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Volumn 60, Issue 5, 2014, Pages 1645-1658

Lysyl oxidase-like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA1 INTEGRIN; ALPHA5 INTEGRIN; COLLAGEN; FIBRONECTIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LYSYL OXIDASE LIKE 2; MESSENGER RNA; MICRORNA; MICRORNA 26; MICRORNA 26A; MICRORNA 29; MYOSIN LIGHT CHAIN 2; PROTEIN LYSINE 6 OXIDASE; RHO KINASE; SHORT HAIRPIN RNA; SMAD4 PROTEIN; TRANSCRIPTOME; TRANSFORMING GROWTH FACTOR BETA; TUMOR MARKER; UNCLASSIFIED DRUG; LOXL2 PROTEIN, HUMAN; LOXL2 PROTEIN, MOUSE; OXIDOREDUCTASE;

EID: 84922254256     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27320     Document Type: Article
Times cited : (206)

References (44)
  • 1
    • 17644392101 scopus 로고    scopus 로고
    • Liver transplantation for malignancy
    • Hertl M, Cosimi AB. Liver transplantation for malignancy. Oncologist 2005;10:269-281.
    • (2005) Oncologist , vol.10 , pp. 269-281
    • Hertl, M.1    Cosimi, A.B.2
  • 2
    • 84856739946 scopus 로고    scopus 로고
    • Hypoxia-inducible factors in physiology and medicine
    • Semenza GL. Hypoxia-inducible factors in physiology and medicine. Cell 2012;148:399-408.
    • (2012) Cell , vol.148 , pp. 399-408
    • Semenza, G.L.1
  • 3
    • 17944375360 scopus 로고    scopus 로고
    • C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
    • Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001;107:43-54.
    • (2001) Cell , vol.107 , pp. 43-54
    • Epstein, A.C.1    Gleadle, J.M.2    McNeill, L.A.3    Hewitson, K.S.4    O'Rourke, J.5    Mole, D.R.6
  • 4
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway
    • Kaelin WG, Jr., Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 2008;30:393-402.
    • (2008) Mol Cell , vol.30 , pp. 393-402
    • Kaelin Jr, W.G.1    Ratcliffe, P.J.2
  • 6
    • 0035112148 scopus 로고    scopus 로고
    • The hepatitis B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis
    • Lee DK, Park SH, Yi Y, Choi SG, Lee C, Parks WT, et al. The hepatitis B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis. Genes Dev 2001;15:455-466.
    • (2001) Genes Dev , vol.15 , pp. 455-466
    • Lee, D.K.1    Park, S.H.2    Yi, Y.3    Choi, S.G.4    Lee, C.5    Parks, W.T.6
  • 7
    • 0035694910 scopus 로고    scopus 로고
    • Smad regulation in TGF-beta signal transduction
    • Moustakas A, Souchelnytskyi S, Heldin CH. Smad regulation in TGF-beta signal transduction. J Cell Sci 2001;114:4359-4369.
    • (2001) J Cell Sci , vol.114 , pp. 4359-4369
    • Moustakas, A.1    Souchelnytskyi, S.2    Heldin, C.H.3
  • 8
    • 77956624954 scopus 로고    scopus 로고
    • Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis
    • Barash U, Cohen-Kaplan V, Dowek I, Sanderson RD, Ilan N, Vlodavsky I. Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis. FEBS J 2010;277:3890-3903.
    • (2010) FEBS J , vol.277 , pp. 3890-3903
    • Barash, U.1    Cohen-Kaplan, V.2    Dowek, I.3    Sanderson, R.D.4    Ilan, N.5    Vlodavsky, I.6
  • 9
    • 28044442504 scopus 로고    scopus 로고
    • Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: growth regulation and the prospect of new cancer therapies
    • Sanderson RD, Yang Y, Kelly T, MacLeod V, Dai Y, Theus A. Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: growth regulation and the prospect of new cancer therapies. J Cell Biochem 2005;96:897-905.
