Phlpp1 facilitates post-traumatic osteoarthritis and is induced by inflammation and promoter demethylation in human osteoarthritis

Osteoarthritis and Cartilage

Volumn 24, Issue 6, 2016, Pages 1021-1028

  Bradley, E W ^a   Carpio, L R ^a   McGee Lawrence, M E ^a,c   Castillejo Becerra, C ^a   Amanatullah, D F ^a   Ta, L E ^a   Otero, M ^d   Goldring, M B ^d   Kakar, S ^a   Westendorf, J J ^a,b  

^a MAYO CLINIC   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

^d HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

Articular cartilage; DMM mouse model; DNA methylation; Il6; Mechanical allodynia; TNF

Indexed keywords

CYTOKINE; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE PHLPP1; UNCLASSIFIED DRUG; NUCLEAR PROTEIN; PHLPP PROTEIN, MOUSE; PHLPP1 PROTEIN, HUMAN;

ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; CONTROLLED STUDY; DEMETHYLATION; DISEASE COURSE; DNA METHYLATION; ENZYME INDUCTION; FEMUR NECK FRACTURE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; JOINT RADIOGRAPHY; KNEE INSTABILITY; KNEE LIGAMENT INJURY; MALE; MOUSE; MURINE MODEL; NONHUMAN; OSTEOARTHRITIS; PAIN ASSESSMENT; POSTTRAUMATIC OSTEOARTHRITIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; VON FREY TEST; ANIMAL; CHONDROCYTE; DISEASE MODEL;

ANIMALS; CARTILAGE, ARTICULAR; CHONDROCYTES; DEMETHYLATION; DISEASE MODELS, ANIMAL; HUMANS; INFLAMMATION; MICE; NUCLEAR PROTEINS; OSTEOARTHRITIS; PHOSPHOPROTEIN PHOSPHATASES;

EID: 84955277705     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2015.12.014     Document Type: Article

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