메뉴 건너뛰기




Volumn 13, Issue 4, 2016, Pages 347-360

Selective internal radiation therapy in treatment of hepatocellular carcinoma: New concepts of personalization

Author keywords

biomarker panel; blood; hepatocellular carcinoma; individual patient profiles; noninvasive methods; patient stratification; predictive preventive personalized medicine; radioresistance; radiosensitivity; selective internal radiation therapy

Indexed keywords

BIOLOGICAL MARKER; CYTOKINE; PROGRAMMED DEATH 1 RECEPTOR; REACTIVE OXYGEN METABOLITE;

EID: 84978820201     PISSN: 17410541     EISSN: 1744828X     Source Type: Journal    
DOI: 10.2217/pme-2016-0014     Document Type: Review
Times cited : (3)

References (113)
  • 2
    • 84992077669 scopus 로고    scopus 로고
    • Time for paradigm in hepatocellular carcinoma management: Is an advanced approach by predictive preventive and personalized medicine in horizon?
    • (Manuscript in press)
    • Abraham JA, Golubnitschaja O. Time for paradigm in hepatocellular carcinoma management: is an advanced approach by predictive, preventive and personalized medicine in horizon? Pers. Med. doi:10.2217/pme-2016-0013 (2016) (Manuscript in press).
    • (2016) Pers. Med
    • Abraham, J.A.1    Golubnitschaja, O.2
  • 4
    • 79251575901 scopus 로고    scopus 로고
    • Radioembolization results in longer time-to-progression and reduced toxicity compared with chemoembolization in patients with hepatocellular carcinoma
    • Salem R, Lewandowski RJ, Kulik L et al. Radioembolization results in longer time-to-progression and reduced toxicity compared with chemoembolization in patients with hepatocellular carcinoma. Gastroenterology 140(2), 497-507 (2011).
    • (2011) Gastroenterology , vol.140 , Issue.2 , pp. 497-507
    • Salem, R.1    Lewandowski, R.J.2    Kulik, L.3
  • 5
    • 84884352541 scopus 로고    scopus 로고
    • Increased quality of life among hepatocellular carcinoma patients treated with radioembolization, compared with chemoembolization
    • Salem R, Gilbertsen M, Butt Z et al. Increased quality of life among hepatocellular carcinoma patients treated with radioembolization, compared with chemoembolization. Clin. Gastroenterol. Hepatol. 11(10), 1358-1365 (2013).
    • (2013) Clin. Gastroenterol. Hepatol. , vol.11 , Issue.10 , pp. 1358-1365
    • Salem, R.1    Gilbertsen, M.2    Butt, Z.3
  • 6
    • 84988352959 scopus 로고    scopus 로고
    • Yttrium-90 radioembolization vs sorafenib for intermediate-locally advanced hepatocellular carcinoma: A cohort study with propensity score analysis
    • Gramenzi A, Golferi R, Mosconi C et al. Yttrium-90 radioembolization vs sorafenib for intermediate-locally advanced hepatocellular carcinoma: a cohort study with propensity score analysis. Liver Int. 35(3), 1036-1047 (2015).
    • (2015) Liver Int. , vol.35 , Issue.3 , pp. 1036-1047
    • Gramenzi, A.1    Golferi, R.2    Mosconi, C.3
  • 7
    • 84978912642 scopus 로고    scopus 로고
    • SorAfenib Versus RADIOEMBOLIZATION in Advanced Hepatocellular Carcinoma (SARAH)
    • SorAfenib Versus RADIOEMBOLIZATION in Advanced Hepatocellular Carcinoma (SARAH). https://clinicaltrials.gov/ct2/show/NCT01482442
  • 8
    • 84978912629 scopus 로고    scopus 로고
    • Y-90 Alone or With Sorafenib for Pre-Transplant Hepatocellular Carcinoma
    • Y-90 Alone or With Sorafenib for Pre-Transplant Hepatocellular Carcinoma. https://clinicaltrials.gov/ct2/show/NCT00846131
  • 9
    • 84978871172 scopus 로고    scopus 로고
    • Sorafenib and Micro-therapy Guided by Primovist Enhanced MRI in Patients With Inoperable Liver Cancer (SORAMIC)
    • Sorafenib and Micro-therapy Guided by Primovist Enhanced MRI in Patients With Inoperable Liver Cancer (SORAMIC). https://clinicaltrials.gov/ct2/show/NCT001126645
  • 10
    • 84978870161 scopus 로고    scopus 로고
    • Study to Compare Selective Internal Radiation Therapy (SIRT) Versus Sorafenib in Locally Advanced Hepatocellular Carcinoma (HCC) (SIRveNIB)
    • Study to Compare Selective Internal Radiation Therapy (SIRT) Versus Sorafenib in Locally Advanced Hepatocellular Carcinoma (HCC) (SIRveNIB). https://clinicaltrials.gov/ct2/show/NCT01135056
  • 11
    • 84978817605 scopus 로고    scopus 로고
    • Transarterial RAdioembolization Versus ChemoEmbolization for the Treatment of Hepatocellular Carcinoma (HCC) (TRACE)
    • Transarterial RAdioembolization Versus ChemoEmbolization for the Treatment of Hepatocellular Carcinoma (HCC) (TRACE). https://clinicaltrials.gov/ct2/show/NCT01381211
  • 12
    • 84978808570 scopus 로고    scopus 로고
    • Chemoembolization Versus Radioembolization in Treating Patients With Liver Cancer That Cannot Be Treated With Radiofrequency Ablation Or Surgery
    • Chemoembolization Versus Radioembolization in Treating Patients With Liver Cancer That Cannot Be Treated With Radiofrequency Ablation Or Surgery. https://clinicaltrials.gov/ct2/show/NCT00956930
  • 13
    • 84995802705 scopus 로고    scopus 로고
    • Radioembolization with Yttrium-90 microspheres for patients with unresectable hepatocellular carcinoma
    • Bhangoo MS, Karnani DR, Hein PN et al. Radioembolization with Yttrium-90 microspheres for patients with unresectable hepatocellular carcinoma. J. Gastrointest. Oncol. 6(5), 469-478 (2015).
    • (2015) J. Gastrointest. Oncol. , vol.6 , Issue.5 , pp. 469-478
    • Bhangoo, M.S.1    Karnani, D.R.2    Hein, P.N.3
  • 15
    • 84927693006 scopus 로고    scopus 로고
    • Radioembolization of hepatocellular carcinoma activates liver regeneration, induces infammation and endothelial stress and activates coagulation
    • Fernandez-Ros N, Inarrairaegui M, Paramo JA et al. Radioembolization of hepatocellular carcinoma activates liver regeneration, induces infammation and endothelial stress and activates coagulation. Liver Int. 35(5), 1590-1596 (2015).