    • (2005) J Cell Biochem , vol.96 , pp. 897-905
    • Sanderson, R.D.1    Yang, Y.2    Kelly, T.3    MacLeod, V.4    Dai, Y.5    Theus, A.6
  • 10
    • 34250366643 scopus 로고    scopus 로고
    • Heparanase enhances syndecan-1 shedding: a novel mechanism for stimulation of tumor growth and metastasis
    • Yang Y, Macleod V, Miao HQ, Theus A, Zhan F, Shaughnessy JD, Jr., et al. Heparanase enhances syndecan-1 shedding: a novel mechanism for stimulation of tumor growth and metastasis. J Biol Chem 2007;282:13326-13333.
    • (2007) J Biol Chem , vol.282 , pp. 13326-13333
    • Yang, Y.1    Macleod, V.2    Miao, H.Q.3    Theus, A.4    Zhan, F.5    Shaughnessy Jr, J.D.6
  • 11
    • 9144268931 scopus 로고    scopus 로고
    • High heparanase activity in multiple myeloma is associated with elevated microvessel density
    • Kelly T, Miao HQ, Yang Y, Navarro E, Kussie P, Huang Y, et al. High heparanase activity in multiple myeloma is associated with elevated microvessel density. Cancer Res 2003;63:8749-8756.
    • (2003) Cancer Res , vol.63 , pp. 8749-8756
    • Kelly, T.1    Miao, H.Q.2    Yang, Y.3    Navarro, E.4    Kussie, P.5    Huang, Y.6
  • 12
    • 21344452789 scopus 로고    scopus 로고
    • Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases
    • Kelly T, Suva LJ, Huang Y, Macleod V, Miao HQ, Walker RC, Sanderson RD. Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases. Cancer Res 2005;65:5778-5784.
    • (2005) Cancer Res , vol.65 , pp. 5778-5784
    • Kelly, T.1    Suva, L.J.2    Huang, Y.3    Macleod, V.4    Miao, H.Q.5    Walker, R.C.6    Sanderson, R.D.7
  • 13
    • 77955021301 scopus 로고    scopus 로고
    • Metastatic growth from dormant cells induced by a col-I-enriched fibrotic environment
    • Barkan D, El Touny LH, Michalowski AM, Smith JA, Chu I, Davis AS, et al. Metastatic growth from dormant cells induced by a col-I-enriched fibrotic environment. Cancer Res 2010;70:5706-5716.
    • (2010) Cancer Res , vol.70 , pp. 5706-5716
    • Barkan, D.1    El Touny, L.H.2    Michalowski, A.M.3    Smith, J.A.4    Chu, I.5    Davis, A.S.6
  • 14
    • 70450222098 scopus 로고    scopus 로고
    • Matrix crosslinking forces tumor progression by enhancing integrin signaling
    • Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, et al. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 2009;139:891-906.
    • (2009) Cell , vol.139 , pp. 891-906
    • Levental, K.R.1    Yu, H.2    Kass, L.3    Lakins, J.N.4    Egeblad, M.5    Erler, J.T.6
  • 15
    • 0035232015 scopus 로고    scopus 로고
    • Lysyl oxidases: a novel multifunctional amine oxidase family
    • Csiszar K. Lysyl oxidases: a novel multifunctional amine oxidase family. Prog Nucleic Acid Res Mol Biol 2001;70:1-32.
    • (2001) Prog Nucleic Acid Res Mol Biol , vol.70 , pp. 1-32
    • Csiszar, K.1
  • 16
    • 57849100048 scopus 로고    scopus 로고
    • Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche
    • Erler JT, Bennewith KL, Cox TR, Lang G, Bird D, Koong A, et al. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell 2009;15:35-44.
    • (2009) Cancer Cell , vol.15 , pp. 35-44
    • Erler, J.T.1    Bennewith, K.L.2    Cox, T.R.3    Lang, G.4    Bird, D.5    Koong, A.6
  • 17
    • 33846798072 scopus 로고    scopus 로고
    • Niche-to-niche migration of bone-marrow-derived cells
    • Kaplan RN, Psaila B, Lyden D. Niche-to-niche migration of bone-marrow-derived cells. Trends Mol Med 2007;13:72-81.
