Exercise training normalizes enhanced sympathetic activation from the paraventricular nucleus in chronic heart failure: Role of angiotensin II

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 303, Issue 4, 2012, Pages

  Zheng, Hong ^a   Sharma, Neeru M ^a   Liu, Xuefei ^a   Patel, Kaushik P ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

At1 receptors; Blood pressure; Central nervous system; Renal nerve activity

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; TRANSCRIPTION FACTOR FOSB; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; LOSARTAN; CITRATE SYNTHASE; NORADRENALIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; EXERCISE; HEART FAILURE; HEART RATE; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; MEAN ARTERIAL PRESSURE; NERVOUS SYSTEM PARAMETERS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RENAL SYMPATHETIC NERVE ACTIVITY; SEDENTARY LIFESTYLE; SHAM PROCEDURE; SYMPATHETIC ACTIVATION; SYMPATHETIC FUNCTION; TREADMILL EXERCISE; WESTERN BLOTTING; ADRENERGIC SYSTEM; ANIMAL; BLOOD PRESSURE; DRUG EFFECT; INNERVATION; KIDNEY; NERVE CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; ENZYME ACTIVITY; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; MALE; SYMPATHETIC NERVE;

ANGIOTENSIN II; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; BLOOD PRESSURE; HEART FAILURE; HEART RATE; KIDNEY; LOSARTAN; NEURONS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PHYSICAL CONDITIONING, ANIMAL; RATS; SYMPATHETIC NERVOUS SYSTEM;

EID: 84865136978     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00046.2012     Document Type: Article

References (48)

