The Concordance and Heritability of Type 2 Diabetes in 34,166 Twin Pairs From International Twin Registers: The Discordant Twin (DISCOTWIN) Consortium

Twin Research and Human Genetics

Volumn 18, Issue 6, 2015, Pages 762-771

  Willemsen, Gonneke ^a   Ward, Kirsten J ^b   Bell, Christopher G ^b   Christensen, Kaare ^c   Bowden, Jocelyn ^d   Dalgård, Christine ^c   Harris, Jennifer R ^e   Kaprio, Jaakko ^f,g   Lyle, Robert ^h   Magnusson, Patrik K E ⁱ   Mather, Karen A ^d   Ordoňana, Juan R ^j,k   Perez Riquelme, Francisco ^k   Pedersen, Nancy L ⁱ   Pietiläinen, Kirsi H ^f,l   Sachdev, Perminder S ^d   Boomsma, Dorret I ^a   Spector, Tim ^b  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

^e NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^f UNIVERSITY OF HELSINKI   (Finland)

^g NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^h OSLO UNIVERSITY HOSPITAL   (Norway)

ⁱ KAROLINSKA INSTITUTE   (Sweden)

^j UNIVERSITY OF MURCIA   (Spain)

^k Murcia Biomedical Research Institute (IMIB)   (Spain)

^l HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

more..

Author keywords

discordant twins; heterogeneity; international comparison; prevalence; type 2 diabetes

Indexed keywords

GLUCOSE; INSULIN;

ADULT; AGE; ARTICLE; AUSTRALIA; BODY MASS; COHORT ANALYSIS; CONTINGENCY TABLE; CONTROLLED STUDY; DENMARK; DISEASE COURSE; DIZYGOTIC TWINS; ENVIRONMENTAL FACTOR; EPIGENETICS; EUROPE; FINLAND; GENETIC LINKAGE; GENOTYPE; GLUCOSE BLOOD LEVEL; HERITABILITY; HUMAN; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MEDICAL RECORD; MONOZYGOTIC TWINS; NETHERLANDS; NON INSULIN DEPENDENT DIABETES MELLITUS; NORWAY; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; SELF REPORT; SOCIAL ASPECT; SPAIN; SWEDEN; TWIN CONCORDANCE; TWIN DISCORDANCE; UNITED KINGDOM; YOUNG ADULT; AGED; DIABETES MELLITUS, TYPE 2; FEMALE; GENETICS; MALE; MIDDLE AGED; REGISTER; TWINS;

AGED; AUSTRALIA; DIABETES MELLITUS, TYPE 2; DISEASES IN TWINS; EUROPE; FEMALE; HUMANS; MALE; MIDDLE AGED; PREVALENCE; REGISTRIES;

EID: 84951004246     PISSN: 18324274     EISSN: 18392628     Source Type: Journal    
DOI: 10.1017/thg.2015.83     Document Type: Article

References (55)

