW (1997). Behavioral, sympathetic and adrenocortical responses to yohimbine in panic disorder patients and normal controls. Psychiatry Res 71, 27–39.
144. Guyenet PG, Stornetta RL, Bochorishvili G, Depuy SD, Burke PG & Abbott SB (2013). C1 neurons: the body's EMTs. Am J Physiol Regul Integr Comp Physiol 305, R187–R204.
145. Haack KK & Zucker IH (2015). Central mechanisms for exercise training-induced reduction in sympatho-excitation in chronic heart failure. Auton Neurosci 188, 44–50.
146. Hainsworth R (2014). Cardiovascular control from cardiac and pulmonary vascular receptors. Exp Physiol 99, 312–319.
147. Haissaguerre M, Jais P, Shah DC, Takahashi A, Hocini M, Quiniou G, Garrigue S, Le Mouroux A, Le Metayer P & Clementy J (1998). Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N Engl J Med 339, 659–666.
148. Hamann JJ, Ruble SB, Stolen C, Wang M, Gupta RC, Rastogi S & Sabbah HN (2013). Vagus nerve stimulation improves left ventricular function in a canine model of chronic heart failure. Eur J Heart Fail 15, 1319–1326.
149. Han FT, Kasirajan V, Kowalski M, Kiser R, Wolfe L, Kalahasty G, Shepard RK, Wood MA & Ellenbogen KA (2009). Results of a minimally invasive surgical pulmonary vein isolation and ganglionic plexi ablation for atrial fibrillation: single-center experience with 12-month follow-up. Circ Arrhythm Electrophysiol 2, 370–377.
150. Han J & Moe GK (1964). Nonuniform recovery of excitability in ventricular muscle. Circ Res 14, 44–60.
151. Han S, Kobayashi K, Joung B, Piccirillo G, Maruyama M & Vinters H (2011). Electroanatomical remodeling of the left stellate ganglion after myocardial infarction. J Am Coll Cardiol 59, 954–961.
152. Harper C (2009). The neuropathology of alcohol-related brain damage. Alcohol Alcohol 44, 136–140.
153. Harper RM, Macey PM, Henderson LA, Woo MA, Macey KE, Frysinger RC, Alger JR, Nguyen KP & Yan-Go FL (2003). fMRI responses to cold pressor challenges in control and obstructive sleep apnea subjects. J Appl Physiol 94, 1583–1595.
154. Hauptman PJ, Schwartz PJ, Gold MR, Borggrefe M, Van Veldhuisen DJ, Starling RC & Mann DL (2012). Rationale and study design of the increase of vagal tone in heart failure study: INOVATE-HF. Am Heart J 163, 954–962.e1.
155. Hayase J, Patel J, Narayan SM & Krummen DE (2013). Percutaneous stellate ganglion block suppressing VT and VF in a patient refractory to VT ablation. J Cardiovasc Electrophysiol 24, 926–928.
156. Heistad DD, Abboud FM, Mark AL & Schmid PG (1974). Interaction of baroreceptor and chemoreceptor reflexes. Modulation of the chemoreceptor reflex by changes in baroreceptor activity. J Clin Invest 53, 1226–1236.
157. Henderson LA, Woo MA, Macey PM, Macey KE, Frysinger RC, Alger JR, Yan-Go F & Harper RM (2003). Neural responses during Valsalva maneuvers in obstructive sleep apnea syndrome. J Appl Physiol 94, 1063–1074.
158. Henegar JR, Zhang Y, Hata C, Narciso I, Hall ME & Hall JE (2015). Catheter-based radiofrequency renal denervation: location effects on renal norepinephrine. Am J Hypertens 28, 909–914.
159. Henning RJ, Khalil IR & Levy MN (1990). Vagal stimulation attenuates sympathetic enhancement of left ventricular function. Am J Physiol Heart Circ Physiol 258, H1470–H1475.
160. Herring N, Cranley J, Lokale MN, Li D, Shanks J, Alston EN, Girard BM, Carter E, Parsons RL, Habecker BA & Paterson DJ (2012). The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: implications for neural control of cardiac excitability. J Mol Cell Cardiol 52, 667–676.
161. Herring N, Lokale MN, Danson EJ, Heaton DA & Paterson DJ (2008). Neuropeptide Y reduces acetylcholine release and vagal bradycardia via a Y2 receptor-mediated, protein kinase C-dependent pathway. J Mol Cell Cardiol 44, 477–485.
162. Himura Y, Felten SY, Kashiki M, Lewandowski TJ, Delehanty JM & Liang CS (1993). Cardiac noradrenergic nerve terminal abnormalities in dogs with experimental congestive heart failure. Circulation 88, 1299–1309.
163. Hindricks G, Piorkowski C, Tanner H, Kobza R, Gerds-Li JH, Carbucicchio C & Kottkamp H (2005). Perception of atrial fibrillation before and after radiofrequency catheter ablation: relevance of asymptomatic arrhythmia recurrence. Circulation 112, 307–313.
164. Hjalmarson A (1997). Effects of beta blockade on sudden cardiac death during acute myocardial infarction and the postinfarction period. Am J Cardiol 80, 35J–39J.
165. Hohnloser SH, Kuck KH, Dorian P, Roberts RS, Hampton JR, Hatala R, Fain E, Gent M & Connolly SJ (2004). Prophylactic use of an implantable cardioverter-defibrillator after acute myocardial infarction. N Engl J Med 351, 2481–2488.
166. Holmqvist F, Guan N, Zhu Z, Kowey PR, Allen LA, Fonarow GC, Hylek EM, Mahaffey KW, Freeman JV, Chang P, Holmes DN, Peterson ED, Piccini JP & Gersh BJ (2015). Impact of obstructive sleep apnea and continuous positive airway pressure therapy on outcomes in patients with atrial fibrillation—Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF). Am Heart J 169, 647–654.e2.
167. Hoover DB, Isaacs ER, Jacques F, Hoard JL, Page P & Armour JA (2009). Localization of multiple neurotransmitters in surgically derived specimens of human atrial ganglia. Neuroscience 164, 1170–1179.
168. Hopkins DA & Armour JA (1984). Localization of sympathetic postganglionic and parasympathetic preganglionic neurons which innervate different regions of the dog heart. J Comp Neurol 229, 186–198.
169. Hopkins DA & Armour JA (1989). Ganglionic distribution of afferent neurons innervating the canine heart and cardiopulmonary nerves. J Auton Nerv Syst 26, 213–222.
170. Hopkins DA, Bieger D, deVente J & Steinbusch WM (1996). Vagal efferent projections: viscerotopy, neurochemistry and effects of vagotomy. Prog Brain Res 107, 79–96.
171. Hsieh MH, Chiou CW, Wen ZC, Wu CH, Tai CT, Tsai CF, Ding YA, Chang MS & Chen SA (1999). Alterations of heart rate variability after radiofrequency catheter ablation of focal atrial fibrillation originating from pulmonary veins. Circulation 100, 2237–2243.
172. Huang MH, Ardell JL, Hanna BD, Wolf SG & Armour JA (1993a). Effects of transient coronary artery occlusion on canine intrinsic cardiac neuronal activity. Integr Physiol Behav Sci 28, 5–21.
173. Huang MH, Sylven C, Pelleg A, Smith FM & Armour JA (1993b). Modulation of in situ canine intrinsic cardiac neuronal activity by locally applied adenosine, ATP, or analogues. Am J Physiol Regul Integr Comp Physiol 265, R914–R922.
174. Ikeda T, Yoshino H, Sugi K, Tanno K, Shimizu H, Watanabe J, Kasamaki Y, Yoshida A & Kato T (2006). Predictive value of microvolt T-wave alternans for sudden cardiac death in patients with preserved cardiac function after acute myocardial infarction: results of a collaborative cohort study. J Am Coll Cardiol 48, 2268–2274.
175. James TN, Zipes DP, Finegan RE, Eisele JW & Carter JE (1979). Cardiac ganglionitis associated with sudden unexpected death. Ann Intern Med 91, 727–730.
176. Janes RD, Brandys JC, Hopkins DA, Johnstone DE, Murphy DA & Armour JA (1986). Anatomy of human extrinsic cardiac nerves and ganglia. Am J Cardiol 57, 299–309.
177. Janig W (1996). Neurobiology of visceral afferent neurons: neuroanatomy, functions, organ regulations and sensations. Biol Psychol 42, 29–51.
178. Janig W (2006). The Integrative Action of the Autonomic Nervous System: Neurobiology of Homeostasis. Cambridge University Press, Cambridge.
179. Jayachandran JV, Sih HJ, Winkle W, Zipes DP, Hutchins GD & Olgin JE (2000). Atrial fibrillation produced by prolonged rapid atrial pacing is associated with heterogeneous changes in atrial sympathetic innervation. Circulation 101, 1185–1191.