    • (2015) Liver Int. , vol.35 , Issue.5 , pp. 1590-1596
    • Fernandez-Ros, N.1    Inarrairaegui, M.2    Paramo, J.A.3
  • 16
    • 84992062425 scopus 로고    scopus 로고
    • "molecular signature" in blood of liver cancer diagnosed patients as a criterion for optimal therapy modalities
    • Golubnitschaja O, Cebioglu M, Yeghiazaryan K, Pieper C, Schild HH. "Molecular signature" in blood of liver cancer diagnosed patients as a criterion for optimal therapy modalities. EPMA J. 5(Suppl. 1), A38 (2014).
    • (2014) EPMA J. , vol.5 , pp. A38
    • Golubnitschaja, O.1    Cebioglu, M.2    Yeghiazaryan, K.3    Pieper, C.4    Schild, H.H.5
  • 17
    • 84992063360 scopus 로고    scopus 로고
    • Predictive and prognostic biomarker panel for targeted application of radioembolisation improving individual outcomes in hepatocellular carcinoma
    • Abraham JA, Golubnitschaja O. Predictive and prognostic biomarker panel for targeted application of radioembolisation improving individual outcomes in hepatocellular carcinoma. EPMA J. 7(Suppl. 1), A1 (2016).
    • (2016) EPMA J. , vol.7 , pp. A1
    • Abraham, J.A.1    Golubnitschaja, O.2
  • 18
    • 84927773122 scopus 로고    scopus 로고
    • Predictive Preventive and Personalised Medicine as the hardcore of "horizon 2020": EPMA position paper
    • Golubnitschaja O, Kinkorova J, Costigliola V Predictive, Preventive and Personalised Medicine as the hardcore of "Horizon 2020": EPMA position paper. EPMA J. 5(1), 6 (2014).
    • (2014) EPMA J. , vol.5 , Issue.1 , pp. 6
    • Golubnitschaja, O.1    Kinkorova, J.2    Costigliola, V.3
  • 19
    • 84978871202 scopus 로고    scopus 로고
    • Radioembolization for the treatment of unresectable hepatocellular carcinoma
    • Kaseb AO (Ed.). InTech, Rijeka, Croatia
    • Ahmadzadehfar H, Sabet A, Biersack HJ. Radioembolization for the treatment of unresectable hepatocellular carcinoma. In: Hepatocellular Carcinoma-Future Outlook. Kaseb AO (Ed.). InTech, Rijeka, Croatia, 41-62 (2013).
    • (2013) Hepatocellular Carcinoma-Future Outlook , pp. 41-62
    • Ahmadzadehfar, H.1    Sabet, A.2    Biersack, H.J.3
  • 20
    • 84928994049 scopus 로고    scopus 로고
    • Radioembolization with Yttrium-90 microspheres in hepatocellular carcinoma: Role and perspectives
    • Mosconi C, Cappelli A, Pettinato C, Golferi R. Radioembolization with Yttrium-90 microspheres in hepatocellular carcinoma: role and perspectives. World J. Hepatol. 7(5), 738-752 (2015).
    • (2015) World J. Hepatol. , vol.7 , Issue.5 , pp. 738-752
    • Mosconi, C.1    Cappelli, A.2    Pettinato, C.3    Golferi, R.4
  • 21
    • 84882840397 scopus 로고    scopus 로고
    • Safety of 90Y radioembolization in patients who have undergone previous external beam radiation therapy
    • Lam MG, Abdelmaksoud MH, Chang DT et al. Safety of 90Y radioembolization in patients who have undergone previous external beam radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 87(2), 323-329 (2013).
    • (2013) Int. J. Radiat. Oncol. Biol. Phys. , vol.87 , Issue.2 , pp. 323-329
    • Lam, M.G.1    Abdelmaksoud, M.H.2    Chang, D.T.3
  • 22
    • 84938862557 scopus 로고    scopus 로고
    • Intraarterial Hepatic SPECT/CT Imaging Using 99mTc-Macroaggregated Albumin in Preparation for Radioembolization
    • Gates VL, Singh N, Lewandowski RJ, Spies S, Salem R. Intraarterial Hepatic SPECT/CT Imaging Using 99mTc-Macroaggregated Albumin in Preparation for Radioembolization. J. Nucl. Med. 56(8), 1157-1162 (2015).
    • (2015) J. Nucl. Med. , vol.56 , Issue.8 , pp. 1157-1162
    • Gates, V.L.1    Singh, N.2    Lewandowski, R.J.3    Spies, S.4    Salem, R.5
  • 23
    • 84889063485 scopus 로고    scopus 로고
    • Selective interarterial radiation therapy (SIRT) in colorectal liver metastases: How do we monitor response?
    • Hipps D, Ausania F, Manas DM, Rose JD, French JJ. Selective interarterial radiation therapy (SIRT) in colorectal liver metastases: how do we monitor response? HPB Surg. 2013, 570808 (2013).
    • (2013) HPB Surg. , vol.2013 , pp. 570808
    • Hipps, D.1    Ausania, F.2    Manas, D.M.3    Rose, J.D.4    French, J.J.5
  • 24
    • 84956597804 scopus 로고    scopus 로고
    • Clinical impact of (99m)Tc-MAA SPECT/CT-based dosimetry in the radioembolization of liver malignancies with (90)Y-loaded microspheres
    • Garin E, Rolland Y, Laffont S, Edeline J. Clinical impact of (99m)Tc-MAA SPECT/CT-based dosimetry in the radioembolization of liver malignancies with (90)Y-loaded microspheres. Eur. J. Nucl. Med. Mol. Imaging 43(3), 559-575 (2016).
    • (2016) Eur. J. Nucl. Med. Mol. Imaging , vol.43 , Issue.3 , pp. 559-575
    • Garin, E.1    Rolland, Y.2    Laffont, S.3    Edeline, J.4
  • 25
    • 84868313408 scopus 로고    scopus 로고
    • Yttrium 90 microspheres for the treatment of hepatocellular carcinoma
    • Vauthey J-N, Brouquet A (Eds.). Springer Berlin Heidelberg, Germany
    • Memon K, Lewandowski RJ, Riaz A, Salem R. Yttrium 90 microspheres for the treatment of hepatocellular carcinoma. In: Multidisciplinary Treatment of Hepatocellular Carcinoma. Vauthey J-N, Brouquet A (Eds.). Springer Berlin Heidelberg, Germany, 207-224 (2013).
    • (2013) Multidisciplinary Treatment of Hepatocellular Carcinoma , pp. 207-224
    • Memon, K.1    Lewandowski, R.J.2    Riaz, A.3    Salem, R.4
  • 26
    • 84868322986 scopus 로고    scopus 로고
    • Transplantation for hepatocellular carcinoma: The North American experience
    • Vauthey J-N, Brouquet A (Eds.). Springer Berlin Heidelberg, Germany
    • Earl TM, Chapman WC. Transplantation for hepatocellular carcinoma: the North American experience. In: Multidisciplinary Treatment of Hepatocellular Carcinoma. Vauthey J-N, Brouquet A (Eds.). Springer Berlin Heidelberg, Germany, 145-164 (2013).