1. Almgren, P., Lehtovirta, M., Isomaa, B., Sarelin, L., Taskinen, M. R., Lyssenko, V., ⋯ Botnia Study Group. (2011). Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study. Diabetologia, 54, 2811-2819.
2. Barnett, A. H., Spiliopoulos, A. J., Pyke, D. A., Stubbs, W. A., Burrin, J., & Alberti, K. G. (1981). Metabolic studies in unaffected co-twins of non-insulin-dependent diabetics. British Medical Journal, 282, 1656-1658.
3. Bonnefond, A., & Froguel, P. (2015). Rare and commongenetic events in type 2 diabetes:What should biologists know? Cell Metabolism, 21, 357-368.
4. Bork-Jensen, J., Scheele, C., Christophersen, D. V., Nilsson, E., Friedrichsen, M., Fernandez-Twinn, D. S., ⋯ Vaag, A. (2015). Glucose tolerance is associated with differential expression of microRNAs inskeletalmuscle: results fromstudies of twins with and without type 2 diabetes Diabetologia, 58, 363-373.
5. Buchwald, D., Kaprio, J., Hopper, J. L., Sung, J., Goldberg, J., Fortier, I., ⋯ Harris, J. R. (2014). International network of twin registries (INTR): Building a platform for international collaboration. Twin Research and Human Genetics, 17, 574-577.
6. Committee on Diabetic Twins. (1988). Japan diabetes society diabetes mellitus in twins: A cooperative study in Japan. Diabetes Research and Clinical Practice, 5, 271-280.
7. De Moor, M. H., Boomsma, D. I., Stubbe, J. H., Willemsen, G., & de Geus, E. J. (2008). Testing causality in the association between regular exercise and symptoms of anxiety and depression. Archives of General Psychiatry, 65, 897-905.
8. European Commission. (2004). Quality of Life and Management of the Living Resource, Fifth Framework Program1998-2002. Luxembough: Author.
9. Falconer, D. S., & Mackay, T. F. C. (1996). Introduction to quantitative genetics. Essex, UK: Pearson Educational Limited.
10. Fejer, R., Hartvigsen, J., & Kyvik, K. O. (2006). Heritability of neck pain: A population-based study of 33,794 Danish twins. Rheumatology, 45, 589-594.
11. Friedman, J. M. (2009). Obesity: Causes and control of excess body fat. Nature, 459, 340-342.
12. Gluckman, P. D., Hanson, M., Zimmet, P., & Forrester, T. (2011). Losing the war against obesity: The need for a developmental perspective. Science Translational Medicine, 27, 93cm19.
13. Hur, Y. M., & Craig, J. M. (2013). Twin registries worldwide: An important resource for scientific research. Twin Research and Human Genetics, 16, 1-12.
14. International Diabetes Federation (IDF). (2015). Diabetes atlas (6th ed.). Retrieved March 20, 2015, from http://www.idf.org/atlasmap/atlasmap.
15. Kaprio, J. (2013). The finnish twin cohort study: An update. Twin Research and Human Genetics, 16, 157-162.
16. Kaprio, J., Tuomilehto, J., Koskenvuo, M., Romanov, K., Reunanen, A., Eriksson, J., ⋯ Kesäniemi, Y. A. (1992). Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a populationbased cohort of twins in Finland. Diabetologia, 35, 1060-1067.
17. Kettunen, J., Perola, M., Martin, N. G., Cornes, B. K., Wilson, S. G., Montgomery, G.W., ⋯ Genom EU twin-project. (2009). Multicenter dizygotic twin cohort study confirms two linkage susceptibility loci for body mass index at 3q29 and 7q36 and identifies three further potential novel loci. International Journal of Obesity, 33, 1235-1242.
18. Korja, M., Silventoinen, K., McCarron, P., Zdravkovic, S., Skytthe, A., Haapanen, A., ⋯ Genom EU twin Project. (2010). Genetic epidemiology of spontaneous subarachnoid hemorrhage: Nordic Twin Study. Stroke, 41, 2458-2462.
19. Kujala, U. M., Kaprio, J., & Koskenvuo, M. (2000). Diabetes in a population-based series of twin pairs discordant for leisure sedentariness. Diabetologia, 43, 259.
20. Kujala, U. M., Kaprio, J., & Koskenvuo, M. (2002). Modifiable risk factors as predictors of all-causemortality: The roles of genetics and childhood environment. American Journal of Epidemiology, 156, 985-993.
21. Landin-Olsson, M. (2002). Latent autoimmune diabetes in adults. Annals of the New York Academy of Sciences, 958, 112-116.
22. Lehtovirta, M., Pietiläinen, K. H., Levälahti, E., Heikkilä, K., Groop, L., Silventoinen, K., ⋯ Koskenvuo, M. (2010). Evidence that BMI and type 2 diabetes share only a minor fraction of genetic variance: A follow-up study of 23,585 monozygotic and dizygotic twins from the Finnish Twin Cohort Study. Diabetologia, 53, 1314-1321.
23. Lichtenstein, P., de Faire, U., Floderus, B., Svartengren, M., Svedberg, P., & Pedersen, N. L. (2002). The Swedish twin registry: A unique resource for clinical, epidemiological and genetic studies. Journal of Internal Medicine, 252, 184-205.