1. Barbella Y, Cierco M, Israel A. Effect of Losartan, a nonpeptide angiotensin II receptor antagonist, on drinking behavior and renal actions of centrally administered renin. Proc Soc Exp Biol Med 202: 401-406, 1993.
2. Belardinelli R. Exercise training in chronic heart failure: how to harmonize oxidative stress, sympathetic outflow, and angiotensin II. Circulation 115: 3042-3044, 2007.
3. Belardinelli R, Georgiou D, Cianci G, Purcaro A. Randomized, controlled trial of long-term moderate exercise training in chronic heart failure: effects on functional capacity, quality of life, and clinical outcome. Circulation 99: 1173-1182, 1999.
4. Brändle M, Patel KP, Wang W, Zucker IH. Hemodynamic and norepinephrine responses to pacing-induced heart failure in conscious sinoaorticdenervated dogs. J Appl Physiol 81: 1855-1862, 1996.
5. Chen QH, Toney GM. Responses to GABA-A receptor blockade in the hypothalamic PVN are attenuated by local AT1 receptor antagonism. Am J Physiol Regul Integr Comp Physiol 285: R1231-R1239, 2003.
6. Coote JH, Sato Y. Reflex regulation of sympathetic activity in the spontaneously hypertensive rat. Circ Res 40: 571-577, 1977.
7. Diz DI, Garcia-Espinosa MA, Gegick S, Tommasi EN, Ferrario CM, Ann Tallant E, Chappell MC, Gallagher KP. Injections of angiotensinconverting enzyme 2 inhibitor MLN4760 into nucleus tractus solitarii reduce baroreceptor reflex sensitivity for heart rate control in rats. Exp Physiol 93: 694-700, 2008.
8. Gao L, Wang W, Li YF, Schultz HD, Liu D, Cornish KG, Zucker IH. Superoxide mediates sympathoexcitation in heart failure: roles of angiotensin II and NAD(P)H oxidase. Circ Res 95: 937-944, 2004.
9. Gao L, Wang W, Liu D, Zucker IH. Exercise training normalizes sympathetic outflow by central antioxidant mechanisms in rabbits with pacing-induced chronic heart failure. Circulation 115: 3095-3102, 2007.
10. Hirooka Y, Kishi T, Sakai K, Takeshita A, Sunagawa K. Imbalance of central nitric oxide and reactive oxygen species in the regulation of sympathetic activity and neural mechanisms of hypertension. Am J Physiol Regul Integr Comp Physiol 300: R818-R826, 2011.
11. Hopp FA, Seagard JL, Kampine JP. Comparison of four methods of averaging nerve activity. Am J Physiol Regul Integr Comp Physiol 251: R700-R711, 1986.
12. Howe BM, Bruno SB, Higgs KA, Stigers RL, Cunningham JT. FosB expression in the central nervous system following isotonic volume expansion in unanesthetized rats. Exp Neurol 187: 190-198, 2004.
13. Kang YM, Ma Y, Elks C, Zheng JP, Yang ZM, Francis J. Cross-talk between cytokines and renin-angiotensin in hypothalamic paraventricular nucleus in heart failure: role of nuclear factor-kappaB. Cardiovasc Res 79: 671-678, 2008.
14. Kannan H, Yamashita H. Connections of neurons in the region of the nucleus tractus solitarius with the hypothalamic paraventricular nucleus: Their possible involvement in neural control of the cardiovascular system in rats. Brain Res 329: 205-212, 1985.
15. Kar S, Gao L, Zucker IH. Exercise training normalizes ACE and ACE2 in the brain of rabbits with pacing-induced heart failure. J Appl Physiol 108: 923-932, 2010.
16. Kaye DM, Lefkovits J, Cox H, Lambert G, Jennings G, Turner A, Esler MD. Regional epinephrine kinetics in human heart failure: Evidence for extra-adrenal, nonneural release. Am J Physiol Heart Circ Physiol 269: H182-H188, 1995.
17. Kleiber AC, Zheng H, Schultz HD, Peuler JD, Patel KP. Exercise training normalizes enhanced glutamate-mediated sympathetic activation from the PVN in heart failure. Am J Physiol Regul Integr Comp Physiol 294: R1863-R1872, 2008.
18. Knight WD, Little JT, Carreno FR, Toney GM, Mifflin SW, Cunningham JT. Chronic intermittent hypoxia increases blood pressure and expression of FosB/DeltaFosB in central autonomic regions. Am J Physiol Regul Integr Comp Physiol 301: R131-R139, 2011.
19. Kumagai K, Reid IA. Angiotensin II exerts differential actions on renal nerve activity and heart rate. Hypertension 24: 451-456, 1994.
20. Latchford KJ, Ferguson AV. ANG II-induced excitation of paraventricular nucleus magnocellular neurons: a role for glutamate interneurons. Am J Physiol Regul Integr Comp Physiol 286: R894-R902, 2004.
21. Leenen FHH, Huang BS, Yu HL, Yuan BX. Brain 'ouabain' mediates sympathetic hyperactivity in congestive heart failure. Circ Res 77: 993-1000, 1995.
22. Leimbach WN, Gunner wallin B, Victor RG, Aylward PE, Sundlof G, Mark AL. Direct evidence from intraneural recordings for increased central symapthetic outflow in patients with heart failure. Circulation 73: 913-919, 1986.
23. Levett JM, Marinelli CC, Lund DD, Pardini BJ, Nader S, Scott BD, Augelli NV, Kerber RE, Schmid PG Jr. Effects of β-blockade on neurohumoral responses and neurochemical markers in pacing-induced heart failure. Am J Physiol Heart Circ Physiol 266: H468-H475, 1994.