    • (2013) Multidisciplinary Treatment of Hepatocellular Carcinoma , pp. 145-164
    • Earl, T.M.1    Chapman, W.C.2
  • 28
    • 84893861481 scopus 로고    scopus 로고
    • Position paper of the EPMA and EFLM: A global vision of the consolidated promotion of an integrative medical approach to advance health care
    • Golubnitschaja O, Watson ID, Topic E, Sandberg S, Ferrari M, Costigliola V. Position paper of the EPMA and EFLM: a global vision of the consolidated promotion of an integrative medical approach to advance health care. EPMA J. 4(1), 12 (2013).
    • (2013) EPMA J. , vol.4 , Issue.1 , pp. 12
    • Golubnitschaja, O.1    Watson, I.D.2    Topic, E.3    Sandberg, S.4    Ferrari, M.5    Costigliola, V.6
  • 29
    • 84887832461 scopus 로고    scopus 로고
    • Risk assessment, disease prevention and personalised treatments in breast cancer: Is clinically qualifed integrative approach in the horizon?
    • Golubnitschaja O, Yeghiazaryan K, Costigliola V et al. Risk assessment, disease prevention and personalised treatments in breast cancer: is clinically qualifed integrative approach in the horizon? EPMA J. 4(1), 6 (2013).
    • (2013) EPMA J. , vol.4 , Issue.1 , pp. 6
    • Golubnitschaja, O.1    Yeghiazaryan, K.2    Costigliola, V.3
  • 30
    • 69249213965 scopus 로고    scopus 로고
    • Complications following radioembolization with Yttrium-90 microspheres: A comprehensive literature review
    • Riaz A, Lewandowski RJ, Kulik LM et al. Complications following radioembolization with Yttrium-90 microspheres: a comprehensive literature review. J. Vasc. Interv. Radiol. 20(9), 1121-1130 (2009).
    • (2009) J. Vasc. Interv. Radiol. , vol.20 , Issue.9 , pp. 1121-1130
    • Riaz, A.1    Lewandowski, R.J.2    Kulik, L.M.3
  • 31
    • 84874478395 scopus 로고    scopus 로고
    • Prognostic factors and prevention of radioembolization-induced liver disease
    • Gil-Alzugaray B, Chopitea A, Inarrairaegui M et al. Prognostic factors and prevention of radioembolization-induced liver disease. Hepatology 57(3), 1078-1087 (2013).
    • (2013) Hepatology , vol.57 , Issue.3 , pp. 1078-1087
    • Gil-Alzugaray, B.1    Chopitea, A.2    Inarrairaegui, M.3
  • 32
    • 41149125065 scopus 로고    scopus 로고
    • Liver disease induced by radioembolization of liver tumors: Description and possible risk factors
    • Sangro B, Gil-Alzugaray B, Rodriguez J et al. Liver disease induced by radioembolization of liver tumors: description and possible risk factors. Cancer 112(7), 1538-1546 (2008).
    • (2008) Cancer , vol.112 , Issue.7 , pp. 1538-1546
    • Sangro, B.1    Gil-Alzugaray, B.2    Rodriguez, J.3
  • 33
    • 84921395900 scopus 로고    scopus 로고
    • Molecular responses of radiation-induced liver damage in rats
    • Cheng W, Xiao L, Ainiwaer A et al. Molecular responses of radiation-induced liver damage in rats. Mol. Med. Rep. 11(4), 2592-2600 (2015).
    • (2015) Mol. Med. Rep. , vol.11 , Issue.4 , pp. 2592-2600
    • Cheng, W.1    Xiao, L.2    Ainiwaer, A.3
  • 34
    • 0027949363 scopus 로고
    • Treatment of inoperable hepatocellular carcinoma with intrahepatic arterial Yttrium-90 microspheres: A Phase i and II study
    • Lau WY, Leung WT, Ho S et al. Treatment of inoperable hepatocellular carcinoma with intrahepatic arterial Yttrium-90 microspheres: a Phase I and II study. Br. J. Cancer 70(5), 994-999 (1994).
    • (1994) Br. J. Cancer , vol.70 , Issue.5 , pp. 994-999
    • Lau, W.Y.1    Leung, W.T.2    Ho, S.3
  • 35
    • 83955163009 scopus 로고    scopus 로고
    • Patient selection and activity planning guide for selective internal radiotherapy with Yttrium-90 resin microspheres
    • Lau W-Y, Kennedy AS, Kim YH et al. Patient selection and activity planning guide for selective internal radiotherapy with Yttrium-90 resin microspheres. Int. J. Radiat. Oncol. Biol. Phys. 82(1), 401-407 (2012).
    • (2012) Int. J. Radiat. Oncol. Biol. Phys. , vol.82 , Issue.1 , pp. 401-407
    • Lau, W.-Y.1    Kennedy, A.S.2    Kim, Y.H.3
  • 36
    • 84856770809 scopus 로고    scopus 로고
    • Dosimetry based on 99mTc-macroaggregated albumin SPECT/CT accurately predicts tumor response and survival in hepatocellular carcinoma patients treated with 90Y-loaded glass microspheres: Preliminary results
    • Garin E, Lenoir L, Rolland Y et al. Dosimetry based on 99mTc-macroaggregated albumin SPECT/CT accurately predicts tumor response and survival in hepatocellular carcinoma patients treated with 90Y-loaded glass microspheres: preliminary results. J. Nucl. Med. 53(2), 255-263 (2012).
    • (2012) J. Nucl. Med. , vol.53 , Issue.2 , pp. 255-263
    • Garin, E.1    Lenoir, L.2    Rolland, Y.3
  • 37
    • 84876743410 scopus 로고    scopus 로고
    • Yttrium-90 radioembolization for intermediate-advanced hepatocellular carcinoma: A Phase 2 study
    • Mazzaferro V, Sposito C, Bhoori S et al. Yttrium-90 radioembolization for intermediate-advanced hepatocellular carcinoma: a Phase 2 study. Hepatology 57(5), 1826-1837 (2013).
    • (2013) Hepatology , vol.57 , Issue.5 , pp. 1826-1837
    • Mazzaferro, V.1    Sposito, C.2    Bhoori, S.3
  • 38
    • 84928106773 scopus 로고    scopus 로고
    • Personalized dosimetry with intensifcation using 90Y-loaded glass microsphere radioembolization induces prolonged overall survival in hepatocellular carcinoma patients with portal vein thrombosis
    • Garin E, Rolland Y, Edeline J et al. Personalized dosimetry with intensifcation using 90Y-loaded glass microsphere radioembolization induces prolonged overall survival in hepatocellular carcinoma patients with portal vein thrombosis. J. Nucl. Med. 56(3), 339-346 (2015).
    • (2015) J. Nucl. Med. , vol.56 , Issue.3 , pp. 339-346
    • Garin, E.1    Rolland, Y.2    Edeline, J.3
  • 41
    • 84934440989 scopus 로고    scopus 로고
    • Analyzing cell cycle checkpoints in response to ionizing radiation in mammalian cells
    • Wang B. Analyzing cell cycle checkpoints in response to ionizing radiation in mammalian cells. Methods Mol. Biol. 1170, 313-320 (2014).
