Chronic vagal stimulation for the treatment of low ejection fraction heart failure: Results of the NEural Cardiac TherApy for Heart Failure (NECTAR-HF) randomized controlled trial

European Heart Journal

Volumn 36, Issue 7, 2015, Pages 425-433

  Zannad, Faiez ^a   De Ferrari, Gaetano M ^b   Tuinenburg, Anton E ^c   Wright, David ^d   Brugada, Josep ^e   Butter, Christian ^f   Klein, Helmut ^g   Stolen, Craig ^h   Meyer, Scott ^h   Stein, Kenneth M ^h   Ramuzat, Agnes ⁱ   Schubert, Bernd ⁱ   Daum, Doug ^h   Neuzil, Petr ^j   Botman, Cornelis ^k   Castel, Maria Angeles ^e   D'Onofrio, Antonio ^l   Solomon, Scott D ^m   Wold, Nicholas ^h   Ruble, Stephen B ^h  

^a UNIVERSITY HOSPITAL OF NANCY   (France)

^b FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d Liverpool Heart and Chest ^*  (United Kingdom)

^e HOSPITAL CLÍNIC   (Spain)

^f Heart Center Brandenburg   (Germany)

^g OTTO VON GUERICKE UNIVERSITY   (Germany)

^h BOSTON SCIENTIFIC CORPORATION   (United States)

ⁱ Guidant Europe   (Belgium)

^j NA HOMOLCE HOSPITAL   (Czech Republic)

^k CATHARINA HOSPITAL   (Netherlands)

^l Azienda Ospedaliera Dei Colli   (Italy)

^m HARVARD MEDICAL SCHOOL   (United States)

more..

Author keywords

Autonomic nervous system; Heart failure; Vagal stimulation

Indexed keywords

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIBIOTIC AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOOP DIURETIC AGENT; MINERALOCORTICOID ANTAGONIST;

ADULT; ANTIBIOTIC THERAPY; ARTICLE; CONTROLLED STUDY; DEVICE INFECTION; ECHOCARDIOGRAPHY; EXERCISE; FEMALE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HOLTER MONITORING; HUMAN; IMPLANTED VAGUS NERVE STIMULATOR; LEFT VENTRICULAR SYSTOLIC DYSFUNCTION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NEW YORK HEART ASSOCIATION CLASS; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SHORT FORM 36; VAGUS NERVE STIMULATION; ADVERSE EFFECTS; CLINICAL TRIAL; ELECTROCARDIOGRAPHY; EXERCISE TOLERANCE; HEART FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART VENTRICLE REMODELING; MIDDLE AGED; PATHOPHYSIOLOGY; PATIENT SAFETY; PHYSIOLOGY; PROCEDURES; TREATMENT OUTCOME;

ELECTROCARDIOGRAPHY, AMBULATORY; EXERCISE TOLERANCE; FEMALE; HEART FAILURE; HUMANS; MALE; MIDDLE AGED; PATIENT SAFETY; QUALITY OF LIFE; TREATMENT OUTCOME; VAGUS NERVE STIMULATION; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 84964698258     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehu345     Document Type: Article

References (17)

1. Mortara A, La Rovere MT, Pinna GD, Prpa A, Maestri R, Febo O et al. Arterial baroreflex modulation of heart rate in chronic heart failure: clinical and hemodynamic correlates and prognostic implications. Circulation 1997;96:3450-3458.
2. Ponikowski P, Anker SD, Chua TP, Szelemej R, Piepoli M, Adamopoulos S et al. Depressed heart rate variability as an independent predictor of death in chronic congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy.Am J Cardiol 1997;79:1645-1650.
3. Li M, Zheng C, Sato T, Kawada T, Sugimachi M, Sunagawa K. Vagal nerve stimulation markedly improves long-term survival after chronic heart failure in rats. Circulation 2004;109:120-124.
4. Sabbah HN, Ilsar I, Zaretsky A, Rastogi S, Wang M, Gupta RC. Vagus nerve stimulation in experimental heart failure. Heart Failure Rev 2011;16:171-178.
5. Schwartz PJ, De Ferrari GM, Sanzo A, Landolina M, Rordorf R, Raineri C et al. Long term vagal stimulation in patients with advanced heart failure: first experience in man. Eur J Heart Failure 2008;10:884-891.
6. De Ferrari GM, Crijns HJ, Borggrefe M, Milasinovic G, Smid J, Zabel M et al. Chronic vagus nerve stimulation: anewand promising therapeutic approach for chronic heart failure. Eur Heart J 2011;32:847-855.
7. MembersATF, McMurray JJV, Adamopoulos S, Anker SD, Auricchio A, BöhmMet al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J 2012;33: 1787-1847.
8. De Ferrari GM, Tuinenburg AE, Ruble S, Brugada J, Klein H, Butter C et al. Rationale and study design of the NEuroCardiac TherApy foR Heart Failure Study: NECTAR-HF. Eur J Heart Failure 2014;16:692-699.
9. Bang H, Ni L, Davis CE. Assessment of blinding in clinical trials. Control Clin Trials 2004; 25:143-156.
10. DeGiorgio CM, Schachter SC, Handforth A, Salinsky M, Thompson J, Uthman B et al. Prospective long-term study of vagus nerve stimulation for the treatment of refractory seizures. Epilepsia 2000;41:1195-1200.
11. Zhang Y, Popovic ZB, Bibevski S, Fakhry I, Sica DA, VanWagoner DR et al. Chronic vagus nerve stimulation improves autonomic control and attenuates systemic inflammation and heart failure progression in a canine high-rate pacing model. Circ Heart Failure 2009;2:692-699.
12. Hamann JJ, Ruble SB, Stolen C, Wang M, Gupta RC, Rastogi S et al. Vagus nerve stimulation improves left ventricular function in a caninemodel of chronic heart failure. Eur J Heart Failure 2013;15:1319-1326.
13. Zannad F, Stough WG, Pina IL, Mehran R, Abraham WT, Anker SD et al. Current challenges for clinical trials of cardiovascular medical devices. Int J Cardiol 2014; 175:30-37.
14. Bhatt DL, Kandzari DE, O'NeillWW, D'Agostino R, Flack JM, Katzen BT et al. Acontrolled trial of renal denervation for resistant hypertension. New Engl J Med 2014; 370:1393-1401.
15. Schulz KF, Grimes DA, Altman DG, Hayes RJ. Blinding and exclusions after allocation in randomised controlled trials: survey of published parallel group trials in obstetrics and gynaecology. BMJ (Clin Res Ed) 1996;312:742-744.
16. De Ferrari GM, Schwartz PJ. Vagus nerve stimulation: from pre-clinical to clinical application: challenges and future directions. Heart Fail Rev 2011;16:195-203.
17. Englot DJ, Chang EF, Auguste KI. Vagus nerve stimulation for epilepsy: a meta-analysis of efficacy and predictors of response. J Neurosurg 2011;115:1248-1255.