180. Johnson DC, Thom NJ, Stanley EA, Haase L, Simmons AN, Shih PA, Thompson WK, Potterat EG, Minor TR & Paulus MP (2014). Modifying resilience mechanisms in at-risk individuals: a controlled study of mindfulness training in Marines preparing for deployment. Am J Psychiatry 171, 844–853.
181. Jones GE (1994). Perception of visceral sensations: a review of recent findings, methodologies, and future directions. In Advances in Psychophysiology: A research annual, ed. Jennings JR and Ackles PK, vol. 5, pp. 155–192. Jessica Kingsley Publishers, London.
182. Jones GE & Hollandsworth JG (1981). Heart rate discrimination before and after exercise-induced augmented cardiac activity. Psychophysiology 18, 252–257.
183. Jones GE, Jones KR, Cunningham RA & Caldwell JA (1985). Cardiac awareness in infarct patients and normals. Psychophysiology 22, 480–487.
184. Jouven X, Empana JP, Schwartz PJ, Desnos M, Courbon D & Ducimetiere P (2005). Heart-rate profile during exercise as a predictor of sudden death. N Engl J Med 352, 1951–1958.
185. Joyner MJ & Casey DP (2015). Regulation of increased blood flow (hyperemia) to muscles during exercise: a hierarchy of competing physiological needs. Physiol Rev 95, 549–601.
186. Joyner MJ & Dietz NM (2003). Sympathetic vasodilation in human muscle. Acta Physiol Scand 177, 329–336.
187. Julien C (2006). The enigma of Mayer waves: facts and models. Cardiovasc Res 70, 12–21.
188. Kaikkonen KM, Korpelainen RI, Tulppo MP, Kaikkonen HS, Vanhala ML, Kallio MA, Keinanen-Kiukaanniemi SM & Korpelainen JT (2014). Physical activity and aerobic fitness are positively associated with heart rate variability in obese adults. J Phys Act Health 11, 1614–1621.
189. Kamibayashi T, Hayashi Y, Mammoto T, Yamatodani A, Taenaka N & Yoshiya I (1995). Thoracic epidural anesthesia attenuates halothane-induced myocardial sensitization to dysrhythmogenic effect of epinephrine in dogs. J Phys Act Health 82, 129–134.
190. Kammerling JJ, Green FJ, Watanabe AM, Inoue H, Barber MJ, Henry DP & Zipes DP (1987). Denervation supersensitivity of refractoriness in noninfarcted areas apical to transmural myocardial infarction. Circulation 76, 383–393.
191. Kanazawa H, Ieda M, Kimura K, Arai T, Kawaguchi-Manabe H, Matsuhashi T, Endo J, Sano M, Kawakami T, Kimura T, Monkawa T, Hayashi M, Iwanami A, Okano H, Okada Y, Ishibashi-Ueda H, Ogawa S & Fukuda K (2010). Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents. J Clin Invest 120, 408–421.
192. Kandzari DE, Bhatt DL, Brar S, Devireddy CM, Esler M, Fahy M, Flack JM, Katzen BT, Lea J, Lee DP, Leon MB, Ma A, Massaro J, Mauri L, Oparil S, O'Neill WW, Patel MR, Rocha-Singh K, Sobotka PA, Svetkey L, Townsend RR & Bakris GL (2015). Predictors of blood pressure response in the SYMPLICITY HTN-3 trial. Eur Heart J 36, 219–227.
193. Katkin ES, Blascovich J & Goldband S (1981). Empirical assessment of visceral self-perception: individual and sex differences in the acquisition of heartbeat discrimination. J Pers Soc Psychol 40, 1095–1101.
194. Katkin ES, Morell MA, Goldband S, Bernstein GL & Wise JA (1982). Individual differences in heartbeat discrimination. Psychophysiology 19, 160–166.
195. Katkin ES, Wiens S & Ohman A (2001). Nonconscious fear conditioning, visceral perception, and the development of gut feelings. Psychol Sci 12, 366–370.
196. Katritsis DG, Giazitzoglou E, Zografos T, Pokushalov E, Po SS & Camm AJ (2011). Rapid pulmonary vein isolation combined with autonomic ganglia modification: a randomized study. Heart Rhythm 8, 672–678.
197. Katritsis DG, Pokushalov E, Romanov A, Giazitzoglou E, Siontis GC, Po SS, Camm AJ & Ioannidis JP (2013). Autonomic denervation added to pulmonary vein isolation for paroxysmal atrial fibrillation: a randomized clinical trial. J Am Coll Cardiol 62, 2318–2325.
198. Kember G, Ardell JL, Armour JA & Zamir M (2014). Vagal nerve stimulation therapy: What is being stimulated? PLoS One 9, e114498.
199. Kember G, Armour JA & Zamir M (2013a). Dynamic neural networking as a basis for plasticity in the control of heart rate. J Theo Biol 317, 39–46.
200. Kember G, Armour JA & Zamir M (2013b). Neural control hierarchy of the heart has not evolved to deal with myocardial ischemia. Physiol Genomics 45, 638–644.
201. Kember GC, Zamir M & Armour JA (2004). “Smart” baroreception along the aortic arch, with reference to essential hypertension. Phys Rev E Stat Nonlin Soft Matter Phys 70, 051914.
202. Kemp AH, Quintana DS, Gray MA, Felmingham KL, Brown K & Gatt JM (2010). Impact of depression and antidepressant treatment on heart rate variability: a review and meta-analysis. Biol Psychiatry 67, 1067–1074.
203. Kern M, Aertsen A, Schulze-Bonhage A & Ball T (2013). Heart cycle-related effects on event-related potentials, spectral power changes, and connectivity patterns in the human ECoG. Neuroimage 81, 178–190.
204. Khalsa S, Rudrauf D & Tranel D (2009a). Interoceptive awareness declines with age. Psychophysiology 46, 1130–1136.
205. Khalsa SS, Craske MG, Li W, Vangala S, Strober M & Feusner JD (2015a). Altered interoceptive awareness in anorexia nervosa: Effects of meal anticipation, consumption and bodily arousal. Int J Eat Disord 48, 889–897.
206. Khalsa SS, Rudrauf D, Damasio AR, Davidson RJ, Lutz A & Tranel D (2008). Interoceptive awareness in experienced meditators. Psychophysiology 45, 671–677.
207. Khalsa SS, Rudrauf D, Davidson RJ & Tranel D (2015b). The effect of meditation on regulation of internal body states. Front Psychol 6, 924.
208. Khalsa SS, Rudrauf D, Sandesara C, Olshansky B & Tranel D (2009a). Bolus isoproterenol infusions provide a reliable method for assessing interoceptive awareness. Int J Psychophysiol 72, 34–45.
209. Khalsa SS, Rudrauf D, Feinstein JS & Tranel D (2009b). The pathways of interoceptive awareness. Nat Neurosci 12, 1494–1496.
210. Kienbaum P, Karlssonn T, Sverrisdottir YB, Elam M & Wallin BG (2001). Two sites for modulation of human sympathetic activity by arterial baroreceptors? J Physiol 531, 861–869.
211. Kim DT, Luthringer DJ, Lai AC, Suh G, Czer L, Chen LS, Chen PS & Fishbein MC (2004). Sympathetic nerve sprouting after orthotopic heart transplantation. J Heart Lung Transplant 23, 1349–1358.
212. Kleckner IR, Wormwood JB, Simmons WK, Barrett LF & Quigley KS (2015). Methodological recommendations for a heartbeat detection-based measure of interoceptive sensitivity. Psychophysiology 52, 1432–1440.
213. Kleiber AC, Zheng H, Schultz HD, Peuler JD & Patel KP (2008). Exercise training normalizes enhanced glutamate-mediated sympathetic activation from the PVN in heart failure. Am J Physiol Regul Integr Comp Physiol 294, R1863–R1872.
214. Kober L, Torp-Pedersen C, Carlsen JE, Bagger H, Eliasen P, Lyngborg K, Videbaek J, Cole DS, Auclert L & Pauly NC (1995). A clinical trial of the angiotensin-converting-enzyme inhibitor trandolapril in patients with left ventricular dysfunction after myocardial infarction. Trandolapril Cardiac Evaluation (TRACE) Study Group. N Engl J Med 333, 1670–1676.
215. Konecny T, Kuniyoshi FH, Orban M, Pressman GS, Kara T, Gami A, Caples SM, Lopez-Jimenez F & Somers VK (2010). Under-diagnosis of sleep apnea in patients after acute myocardial infarction. J Am Coll Cardiol 56, 742–743.
216. Kopp UC, Smith LA & DiBona GF (1985). Renorenal reflexes: neural components of ipsilateral and contralateral renal responses. Am J Physiol Renal Physiol 249, F507–F517.
217. Koroboki E, Zakopoulos N, Manios E, Rotas V, Papadimitriou G & Papageorgiou C (2010). Interoceptive awareness in essential hypertension. Int J Psychophysiol 78, 158–162.