    • (2014) Methods Mol. Biol. , vol.1170 , pp. 313-320
    • Wang, B.1
  • 42
    • 84907189603 scopus 로고    scopus 로고
    • Radiation-induced signaling pathways that promote cancer cell survival (review)
    • Hein AL, Ouellette MM, Yan Y Radiation-induced signaling pathways that promote cancer cell survival (review). Int. J. Oncol. 45(5), 1813-1819 (2014).
    • (2014) Int. J. Oncol. , vol.45 , Issue.5 , pp. 1813-1819
    • Hein, A.L.1    Ouellette, M.M.2    Yan, Y.3
  • 43
    • 84933050304 scopus 로고    scopus 로고
    • The tumour microenvironment after radiotherapy: Mechanisms of resistance and recurrence
    • Barker HE, Paget JTE, Khan AA, Harrington KJ. The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence. Nat. Rev. Cancer 15(7), 409-425 (2015).
    • (2015) Nat. Rev. Cancer , vol.15 , Issue.7 , pp. 409-425
    • Barker, H.E.1    Jte, P.2    Khan, A.A.3    Harrington, K.J.4
  • 44
    • 84874084734 scopus 로고    scopus 로고
    • Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma
    • Hernandez-Gea V, Toffanin S, Friedman SL, Llovet JM. Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma. Gastroenterology 144(3), 512-527 (2013).
    • (2013) Gastroenterology , vol.144 , Issue.3 , pp. 512-527
    • Hernandez-Gea, V.1    Toffanin, S.2    Friedman, S.L.3    Llovet, J.M.4
  • 45
    • 84941877287 scopus 로고    scopus 로고
    • The effect of ionizing radiation on regulatory T cells in health and disease
    • Persa E, Balogh A, Safrany G, Lumniczky K. The effect of ionizing radiation on regulatory T cells in health and disease. Cancer Lett. 368(2), 252-261 (2015).
    • (2015) Cancer Lett. , vol.368 , Issue.2 , pp. 252-261
    • Persa, E.1    Balogh, A.2    Safrany, G.3    Lumniczky, K.4
  • 46
    • 84884583548 scopus 로고    scopus 로고
    • Ionizing radiation, ion transports, and radioresistance of cancer cells
    • Huber SM, Butz L, Stegen B et al. Ionizing radiation, ion transports, and radioresistance of cancer cells. Front Physiol. 4, 212 (2013).
    • (2013) Front Physiol. , vol.4 , pp. 212
    • Huber, S.M.1    Butz, L.2    Stegen, B.3
  • 47
    • 84912525332 scopus 로고    scopus 로고
    • The impact of radiation therapy on the antitumor immunity: Local effects and systemic consequences
    • Lumniczky K, Safrany G. The impact of radiation therapy on the antitumor immunity: local effects and systemic consequences. Cancer Lett. 356(1), 114-125 (2015).
    • (2015) Cancer Lett. , vol.356 , Issue.1 , pp. 114-125
    • Lumniczky, K.1    Safrany, G.2
  • 48
    • 70449717008 scopus 로고    scopus 로고
    • Challenge and hope in radiotherapy of hepatocellular carcinoma
    • Seong J. Challenge and hope in radiotherapy of hepatocellular carcinoma. Yonsei Med. J. 50(5), 601-612 (2009).
    • (2009) Yonsei Med. J. , vol.50 , Issue.5 , pp. 601-612
    • Seong, J.1
  • 49
    • 84923061850 scopus 로고    scopus 로고
    • Xie y Pure transcatheter arterial chemoembolization therapy for intrahepatic tumors causes a shrink in pulmonary metastases of hepatocellular carcinoma
    • Wu H, Zhao W, Liu S, Zheng J, Ji G, Xie Y Pure transcatheter arterial chemoembolization therapy for intrahepatic tumors causes a shrink in pulmonary metastases of hepatocellular carcinoma. Int. J. Clin. Exp. Med. 8(1), 1035-1042 (2015).
    • (2015) Int. J. Clin. Exp. Med. , vol.8 , Issue.1 , pp. 1035-1042
    • Wu, H.1    Zhao, W.2    Liu, S.3    Zheng, J.4    Ji, G.5
  • 50
    • 84864465226 scopus 로고    scopus 로고
    • Clinical implications of cancer stem cell biology in hepatocellular carcinoma
    • Ji J, Wang XW Clinical implications of cancer stem cell biology in hepatocellular carcinoma. Semin. Oncol. 39(4), 461-472 (2012).
    • (2012) Semin. Oncol. , vol.39 , Issue.4 , pp. 461-472
    • Ji, J.1    Wang, X.W.2
  • 51
    • 84858855476 scopus 로고    scopus 로고
    • The role of LDH serum levels in predicting global outcome in HCC patients undergoing TACE: Implications for clinical management
    • Scartozzi M, Faloppi L, Bianconi M et al. The role of LDH serum levels in predicting global outcome in HCC patients undergoing TACE: implications for clinical management. PLoS ONE 7(3), e32653 (2012).
    • (2012) PLoS ONE , vol.7 , Issue.3 , pp. e32653
    • Scartozzi, M.1    Faloppi, L.2    Bianconi, M.3
  • 52
    • 84921325256 scopus 로고    scopus 로고
    • Reactive oxygen species as mediator of tumor radiosensitivity
    • Dayal R, Singh A, Pandey A, Mishra KP. Reactive oxygen species as mediator of tumor radiosensitivity. J. Cancer Res. Ther. 10(4), 811-818 (2014).
    • (2014) J. Cancer Res. Ther. , vol.10 , Issue.4 , pp. 811-818
    • Dayal, R.1    Singh, A.2    Pandey, A.3    Mishra, K.P.4
  • 53
    • 84938953481 scopus 로고    scopus 로고
    • Infammation-induced radioresistance is mediated by ROS-dependent inactivation of protein phosphatase 1 in non-small cell lung cancer cells
    • Kim W, Youn H, Kang C, Youn B. Infammation-induced radioresistance is mediated by ROS-dependent inactivation of protein phosphatase 1 in non-small cell lung cancer cells. Apoptosis 20(9), 1242-1252 (2015).
    • (2015) Apoptosis , vol.20 , Issue.9 , pp. 1242-1252
    • Kim, W.1    Youn, H.2    Kang, C.3    Youn, B.4
  • 54
    • 84903971446 scopus 로고    scopus 로고
    • Oxidative stress as a crucial factor in liver diseases
    • Cichoz-Lach H, Michalak A. Oxidative stress as a crucial factor in liver diseases. World J. Gastroenterol. 20(25), 8082-8091 (2014).
    • (2014) World J. Gastroenterol. , vol.20 , Issue.25 , pp. 8082-8091
    • Cichoz-Lach, H.1    Michalak, A.2
  • 55
    • 84878703659 scopus 로고    scopus 로고
    • Role of the Nrf2-ARE pathway in liver diseases
    • Shin SM, Yang JH, Ki SH. Role of the Nrf2-ARE pathway in liver diseases. Oxid. Med. Cell Longev. 2013, 763257 (2013).
