메뉴 건너뛰기




Volumn 44, Issue 3, 2008, Pages 477-485

Neuropeptide Y reduces acetylcholine release and vagal bradycardia via a Y2 receptor-mediated, protein kinase C-dependent pathway

Author keywords

Acetylcholine; Heart rate; Neuropeptide Y; Protein kinase C; Sinoatrial node

Indexed keywords

ACETYLCHOLINE; CALPHOSTIN; CARBACHOL; CHOLINE ACETYLTRANSFERASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; ENZYME INHIBITOR; NEUROPEPTIDE Y; NEUROPEPTIDE Y2 RECEPTOR; PROTEIN KINASE C;

EID: 40649086450     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2007.10.001     Document Type: Article
Times cited : (72)

References (43)
  • 1
    • 0021194420 scopus 로고
    • Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure
    • Cohn J.N., Levine T.B., Olivari M.T., Garberg V., Lura D., Francis G.S., et al. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N Engl J Med 311 (1984) 819-823
    • (1984) N Engl J Med , vol.311 , pp. 819-823
    • Cohn, J.N.1    Levine, T.B.2    Olivari, M.T.3    Garberg, V.4    Lura, D.5    Francis, G.S.6
  • 2
    • 0023100673 scopus 로고
    • Decreased heart rate variability and its association with increased mortality after acute myocardial infarction
    • Kleiger R.E., Miller J.P., Bigger Jr. J.T., and Moss A.J. Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol 59 (1987) 256-262
    • (1987) Am J Cardiol , vol.59 , pp. 256-262
    • Kleiger, R.E.1    Miller, J.P.2    Bigger Jr., J.T.3    Moss, A.J.4
  • 3
    • 0032515622 scopus 로고    scopus 로고
    • Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators
    • La Rovere M.T., Bigger Jr. J.T., Marcus F.I., Mortara A., and Schwartz P.J. Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators. Lancet 351 (1998) 478-484
    • (1998) Lancet , vol.351 , pp. 478-484
    • La Rovere, M.T.1    Bigger Jr., J.T.2    Marcus, F.I.3    Mortara, A.4    Schwartz, P.J.5
  • 4
    • 0032514658 scopus 로고    scopus 로고
    • Prospective study of heart rate variability and mortality in chronic heart failure: results of the United Kingdom heart failure evaluation and assessment of risk trial (UK-heart)
    • Nolan J., Batin P.D., Andrews R., Lindsay S.J., Brooksby P., and Mullen M. Prospective study of heart rate variability and mortality in chronic heart failure: results of the United Kingdom heart failure evaluation and assessment of risk trial (UK-heart). Circulation 98 (1998) 1510-1516
    • (1998) Circulation , vol.98 , pp. 1510-1516
    • Nolan, J.1    Batin, P.D.2    Andrews, R.3    Lindsay, S.J.4    Brooksby, P.5    Mullen, M.6
  • 5
    • 0021856095 scopus 로고
    • Prolonged non-adrenergic inhibition of cardiac vagal action following sympathetic stimulation: neuromodulation by neuropeptide Y?
    • Potter E.K. Prolonged non-adrenergic inhibition of cardiac vagal action following sympathetic stimulation: neuromodulation by neuropeptide Y?. Neurosci Lett 54 2-3 (1985) 117-121
    • (1985) Neurosci Lett , vol.54 , Issue.2-3 , pp. 117-121
    • Potter, E.K.1
  • 6
    • 0141841750 scopus 로고    scopus 로고
    • Galanin and neuropeptide Y reduce cholinergic transmission in the heart of the anaesthetised mouse
    • Smith-White M.A., Iismaa T.P., and Potter E.K. Galanin and neuropeptide Y reduce cholinergic transmission in the heart of the anaesthetised mouse. Br J Pharmacol 140 1 (2003) 170-178
    • (2003) Br J Pharmacol , vol.140 , Issue.1 , pp. 170-178
    • Smith-White, M.A.1    Iismaa, T.P.2    Potter, E.K.3
  • 7
    • 26044478415 scopus 로고    scopus 로고
    • Influence of endogenous neuropeptide Y (NPY) on the sympathetic-parasympathetic interaction in the canine heart