218. Kostreva DR, Armour JA & Bosnjak ZJ (1985). Metabolic mapping of a cardiac reflex mediated by sympathetic ganglia in dogs. Am J Physiol Regul Integr Comp Physiol 249, R317–R322.
219. Krul SP, Driessen AH, van Boven WJ, Linnenbank AC, Geuzebroek GS, Jackman WM, Wilde AA, de Bakker JM & de Groot JR (2011). Thoracoscopic video-assisted pulmonary vein antrum isolation, ganglionated plexus ablation, and periprocedural confirmation of ablation lesions: first results of a hybrid surgical-electrophysiological approach for atrial fibrillation. Circ Arrhythm Electrophysiol 4, 262–270.
220. Krum H, Schlaich M, Whitbourn R, Sobotka PA, Sadowski J, Bartus K, Kapelak B, Walton A, Sievert H, Thambar S, Abraham WT & Esler M (2009). Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet 373, 1275–1281.
221. Kuck KH, Schaumann A, Eckardt L, Willems S, Ventura R, Delacretaz E, Pitschner HF, Kautzner J, Schumacher B, Hansen PS; VTACH study group (2010). Catheter ablation of stable ventricular tachycardia before defibrillator implantation in patients with coronary heart disease (VTACH): a multicentre randomised controlled trial. Lancet 375, 31–40.
222. Kumar R, Birrer BV, Macey PM, Woo MA, Gupta RK, Yan-Go FL & Harper RM (2008). Reduced mammillary body volume in patients with obstructive sleep apnea. Neurosci Lett 438, 330–334.
223. Kumar R, Chavez AS, Macey PM, Woo MA, Yan-Go FL & Harper RM (2012). Altered global and regional brain mean diffusivity in patients with obstructive sleep apnea. J Neurosci Res 90, 2043–2052.
224. Kumar R, Pham TT, Macey PM, Woo MA, Yan-Go FL & Harper RM (2014). Abnormal myelin and axonal integrity in recently diagnosed patients with obstructive sleep apnea. Sleep 37, 723–732.
225. Kumar R, Woo MA, Birrer BV, Macey PM, Fonarow GC, Hamilton MA & Harper RM (2009). Mammillary bodies and fornix fibers are injured in heart failure. Neurobiol Dis 33, 236–242.
226. Kumar R, Woo MA, Macey PM, Fonarow GC, Hamilton MA & Harper RM (2011). Brain axonal and myelin evaluation in heart failure. J Neurol Sci 307, 106–113.
227. Kuniyoshi FH, Garcia-Touchard A, Gami AS, Romero-Corral A, van der Walt C, Pusalavidyasagar S, Kara T, Caples SM, Pressman GS, Vasquez EC, Lopez-Jimenez F & Somers VK (2008). Day-night variation of acute myocardial infarction in obstructive sleep apnea. J Am Coll Cardiol 52, 343–346.
228. Kuntz A & Morehouse A (1930). Thoracic sympathetic cardiac nerves in man: Their relation to cervical sympathetic ganglionectomy. Arch Surg 20, 607–613.
229. La Rovere MT, Bigger JT Jr, Marcus FI, Mortara A & Schwartz PJ (1998). Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators. Lancet 351, 478–484.
230. La Rovere MT, Specchia G, Mortara A & Schwartz PJ (1988). Baroreflex sensitivity, clinical correlates, and cardiovascular mortality among patients with a first myocardial infarction. A prospective study. Circulation 78, 816–824.
231. Lahiri MK, Kannankeril PJ & Goldberger JJ (2008). Assessment of autonomic function in cardiovascular disease: physiological basis and prognostic implications. J Am Coll Cardiol 51, 1725–1733.
232. Lakkireddy D, Atkins D, Pillarisetti J, Ryschon K, Bommana S, Drisko J, Vanga S & Dawn B (2013). Effect of yoga on arrhythmia burden, anxiety, depression, and quality of life in paroxysmal atrial fibrillation. J Am Coll Cardiol 61, 1177–1182.
233. Lampert R, Joska T, Burg MM, Batsford WP, McPherson CA & Jain D (2002). Emotional and physical precipitants of ventricular arrhythmia. Circulation 106, 1800–1805.
234. Lane RD, McRae K, Reiman EM, Chen K, Ahern GL & Thayer JF (2009). Neural correlates of heart rate variability during emotion. Neuroimage 44, 213–222.
235. Laterza MC, de Matos LD, Trombetta IC, Braga AM, Roveda F, Alves MJ, Krieger EM, Negrao CE & Rondon MU (2007). Exercise training restores baroreflex sensitivity in never-treated hypertensive patients. Hypertension 49, 1298–1306.
236. Lemola K, Chartier D, Yeh YH, Dubuc M, Cartier R, Armour A, Ting M, Sakabe M, Shiroshita-Takeshita A, Comtois P & Nattel S (2008). Pulmonary vein region ablation in experimental vagal atrial fibrillation: role of pulmonary veins versus autonomic ganglia. Circulation 117, 470–477.
237. Leor J, Poole WK & Kloner RA (1996). Sudden cardiac death triggered by an earthquake. N Engl J Med 334, 413–419.
238. Lepicovska V, Novak P & Nadeau R (1992). Time-frequency dynamics in neurally mediated syncope. Clin Auton Res 2, 317–326.
239. Levin MD, Lu MM, Petrenko NB, Hawkins BJ, Gupta TH, Lang D, Buckley PT, Jochems J, Liu F, Spurney CF, Yuan LJ, Jacobson JT, Brown CB, Huang L, Beermann F, Margulies KB, Madesh M, Eberwine JH, Epstein JA & Patel VV (2009). Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers. J Clin Invest 119, 3420–3436.
240. Levy MN & Zieske H (1969). Autonomic control of cardiac pacemaker activity and atrioventricular transmission. J Appl Physiol 27, 465–470.
241. Li D, Nikiforova N, Lu CJ, Wannop K, McMenamin M, Lee CW, Buckler KJ & Paterson DJ (2013). Targeted neuronal nitric oxide synthase transgene delivery into stellate neurons reverses impaired intracellular calcium transients in prehypertensive rats. Hypertension 61, 202–207.
242. Li D, Wang L, Lee CW, Dawson TA & Paterson DJ (2007). Noradrenergic cell specific gene transfer with neuronal nitric oxide synthase reduces cardiac sympathetic neurotransmission in hypertensive rats. Hypertension 50, 69–74.
243. Li M, Zheng C, Sato T, Kawada T, Sugimachi M & Sunagawa K (2004). Vagal nerve stimulation markedly improves long-term survival after chronic heart failure in rats. Circulation 109, 120–124.
244. Li S, Scherlag BJ, Yu L, Sheng X, Zhang Y, Ali R, Dong Y, Ghias M & Po SS (2009). Low-level vagosympathetic stimulation: a paradox and potential new modality for the treatment of focal atrial fibrillation. Circ Arrhythm Electrophysiol 2, 645–651.
245. Liu L & Barajas L (1993). The rat renal nerves during development. Anat Embryol 188, 345–361.
246. Liu L & Nattel S (1997). Differing sympathetic and vagal effects on atrial fibrillation in dogs: role of refractoriness heterogeneity. Am J Physiol Heart Circ Physiol 273, H805–H816.
247. Liu Z, Hesse C, Curry TB, Pike TL, Issa A, Bernal M, Charkoudian N, Joyner MJ & Eisenach JH (2009). Ambulatory arterial stiffness index is not correlated with the pressor response to laboratory stressors in normotensive humans. J Hypertens 27, 763–768.
248. Lloyd R, Okada R, Stagg J, Anderson R, Hattler B & Marcus F (1974). The treatment of recurrent ventricular tachycardia with bilateral cervico-thoracic sympathetic-ganglionectomy. A report of two cases. Circulation 50, 382–388.
249. Low PA (2003). Testing the autonomic nervous system. Semin Neurol 23, 407–421.
250. Low PA (2008). Prevalence of orthostatic hypotension. Clin Auton Res 18 Suppl 1, 8–13.
251. Lown B & DeSilva RA (1978). Roles of psychologic stress and autonomic nervous system changes in provocation of ventricular premature complexes. Am J Cardiol 41, 979–985.
252. Lown B, Temte JV, Reich P, Gaughan C, Regestein Q & Hal H (1976). Basis for recurring ventricular fibrillation in the absence of coronary heart disease and its management. N Engl J Med 294, 623–629.
253. Loyalka P, Hariharan R, Gholkar G, Gregoric ID, Tamerisa R, Nathan S & Kar B (2011). Left stellate ganglion block for continuous ventricular arrhythmias during percutaneous left ventricular assist device support. Texas Heart Inst J 38, 409–411.
254. Lu CJ, Hao G, Nikiforova N, Larsen HE, Liu K, Crabtree MJ, Li D, Herring N & Paterson DJ (2015). CAPON modulates neuronal calcium handling and cardiac sympathetic neurotransmission during dysautonomia in hypertension. Hypertension 65, 1288–1297.