    • (2007) Trends Mol Med , vol.13 , pp. 72-81
    • Kaplan, R.N.1    Psaila, B.2    Lyden, D.3
  • 18
    • 28644432204 scopus 로고    scopus 로고
    • VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
    • Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 2005;438:820-827.
    • (2005) Nature , vol.438 , pp. 820-827
    • Kaplan, R.N.1    Riba, R.D.2    Zacharoulis, S.3    Bramley, A.H.4    Vincent, L.5    Costa, C.6
  • 19
    • 80053645045 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
    • Wong CC, Gilkes DM, Zhang H, Chen J, Wei H, Chaturvedi P, et al. Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proc Natl Acad Sci USA 2011;108:16369-16374.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 16369-16374
    • Wong, C.C.1    Gilkes, D.M.2    Zhang, H.3    Chen, J.4    Wei, H.5    Chaturvedi, P.6
  • 20
    • 84865149277 scopus 로고    scopus 로고
    • Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis
    • Wong CC, Zhang H, Gilkes DM, Chen J, Wei H, Chaturvedi P, et al. Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. J Mol Med (Berl) 2012;90:803-815.
    • (2012) J Mol Med (Berl) , vol.90 , pp. 803-815
    • Wong, C.C.1    Zhang, H.2    Gilkes, D.M.3    Chen, J.4    Wei, H.5    Chaturvedi, P.6
  • 21
    • 77949879672 scopus 로고    scopus 로고
    • The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1
    • Schietke R, Warnecke C, Wacker I, Schodel J, Mole DR, Campean V, et al. The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1. J Biol Chem 2010;285:6658-6669.
    • (2010) J Biol Chem , vol.285 , pp. 6658-6669
    • Schietke, R.1    Warnecke, C.2    Wacker, I.3    Schodel, J.4    Mole, D.R.5    Campean, V.6
  • 22
    • 84859986442 scopus 로고    scopus 로고
    • Sequential alterations of microRNA expression in hepatocellular carcinoma development and venous metastasis
    • Wong CM, Wong CC, Lee JM, Fan DN, Au SL, Ng IO. Sequential alterations of microRNA expression in hepatocellular carcinoma development and venous metastasis. Hepatology 2012;55:1453-1461.
    • (2012) Hepatology , vol.55 , pp. 1453-1461
    • Wong, C.M.1    Wong, C.C.2    Lee, J.M.3    Fan, D.N.4    Au, S.L.5    Ng, I.O.6
  • 23
    • 66149095045 scopus 로고    scopus 로고
    • Rho-kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion
    • Wong CC, Wong CM, Tung EK, Man K, Ng IO. Rho-kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion. Hepatology 2009;49:1583-1594.
    • (2009) Hepatology , vol.49 , pp. 1583-1594
    • Wong, C.C.1    Wong, C.M.2    Tung, E.K.3    Man, K.4    Ng, I.O.5
  • 24
    • 84877139427 scopus 로고    scopus 로고
    • Hepatic stellate cells in liver development, regeneration, and cancer
    • Yin C, Evason KJ, Asahina K, Stainier DY. Hepatic stellate cells in liver development, regeneration, and cancer. J Clin Invest 2013;123:1902-1910.
    • (2013) J Clin Invest , vol.123 , pp. 1902-1910
    • Yin, C.1    Evason, K.J.2    Asahina, K.3    Stainier, D.Y.4
  • 25
    • 84875445066 scopus 로고    scopus 로고
    • LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis
    • Cox TR, Bird D, Baker AM, Barker HE, Ho MW, Lang G, Erler JT. LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis. Cancer Res 2013;73:1721-1732.
    • (2013) Cancer Res , vol.73 , pp. 1721-1732
    • Cox, T.R.1    Bird, D.2    Baker, A.M.3    Barker, H.E.4    Ho, M.W.5    Lang, G.6    Erler, J.T.7
  • 26
    • 23444453195 scopus 로고    scopus 로고
    • Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2
    • Vadasz Z, Kessler O, Akiri G, Gengrinovitch S, Kagan HM, Baruch Y, et al. Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2. J Hepatol 2005;43:499-507.