    • Ilebekk A., Bjorkman J.A., and Nordlander M. Influence of endogenous neuropeptide Y (NPY) on the sympathetic-parasympathetic interaction in the canine heart. J Cardiovasc Pharmacol 46 4 (2005) 474-480
    • (2005) J Cardiovasc Pharmacol , vol.46 , Issue.4 , pp. 474-480
    • Ilebekk, A.1    Bjorkman, J.A.2    Nordlander, M.3
  • 8
    • 0025675455 scopus 로고
    • Elevation of plasma neuropeptide Y-like immunoreactivity and noradrenaline during myocardial ischaemia in man
    • Ullman B., Franco-Cereceda A., Hulting J., Lundberg J.M., and Sollevi A. Elevation of plasma neuropeptide Y-like immunoreactivity and noradrenaline during myocardial ischaemia in man. J Intern Med 228 6 (1990) 583-589
    • (1990) J Intern Med , vol.228 , Issue.6 , pp. 583-589
    • Ullman, B.1    Franco-Cereceda, A.2    Hulting, J.3    Lundberg, J.M.4    Sollevi, A.5
  • 10
    • 85047679362 scopus 로고
    • Plasma neuropeptide Y on admission to a coronary care unit: raised levels in patients with left heart failure
    • Hulting J., Sollevi A., Ullman B., Franco-Cereceda A., and Lundberg J.M. Plasma neuropeptide Y on admission to a coronary care unit: raised levels in patients with left heart failure. Cardiovasc Res 24 2 (1990) 102-108
    • (1990) Cardiovasc Res , vol.24 , Issue.2 , pp. 102-108
    • Hulting, J.1    Sollevi, A.2    Ullman, B.3    Franco-Cereceda, A.4    Lundberg, J.M.5
  • 11
    • 0021266265 scopus 로고
    • Effects of neuropeptide Y (NPY) on mechanical activity and neurotransmission in the heart, vas deferens and urinary bladder of the guinea-pig
    • Lundberg J.M., Hua X.Y., and Franco-Cereceda A. Effects of neuropeptide Y (NPY) on mechanical activity and neurotransmission in the heart, vas deferens and urinary bladder of the guinea-pig. Acta Physiol Scand 121 4 (1984) 325-332
    • (1984) Acta Physiol Scand , vol.121 , Issue.4 , pp. 325-332
    • Lundberg, J.M.1    Hua, X.Y.2    Franco-Cereceda, A.3
  • 12
    • 0023501962 scopus 로고
    • Presynaptic inhibition of cardiac vagal postganglionic nerves by neuropeptide Y
    • Potter E. Presynaptic inhibition of cardiac vagal postganglionic nerves by neuropeptide Y. Neurosci Lett 83 1-2 (1987) 101-106
    • (1987) Neurosci Lett , vol.83 , Issue.1-2 , pp. 101-106
    • Potter, E.1
  • 13
    • 0026522218 scopus 로고
    • Sites at which neuropeptide Y modulates parasympathetic control of heart rate in guinea pigs and rats
    • Pardini B.J., Lund D.D., and Puk D.E. Sites at which neuropeptide Y modulates parasympathetic control of heart rate in guinea pigs and rats. J Auton Nerv Syst 38 2 (1992) 139-145
    • (1992) J Auton Nerv Syst , vol.38 , Issue.2 , pp. 139-145
    • Pardini, B.J.1    Lund, D.D.2    Puk, D.E.3
  • 14
    • 0023655177 scopus 로고
    • Cardiac vagal action and plasma levels of neuropeptide Y following intravenous injection in the dog
    • Potter E.K. Cardiac vagal action and plasma levels of neuropeptide Y following intravenous injection in the dog. Neurosci Lett 77 2 (1987) 243-247
    • (1987) Neurosci Lett , vol.77 , Issue.2 , pp. 243-247
    • Potter, E.K.1
  • 15
    • 0033034155 scopus 로고    scopus 로고
    • Sympathetic-parasympathetic interactions at the heart in the anaesthetised rat
    • Smith-White M.A., Wallace D., and Potter E.K. Sympathetic-parasympathetic interactions at the heart in the anaesthetised rat. J Auton Nerv Syst 75 2-3 (1999) 171-175
    • (1999) J Auton Nerv Syst , vol.75 , Issue.2-3 , pp. 171-175
    • Smith-White, M.A.1    Wallace, D.2    Potter, E.K.3
  • 16
    • 0035123777 scopus 로고    scopus 로고
    • Effects of a selective neuropeptide Y Y2 receptor antagonist, BIIE0246, on Y2 receptors at peripheral neuroeffector junctions