255. Ludwick-Rosenthal R & Neufeld RW (1985). Heart beat interoception: a study of individual differences. Int J Psychophysiol 3, 57–65.
256. Lundblad LC, Fatouleh RH, Hammam E, McKenzie DK, Macefield VG & Henderson LA (2014). Brainstem changes associated with increased muscle sympathetic drive in obstructive sleep apnoea. Neuroimage 103, 258–266.
257. Lutherer LO, Lutherer BC, Dormer KJ, Janssen HF & Barnes CD (1983). Bilateral lesions of the fastigial nucleus prevent the recovery of blood pressure following hypotension induced by hemorrhage or administration of endotoxin. Brain Res 269, 251–257.
258. Lutherer LO, Williams JL & Everse SJ (1989). Neurons of the rostral fastigial nucleus are responsive to cardiovascular and respiratory challenges. J Auton Nerv Syst 27, 101–111.
259. Macey PM, Henderson LA, Macey KE, Alger JR, Frysinger RC, Woo MA, Harper RK, Yan-Go FL & Harper RM (2002). Brain morphology associated with obstructive sleep apnea. Am J Respir Crit Care Med 166, 1382–1387.
260. Macey PM, Kumar R, Ogren JA, Woo MA & Harper RM (2014). Global brain blood-oxygen level responses to autonomic challenges in obstructive sleep apnea. PLoS One 9, e105261.
261. Macey PM, Kumar R, Woo MA, Valladares EM, Yan-Go FL & Harper RM (2008). Brain structural changes in obstructive sleep apnea. Sleep 31, 967–977.
262. Macey PM, Kumar R, Woo MA, Yan-Go FL & Harper RM (2013). Heart rate responses to autonomic challenges in obstructive sleep apnea. PLoS One 8, e76631.
263. Mahajan A, Moore J, Cesario DA & Shivkumar K (2005). Use of thoracic epidural anesthesia for management of electrical storm: a case report. Heart Rhythm 2, 1359–1362.
264. Mahfoud F & Luscher TF (2015). Renal denervation: symply trapped by complexity? Eur Heart J 36, 199–202.
265. Malik M (1996). Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 93, 1043–1065.
266. Malliani A, Recordati G & Schwartz PJ (1973). Nervous activity of afferent cardiac sympathetic fibres with atrial and ventricular endings. J Physiol 229, 457–469.
267. Mark AL, Victor RG, Nerhed C & Wallin BG (1985). Microneurographic studies of the mechanisms of sympathetic nerve responses to static exercise in humans. Circ Res 57, 461–469.
268. Masani F (1986). Node-like cells in the myocardial layer of the pulmonary vein of rats: an ultrastructural study. J Anat 145, 133–142.
269. Masson GS, Nair AR, Silva Soares PP, Michelini LC & Francis J (2015). Aerobic training normalizes autonomic dysfunction, HMGB1 content, microglia activation and inflammation in hypothalamic paraventricular nucleus of SHR. Am J Physiol Heart Circ Physiol 309, H1115–H1122.
270. Mathuria N, Tung R & Shivkumar K (2012). Advances in ablation of ventricular tachycardia in nonischemic cardiomyopathy. Curr Cardiol Rep 14, 577–583.
271. Matthews KA, Katholi CR, McCreath H, Whooley MA, Williams DR, Zhu S & Markovitz JH (2004). Blood pressure reactivity to psychological stress predicts hypertension in the CARDIA study. Circulation 110, 74–78.
272. Meissner A, Eckardt L, Kirchhof P, Weber T, Rolf N, Breithardt G, Van Aken H & Haverkamp W (2001). Effects of thoracic epidural anesthesia with and without autonomic nervous system blockade on cardiac monophasic action potentials and effective refractoriness in awake dogs. Anesthesiology 95, 132–138.
273. Mitchell GAG (1956). Cardiovascular Innervation. E. & S. Livingstone, Edinburgh.
274. Miyauchi Y, Zhou S, Miyauchi M, Omichi C, Okuyama Y, Hamabe A, Hayashi H, Mandel WJ, Fishbein MC, Chen LS, Chen PS & Karagueuzian HS (2001). Induction of atrial sympathetic nerve sprouting and increased vulnerability to atrial fibrillation by chronic left ventricular myocardial infarction. Circulation 104, II–17.
275. Mizeres NJ (1963). The cardiac plexus in man. Am J Anat 112, 141–151.
276. Montgomery WA, Jones GE & Hollandsworth JG Jr (1984). The effects of physical fitness and exercise on cardiac awareness. Biol Psychol 18, 11–22.
277. Mooe T, Franklin KA, Wiklund U, Rabben T & Holmstrom K (2000). Sleep-disordered breathing and myocardial ischemia in patients with coronary artery disease. Chest 117, 1597–1602.
278. Moss AJ & McDonald J (1971). Unilateral cervicothoracic sympathetic ganglionectomy for the treatment of long QT interval syndrome. N Engl J Med 285, 903–904.
279. Mousa TM, Liu D, Cornish KG & Zucker IH (2008). Exercise training enhances baroreflex sensitivity by an angiotensin II-dependent mechanism in chronic heart failure. J Appl Physiol 104, 616–624.
280. Murphy DA, O'Blenes S, Hanna BD & Armour JA (1994). Functional capacity of nicotine-sensitive canine intrinsic cardiac neurons to modify the heart. Am J Physiol Regul Integr Comp Physiol 266, R1127–R1135.
281. Murphy DA, Thompson GW, Ardell JL, McCraty R, Stevenson RS, Sangalang VE, Cardinal R, Wilkinson M, Craig S, Smith FM, Kingma JG & Armour JA (2000). The heart reinnervates after transplantation. Ann Thoracic Surg 69, 1769–1781.
282. Nademanee K, Taylor R, Bailey WE, Rieders DE & Kosar EM (2000). Treating electrical storm: sympathetic blockade versus advanced cardiac life support-guided therapy. Circulation 102, 742–747.
283. Narkiewicz K, van de Borne PJ, Montano N, Dyken ME, Phillips BG & Somers VK (1998). Contribution of tonic chemoreflex activation to sympathetic activity and blood pressure in patients with obstructive sleep apnea. Circulation 97, 943–945.
284. Nathan S & Bakris GL (2014). The future of renal denervation in resistant hypertension. Curr Hypertens Rep 16, 494.
285. Naughton MT (2012). Cheyne-Stokes respiration: friend or foe? Thorax 67, 357–360.
286. Nemeroff CB & Goldschmidt-Clermont PJ (2012). Heartache and heartbreak–the link between depression and cardiovascular disease. Nat Rev Cardiol 9, 526–539.
287. Ng GA (2014). Vagal modulation of cardiac ventricular arrhythmia. Exp Physiol 99, 295–299.
288. Nguyen BL, Fishbein MC, Chen LS, Chen PS & Masroor S (2009). Histopathological substrate for chronic atrial fibrillation in humans. Heart Rhythm 6, 454–460.
289. Nguyen BL, Li H, Fishbein MC, Lin SF, Gaudio C, Chen PS & Chen LS (2011). Acute myocardial infarction induces bilateral stellate ganglia neural remodeling in rabbits. Cardiovasc Pathol 21, 143–148.
290. Nitter-Hauge S & Storstein O (1973). Surgical treatment of recurrent ventricular tachycardia. Br Heart J 35, 1132–1135.
291. Nomura S & Mizuno N (1984). Central distribution of primary afferent fibers in the Arnold's nerve (the auricular branch of the vagus nerve): a transganglionic HRP study in the cat. Brain Res 292, 199–205.
292. Norris JE, Foreman RD & Wurster RK (1974). Responses of the canine heart to stimulation of the first five ventral thoracic roots. Am J Physiol 227, 9–12.
293. Norris JE, Lippincott D & Wurster RD (1977). Responses of canine endocardium to stimulation of the upper thoracic roots. Am J Physiol Heart Circ Physiol 233, H655–H659.
294. Nygard E, Kofoed KF, Freiberg J, Holm S, Aldershvile J, Eliasen K & Kelbaek H (2005). Effects of high thoracic epidural analgesia on myocardial blood flow in patients with ischemic heart disease. Circulation 111, 2165–2170.
295. O'Brien WH, Reid GJ & Jones KR (1998). Differences in heartbeat awareness among males with higher and lower levels of systolic blood pressure. Int J Psychophysiol 29, 53–63.
296. Ogren JA, Macey PM, Kumar R, Fonarow GC, Hamilton MA, Harper RM & Woo MA (2012). Impaired cerebellar and limbic responses to the valsalva maneuver in heart failure. Cerebellum 11, 931–938.
297. Oh S, Choi EK, Zhang Y & Mazgalev TN (2011). Botulinum toxin injection in epicardial autonomic ganglia temporarily suppresses vagally mediated atrial fibrillation. Circ Arrhythm Electrophysiol 4, 560–565.