    • (2005) J Hepatol , vol.43 , pp. 499-507
    • Vadasz, Z.1    Kessler, O.2    Akiri, G.3    Gengrinovitch, S.4    Kagan, H.M.5    Baruch, Y.6
  • 27
    • 84883477750 scopus 로고    scopus 로고
    • Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-beta-deficient mouse mammary carcinomas
    • Pickup MW, Laklai H, Acerbi I, Owens P, Gorska AE, Chytil A, et al. Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-beta-deficient mouse mammary carcinomas. Cancer Res 2013;73:5336-5346.
    • (2013) Cancer Res , vol.73 , pp. 5336-5346
    • Pickup, M.W.1    Laklai, H.2    Acerbi, I.3    Owens, P.4    Gorska, A.E.5    Chytil, A.6
  • 28
    • 80052616166 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells
    • Sethi A, Mao W, Wordinger RJ, Clark AF. Transforming growth factor-beta induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells. Invest Ophthalmol Vis Sci 2011;52:5240-5250.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 5240-5250
    • Sethi, A.1    Mao, W.2    Wordinger, R.J.3    Clark, A.F.4
  • 30
    • 35649020283 scopus 로고    scopus 로고
    • MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
    • Fabbri M, Garzon R, Cimmino A, Liu Z, Zanesi N, Callegari E, et al. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci U S A 2007;104:15805-15810.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 15805-15810
    • Fabbri, M.1    Garzon, R.2    Cimmino, A.3    Liu, Z.4    Zanesi, N.5    Callegari, E.6
  • 32
    • 79959975720 scopus 로고    scopus 로고
    • Progressive miRNA expression profiles in cervical carcinogenesis and identification of HPV-related target genes for miR-29
    • Li Y, Wang F, Xu J, Ye F, Shen Y, Zhou J, et al. Progressive miRNA expression profiles in cervical carcinogenesis and identification of HPV-related target genes for miR-29. J Pathol 2011;224:484-495.
    • (2011) J Pathol , vol.224 , pp. 484-495
    • Li, Y.1    Wang, F.2    Xu, J.3    Ye, F.4    Shen, Y.5    Zhou, J.6
  • 33
    • 78651411120 scopus 로고    scopus 로고
    • MiR-26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression of EZH2
    • Lu J, He ML, Wang L, Chen Y, Liu X, Dong Q, et al. MiR-26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression of EZH2. Cancer Res 2011;71:225-233.
    • (2011) Cancer Res , vol.71 , pp. 225-233
    • Lu, J.1    He, M.L.2    Wang, L.3    Chen, Y.4    Liu, X.5    Dong, Q.6
  • 34
    • 79952421239 scopus 로고    scopus 로고
    • Downregulation of microRNA-29c is associated with hypermethylation of tumor-related genes and disease outcome in cutaneous melanoma
    • Nguyen T, Kuo C, Nicholl MB, Sim MS, Turner RR, Morton DL, Hoon DS. Downregulation of microRNA-29c is associated with hypermethylation of tumor-related genes and disease outcome in cutaneous melanoma. Epigenetics 2011;6:388-394.
    • (2011) Epigenetics , vol.6 , pp. 388-394
    • Nguyen, T.1    Kuo, C.2    Nicholl, M.B.3    Sim, M.S.4    Turner, R.R.5    Morton, D.L.6    Hoon, D.S.7
  • 35
    • 44449111693 scopus 로고    scopus 로고
    • MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins
    • Sengupta S, den Boon JA, Chen IH, Newton MA, Stanhope SA, Cheng YJ, et al. MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins. Proc Natl Acad Sci USA 2008;105:5874-5878.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 5874-5878
    • Sengupta, S.1    den Boon, J.A.2    Chen, I.H.3    Newton, M.A.4    Stanhope, S.A.5    Cheng, Y.J.6
  • 36
    • 77950602604 scopus 로고    scopus 로고
    • Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma
    • Xiong Y, Fang JH, Yun JP, Yang J, Zhang Y, Jia WH, Zhuang SM. Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma. Hepatology 2010;51:836-845.
