ELF3 modulates type II collagen gene (COL2A1) transcription in chondrocytes by inhibiting SOX9-CBP/p300-driven histone acetyltransferase activity

Connective Tissue Research

Volumn 58, Issue 1, 2017, Pages 15-26

  Otero, Miguel ^a   Peng, Haibing ^b,g   Hachem, Karim El ^a,h   Culley, Kirsty L ^a   Wondimu, Elisabeth B ^a,c   Quinn, Justin ^a   Asahara, Hiroshi ^d   Tsuchimochi, Kaneyuki ^a,i   Hashimoto, Ko ^a,e   Goldring, Mary B ^a,c,f  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c Weill Graduate School of Medical Sciences of Cornell University   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e TOHOKU UNIVERSITY HOSPITAL   (Japan)

^f WEILL CORNELL MEDICAL COLLEGE   (United States)

^g NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^h MOUNT SINAI SCHOOL OF MEDICINE   (United States)

ⁱ Onga Health Center   (Japan)

Author keywords

Chondrocytes; collagen; methylation; osteoarthritis; transcription

Indexed keywords

5 HYDROXYMETHYLCYTOSINE; COLLAGEN TYPE 2; E1A ASSOCIATED P300 PROTEIN; MESSENGER RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E74 LIKE FACTOR 3; TRANSCRIPTION FACTOR GAL4; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG; COL2A1 PROTEIN, HUMAN; DNA BINDING PROTEIN; ELF3 PROTEIN, HUMAN; HISTONE ACETYLTRANSFERASE PCAF; SOX9 PROTEIN, HUMAN; TRANSCRIPTION FACTOR ETS;

ARTICLE; BINDING SITE; CHONDROCYTE; CONTROLLED STUDY; DNA METHYLATION; ENZYME INHIBITION; EPIGENETICS; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MODULATION; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TRANSACTIVATION; BIOSYNTHESIS; DNA RESPONSIVE ELEMENT; GENETICS; METABOLISM; PHYSIOLOGY; TRANSFORMED CELL LINE;

CELL LINE, TRANSFORMED; CHONDROCYTES; COLLAGEN TYPE II; DNA-BINDING PROTEINS; HUMANS; P300-CBP TRANSCRIPTION FACTORS; PROTO-ONCOGENE PROTEINS C-ETS; RESPONSE ELEMENTS; SOX9 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 84978473097     PISSN: 03008207     EISSN: 16078438     Source Type: Journal    
DOI: 10.1080/03008207.2016.1200566     Document Type: Article

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