298. Oka T, Ozawa Y & Ohkubo Y (2001). Thoracic epidural bupivacaine attenuates supraventricular tachyarrhythmias after pulmonary resection. Anesth Analg 93, 253–259.
299. Olausson K, Magnusdottir H, Lurje L, Wennerblom B, Emanuelsson H & Ricksten SE (1997). Anti-ischemic and anti-anginal effects of thoracic epidural anesthesia versus those of conventional medical therapy in the treatment of severe refractory unstable angina pectoris. Circulation 96, 2178–2182.
300. Oldham JB (1950). Denervation of the kidney. Ann R Coll Surg Engl 7, 222–245.
301. Olex S, Newberg A & Figueredo VM (2013). Meditation: should a cardiologist care? Int J Cardiol 168, 1805–1810.
302. O'Regan RG & Majcherczyk S (1982). Role of peripheral chemoreceptors and central chemosensitivity in the regulation of respiration and circulation. J Exp Biol 100, 23–40.
303. Ospina MB, Bond K, Karkhaneh M, Tjosvold L, Vandermeer B, Liang Y, Bialy L, Hooton N, Buscemi N, Dryden DM & Klassen TP (2007). Meditation practices for health: state of the research. Evid Rep Technol Assess, 1–263.
304. Pae EK, Chien P & Harper RM (2005). Intermittent hypoxia damages cerebellar cortex and deep nuclei. Neurosci Lett 375, 123–128.
305. Pagani M, Montano N, Porta A, Malliani A, Abboud FM, Birkett C & Somers VK (1997). Relationship between spectral components of cardiovascular variabilities and direct measures of muscle sympathetic nerve activity in humans. Circulation 95, 1441–1448.
306. Palomares JA, Tummala S, Wang DJ, Park B, Woo MA, Kang DW, Lawrence KS, Harper RM & Kumar R (2015). Water exchange across the blood-brain barrier in obstructive sleep apnea: an MRI diffusion-weighted pseudo-continuous arterial spin labeling study. J Neuroimaging 25, 900–905.
307. Pappone C, Santinelli V, Manguso F, Vicedomini G, Gugliotta F, Augello G, Mazzone P, Tortoriello V, Landoni G, Zangrillo A, Lang C, Tomita T, Mesas C, Mastella E & Alfieri O (2004). Pulmonary vein denervation enhances long-term benefit after circumferential ablation for paroxysmal atrial fibrillation. Circulation 109, 327–334.
308. Patel RA, Priore DL, Szeto WY & Slevin KA (2011). Left stellate ganglion blockade for the management of drug-resistant electrical storm. Pain Med 12, 1196–1198.
309. Paulus MP & Stein MB (2010). Interoception in anxiety and depression. Brain Struct Funct 214, 451–463.
310. Pauza DH, Rysevaite-Kyguoliene K, Vismantaite J, Brack KE, Inokaitis H, Pauza AG, Rimasauskaite-Petraitiene V, Pauzaite JI & Pauziene N (2014). A combined acetylcholinesterase and immunohistochemical method for precise anatomical analysis of intrinsic cardiac neural structures. Ann Anat 196, 430–440.
311. Peng CK, Henry IC, Mietus JE, Hausdorff JM, Khalsa G, Benson H & Goldberger AL (2004). Heart rate dynamics during three forms of meditation. Int J Cardiol 95, 19–27.
312. Perez-Lugones A, McMahon JT, Ratliff NB, Saliba WI, Schweikert RA, Marrouche NF, Saad EB, Navia JL, McCarthy PM, Tchou P, Gillinov AM & Natale A (2003). Evidence of specialized conduction cells in human pulmonary veins of patients with atrial fibrillation. J Cardiovasc Electrophysiol 14, 803–809.
313. Peuker ET & Filler TJ (2002). The nerve supply of the human auricle. Clin Anat 15, 35–37.
314. Pfeffer JM & Pfeffer MA (1988). Angiotensin converting enzyme inhibition and ventricular remodeling in heart failure. Am J Med 84, 37–44.
315. Pfeiffer D, Fiehring H, Henkel HG, Rostock KJ & Rathgen K (1989). Long QT syndrome associated with inflammatory degeneration of the stellate ganglia. Clin Cardiol 12, 222–224.
316. Pohl R, Yeragani VK, Balon R, Rainey JM, Lycaki H, Ortiz A, Berchou R & Weinberg P (1988). Isoproterenol-induced panic attacks. Biol Psychiatry 24, 891–902.
317. Pokushalov E, Kozlov B, Romanov A, Strelnikov A, Bayramova S, Sergeevichev D, Bogachev-Prokophiev A, Zheleznev S, Shipulin V, Lomivorotov VV, Karaskov A, Po SS & Steinberg JS (2015). Long-term suppression of atrial fibrillation by botulinum toxin injection into epicardial fat pads in patients undergoing cardiac surgery: one-year follow-up of a randomized pilot study. Circ Arrhythm Electrophysiol 8, 1334–1341.
318. Polak T, Markulin F, Ehlis AC, Langer JB, Ringel TM & Fallgatter AJ (2009). Far field potentials from brain stem after transcutaneous vagus nerve stimulation: optimization of stimulation and recording parameters. J Neural Transm (Vienna) 116, 1237–1242.
319. Premchand RK, Sharma K, Mittal S, Monteiro R, Dixit S, Libbus I, DiCarlo LA, Ardell JL, Rector TS, Amurthur B, KenKnight BH & Anand IS (2014). Autonomic regulation therapy via left or right cervical vagus nerve stimulation in patients with chronic heart failure: results of the ANTHEM-HF trial. J Cardiac Fail 20, 808–816.
320. Premchand RK, Sharma K, Mittal S, Monteiro R, Dixit S, Libbus I, DiCarlo LA, Ardell JL, Rector TS, Amurthur B, KenKnight BH & Anand IS (2016). Extended follow-up of patients with heart failure receiving autonomic regulation therapy in the ANTHEM-HF study. J Cardiac Fail DOI: 10.1016/j.cardfail.2015.11.002.
321. Priori SG, Wilde AA, Horie M, Cho Y, Behr ER, Berul C, Blom N, Brugada J, Chiang CE, Huikuri H, Kannankeril P, Krahn A, Leenhardt A, Moss A, Schwartz PJ, Shimizu W, Tomaselli G & Tracy C (2013). HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes: document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013. Heart Rhythm 10, 1932–1963.
322. Rajan P & Greenberg H (2015). Obstructive sleep apnea as a risk factor for type 2 diabetes mellitus. Nat Sci Sleep 7, 113–125.
323. Rajendran PS, Nakamura K, Ajijola OA, Vaseghi M, Armour JA, Ardell JL & Shivkumar K (2016). Myocardial infarction induces structural and functional remodelling of the intrinsic cardiac nervous system. J Physiol 594, 321–341.
324. Randall WC, Armour JA, Geis WP & Lippincott DB (1972). Regional cardiac distribution of the sympathetic nerves. Fed Proc 31, 1199–1208.
325. Rassovsky Y & Kushner MG (2003). Carbon dioxide in the study of panic disorder: issues of definition, methodology, and outcome. J Anxiety Disord 17, 1–32.
326. Re RN (2004). Mechanisms of disease: local renin-angiotensin-aldosterone systems and the pathogenesis and treatment of cardiovascular disease. Nat Clin Pract Cardiovasc Med 1, 42–47.
327. Ring C & Brener J (1992). The temporal locations of heartbeat sensations. Psychophysiology 29, 535–545.
328. Ring C, Brener J, Knapp K & Mailloux J (2015). Effects of heartbeat feedback on beliefs about heart rate and heartbeat counting: a cautionary tale about interoceptive awareness. Biol Psychol 104, 193–198.
329. Rizzo S, Basso C, Troost D, Aronica E, Frigo AC, Driessen AH, Thiene G, Wilde AA & van der Wal AC (2014). T-cell-mediated inflammatory activity in the stellate ganglia of patients with ion-channel disease and severe ventricular arrhythmias. Circ Arrhythm Electrophysiol 7, 224–229.
330. Roddie IC (1977). Human responses to emotional stress. Ir J Med Sci 146, 395–417.
331. Rodrigues B, Jorge L, Mostarda CT, Rosa KT, Medeiros A, Malfitano C, de Souza AL Jr, Viegas KA, Lacchini S, Curi R, Brum PC, De Angelis K & Irigoyen MC (2012). Aerobic exercise training delays cardiac dysfunction and improves autonomic control of circulation in diabetic rats undergoing myocardial infarction. J Card Fail 18, 734–744.
332. Rodrigues F, Feriani DJ, Barboza CA, Abssamra ME, Rocha LY, Carrozi NM, Mostarda C, Figueroa D, Souza GI, De Angelis K, Irigoyen MC & Rodrigues B (2014). Cardioprotection afforded by exercise training prior to myocardial infarction is associated with autonomic function improvement. BMC Cardiovasc Disord 14, 84.