24. Li DP, Chen SR, Pan HL. Angiotensin II stimulates spinally projecting paraventricular neurons through presynaptic disinhibition. J Neurosci 23: 5041-5049, 2003.
25. Li YF, Cornish KG, Patel KP. Alteration of NMDA NR1 receptors within the paraventricular nucleus of hypothalamus in rats with heart failure. Circ Res 93: 990-997, 2003.
26. Liu JL, Irvine S, Reid IA, Patel KP, Zucker IH. Chronic exercise reduces sympathetic nerve activity in rabbits with pacing-induced heart failure-A role for angiotensin II. Circulation 102: 1854-1862, 2000.
27. Liu JL, Kulakofsky J, Zucker IH. Exercise training enhances baroreflex control of heart rate by a vagal mechanism in rabbits with heart failure. J Appl Physiol 92: 2403-2408, 2002.
28. Musch TI, Terrell JA. Skeletal muscle blood flow abnormalities in rats with a chronic myocardial infarction: rest and exercise. Am J Physiol Heart Circ Physiol 262: H411-H419, 1992.
29. O'Connor CM, Whellan DJ, Lee KL, Keteyian SJ, Cooper LS, Ellis SJ, Leifer ES, Kraus WE, Kitzman DW, Blumenthal JA, Rendall DS, Miller NH, Fleg JL, Schulman KA, McKelvie RS, Zannad F, Pina IL, Investigators HA. Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA 301: 1439-1450, 2009.
30. Packer M. Neurohormonal interactions and adaptations in congestive heart failure. Circulation 77: 721-730, 1988.
31. Palkovits M, Brownstein M. Brain microdissection techniques. In: Brain Microdissection Techniques, edited by Cuello AE. Chichester: Wiley, 1983.
32. Patel KP. Neural regulation in experimental heart failure. Baillieres Clin Neurol 6: 283-296, 1997.
33. Patel KP, Zhang PL, Krukoff TL. Alterations in brain hexokinase activity associated with heart failure in rats. Am J Physiol Regul Integr Comp Physiol 265: R923-R928, 1993.
34. Patel KP, Zheng H. Central neural control of sympathetic nerve activity in heart failure following exercise training. Am J Physiol Heart Circ Physiol 302: H527-H537, 2012.
35. Roveda F, Middlekauff HR, Rondon MU, Reis SF, Souza M, Nastari L, Barretto AC, Krieger EM, Negrao CE. The effects of exercise training on sympathetic neural activation in advanced heart failure: a randomized controlled trial. J Am Coll Cardiol 42: 854-860, 2003.
36. Shafton AD, Ryan A, Badoer E. Neurons in the hypothalamic paraventricular nucleus send collaterals to the spinal cord and to the rostral ventrolateral medulla in the rat. Brain Res 801: 239-243, 1998.
37. Sharma NM, Zheng H, Li YF, Patel KP. Nitric oxide inhibits the expression of AT1 receptors in neurons. Am J Physiol Cell Physiol 302: C1162-C1173, 2012.
38. Srere PA. Citrate synthase. In: Methods in Enzymology 1969, vol. 13, p. 3-11.
39. Swanson LW, Sawchenko PE. Paraventricular nucleus: a site for the integration of neuroendocrine and autonomic mechanisms. Neuroendocrinology 31: 410-417, 1980.
40. Wang HJ, Zhang F, Zhang Y, Gao XY, Wang W, Zhu GQ. AT1 receptor in paraventricular nucleus mediates the enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure. Auton Neurosci 121: 56-63, 2005.
41. Xu B, Zheng H, Patel KP. Enhanced activation of RVLM projecting PVN neurons in rats with chronic heart failure. Am J Physiol Heart Circ Physiol 302: H1700-H1711, 2012.
42. Yamazato M, Yamazato Y, Sun C, Diez-Freire C, Raizada MK. Overexpression of angiotensin-converting enzyme 2 in the rostral ventrolateral medulla causes long-term decrease in blood pressure in the spontaneously hypertensive rats. Hypertension 49: 926-931, 2007.
43. Zhang K, Li YF, Patel KP. Blunted nitric oxide-mediated inhibition of renal nerve discharge within PVN of rats with heart failure. Am J Physiol Heart Circ Physiol 281: H995-H1004, 2001.
44. Zhang K, Li YF, Patel KP. Reduced endogenous GABA-mediated inhibition in the PVN on renal nerve discharge in rats with heart failure. Am J Physiol Regul Integr Comp Physiol 282: R1006-R1015, 2002.
45. Zhang K, Patel KP. Effect of nitric oxide within the paraventricular nucleus on renal sympathetic nerve discharge: role of GABA. Am J Physiol Regul Integr Comp Physiol 275: R728-R734, 1998.
46. Zheng H, Li YF, Cornish KG, Zucker IH, Patel KP. Exercise training improves endogenous nitric oxide mechanisms within the paraventricular nucleus in rats with heart failure. Am J Physiol Heart Circ Physiol 288: H2332-H2341, 2005.
47. Zheng H, Li YF, Wang W, Patel KP. Enhanced angiotensin-mediated excitation of renal sympathetic nerve activity within the paraventricular nucleus of anesthetized rats with heart failure. Am J Physiol Regul Integr Comp Physiol 297: R1364-R1374, 2009.
48. Zhu GQ, Gao L, Li Y, Patel KP, Zucker IH, Wang W. AT1 receptor mRNA antisense normalizes enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure. Am J Physiol Heart Circ Physiol 287: H1828-H1835, 2004.