    • (2013) Oxid. Med. Cell Longev. , vol.2013 , pp. 763257
    • Shin, S.M.1    Yang, J.H.2    Ki, S.H.3
  • 56
    • 79953220445 scopus 로고    scopus 로고
    • Hepatitis C virus impairs the induction of cytoprotective Nrf2 target genes by delocalization of small Maf proteins
    • Carvajal-Yepes M, Himmelsbach K, Schaedler S et al. Hepatitis C virus impairs the induction of cytoprotective Nrf2 target genes by delocalization of small Maf proteins. J. Biol. Chem. 286(11), 8941-8951 (2011).
    • (2011) J. Biol. Chem. , vol.286 , Issue.11 , pp. 8941-8951
    • Carvajal-Yepes, M.1    Himmelsbach, K.2    Schaedler, S.3
  • 58
    • 77950023207 scopus 로고    scopus 로고
    • Oxidative stress and oxidative damage in carcinogenesis
    • Klaunig JE, Kamendulis LM, Hocevar BA. Oxidative stress and oxidative damage in carcinogenesis. Toxicol. Pathol. 38(1), 96-109 (2010).
    • (2010) Toxicol. Pathol. , vol.38 , Issue.1 , pp. 96-109
    • Klaunig, J.E.1    Kamendulis, L.M.2    Hocevar, B.A.3
  • 59
    • 27144499267 scopus 로고    scopus 로고
    • Differential expression of antioxidant enzymes in various hepatocellular carcinoma cell lines
    • Yang LY, Chen WL, Lin JW et al. Differential expression of antioxidant enzymes in various hepatocellular carcinoma cell lines. J. Cell Biochem. 96(3), 622-631 (2005).
    • (2005) J. Cell Biochem. , vol.96 , Issue.3 , pp. 622-631
    • Yang, L.Y.1    Chen, W.L.2    Lin, J.W.3
  • 60
    • 84907367977 scopus 로고    scopus 로고
    • Expression of thioredoxins and glutaredoxins in human hepatocellular carcinoma: Correlation to cell proliferation, tumor size and metabolic syndrome
    • Mollbrink A, Jawad R, Vlamis-Gardikas A et al. Expression of thioredoxins and glutaredoxins in human hepatocellular carcinoma: correlation to cell proliferation, tumor size and metabolic syndrome. Int. J. Immunopathol. Pharmacol. 27(2), 169-183 (2014).
    • (2014) Int. J. Immunopathol. Pharmacol. , vol.27 , Issue.2 , pp. 169-183
    • Mollbrink, A.1    Jawad, R.2    Vlamis-Gardikas, A.3
  • 61
    • 79953039898 scopus 로고    scopus 로고
    • Prediction of diabetic retinopathy: Role of oxidative stress and relevance of apoptotic biomarkers
    • Al-Shabrawey M, Smith S. Prediction of diabetic retinopathy: role of oxidative stress and relevance of apoptotic biomarkers. EPMA J. 1(1), 56-72 (2010).
    • (2010) EPMA J. , vol.1 , Issue.1 , pp. 56-72
    • Al-Shabrawey, M.1    Smith, S.2
  • 62
    • 38149112650 scopus 로고    scopus 로고
    • Irradiated breast cancer patients demonstrate subgroup-specifc regularities in protein expression patterns of circulating leukocytes
    • Yeghiazaryan K, Mamlouk S, Trog D et al. Irradiated breast cancer patients demonstrate subgroup-specifc regularities in protein expression patterns of circulating leukocytes. Cancer Genomics Proteomics 4(6), 411-418 (2007).
    • (2007) Cancer Genomics Proteomics , vol.4 , Issue.6 , pp. 411-418
    • Yeghiazaryan, K.1    Mamlouk, S.2    Trog, D.3
  • 63
    • 84927948542 scopus 로고    scopus 로고
    • 4Ps medicine of the fatty liver: The research model of predictive, preventive, personalized and participatory medicine-recommendations for facing obesity, fatty liver and fbrosis epidemics
    • Trovato FM, Catalano D, Musumeci G, Trovato GM. 4Ps medicine of the fatty liver: the research model of predictive, preventive, personalized and participatory medicine-recommendations for facing obesity, fatty liver and fbrosis epidemics. EPMA J. 5(1), 21 (2014).
    • (2014) EPMA J. , vol.5 , Issue.1 , pp. 21
    • Trovato, F.M.1    Catalano, D.2    Musumeci, G.3    Trovato, G.M.4
  • 64
    • 79955580873 scopus 로고    scopus 로고
    • HCC and angiogenesis: Possible targets and future directions
    • Zhu AX, Duda DG, Sahani DV, Jain RK. HCC and angiogenesis: possible targets and future directions. Nat. Rev. Clin. Oncol. 8 (5), 292-301 (2011).
    • (2011) Nat. Rev. Clin. Oncol. , vol.8 , Issue.5 , pp. 292-301
    • Zhu, A.X.1    Duda, D.G.2    Sahani, D.V.3    Jain, R.K.4
  • 65
    • 58149216579 scopus 로고    scopus 로고
    • Multimodality imaging can predict the metabolic response of unresectable colorectal liver metastases to radioembolization therapy with Yttrium-90 labeled resin microspheres
    • Flamen P, Vanderlinden B, Delatte P et al. Multimodality imaging can predict the metabolic response of unresectable colorectal liver metastases to radioembolization therapy with Yttrium-90 labeled resin microspheres. Phys. Med. Biol. 53(22), 6591-6603 (2008).
    • (2008) Phys. Med. Biol. , vol.53 , Issue.22 , pp. 6591-6603
    • Flamen, P.1    Vanderlinden, B.2    Delatte, P.3
  • 66
    • 84901405352 scopus 로고    scopus 로고
    • Novel aspects of the liver microenvironment in hepatocellular carcinoma pathogenesis and development
    • Tu T, Budzinska MA, Maczurek AE et al. Novel aspects of the liver microenvironment in hepatocellular carcinoma pathogenesis and development. Int. J. Mol. Sci. 15 (6), 9422-9458 (2014).
    • (2014) Int. J. Mol. Sci. , vol.15 , Issue.6 , pp. 9422-9458
    • Tu, T.1    Ma, B.2    Maczurek, A.E.3
  • 67
    • 0038176480 scopus 로고    scopus 로고
    • Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents: Exploring mechanisms of interaction
    • Wachsberger P, Burd R, Dicker AP. Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents: exploring mechanisms of interaction. Clin. Cancer Res. 9 (6), 1957-1971 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.6 , pp. 1957-1971
    • Wachsberger, P.1    Burd, R.2    Dicker, A.P.3
  • 68
    • 34547690632 scopus 로고    scopus 로고
    • Hypoxia and hepatocellular carcinoma: The therapeutic target for hepatocellular carcinoma
    • Wu XZ, Xie GR, Chen D. Hypoxia and hepatocellular carcinoma: The therapeutic target for hepatocellular carcinoma. J. Gastroenterol. Hepatol. 22(8), 1178-1182 (2007).
