α-Synuclein fibrils exhibit gain of toxic function, promoting tau aggregation and inhibiting microtubule assembly

Journal of Biological Chemistry

Volumn 291, Issue 29, 2016, Pages 15046-15056

  Oikawa, Takayuki ^a,b   Nonaka, Takashi ^a   Terada, Makoto ^a,c   Tamaoka, Akira ^c   Hisanaga, Shin Ichi ^b   Hasegawa, Masato ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b TOKYO METROPOLITAN UNIVERSITY   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BINS; POLYMERIZATION;

C-TERMINAL REGIONS; CONFORMATIONAL CHANGE; GLIAL CYTOPLASMIC; INHIBITORY EFFECT; MICROTUBULE ASSEMBLY; MICROTUBULE POLYMERIZATION; MULTIPLE SYSTEM ATROPHIES; PARKINSON DISEASE;

NEURONS;

ALPHA SYNUCLEIN; MUTANT PROTEIN; TAU PROTEIN; MAPT PROTEIN, HUMAN; PROTEIN AGGREGATE; PROTEIN BINDING; RECOMBINANT PROTEIN;

ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; FIBER; MICROTUBULE ASSEMBLY; NERVE CELL LESION; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; CELL LINE; CHEMISTRY; GENE DELETION; GENETICS; HUMAN; IN VITRO STUDY; LEWY BODY; METABOLISM; MICROTUBULE; NERVE CELL; PARKINSON DISEASE; PROTEINOSIS;

ALPHA-SYNUCLEIN; CELL LINE; HUMANS; IN VITRO TECHNIQUES; LEWY BODIES; MICROTUBULES; NEURONS; PARKINSON DISEASE; PROTEIN AGGREGATES; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SEQUENCE DELETION; TAU PROTEINS;

EID: 84978406298     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.736355     Document Type: Article

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