333. Roston TM, Vinocur JM, Maginot KR, Mohammed S, Salerno JC, Etheridge SP, Cohen M, Hamilton RM, Pflaumer A, Kanter RJ, Potts JE, LaPage MJ, Collins KK, Gebauer RA, Temple JD, Batra AS, Erickson C, Miszczak-Knecht M, Kubus P, Bar-Cohen Y, Kantoch M, Thomas VC, Hessling G, Anderson C, Young ML, Cabrera Ortega M, Lau YR, Johnsrude CL, Fournier A, Kannankeril PJ & Sanatani S (2015). Catecholaminergic polymorphic ventricular tachycardia in children: analysis of therapeutic strategies and outcomes from an international multicenter registry. Circ Arrhythm Electrophysiol 8, 633–642.
334. Rouse CH, Jones GE & Jones KR (1988). The effect of body composition and gender on cardiac awareness. Psychophysiology 25, 400–407.
335. Rowan RA & Billingham ME (1988). Myocardial innervation in long-term heart transplant survivors: a quantitative ultrastructural survey. J Heart Transplant 7, 448–452.
336. Rudas L, Crossman AA, Morillo CA, Halliwill JR, Tahvanainen KU, Kuusela TA & Eckberg DL (1999). Human sympathetic and vagal baroreflex responses to sequential nitroprusside and phenylephrine. Am J Physiol Heart Circ Physiol 276, H1691–H1698.
337. Sa JC, Costa EC, da Silva E, Tamburus NY, Porta A, Medeiros LF, Lemos TM, Soares EM & Azevedo GD (2016). Aerobic exercise improves cardiac autonomic modulation in women with polycystic ovary syndrome. Int J Cardiol 202, 356–361.
338. Saccomanno G (1943). The components of the upper thoracic sympathetic nerves. J Comp Neurol 79, 355–378.
339. Sakakura K, Ladich E, Cheng Q, Otsuka F, Yahagi K, Fowler DR, Kolodgie FD, Virmani R & Joner M (2014). Anatomic assessment of sympathetic peri-arterial renal nerves in man. J Am Coll Cardiol 64, 635–643.
340. Schachter SC (2002). Vagus nerve stimulation therapy summary: five years after FDA approval. Neurology 59, S15–S20.
341. Schandry R (1981). Heart beat perception and emotional experience. Psychophysiology 18, 483–488.
342. Schandry R, Bestler M & Montoya P (1993). On the relation between cardiodynamics and heartbeat perception. Psychophysiology 30, 467–474.
343. Schauerte P, Scherlag BJ, Pitha J, Scherlag MA, Reynolds D, Lazzara R & Jackman WM (2000). Catheter ablation of cardiac autonomic nerves for prevention of vagal atrial fibrillation. Circulation 102, 2774–2780.
344. Schmidt G, Malik M, Barthel P, Schneider R, Ulm K, Rolnitzky L, Camm AJ, Bigger JT Jr & Schomig A (1999). Heart-rate turbulence after ventricular premature beats as a predictor of mortality after acute myocardial infarction. Lancet 353, 1390–1396.
345. Schneider TR, Ring C & Katkin ES (1998). A test of the validity of the method of constant stimuli as an index of heartbeat detection. Psychophysiology 35, 86–89.
346. Schoonmaker FW, Carey T & Grow JB Sr (1975). Treatment of tachyarrhythmias and bradyarrhythmias by cardiac sympathectomy and permanent ventricular pacing. Ann Thoracic Surg 19, 80–87.
347. Schroeder S, Gerlach AL, Achenbach S & Martin A (2015). The relevance of accuracy of heartbeat perception in noncardiac and cardiac chest pain. Int J Behav Med 22, 258–267.
348. Schunck T, Erb G, Mathis A, Gilles C, Namer IJ, Hode Y, Demaziere A, Luthringer R & Macher JP (2006). Functional magnetic resonance imaging characterization of CCK-4-induced panic attack and subsequent anticipatory anxiety. Neuroimage 31, 1197–1208.
349. Schwaiblmair M, von Scheidt W, Uberfuhr P, Ziegler S, Schwaiger M, Reichart B & Vogelmeier C (1999). Functional significance of cardiac reinnervation in heart transplant recipients. J Heart Lung Transplant 18, 838–845.
350. Schwartz PJ (2014). Cardiac sympathetic denervation to prevent life-threatening arrhythmias. Nat Rev Cardiol 11, 346–353.
351. Schwartz PJ (2015). When the risk is sudden death, does quality of life matter? Heart Rhythm 13, 70–71.
352. Schwartz PJ & Ackerman MJ (2013). The long QT syndrome: a transatlantic clinical approach to diagnosis and therapy. Eur Heart J 34, 3109–3116.
353. Schwartz PJ, De Ferrari GM, Sanzo A, Landolina M, Rordorf R, Raineri C, Campana C, Revera M, Ajmone-Marsan N, Tavazzi L & Odero A (2008). Long term vagal stimulation in patients with advanced heart failure: first experience in man. Eur J Heart Fail 10, 884–891.
354. Schwartz PJ, Periti M & Malliani A (1975). The long Q-T syndrome. Am Heart J 89, 378–390.
355. Schwartz PJ, Priori SG, Cerrone M, Spazzolini C, Odero A, Napolitano C, Bloise R, De Ferrari GM, Klersy C, Moss AJ, Zareba W, Robinson JL, Hall WJ, Brink PA, Toivonen L, Epstein AE, Li C & Hu D (2004). Left cardiac sympathetic denervation in the management of high-risk patients affected by the long-QT syndrome. Circulation 109, 1826–1833.
356. Schwenk TL (2008). Cardiovascular events during World Cup soccer. N Engl J Med 358, 2408.
357. Seth AK & Critchley HD (2013). Extending predictive processing to the body: Emotion as interoceptive inference. Behav Brain Sci 36, 227–228.
358. Sha Y, Scherlag BJ, Yu L, Sheng X, Jackman WM, Lazzara R & Po SS (2011). Low-level right vagal stimulation: anticholinergic and antiadrenergic effects. J Cardiovasc Electrophysiol 22, 1147–1153.
359. Shen MJ, Hao-Che C, Park HW, George Akingba A, Chang PC, Zheng Z, Lin SF, Shen C, Chen LS, Chen Z, Fishbein MC, Chiamvimonvat N & Chen PS (2013). Low-level vagus nerve stimulation upregulates small conductance calcium-activated potassium channels in the stellate ganglion. Heart Rhythm 10, 910–915.
360. Shen MJ, Shinohara T, Park HW, Frick K, Ice DS, Choi EK, Han S, Maruyama M, Sharma R, Shen C, Fishbein MC, Chen LS, Lopshire JC, Zipes DP, Lin SF & Chen PS (2011). Continuous low-level vagus nerve stimulation reduces stellate ganglion nerve activity and paroxysmal atrial tachyarrhythmias in ambulatory canines. Circulation 123, 2204–2212.
361. Shen MJ & Zipes DP (2014). Role of the autonomic nervous system in modulating cardiac arrhythmias. Circ Res 114, 1004–1021.
362. Sheng X, Scherlag BJ, Yu L, Li S, Ali R, Zhang Y, Fu G, Nakagawa H, Jackman WM, Lazzara R & Po SS (2011). Prevention and reversal of atrial fibrillation inducibility and autonomic remodeling by low-level vagosympathetic nerve stimulation. J Am Coll Cardiol 57, 563–571.
363. Sherrington C (1961). The Integrative Action of the Nervous System. Yale University Press, New Haven.
364. Sica AL, Gootman PM, Gootman N & Armour JA (1994). Neuronal activity of the stellate ganglia in neonatal swine. J Auton Nerv Syst 48, 273–277.
365. Smeets JL, Allessie MA, Lammers WJ, Bonke FI & Hollen J (1986). The wavelength of the cardiac impulse and reentrant arrhythmias in isolated rabbit atrium. The role of heart rate, autonomic transmitters, temperature, and potassium. Circ Res 58, 96–108.
366. Smyth HS, Sleight P & Pickering GW (1969). Reflex regulation of arterial pressure during sleep in man. A quantitative method of assessing baroreflex sensitivity. Circ Res 24, 109–121.
367. Somers VK, Dyken ME, Clary MP & Abboud FM (1995). Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 96, 1897–1904.
368. Somers VK, Dyken ME, Mark AL & Abboud FM (1992). Parasympathetic hyperresponsiveness and bradyarrhythmias during apnoea in hypertension. Clin Auton Res 2, 171–176.
369. Somers VK, Mark AL & Abboud FM (1988). Potentiation of sympathetic nerve responses to hypoxia in borderline hypertensive subjects. Hypertension 11, 608–612.
