Altered interoceptive awareness in anorexia nervosa: Effects of meal anticipation, consumption and bodily arousal

International Journal of Eating Disorders

Volumn 48, Issue 7, 2015, Pages 889-897

  Khalsa, Sahib S ^a   Craske, Michelle G ^a,b   Li, Wei ^b   Vangala, Sitaram ^c   Strober, Michael ^a   Feusner, Jamie D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

anorexia nervosa; anxiety; arousal; autonomic; eating; heartbeat; interoception; interoceptive awareness; isoproterenol; respiration

Indexed keywords

ISOPRENALINE; SODIUM CHLORIDE;

ACCURACY; ADULT; ANOREXIA NERVOSA; ANTICIPATION; ANXIETY; AROUSAL; ARTICLE; BREATHING; CALORIC INTAKE; CLINICAL ARTICLE; COMORBIDITY; CONTROLLED STUDY; CORRELATION ANALYSIS; DYSPNEA; FEMALE; FOOD INTAKE; GENERALIZED ANXIETY DISORDER; HEART BEAT; HEART PALPITATION; HUMAN; INTEROCEPTION; INTEROCEPTIVE AWARENESS; MAJOR DEPRESSION; OBSESSIVE COMPULSIVE DISORDER; PERCEPTIVE THRESHOLD; PHENOTYPE; PREDICTION; PRIORITY JOURNAL; AWARENESS; PATHOPHYSIOLOGY; PERCEPTION; RETROSPECTIVE STUDY; YOUNG ADULT;

ANOREXIA NERVOSA; AROUSAL; AWARENESS; FEMALE; HUMANS; PERCEPTION; RETROSPECTIVE STUDIES; YOUNG ADULT;

EID: 84944570506     PISSN: 02763478     EISSN: 1098108X     Source Type: Journal    
DOI: 10.1002/eat.22387     Document Type: Article

References (43)