    • Smith-White M.A., Hardy T.A., Brock J.A., and Potter E.K. Effects of a selective neuropeptide Y Y2 receptor antagonist, BIIE0246, on Y2 receptors at peripheral neuroeffector junctions. Br J Pharmacol 132 4 (2001) 861-868
    • (2001) Br J Pharmacol , vol.132 , Issue.4 , pp. 861-868
    • Smith-White, M.A.1    Hardy, T.A.2    Brock, J.A.3    Potter, E.K.4
  • 17
    • 0037082933 scopus 로고    scopus 로고
    • Role of neuropeptide Y Y(2) receptors in modulation of cardiac parasympathetic neurotransmission
    • Smith-White M.A., Herzog H., and Potter E.K. Role of neuropeptide Y Y(2) receptors in modulation of cardiac parasympathetic neurotransmission. Regul Pept 103 2-3 (2002) 105-111
    • (2002) Regul Pept , vol.103 , Issue.2-3 , pp. 105-111
    • Smith-White, M.A.1    Herzog, H.2    Potter, E.K.3
  • 18
    • 0029952193 scopus 로고    scopus 로고
    • Effects of exogenous neuropeptide Y on automaticity of isolated Purkinje fibers and atrium
    • Sosunov E.A., Anyukhovsky E.P., and Rosen M.R. Effects of exogenous neuropeptide Y on automaticity of isolated Purkinje fibers and atrium. J Mol Cell Cardiol 28 5 (1996) 967-975
    • (1996) J Mol Cell Cardiol , vol.28 , Issue.5 , pp. 967-975
    • Sosunov, E.A.1    Anyukhovsky, E.P.2    Rosen, M.R.3
  • 19
    • 0025908658 scopus 로고
    • Receptors for neuropeptide Y: multiple subtypes and multiple second messengers
    • Michel M.C. Receptors for neuropeptide Y: multiple subtypes and multiple second messengers. Trends Pharmacol Sci 12 10 (1991) 389-394
    • (1991) Trends Pharmacol Sci , vol.12 , Issue.10 , pp. 389-394
    • Michel, M.C.1
  • 20
    • 0031006827 scopus 로고    scopus 로고
    • Neuropeptide Y family of hormones: receptor subtypes and antagonists
    • Balasubramaniam A.A. Neuropeptide Y family of hormones: receptor subtypes and antagonists. Peptides 18 3 (1997) 445-457
    • (1997) Peptides , vol.18 , Issue.3 , pp. 445-457
    • Balasubramaniam, A.A.1
  • 21
    • 0033753142 scopus 로고    scopus 로고
    • Pre-synaptic NO-cGMP pathway modulates vagal control of heart rate in isolated adult guinea pig atria
    • Herring N., Golding S., and Paterson D.J. Pre-synaptic NO-cGMP pathway modulates vagal control of heart rate in isolated adult guinea pig atria. J Mol Cell Cardiol 32 (2000) 1795-1804
    • (2000) J Mol Cell Cardiol , vol.32 , pp. 1795-1804
    • Herring, N.1    Golding, S.2    Paterson, D.J.3
  • 22
    • 0035449929 scopus 로고    scopus 로고
    • Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitro
    • Herring N., and Paterson D.J. Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitro. J Physiol 535 2 (2001) 507-518
    • (2001) J Physiol , vol.535 , Issue.2 , pp. 507-518
    • Herring, N.1    Paterson, D.J.2
  • 23
    • 0035665507 scopus 로고    scopus 로고
    • Natriuretic peptides like NO facilitate cardiac vagal neurotransmission and bradycardia via a cGMP pathway
    • Herring N., Zaman J.A., and Paterson D.J. Natriuretic peptides like NO facilitate cardiac vagal neurotransmission and bradycardia via a cGMP pathway. Am J Physiol Heart Circ Physiol 281 6 (2001) H2318-H2327
    • (2001) Am J Physiol Heart Circ Physiol , vol.281 , Issue.6
    • Herring, N.1    Zaman, J.A.2    Paterson, D.J.3
  • 24
    • 0031860090 scopus 로고    scopus 로고
    • Neuropeptide Y inhibition of calcium channels in PC-12 pheochromocytoma cells
    • McCullough L.A., Egan T.M., and Westfall T.C. Neuropeptide Y inhibition of calcium channels in PC-12 pheochromocytoma cells. Am J Physiol 274 5 Pt 1 (1998) C1290-C1297
    • (1998) Am J Physiol , vol.274 , Issue.5 PART 1
    • McCullough, L.A.1    Egan, T.M.2    Westfall, T.C.3
  • 25
    • 0036965996 scopus 로고    scopus 로고