    • (2007) J. Gastroenterol. Hepatol. , vol.22 , Issue.8 , pp. 1178-1182
    • Wu, X.Z.1    Xie, G.R.2    Chen, D.3
  • 69
    • 84940663493 scopus 로고    scopus 로고
    • A hypoxic ticket to the bone metastatic niche
    • Vanharanta S. A hypoxic ticket to the bone metastatic niche. Breast Cancer Res. 17, 122 (2015).
    • (2015) Breast Cancer Res. , vol.17 , pp. 122
    • Vanharanta, S.1
  • 70
    • 84922254256 scopus 로고    scopus 로고
    • Lysyl oxidase-like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma
    • Wong CC, Tse AP, Huang YP et al. Lysyl oxidase-like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma. Hepatology 60(5), 1645-1658 (2014).
    • (2014) Hepatology , vol.60 , Issue.5 , pp. 1645-1658
    • Wong, C.C.1    Tse, A.P.2    Huang, Y.P.3
  • 71
    • 84875445066 scopus 로고    scopus 로고
    • LOX-mediated collagen crosslinking is responsible for fbrosis-enhanced metastasis
    • Cox TR, Bird D, Baker AM et al. LOX-mediated collagen crosslinking is responsible for fbrosis-enhanced metastasis. Cancer Res. 73(6), 1721-1732 (2013).
    • (2013) Cancer Res. , vol.73 , Issue.6 , pp. 1721-1732
    • Cox, T.R.1    Bird, D.2    Baker, A.M.3
  • 72
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: Functions of cells recruited to the tumor microenvironment
    • Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 21(3), 309-322 (2012).
    • (2012) Cancer Cell , vol.21 , Issue.3 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 73
    • 84870486012 scopus 로고    scopus 로고
    • Methods for analysis of the cancer microenvironment and their potential for disease prediction, monitoring and personalized treatments
    • Clausson C-M, Grundberg I, Weibrecht I, Nilsson M, Söderberg O. Methods for analysis of the cancer microenvironment and their potential for disease prediction, monitoring and personalized treatments. EPMA J. 3(1), 7 (2012).
    • (2012) EPMA J. , vol.3 , Issue.1 , pp. 7
    • Clausson, C.-M.1    Grundberg, I.2    Weibrecht, I.3    Nilsson, M.4    Söderberg, O.5
  • 74
    • 79952038728 scopus 로고    scopus 로고
    • The tumor microenvironment in hepatocellular carcinoma: Current status and therapeutic targets
    • Yang JD, Nakamura I, Roberts LR. The tumor microenvironment in hepatocellular carcinoma: current status and therapeutic targets. Semin. Cancer Biol. 21(1), 35-43 (2011).
    • (2011) Semin. Cancer Biol. , vol.21 , Issue.1 , pp. 35-43
    • Yang, J.D.1    Nakamura, I.2    Roberts, L.R.3
  • 75
    • 84897450600 scopus 로고    scopus 로고
    • Transforming growth factor-p as a therapeutic target in hepatocellular carcinoma
    • Giannelli G, Villa E, Lahn M. Transforming growth factor-p as a therapeutic target in hepatocellular carcinoma. Cancer Res. 74(7), 1890-1894 (2014).
    • (2014) Cancer Res. , vol.74 , Issue.7 , pp. 1890-1894
    • Giannelli, G.1    Villa, E.2    Lahn, M.3
  • 76
    • 84992020606 scopus 로고    scopus 로고
    • Stem cell expression profle in hepatocellular carcinoma, small cell dysplasia, and cirrhosis
    • Akyol G, Yilmaz G. Stem cell expression profle in hepatocellular carcinoma, small cell dysplasia, and cirrhosis. Stem Cell Transl. Investig. 1, e232 (2014).
    • (2014) Stem Cell Transl. Investig. , vol.1 , pp. e232
    • Akyol, G.1    Yilmaz, G.2
  • 77
    • 84955725054 scopus 로고    scopus 로고
    • Adult hepatic progenitor cell niche: How it affects the progenitor cell fate
    • Katoonizadeh A, Poustchi H. Adult hepatic progenitor cell niche: how it affects the progenitor cell fate. Middle East J. Dig. Dis. 6(2), 57-64 (2014).
    • (2014) Middle East J. Dig. Dis. , vol.6 , Issue.2 , pp. 57-64
    • Katoonizadeh, A.1    Poustchi, H.2
  • 78
    • 60449087921 scopus 로고    scopus 로고
    • EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features
    • Yamashita T, Ji J, Budhu A et al. EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology 136(3), 1012-1024 (2009).
    • (2009) Gastroenterology , vol.136 , Issue.3 , pp. 1012-1024
    • Yamashita, T.1    Ji, J.2    Budhu, A.3
  • 79
    • 84355162060 scopus 로고    scopus 로고
    • + liver cancer stem cells modulate radioresistance in human hepatocellular carcinoma
    • + liver cancer stem cells modulate radioresistance in human hepatocellular carcinoma. Cancer Lett. 315(2), 129-137 (2012).
    • (2012) Cancer Lett. , vol.315 , Issue.2 , pp. 129-137
    • Piao, L.S.1    Hur, W.2    Kim, T.K.3
  • 80
    • 84978799339 scopus 로고    scopus 로고
    • Liver cancer stem cells: A new paradigm for hepatocellular carcinoma treatment
    • Lui SK, Vilchez V, Gedaly R. Liver cancer stem cells: a new paradigm for hepatocellular carcinoma treatment. J. Stem Cell Res. Ther. 5, 283 (2015).
    • (2015) J. Stem Cell Res. Ther. , vol.5 , pp. 283
    • Lui, S.K.1    Vilchez, V.2    Gedaly, R.3
  • 81
    • 84876397801 scopus 로고    scopus 로고
    • Standing out from the crowd: Cancer stem cells in hepatocellular carcinoma
    • Sainz B, Heeschen C. Standing out from the crowd: cancer stem cells in hepatocellular carcinoma. Cancer Cell 23(4), 431-433 (2013).
    • (2013) Cancer Cell , vol.23 , Issue.4 , pp. 431-433
    • Sainz, B.1    Heeschen, C.2
  • 82
    • 84870751884 scopus 로고    scopus 로고
    • + liver cancer stem cells
    • + liver cancer stem cells. Exp. Cell Res. 319(2), 126-132 (2013).
    • (2013) Exp. Cell Res. , vol.319 , Issue.2 , pp. 126-132
    • Ma, S.1
  • 83
    • 84883445521 scopus 로고    scopus 로고
    • + liver cancer stem cells in the hypoxic and nutrient-deprived tumor microenvironment
    • + liver cancer stem cells in the hypoxic and nutrient-deprived tumor microenvironment. Cancer Lett. 339(1), 70-81 (2013).
    • (2013) Cancer Lett. , vol.339 , Issue.1 , pp. 70-81
    • Song, Y.J.1    Zhang, S.S.2    Guo, X.L.3
  • 84
    • 77952429537 scopus 로고    scopus 로고
    • Expression of CD133 confers malignant potential by regulating metalloproteinases in human hepatocellular carcinoma
    • Kohga K, Tatsumi T, Takehara T et al. Expression of CD133 confers malignant potential by regulating metalloproteinases in human hepatocellular carcinoma. J. Hepatol. 52 (6), 872-879 (2010).