1. Bruch H., Perceptual and conceptual disturbances in anorexia nervosa. Psychosom Med 1962; 24: 187- 194.
2. Bruch H., Transformation of oral impulses in eating disorders: A conceptual approach. Psychiatr Q 1961; 35: 458- 481.
3. Garner DM, Olmstead MP, Polivy J., Development and validation of a multidimensional eating disorder inventory for anorexia nervosa and bulimia. Int J Eat Disord 1983; 2: 15-34.
4. Clausen L, Rosenvinge JH, Friborg O, Rokkedal K., Validating the eating disorder inventory-3 (EDI-3): A comparison between 561 female eating disorders patients and 878 females from the general population. J Psychopathol Behav Assess 2011; 33: 101- 110.
5. Coddington RD, Bruch H., Gastric perceptivity in normal, obese and schizophrenic subjects. Psychosomatics 1970; 11: 571- 579.
6. Crisp AH., Some aspects of the evolution, presentation and follow-up of anorexia nervosa. Proc R Soc Med 1965; 58: 814- 820.
7. Silverstone JT, Russell GF., Gastric "hunger" contractions in anorexia nervosa. Br J Psychiatry 1967; 113: 257- 263.
8. Garfinkel PE., Perception of hunger and satiety in anorexia nervosa. Psychol Med 1974; 4: 309- 315.
9. Halmi KA, Sunday SR., Temporal patterns of hunger and fullness ratings and related cognitions in anorexia and bulimia. Appetite 1991; 16: 219- 237.
10. Garfinkel PE, Moldofsky H, Garner DM, Stancer HC, Coscina DV., Body awareness in anorexia nervosa: Disturbances in "body image" and "satiety". Psychosom Med 1978; 40: 487- 498.
11. Steinglass JE, Sysko R, Mayer L, Berner LA, Schebendach J, Wang Y, Chen H, Albano AM, Simpson HB, Walsh BT., Pre-meal anxiety and food intake in anorexia nervosa. Appetite 2010; 55: 214- 218.
12. Wierenga CE, Bischoff-Grethe A, Melrose AJ, Irvine Z, Torres L, Bailer U, Simmons A, Fudge JL, McClure SL, Ely A, Kaye, WH., Hunger does not motivate reward in women remitted from anorexia nervosa. Biol Psychiatry, in press. DOI: http://dx.doi.org/ 10.1016/j.biopsych.2014.09.024.
13. Kaye WH, Fudge JL, Paulus M., New insights into symptoms and neurocircuit function of anorexia nervosa. Nat Rev Neurosci 2009; 10: 573- 584.
14. Kaye WH, Wagner A, Fudge JL, Paulus M., Neurocircuity of eating disorders. Curr Top Behav Neurosci 2011; 6: 7- 57.
15. Oberndorfer T, Simmons A, McCurdy D, Strigo I, Matthews S, Yang T, Irvine Z, Kaye W., Greater anterior insula activation during anticipation of food images in women recovered from anorexia nervosa versus controls. Psychiatry Res 2013; 214: 132- 141.
16. Cowdrey FA, Park RJ, Harmer CJ, McCabe C., Increased neural processing of rewarding and aversive food stimuli in recovered anorexia nervosa. Biol Psychiatry 2011; 70: 736- 743.
17. Strigo IA, Matthews SC, Simmons AN, Oberndorfer T, Klabunde M, Reinhardt LE, Kaye WH., Altered insula activation during pain anticipation in individuals recovered from anorexia nervosa: Evidence of interoceptive dysregulation. Int J Eat Disord 2013; 46: 23- 33.
18. Oberndorfer TA, Frank GK, Simmons AN, Wagner A, McCurdy D, Fudge JL, Yang TT, Paulus MP, Kaye WH., Altered insula response to sweet taste processing after recovery from anorexia and bulimia nervosa. Am J Psychiatry 2013; 170: 1143- 1151.
19. Wagner A, Aizenstein H, Mazurkewicz L, Fudge J, Frank GK, Putnam K, Bailer UF, Fischer L, Kaye WH., Altered insula response to taste stimuli in individuals recovered from restricting-type anorexia nervosa. Neuropsychopharmacology 2008; 33: 513- 523.
20. Pollatos O, Kurz AL, Albrecht J, Schreder T, Kleemann AM, Schopf V, Kopietz R, Wiesmann M, Schandry R., Reduced perception of bodily signals in anorexia nervosa. Eat Behav 2008; 9: 381- 388.
21. Klabunde M, Acheson DT, Boutelle KN, Matthews SC, Kaye WH., Interoceptive sensitivity deficits in women recovered from bulimia nervosa. Eat Behav 2013; 14: 488- 492.
22. Khalsa SS, Rudrauf D, Damasio AR, Davidson RJ, Lutz A, Tranel D., Interoceptive awareness in experienced meditators. Psychophysiology 2008; 45: 671- 677.
23. Ring C, Brener J., Influence of beliefs about heart rate and actual heart rate on heartbeat counting. Psychophysiology 1996; 33: 541- 546.
24. Windmann S, Schonecke, OW, Frohlig G, Maldener G., Dissociating beliefs about heart rates and actual heart rates in patients with cardiac pacemakers. Psychophysiology 1999; 36: 339- 342.
25. Schandry R, Bestler M., Montoya P., On the relation between cardiodynamics and heartbeat perception. Psychophysiology 1993; 30: 467- 474.
26. Eshkevari E, Rieger E, Musiat P, Treasure J., An investigation of interoceptive sensitivity in eating disorders using a heartbeat detection task and a self-report measure. Eur Eat Disord Rev 2014; 22: 383- 388.
27. Kaye WH, George DT, Gwirtsman HE, Jimerson DC, Goldstein DS, Ebert MH, Lake CR., Isoproterenol infusion test in anorexia nervosa: Assessment of pre- and post-beta-noradrenergic receptor activity. Psychopharmacol Bull 1990; 26: 355- 359.
28. Khalsa SS, Rudrauf D, Sandesara C, Olshansky B, Tranel D., Bolus isoproterenol infusions provide a reliable method for assessing interoceptive awareness. Int J Psychophysiol 2009; 72: 34- 45.
29. Cameron OG, Minoshima S., Regional brain activation due to pharmacologically induced adrenergic interoceptive stimulation in humans. Psychosom Med 2002; 64: 851- 861.
30. Khalsa SS, Rudrauf D, Feinstein JS, Tranel D., The pathways of interoceptive awareness. Nat Neurosci 2009; 12: 1494- 1496.
31. Domschke K, Stevens S, Pfleiderer B, Gerlach AL., Interoceptive sensitivity in anxiety and anxiety disorders: An overview and integration of neurobiological findings. Clin Psychol Rev 2010; 30: 1- 11.
32. Ehlers A, Breuer P., How good are patients with panic disorder at perceiving their heartbeats? Biol Psychol 1996; 42: 165- 182.
33. Arnold JM, McDevitt DG., Heart rate and blood pressure responses to intravenous boluses of isoprenaline in the presence of propranolol, practolol and atropine. Br J Clin Pharmacol 1983; 16: 175- 184.
34. Mills PJ, Dimsdale JE, Ancoli-Israel S, Clausen J, Loredo JS., The effects of hypoxia and sleep apnea on isoproterenol sensitivity. Sleep 1998; 21: 731- 735.
35. Pollatos O, Kurz A-L, Albrecht J, Schreder T, Kleemann AM, Schöpf V, Kopietz R, Wiesmann M, Schandry R., Reduced perception of bodily signals in anorexia nervosa. Eat Behav 2008; 9: 381- 388.
36. Paulus MP, Stein MB., An insular view of anxiety. Biol Psychiatry 2006; 60: 383- 387.
37. Zucker NL, Merwin RM, Bulik CM, Moskovich A, Wildes JE, Groh J., Subjective experience of sensation in anorexia nervosa. Behav Res Ther 2013; 51: 256- 265.
38. Keizer A, Smeets MA, Dijkerman HC, van den Hout M, Klugkist I, van Elburg A, Postma A, Tactile body image disturbance in anorexia nervosa. Psychiatry Res 2011; 190: 115- 120.
39. Keizer A, Smeets MA, Dijkerman HC, van Elburg A, Postma A., Aberrant somatosensory perception in Anorexia Nervosa. Psychiatry Res 2012; 200: 530- 537.
40. Zoellner LA, Craske MG., Interoceptive accuracy and panic. Behav Res Ther 1999; 37: 1141- 1158.
41. Dunn BD, Dalgleish T, Ogilvie AD, Lawrence AD., Heartbeat perception in depression. Behav Res Ther 2007; 45: 1921- 1930.
42. Avery JA, Drevets WC, Moseman SE, Bodurka J, Barcalow JC, Simmons WK,. Major depressive disorder is associated with abnormal interoceptive activity and functional connectivity in the Insula. Biol Psychiatry 2014; 76: 258-266.
43. Marona-Lewicka D, Nichols DE., Drug discrimination studies of the interoceptive cues produced by selective serotonin uptake inhibitors and selective serotonin releasing agents. Psychopharmacology (Berl) 1998; 138: 67- 75.