    • Neuropeptide Y increases 4-aminopyridine-sensitive transient outward potassium current in rat ventricular myocytes
    • Heredia M.P., Fernandez-Velasco M., Benito G., and Delgado C. Neuropeptide Y increases 4-aminopyridine-sensitive transient outward potassium current in rat ventricular myocytes. Br J Pharmacol 135 7 (2002) 1701-1706
    • (2002) Br J Pharmacol , vol.135 , Issue.7 , pp. 1701-1706
    • Heredia, M.P.1    Fernandez-Velasco, M.2    Benito, G.3    Delgado, C.4
  • 26
    • 0030271762 scopus 로고    scopus 로고
    • Presence of neuronal nitric oxide synthase in the suprachiasmatic nuclei of mouse and rat
    • Wang H., and Morris J.F. Presence of neuronal nitric oxide synthase in the suprachiasmatic nuclei of mouse and rat. Neuroscience 74 (1996) 1059-1068
    • (1996) Neuroscience , vol.74 , pp. 1059-1068
    • Wang, H.1    Morris, J.F.2
  • 27
    • 0031969455 scopus 로고    scopus 로고
    • Inhibition of nitric oxide synthase slows heart rate recovery from cholinergic activation
    • Sears C.E., Choate J.K., and Paterson D.J. Inhibition of nitric oxide synthase slows heart rate recovery from cholinergic activation. J Appl Physiol 84 (1998) 1596-1603
    • (1998) J Appl Physiol , vol.84 , pp. 1596-1603
    • Sears, C.E.1    Choate, J.K.2    Paterson, D.J.3
  • 28
    • 0020573797 scopus 로고
    • Relationships between choline uptake, acetylcholine synthesis and acetylcholine release in isolated rat atria
    • Wetzel G.T., and Brown J.H. Relationships between choline uptake, acetylcholine synthesis and acetylcholine release in isolated rat atria. J Pharmacol Exp Ther 226 2 (1983) 343-348
    • (1983) J Pharmacol Exp Ther , vol.226 , Issue.2 , pp. 343-348
    • Wetzel, G.T.1    Brown, J.H.2
  • 29
    • 0034021430 scopus 로고    scopus 로고
    • BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y(2) receptor antagonist
    • Dumont Y., Cadieux A., Doods H., Pheng L.H., Abounader R., Hamel E., et al. BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y(2) receptor antagonist. Br J Pharmacol 129 6 (2000) 1075-1088
    • (2000) Br J Pharmacol , vol.129 , Issue.6 , pp. 1075-1088
    • Dumont, Y.1    Cadieux, A.2    Doods, H.3    Pheng, L.H.4    Abounader, R.5    Hamel, E.6
  • 30
    • 0024550448 scopus 로고
    • Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C
    • Kobayashi E., Nakano H., Morimoto M., and Tamaoki T. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun 159 2 (1989) 548-553
    • (1989) Biochem Biophys Res Commun , vol.159 , Issue.2 , pp. 548-553
    • Kobayashi, E.1    Nakano, H.2    Morimoto, M.3    Tamaoki, T.4
  • 32
    • 0025248571 scopus 로고
    • Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells
    • Chijiwa T., Mishima A., Hagiwara M., Sano M., Hayashi K., Inoue T., et al. Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J Biol Chem 265 9 (1990) 5267-5272
    • (1990) J Biol Chem , vol.265 , Issue.9 , pp. 5267-5272
    • Chijiwa, T.1    Mishima, A.2    Hagiwara, M.3    Sano, M.4    Hayashi, K.5    Inoue, T.6
  • 34
    • 0032837448 scopus 로고    scopus 로고
    • Anti-arrhythmic effect of kappa-opioid receptor stimulation in the perfused rat heart: involvement of a cAMP-dependent pathway
    • Yu X.C., Wang H.X., Pei J.M., and Wong T.M. Anti-arrhythmic effect of kappa-opioid receptor stimulation in the perfused rat heart: involvement of a cAMP-dependent pathway. J Mol Cell Cardiol 31 10 (1999) 1809-1819
    • (1999) J Mol Cell Cardiol , vol.31 , Issue.10 , pp. 1809-1819
    • Yu, X.C.1    Wang, H.X.2    Pei, J.M.3    Wong, T.M.4
  • 35
    • 0037409228 scopus 로고    scopus 로고