    • (2010) Hepatology , vol.51 , pp. 836-845
    • Xiong, Y.1    Fang, J.H.2    Yun, J.P.3    Yang, J.4    Zhang, Y.5    Jia, W.H.6    Zhuang, S.M.7
  • 37
    • 84862762321 scopus 로고    scopus 로고
    • MicroRNA-26a promotes cholangiocarcinoma growth by activating beta-catenin
    • Zhang J, Han C, Wu T. MicroRNA-26a promotes cholangiocarcinoma growth by activating beta-catenin. Gastroenterology 2012;143:246-256.e8.
    • (2012) Gastroenterology , vol.143 , pp. 246-256e8
    • Zhang, J.1    Han, C.2    Wu, T.3
  • 38
    • 77951003346 scopus 로고    scopus 로고
    • microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma
    • Zhao JJ, Lin J, Lwin T, Yang H, Guo J, Kong W, et al. microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma. Blood 2010;115:2630-2639.
    • (2010) Blood , vol.115 , pp. 2630-2639
    • Zhao, J.J.1    Lin, J.2    Lwin, T.3    Yang, H.4    Guo, J.5    Kong, W.6
  • 39
    • 84873364088 scopus 로고    scopus 로고
    • GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression
    • Chou J, Lin JH, Brenot A, Kim JW, Provot S, Werb Z. GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression. Nat Cell Biol 2013;15:201-213.
    • (2013) Nat Cell Biol , vol.15 , pp. 201-213
    • Chou, J.1    Lin, J.H.2    Brenot, A.3    Kim, J.W.4    Provot, S.5    Werb, Z.6
  • 40
    • 77956425361 scopus 로고    scopus 로고
    • Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment
    • Barry-Hamilton V, Spangler R, Marshall D, McCauley S, Rodriguez HM, Oyasu M, et al. Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment. Nat Med 2010;16:1009-1017.
    • (2010) Nat Med , vol.16 , pp. 1009-1017
    • Barry-Hamilton, V.1    Spangler, R.2    Marshall, D.3    McCauley, S.4    Rodriguez, H.M.5    Oyasu, M.6
  • 41
    • 79952216583 scopus 로고    scopus 로고
    • LOXL2-mediated matrix remodeling in metastasis and mammary gland involution
    • Barker HE, Chang J, Cox TR, Lang G, Bird D, Nicolau M, et al. LOXL2-mediated matrix remodeling in metastasis and mammary gland involution. Cancer Res 2011;71:1561-1572.
    • (2011) Cancer Res , vol.71 , pp. 1561-1572
    • Barker, H.E.1    Chang, J.2    Cox, T.R.3    Lang, G.4    Bird, D.5    Nicolau, M.6
  • 42
    • 38849203274 scopus 로고    scopus 로고
    • Current treatment strategy for hepatocellular carcinoma
    • Ng KK, Poon RT. Current treatment strategy for hepatocellular carcinoma. Saudi Med J 2007;28:1330-1338.
    • (2007) Saudi Med J , vol.28 , pp. 1330-1338
    • Ng, K.K.1    Poon, R.T.2
  • 43
    • 0032857003 scopus 로고    scopus 로고
    • Local ablation therapy for hepatocellular carcinoma
    • Okada S. Local ablation therapy for hepatocellular carcinoma. Semin Liver Dis 1999;19:323-328.
    • (1999) Semin Liver Dis , vol.19 , pp. 323-328
    • Okada, S.1
  • 44
    • 64049098319 scopus 로고    scopus 로고
    • Antisense hypoxia-inducible factor-1alpha augments transcatheter arterial embolization in the treatment of hepatocellular carcinomas in rats
    • Sun X, Jiang H, Jiang X, Tan H, Meng Q, Sun B, et al. Antisense hypoxia-inducible factor-1alpha augments transcatheter arterial embolization in the treatment of hepatocellular carcinomas in rats. Hum Gene Ther 2009;20:314-324.
    • (2009) Hum Gene Ther , vol.20 , pp. 314-324
    • Sun, X.1    Jiang, H.2    Jiang, X.3    Tan, H.4    Meng, Q.5    Sun, B.6


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