    • (2010) J. Hepatol. , vol.52 , Issue.6 , pp. 872-879
    • Kohga, K.1    Tatsumi, T.2    Takehara, T.3
  • 85
    • 84952872085 scopus 로고    scopus 로고
    • Expression of cancer stem cell biomarkers as a tool for a correct therapeutic approach to hepatocellular carcinoma
    • Romano M, De Francesco F, Pirozzi G et al. Expression of cancer stem cell biomarkers as a tool for a correct therapeutic approach to hepatocellular carcinoma. Oncoscience 2(5), 443-456 (2015).
    • (2015) Oncoscience , vol.2 , Issue.5 , pp. 443-456
    • Romano, M.1    De Francesco, F.2    Pirozzi, G.3
  • 86
    • 84876956778 scopus 로고    scopus 로고
    • + T regulatory cells and myeloid-derived suppressor cells in hepatocellular carcinoma patients are associated with impaired T-cell functionality
    • + T regulatory cells and myeloid-derived suppressor cells in hepatocellular carcinoma patients are associated with impaired T-cell functionality. Cancer Res. 73(8), 2435-2444 (2013).
    • (2013) Cancer Res. , vol.73 , Issue.8 , pp. 2435-2444
    • Kalathil, S.1    Lugade, A.A.2    Miller, A.3    Iyer, R.4    Thanavala, Y.5
  • 87
    • 78650621479 scopus 로고    scopus 로고
    • + T-cell apoptosis and postoperative recurrence in hepatocellular carcinoma patients
    • + T-cell apoptosis and postoperative recurrence in hepatocellular carcinoma patients. Int. J. Cancer 128(4), 887-896 (2011).
    • (2011) Int. J. Cancer , vol.128 , Issue.4 , pp. 887-896
    • Shi, F.1    Shi, M.2    Zeng, Z.3
  • 88
    • 34247884612 scopus 로고    scopus 로고
    • The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
    • Sharpe AH, Wherry EJ, Ahmed R, Freeman GJ. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat. Immunol. 8(3), 239-245 (2007).
    • (2007) Nat. Immunol. , vol.8 , Issue.3 , pp. 239-245
    • Sharpe, A.H.1    Wherry, E.J.2    Ahmed, R.3    Freeman, G.J.4
  • 89
    • 84928116687 scopus 로고    scopus 로고
    • The immune system in hepatocellular carcinoma and potential new immunotherapeutic strategies
    • Bertino G, Demma S, Ardiri A et al. The immune system in hepatocellular carcinoma and potential new immunotherapeutic strategies. Biomed Res. Int. 2015, 731469 (2015).
    • (2015) Biomed Res. Int. , vol.2015 , pp. 731469
    • Bertino, G.1    Demma, S.2    Ardiri, A.3
  • 90
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366(26), 2443-2454 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 91
    • 85028479904 scopus 로고    scopus 로고
    • Programmed death-1in cancer stem cells may serve as a novel immunotherapy marker
    • Baban B, Liu JY, Zheng M, Lee J, Grochowska K, Mozaffari M. Programmed death-1in cancer stem cells may serve as a novel immunotherapy marker. EPMA J. 5(Suppl. 1), A115 (2014).
    • (2014) EPMA J. , vol.5 , pp. A115
    • Baban, B.1    Liu, J.Y.2    Zheng, M.3    Lee, J.4    Grochowska, K.5    Mozaffari, M.6
  • 92
    • 33748098860 scopus 로고    scopus 로고
    • PD-L1 is induced in hepatocytes by viral infection and by interferon-α and-γ and mediates T cell apoptosis
    • Muehlbauer M, Fleck M, Schütz C et al. PD-L1 is induced in hepatocytes by viral infection and by interferon-α and-γ and mediates T cell apoptosis. J. Hepatol. 45(4), 520-528 (2006).
    • (2006) J. Hepatol. , vol.45 , Issue.4 , pp. 520-528
    • Muehlbauer, M.1    Fleck, M.2    Schütz, C.3
  • 93
    • 72949086641 scopus 로고    scopus 로고
    • Chronically infamed livers up-regulate expression of inhibitory B7 family members
    • Kassel R, Cruise MW, Iezzoni JC, Taylor NA, Pruett TL, Hahn YS. Chronically infamed livers up-regulate expression of inhibitory B7 family members. Hepatology 50(5), 1625-1637 (2009).
    • (2009) Hepatology , vol.50 , Issue.5 , pp. 1625-1637
    • Kassel, R.1    Cruise, M.W.2    Iezzoni, J.C.3    Taylor, N.A.4    Pruett, T.L.5    Hahn, Y.S.6
  • 94
    • 10644293881 scopus 로고    scopus 로고
    • Inhibition of T-cell responses by hepatic stellate cells via B7-H1-mediated T-cell apoptosis in mice
    • Yu MC, Chen CH, Liang X et al. Inhibition of T-cell responses by hepatic stellate cells via B7-H1-mediated T-cell apoptosis in mice. Hepatology 40(6), 1312-1321 (2004).
    • (2004) Hepatology , vol.40 , Issue.6 , pp. 1312-1321
    • Yu, M.C.1    Ch, C.2    Liang, X.3
  • 95
    • 84893876109 scopus 로고    scopus 로고
    • Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice
    • Deng L, Liang H, Burnette B et al. Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. J. Clin. Invest. 124(2), 687-695 (2014).
    • (2014) J. Clin. Invest. , vol.124 , Issue.2 , pp. 687-695
    • Deng, L.1    Liang, H.2    Burnette, B.3
  • 96
    • 33845420396 scopus 로고    scopus 로고
    • The role of cytokines in hepatocellular carcinoma
    • Budhu A, Wang XW. The role of cytokines in hepatocellular carcinoma. J. Leukoc. Biol. 80(6), 1197-1213 (2006).
    • (2006) J. Leukoc. Biol. , vol.80 , Issue.6 , pp. 1197-1213
    • Budhu, A.1    Wang, X.W.2
  • 97
    • 84893760158 scopus 로고    scopus 로고
    • Using multiple cytokines to predict hepatocellular carcinoma recurrence in two patient cohorts
    • Chen ZY, Wei W, Guo ZX et al. Using multiple cytokines to predict hepatocellular carcinoma recurrence in two patient cohorts. Br. J. Cancer 110(3), 733-740 (2014).
    • (2014) Br. J. Cancer , vol.110 , Issue.3 , pp. 733-740
    • Chen, Z.Y.1    Wei, W.2    Guo, Z.X.3
  • 98
    • 84941342205 scopus 로고    scopus 로고
    • The relationship between serum interleukin-6 and the recurrence of hepatitis B virus related hepatocellular carcinoma after curative resection
    • Sheng T, Wang B, Wang SY et al. The relationship between serum interleukin-6 and the recurrence of hepatitis B virus related hepatocellular carcinoma after curative resection. Med. Baltim. 94(24), e941 (2015).