370. Somers VK, Mark AL & Abboud FM (1991). Interaction of baroreceptor and chemoreceptor reflex control of sympathetic nerve activity in normal humans. J Clin Invest 87, 1953–1957.
371. Somers VK, Mark AL, Zavala DC & Abboud FM (1989). Contrasting effects of hypoxia and hypercapnia on ventilation and sympathetic activity in humans. J Appl Physiol 67, 2101–2106.
372. Somers VK, White DP, Amin R, Abraham WT, Costa F, Culebras A, Daniels S, Floras JS, Hunt CE, Olson LJ, Pickering TG, Russell R, Woo M & Young T (2008). Sleep apnea and cardiovascular disease: an American Heart Association/American College Of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council On Cardiovascular Nursing. In collaboration with the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health). Circulation 118, 1080–1111.
373. Soukhova-O'Hare GK, Cheng ZJ, Roberts AM & Gozal D (2006). Postnatal intermittent hypoxia alters baroreflex function in adult rats. Am J Physiol Heart Circ Physiol 290, H1157–1164.
374. Spierer DK, DeMeersman RE, Kleinfeld J, McPherson E, Fullilove RE, Alba A & Zion AS (2007). Exercise training improves cardiovascular and autonomic profiles in HIV. Clin Auton Res 17, 341–348.
375. Spuck S, Tronnier V, Orosz I, Schonweiler R, Sepehrnia A, Nowak G & Sperner J (2010). Operative and technical complications of vagus nerve stimulator implantation. Neurosurgery 67, 489–494.
376. Starling EH (1908). The chemical control of the body. JAMA L, 835–840.
377. Stavrakis S, Humphrey MB, Scherlag BJ, Hu Y, Jackman WM, Nakagawa H, Lockwood D, Lazzara R & Po SS (2015). Low-level transcutaneous electrical vagus nerve stimulation suppresses atrial fibrillation. J Am Coll Cardiol 65, 867–875.
378. Stavrakis S, Scherlag BJ, Fan Y, Liu Y, Liu Q, Mao J, Cai H, Lazzara R & Po SS (2012). Antiarrhythmic effects of vasostatin-1 in a canine model of atrial fibrillation. J Cardiovasc Electrophysiol 23, 771–777.
379. Steinbeck G, Andresen D, Seidl K, Brachmann J, Hoffmann E, Wojciechowski D, Kornacewicz-Jach Z, Sredniawa B, Lupkovics G, Hofgartner F, Lubinski A, Rosenqvist M, Habets A, Wegscheider K & Senges J (2009). Defibrillator implantation early after myocardial infarction. N Engl J Med 361, 1427–1436.
380. Steinberg JS, Pokushalov E & Mittal S (2013). Renal denervation for arrhythmias: hope or hype? Curr Cardiol Rep 15, 392.
381. Stella A & Zanchetti A (1991). Functional role of renal afferents. Physiol Rev 71, 659–682.
382. Taggart P, Boyett MR, Logantha S & Lambiase PD (2011). Anger, emotion, and arrhythmias: from brain to heart. Front Physiol 2, 67.
383. Tai CT, Chiou CW, Wen ZC, Hsieh MH, Tsai CF, Lin WS, Chen CC, Lin YK, Yu WC, Ding YA, Chang MS & Chen SA (2000). Effect of phenylephrine on focal atrial fibrillation originating in the pulmonary veins and superior vena cava. J Am Coll Cardiol 36, 788–793.
384. Tan AY, Li H, Wachsmann-Hogiu S, Chen LS, Chen PS & Fishbein MC (2006). Autonomic innervation and segmental muscular disconnections at the human pulmonary vein-atrial junction: implications for catheter ablation of atrial-pulmonary vein junction. J Am Coll Cardiol 48, 132–143.
385. Taylor JA, Halliwill JR, Brown TE, Hayano J & Eckberg DL (1995). ‘Non-hypotensive’ hypovolaemia reduces ascending aortic dimensions in humans. J Physiol 483, 289–298.
386. Telles S, Nagarathna R & Nagendra HR (1995). Autonomic changes during “OM” meditation. Indian J Physiol Pharmacol 39, 418–420.
387. Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski M, Cammann VL, Sarcon A, Geyer V, Neumann CA, Seifert B, Hellermann J, Schwyzer M, Eisenhardt K, Jenewein J, Franke J, Katus HA, Burgdorf C, Schunkert H, Moeller C, Thiele H, Bauersachs J, Tschope C, Schultheiss HP, Laney CA, Rajan L, Michels G, Pfister R, Ukena C, Bohm M, Erbel R, Cuneo A, Kuck KH, Jacobshagen C, Hasenfuss G, Karakas M, Koenig W, Rottbauer W, Said SM, Braun-Dullaeus RC, Cuculi F, Banning A, Fischer TA, Vasankari T, Airaksinen KE, Fijalkowski M, Rynkiewicz A, Pawlak M, Opolski G, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Crea F, Dichtl W, Franz WM, Empen K, Felix SB, Delmas C, Lairez O, Erne P, Bax JJ, Ford I, Ruschitzka F, Prasad A & Luscher TF (2015). Clinical features and outcomes of takotsubo (stress) cardiomyopathy. N Engl J Med 373, 929–938.
388. ten Harkel AD, van Lieshout JJ, Karemaker JM & Wieling W (1993). Differences in circulatory control in normal subjects who faint and who do not faint during orthostatic stress. Clin Auton Res 3, 117–124.
389. Thalmann M, Trampitsch E, Haberfellner N, Eisendle E, Kraschl R & Kobinia G (2001). Resuscitation in near drowning with extracorporeal membrane oxygenation. The Ann Thorac Surg 72, 607–608.
390. Thayer JF & Lane RD (2000). A model of neurovisceral integration in emotion regulation and dysregulation. J Affect Disord 61, 201–216.
391. Thayer JF & Lane RD (2009). Claude Bernard and the heart-brain connection: further elaboration of a model of neurovisceral integration. Neurosci Biobehav Rev 33, 81–88.
392. Thoren PN (1977). Characteristics of left ventricular receptors with nonmedullated vagal afferents in cats. Circ Res 40, 415–421.
393. Thurston RC, Rewak M & Kubzansky LD (2013). An anxious heart: anxiety and the onset of cardiovascular diseases. Prog Cardiovasc Dis 55, 524–537.
394. Tomney PA, Hopkins DA & Armour JA (1985). Axonal branching of canine sympathetic postganglionic cardiopulmonary neurons. A retrograde fluorescent labeling study. Brain Res Bull 14, 443–452.
395. Trzebski A, Tafil M, Zoltowski M & Przybylski J (1982). Increased sensitivity of the arterial chemoreceptor drive in young men with mild hypertension. Cardiovasc Res 16, 163–172.
396. Tsai CF, Chen SA, Tai CT, Chiou CW, Prakash VS, Yu WC, Hsieh MH, Ding YA & Chang MS (1999). Bezold-Jarisch-like reflex during radiofrequency ablation of the pulmonary vein tissues in patients with paroxysmal focal atrial fibrillation. J Cardiovasc Electrophysiol 10, 27–35.
397. Tzafriri AR, Keating JH, Markham PM, Spognardi AM, Stanley JR, Wong G, Zani BG, Highsmith D, O'Fallon P, Fuimaono K, Mahfoud F & Edelman ER (2015). Arterial microanatomy determines the success of energy-based renal denervation in controlling hypertension. Sci Transl Med 7, 285ra265.
398. Valderrabano M, Chen HR, Sidhu J, Rao L, Ling Y & Khoury DS (2009). Retrograde ethanol infusion in the vein of Marshall: regional left atrial ablation, vagal denervation and feasibility in humans. Circ Arrhythm Electrophysiol 2, 50–56.
399. Vance WH & Bowker RC (1983). Spinal origins of cardiac afferents from the region of the left anterior descending artery. Brain Res 258, 96–100.
400. Van der Does AJW, Antony MM, Ehlers A & Barsky AJ (2000). Heartbeat perception in panic disorder: a reanalysis. Behav Res Ther 38, 47–62.
401. Vanoli E, De Ferrari GM, Stramba-Badiale M, Hull SS Jr, Foreman RD & Schwartz PJ (1991). Vagal stimulation and prevention of sudden death in conscious dogs with a healed myocardial infarction. Circ Res 68, 1471–1481.
402. Vaseghi M, Gima J, Kanaan C, Ajijola OA, Marmureanu A, Mahajan A & Shivkumar K (2014). Cardiac sympathetic denervation in patients with refractory ventricular arrhythmias or electrical storm: intermediate and long-term follow-up. Heart Rhythm 11, 360–366.
403. Vaseghi M, Lellouche N, Ritter H, Fonarow GC, Patel JK, Moriguchi J, Fishbein MC, Kobashigawa JA & Shivkumar K (2009). Mode and mechanisms of death after orthotopic heart transplantation. Heart Rhythm 6, 503–509.
