Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions

Journal of Rheumatology

Volumn 32, Issue 5, 2005, Pages 876-886

  Tchetina, Elena V ^a,b,c   Squires, Ginette ^d   Poole, A Robin ^d  

^a Joint Diseases Laboratory   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c SHRINERS HOSPITAL FOR CHILDREN   (Canada)

^d NONE

Author keywords

Articular cartilage; Focal lesions; Gene expression chondrocyte differentiation

Indexed keywords

AGGRECAN; AGGRECANASE; CASPASE 3; COLLAGEN TYPE 10 A1; COLLAGEN TYPE 2; COLLAGEN TYPE 2 A1; COLLAGENASE; COLLAGENASE 3; GENE PRODUCT; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE 14; MATRIX PROTEIN; PROTEIN ADAMTS 5; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR SOX9; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CHONDROPATHY; DISEASE ASSOCIATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; FEMUR CONDYLE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; OSTEOARTHRITIS; PATELLA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGED; CARTILAGE, ARTICULAR; CELL DIFFERENTIATION; CHONDROCYTES; COLLAGEN TYPE II; CYTOKINES; EARLY DIAGNOSIS; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; KNEE JOINT; MALE; METALLOPROTEASES; MIDDLE AGED; UP-REGULATION;

EID: 18744385527     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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