    • The mechanism underlying the positive inotropic effect of angiotensin II in the isolated perfused rabbit heart: a 31P NMR study
    • Mielke M., Paterson D.J., Sang A.E., Radda G.K., and Clarke K. The mechanism underlying the positive inotropic effect of angiotensin II in the isolated perfused rabbit heart: a 31P NMR study. Int J Biochem Cell Biol 35 6 (2003) 984-991
    • (2003) Int J Biochem Cell Biol , vol.35 , Issue.6 , pp. 984-991
    • Mielke, M.1    Paterson, D.J.2    Sang, A.E.3    Radda, G.K.4    Clarke, K.5
  • 37
    • 0035958638 scopus 로고    scopus 로고
    • Inhibition of acetylcholine-activated K(+) current by chelerythrine and bisindolylmaleimide I in atrial myocytes from mice
    • Cho H., Youm J.B., Earm Y.E., and Ho W.K. Inhibition of acetylcholine-activated K(+) current by chelerythrine and bisindolylmaleimide I in atrial myocytes from mice. Eur J Pharmacol 424 3 (2001) 173-178
    • (2001) Eur J Pharmacol , vol.424 , Issue.3 , pp. 173-178
    • Cho, H.1    Youm, J.B.2    Earm, Y.E.3    Ho, W.K.4
  • 39
    • 0027325802 scopus 로고
    • Mechanism of presynaptic inhibition by neuropeptide Y at sympathetic nerve terminals
    • Toth P.T., Bindokas V.P., Bleakman D., Colmers W.F., and Miller R.J. Mechanism of presynaptic inhibition by neuropeptide Y at sympathetic nerve terminals. Nature 364 6438 (1993) 635-639
    • (1993) Nature , vol.364 , Issue.6438 , pp. 635-639
    • Toth, P.T.1    Bindokas, V.P.2    Bleakman, D.3    Colmers, W.F.4    Miller, R.J.5
  • 40
    • 0025007074 scopus 로고
    • Inhibition of calcium currents in cultured myenteric neurons by neuropeptide Y: evidence for direct receptor/channel coupling
    • Hirning L.D., Fox A.P., and Miller R.J. Inhibition of calcium currents in cultured myenteric neurons by neuropeptide Y: evidence for direct receptor/channel coupling. Brain Res 5:532 1-2 (1990) 120-130
    • (1990) Brain Res , vol.5 532 , Issue.1-2 , pp. 120-130
    • Hirning, L.D.1    Fox, A.P.2    Miller, R.J.3
  • 41
    • 0025290908 scopus 로고
    • Neuropeptide Y reduces calcium current and inhibits acetylcholine release in nodose neurons via a pertussis toxin-sensitive mechanism
    • Wiley J.W., Gross R.A., Lu Y.X., and Macdonald R.L. Neuropeptide Y reduces calcium current and inhibits acetylcholine release in nodose neurons via a pertussis toxin-sensitive mechanism. J Neurophysiol 63 6 (1990) 1499-1507
    • (1990) J Neurophysiol , vol.63 , Issue.6 , pp. 1499-1507
    • Wiley, J.W.1    Gross, R.A.2    Lu, Y.X.3    Macdonald, R.L.4
  • 42
    • 0028972704 scopus 로고
    • Inhibition of Ca2+ channel currents in human neuroblastoma (SH-SY5Y) cells by neuropeptide Y and a novel cyclic neuropeptide Y analogue
    • McDonald R.L., Vaughan P.F., Beck-Sickinger A.G., and Peers C. Inhibition of Ca2+ channel currents in human neuroblastoma (SH-SY5Y) cells by neuropeptide Y and a novel cyclic neuropeptide Y analogue. Neuropharmacology 34 11 (1995) 1507-1514
    • (1995) Neuropharmacology , vol.34 , Issue.11 , pp. 1507-1514
    • McDonald, R.L.1    Vaughan, P.F.2    Beck-Sickinger, A.G.3    Peers, C.4
  • 43
    • 22744436073 scopus 로고    scopus 로고
    • Disruption of inhibitory G-proteins mediates a reduction in atrial beta-adrenergic signaling by enhancing eNOS expression
    • Danson E.J., Zhang Y.H., Sears C.E., Edwards A.R., Casadei B., and Paterson D.J. Disruption of inhibitory G-proteins mediates a reduction in atrial beta-adrenergic signaling by enhancing eNOS expression. Cardiovasc Res 67 4 (2005) 613-623
    • (2005) Cardiovasc Res , vol.67 , Issue.4 , pp. 613-623
    • Danson, E.J.1    Zhang, Y.H.2    Sears, C.E.3    Edwards, A.R.4    Casadei, B.5    Paterson, D.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.