404. Vaseghi M, Lux RL, Mahajan A & Shivkumar K (2012). Sympathetic stimulation increases dispersion of repolarization in humans with myocardial infarction. Am J Physiol Heart Circ Physiol 302, H1838–H1846.
405. Vaseghi M & Shivkumar K (2008). The role of the autonomic nervous system in sudden cardiac death. Prog Cardiovasc Dis 50, 404–419.
406. Vracko R, Thorning D & Frederickson RG (1991). Nerve fibers in human myocardial scars. Hum Pathol 22, 138–146.
407. i in cardiac sympathetic neurons. J Mol Cell Cardiol 43, 717–725.
408. Wehrwein EA, Joyner MJ, Hart EC, Wallin BG, Karlsson T & Charkoudian N (2010). Blood pressure regulation in humans: calculation of an “error signal” in control of sympathetic nerve activity. Hypertension 55, 264–269.
409. Wellens HJ, Schwartz PJ, Lindemans FW, Buxton AE, Goldberger JJ, Hohnloser SH, Huikuri HV, Kaab S, La Rovere MT, Malik M, Myerburg RJ, Simoons ML, Swedberg K, Tijssen J, Voors AA & Wilde AA (2014). Risk stratification for sudden cardiac death: current status and challenges for the future. Eur Heart J 35, 1642–1651.
410. Whitehead WE, Drescher VM & Heiman P (1977). Relation of heart rate control to heartbeat perception. Biofeedback Self Regul 2, 371–392.
411. Wilbert-Lampen U, Leistner D, Greven S, Pohl T, Sper S, Volker C, Guthlin D, Plasse A, Knez A, Kuchenhoff H & Steinbeck G (2008). Cardiovascular events during World Cup soccer. N Engl J Med 358, 475–483.
412. Wilbert-Lampen U, Nickel T, Leistner D, Guthlin D, Matis T, Volker C, Sper S, Kuchenhoff H, Kaab S & Steinbeck G (2010). Modified serum profiles of inflammatory and vasoconstrictive factors in patients with emotional stress-induced acute coronary syndrome during World Cup Soccer 2006. J Am Coll Cardiol 55, 637–642.
413. Wilde AA, Bhuiyan ZA, Crotti L, Facchini M, De Ferrari GM, Paul T, Ferrandi C, Koolbergen DR, Odero A & Schwartz PJ (2008). Left cardiac sympathetic denervation for catecholaminergic polymorphic ventricular tachycardia. N Engl J Med 358, 2024–2029.
414. Wilhelm M (2014). Atrial fibrillation in endurance athletes. Eur J Prev Cardiol 21, 1040–1048.
415. Windmann S, Schonecke OW, Frohlig G & Maldener G (1999). Dissociating beliefs about heart rates and actual heart rates in patients with cardiac pacemakers. Psychophysiology 36, 339–342.
416. Wittstein IS, Thiemann DR, Lima JA, Baughman KL, Schulman SP, Gerstenblith G, Wu KC, Rade JJ, Bivalacqua TJ & Champion HC (2005). Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med 352, 539–548.
417. Woo MA, Kumar R, Macey PM, Fonarow GC & Harper RM (2009). Brain injury in autonomic, emotional, and cognitive regulatory areas in patients with heart failure. J Card Fail 15, 214–223.
418. Woo MA, Macey PM, Fonarow GC, Hamilton MA & Harper RM (2003). Regional brain gray matter loss in heart failure. J Appl Physiol 95, 677–684.
419. Woo MA, Macey PM, Keens PT, Kumar R, Fonarow GC, Hamilton MA & Harper RM (2005). Functional abnormalities in brain areas that mediate autonomic nervous system control in advanced heart failure. J Card Fail 11, 437–446.
420. Woo MA, Macey PM, Keens PT, Kumar R, Fonarow GC, Hamilton MA & Harper RM (2007). Aberrant central nervous system responses to the Valsalva maneuver in heart failure. Congest Heart Fail 13, 29–35.
421. Woo MA, Palomares JA, Macey PM, Fonarow GC, Harper RM & Kumar R (2015). Global and regional brain mean diffusivity changes in patients with heart failure. J Neurosci Res 93, 678–685.
422. Wood A, Docimo S & Elkowitz DE (2010). Cardiovascular disease and its association with histological changes of the left stellate ganglion. Clin Med Insights Pathol 3, 19–24.
423. Yamakawa K, Rajendran PS, Takamiya T, Yagishita D, So EL, Mahajan A, Shivkumar K & Vaseghi M (2015). Vagal nerve stimulation activates vagal afferent fibers that reduce cardiac efferent parasympathetic effects. Am J Physiol Heart Circ Physiol 309, H1579–1590.
424. Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Drazner MH, Fonarow GC, Geraci SA, Horwich T, Januzzi JL, Johnson MR, Kasper EK, Levy WC, Masoudi FA, McBride PE, McMurray JJ, Mitchell JE, Peterson PN, Riegel B, Sam F, Stevenson LW, Tang WH, Tsai EJ & Wilkoff BL (2013). 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation 128, e240–e327.
425. Ye S, Zhong H, Yanamadala V & Campese VM (2002). Renal injury caused by intrarenal injection of phenol increases afferent and efferent renal sympathetic nerve activity. Am J Hypertens 15, 717–724.
426. Yu L, Scherlag BJ, Li S, Fan Y, Dyer J, Male S, Varma V, Sha Y, Stavrakis S & Po SS (2013). Low-level transcutaneous electrical stimulation of the auricular branch of the vagus nerve: a noninvasive approach to treat the initial phase of atrial fibrillation. Heart Rhythm 10, 428–435.
427. Yuan BX, Ardell JL, Hopkins DA, Losier AM & Armour JA (1994). Gross and microscopic anatomy of the canine intrinsic cardiac nervous system. Anat Rec 239, 75–87.
428. Zamir M, Kimmerly DS & Shoemaker JK (2012). Cardiac mechanoreceptor function implicated during premature ventricular contraction. Auton Neurosci 167, 50–55.
429. Zannad F, De Ferrari GM, Tuinenburg AE, Wright D, Brugada J, Butter C, Klein H, Neuzil P, Botman C, Castel MA, D'Onofrio A, De Borst GJ, Solomon S, Stein KM, Meyer S, Schubert B, Stalsberg K, Wold N, Ruble S & Stolen C (2015a). Long term safety and efficacy results of the NEural Cardiac TherApy foR Heart Failure (NECTAR-HF) trial. J Cardiac Fail 21, 936.
430. Zannad F, De Ferrari GM, Tuinenburg AE, Wright D, Brugada J, Butter C, Klein H, Stolen C, Meyer S, Stein KM, Ramuzat A, Schubert B, Daum D, Neuzil P, Botman C, Castel MA, D'Onofrio A, Solomon SD, Wold N & Ruble SB (2015b). Chronic vagal stimulation for the treatment of low ejection fraction heart failure: results of the NEural Cardiac TherApy foR Heart Failure (NECTAR-HF) randomized controlled trial. Eur Heart J 36, 425–433.
431. Zhang Y, Popovic ZB, Bibevski S, Fakhry I, Sica DA, Van Wagoner DR & Mazgalev TN (2009). Chronic vagus nerve stimulation improves autonomic control and attenuates systemic inflammation and heart failure progression in a canine high-rate pacing model. Circ Heart Fail 2, 692–699.
432. Zheng H, Sharma NM, Liu X & Patel KP (2012). Exercise training normalizes enhanced sympathetic activation from the paraventricular nucleus in chronic heart failure: role of angiotensin II. Am J Physiol Regul Integr Comp Physiol 303, R387–R394.
433. Zhou S, Chen LS, Miyauchi Y, Miyauchi M, Kar S, Kangavari S, Fishbein MC, Sharifi B & Chen PS (2004). Mechanisms of cardiac nerve sprouting after myocardial infarction in dogs. Circ Res 95, 76–83.
434. Ziegelstein RC (2007). Acute emotional stress and cardiac arrhythmias. JAMA 298, 324–329.
435. Zipes DP, Festoff B, Schaal SF, Cox C, Sealy WC & Wallace AG (1968). Treatment of ventricular arrhythmia by permanent atrial pacemaker and cardiac sympathectomy. Ann Intern Med 68, 591–597.
436. Zipes DP, Mihalick MJ & Robbins GT (1974). Effects of selective vagal and stellate ganglion stimulation of atrial refractoriness. Cardiovasc Res 8, 647–655.
437. Zipes DP, Neuzil P, Theres H, Caraway D, Mann DL, Mannheimer C, Van Buren P, Linde C, Linderoth B, Kueffer F, Sarazin SA & DeJongste MJ (2016). Determining the feasibility of spinal cord neuromodulation for the treatment of chronic systolic heart failure: The DEFEAT-HF study. JACC Heart Fail 4, 129–136.
438. Zoellner LA & Craske MG (1999). Interoceptive accuracy and panic. Behav Res Ther 37, 1141–1158.