    • (2015) Med. Baltim. , vol.94 , Issue.24 , pp. e941
    • Sheng, T.1    Wang, B.2    Wang, S.Y.3
  • 99
    • 84947066841 scopus 로고    scopus 로고
    • Evaluation of percutaneous liver biopsy complications in patients with chronic viral hepatitis
    • Kose S, Ersan G, Tatar B, Adar P, Sengel BE. Evaluation of percutaneous liver biopsy complications in patients with chronic viral hepatitis. Eurasian J. Med. 47(3), 161-164 (2015).
    • (2015) Eurasian J. Med. , vol.47 , Issue.3 , pp. 161-164
    • Kose, S.1    Ersan, G.2    Tatar, B.3    Adar, P.4    Sengel, B.E.5
  • 101
    • 84978920803 scopus 로고    scopus 로고
    • Simtuzumab (GS-6624) in the Treatment of Cirrhosis Due to NASH (NASH)
    • Simtuzumab (GS-6624) in the Treatment of Cirrhosis Due to NASH (NASH). https://clinicaltrials.gov/ct2/show/NCT01672879
  • 102
    • 40949160140 scopus 로고    scopus 로고
    • Identifcation of local and circulating cancer stem cells in human liver cancer
    • Yang ZF, Ngai P, Ho DW et al. Identifcation of local and circulating cancer stem cells in human liver cancer. Hepatology 47(3), 919-928 (2008).
    • (2008) Hepatology , vol.47 , Issue.3 , pp. 919-928
    • Yang, Z.F.1    Ngai, P.2    Ho, D.W.3
  • 103
    • 84952718773 scopus 로고    scopus 로고
    • Targeting cancer stem cells as a therapeutic approach in liver cancer
    • Zhou G, Wilson G, George J, Qiao L. Targeting cancer stem cells as a therapeutic approach in liver cancer. Curr. Gene Ther. 15(2), 161-170 (2015).
    • (2015) Curr. Gene Ther. , vol.15 , Issue.2 , pp. 161-170
    • Zhou, G.1    Wilson, G.2    George, J.3    Qiao, L.4
  • 104
    • 84882837451 scopus 로고    scopus 로고
    • Coagulation in liver disease: A guide for the clinician
    • Northup PG, Caldwell SH. Coagulation in liver disease: a guide for the clinician. Clin. Gastroenterol. Hepatol. 11 (9), 1064-1074 (2013).
    • (2013) Clin. Gastroenterol. Hepatol. , vol.11 , Issue.9 , pp. 1064-1074
    • Northup, P.G.1    Caldwell, S.H.2
  • 105
    • 84925353780 scopus 로고    scopus 로고
    • + regulatory T cells in peripheral blood of Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma patients
    • + regulatory T cells in peripheral blood of Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma patients. Clin. Chem. Lab. Med. 52(9), 1357-1365 (2014).
    • (2014) Clin. Chem. Lab. Med. , vol.52 , Issue.9 , pp. 1357-1365
    • Li, F.1    Guo, Z.2    Lizee, G.3    Yu, H.4    Wang, H.5    Si, T.6
  • 106
    • 84879141840 scopus 로고    scopus 로고
    • A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C
    • Sangro B, Gomez-Martin C, de la Mata M et al. A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C. J. Hepatol. 59(1), 81-88 (2013).
    • (2013) J. Hepatol. , vol.59 , Issue.1 , pp. 81-88
    • Sangro, B.1    Gomez-Martin, C.2    De La Mata, M.3
  • 107
    • 84978844147 scopus 로고    scopus 로고
    • Immune Checkpoint Inhibition (Tremelimumab and/or MEDI4736) in Combination With Radiation Therapy in Patients With Unresectable Pancreatic Cancer
    • Immune Checkpoint Inhibition (Tremelimumab and/or MEDI4736) in Combination With Radiation Therapy in Patients With Unresectable Pancreatic Cancer. https://clinicaltrials.gov/ct2/show/NCT02311361
  • 108
    • 84978830640 scopus 로고    scopus 로고
    • A Study to Evaluate the Effectiveness, Safety and Tolerability of Nivolumab and the Combination Nivolumab Plus Ipilimumab in Patients With Advanced Liver Cancer
    • A Study to Evaluate the Effectiveness, Safety and Tolerability of Nivolumab and the Combination Nivolumab Plus Ipilimumab in Patients With Advanced Liver Cancer. https://clinicaltrials.gov/show/NCT01658878
  • 109
    • 61449181280 scopus 로고    scopus 로고
    • Synergistic reversal of intrahepatic HCV-specifc CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade
    • Nakamoto N, Cho H, Shaked A et al. Synergistic reversal of intrahepatic HCV-specifc CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade. PLoS Pathog. 5(2), e1000313 (2009).
    • (2009) PLoS Pathog. , vol.5 , Issue.2 , pp. e1000313
    • Nakamoto, N.1    Cho, H.2    Shaked, A.3
  • 110
    • 84976905617 scopus 로고    scopus 로고
    • Multi-parameter systematic strategies for predictive, preventive and personalised medicine in cancer
    • Hu R, Wang X, Zhan X. Multi-parameter systematic strategies for predictive, preventive and personalised medicine in cancer. EPMA J. 4(1), 2 (2013).
    • (2013) EPMA J. , vol.4 , Issue.1 , pp. 2
    • Hu, R.1    Wang, X.2    Zhan, X.3
  • 111
    • 84978847966 scopus 로고    scopus 로고
    • Safety and Effcacy of Simtuzumab (GS-6624) in Adults With Advanced Liver Fibrosis But Not Cirrhosis Secondary to Non-Alcoholic Steatohepatitis (NASH)
    • Safety and Effcacy of Simtuzumab (GS-6624) in Adults With Advanced Liver Fibrosis But Not Cirrhosis Secondary to Non-Alcoholic Steatohepatitis (NASH). https://clinicaltrials.gov/ct2/show/NCT01672866
  • 112
    • 84978847967 scopus 로고    scopus 로고
    • A Study of Galunisertib (LY2157299) in Combination With Nivolumab in Advanced Refractory Solid Tumors and in Recurrent or Refractory NSCLC, Hepatocellular Carcinoma, or Glioblastoma
    • A Study of Galunisertib (LY2157299) in Combination With Nivolumab in Advanced Refractory Solid Tumors and in Recurrent or Refractory NSCLC, Hepatocellular Carcinoma, or Glioblastoma. https://clinicaltrials.gov/ct2/show/NCT02423343
  • 113
    • 84978844571 scopus 로고    scopus 로고
    • Clinical Trial to Evaluation the Safety and Effcacy of GR-MD-02 for the Treatment of Liver Fibrosis and Resultant Portal Hypertension in Patients With Nash Cirrhosis (NASH-CX)
    • Clinical Trial to Evaluation the Safety and Effcacy of GR-MD-02 for the Treatment of Liver Fibrosis and Resultant Portal Hypertension in Patients With Nash Cirrhosis (NASH-CX). https://clinicaltrials.gov/ct2/show/NCT02462967


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.