24. Lichtenstein, P., Sullivan, P. F., Cnattingius, S., Gatz, M., Johansson, S., Carlström, E., ⋯ Pedersen, N. L. (2006). The Swedish twin registry in the third millennium: An update. Twin Research and Human Genetics, 9, 875-982.
25. McCarthy, M. I. (2010). Genomics, type 2 diabetes, and obesity. New England Journal of Medicine, 363, 2339-2350.
26. Medici, F., Hawa, M., Ianari, A., Pyke, D. A., & Leslie, R. D. (1999). Concordance rate for type II diabetes mellitus in monozygotic twins: Actuarial analysis. Diabetologia, 42, 146-150.
27. Mill, J., & Heijmans, B. T. (2013). From promises to practical strategies in epigenetic epidemiology. Nature Reviews Genetics, 14, 585-594.
28. Moayyeri, A., Hammond, C. J., Hart, D. J., & Spector, T. D. (2013). The UK adult twin registry (Twins UK Resource). Twin Research and Human Genetics, 16, 144-149.
29. Moayyeri, A., Hammond, C. J., Valdes, A. M., & Spector, T. D. (2013). Cohort profile: Twins UK and healthy ageing twin study. International Journal of Epidemiology, 42, 76-85.
30. Mulder, E. J., Van Baal, C., Gaist, D., Kallela, M., Kaprio, J., Svensson, D. A., ⋯ Palotie, A. (2003). Genetic and environmental influences on migraine: A twin study across six countries. Twin Research, 6, 422-431.
31. Naukkarinen, J., Rissanen, A., Kaprio, J., & Pietiläinen, K. H. (2012). Causes and consequences of obesity: The contribution of recent twin studies. International Journal of Obesity, 36, 1017-1024.
32. Neale, M. C., Boker, S. M., Xie, G., & Maes, H. H. (2003). Mx: Statistical modelling (6th ed.), Richmond, VA: Department of Psychiatry, Virginia Commonwealth University.
33. Newman, B., Selby, J. V., King, M. C., Slemenda, C., Fabsitz, R., & Friedman, G. D. (1987). Concordance for type 2 (noninsulin-dependent) diabetes mellitus in male twins. Diabetologia, 30, 763-768.
34. Nilsen, T. S., Brandt, I., Magnus, P., & Harris, J. R. (2012). The Norwegian twin registry. Twin Research and Human Genetics, 15, 775-780.
35. Nilsen, T. S., Knudsen, G. P., Gervin, K., Brandt, I., Røysamb, E., Tambs, K., ⋯ Harris, J. R. (2013). The Norwegian twin registry froma public health perspective:Aresearch update. Twin Research and Human Genetics, 16, 285-295.
36. Ordoñana, J. R., Rebollo-Mesa, I., Carrillo, E., Colodro-Conde, L., García-Palomo, F. J., González-Javier, F., ⋯ Pérez-Riquelme, F. (2013). The Murcia twin registry: A population-based registry of adultmultiples in Spain. Twin Research and Human Genetics, 16, 302-306.
37. Pallister, T., Spector, T. D., & Menni, C. (2014). Twin studies Advance the understanding of gene-environment interplay in human nutrigenomics. Nutrition Research Reviews, 27, 242-251.
38. Peltonen, L., & Genom EU twin, (2003). Genom EU twin: A strategy to identify genetic influences on health and disease. Twin Research, 6, 354-360.
39. Perola, M., Sammalisto, S., Hiekkalinna, T., Martin, N. G., Visscher, P. M., Montgomery, G.W., ⋯ Genom EU twin Project. (2007). Combined genome scans for body stature in 6,602 European twins: Evidence for common Caucasian loci. PLoS Genetics, 3, e97.
40. Poulsen, P., Kyvik, K. O., Vaag, A., & Beck-Nielsen, H. (1999). Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance-A populationbased twin study. Diabetologia, 42, 139-145.
41. Rakyan, V. K., Down, T. A., Balding, D. J., & Beck, S. (2011). Epigenome-wide association studies for common human diseases. Nature Reviews Genetics, 12, 529-541.
42. Ribel-Madsen, R., Fraga, M. F., Jacobsen, S., Bork-Jensen, J., Lara, E., Calvanese, V., ⋯ Poulsen, P. (2012). Genomewide analysis of DNA methylation differences inmuscle and fat from monozygotic twins discordant for type 2 diabetes. PLoS One, 7, e51302.
43. Rijsdijk, F., & Sham, P. (2002). Analytic approaches to twin data using structural equation models. Briefings in Bioinformatics, 3, 119-133.
44. Sachdev, P.S., Lee, T., Wen, W., Ames, D., Batouli, A.H., Bowden, J., ⋯ OATS Research Team. (2013). The contribution of twins to the study of cognitive ageing and dementia: The older Australian twins study. International Review of Psychiatry, 25, 738-747.
45. Schousboe, K., Willemsen, G., Kyvik, K. O., Mortensen, J., Boomsma, D. I., Cornes, B. K., ⋯ Harris, J. R. (2003). Sex differences in heritability of BMI: A comparative study of results from twin studies in eight countries. Twin Research, 6, 409-421.
46. Silventoinen, K., Sammalisto, S., Perola, M., Boomsma, D. I., Cornes, B. K., Davis, C., ⋯ Kaprio, J. (2003). Heritability of adult body height: A comparative study of twin cohorts in eight countries. Twin Research, 6, 399-408.
47. Skytthe, A., Christiansen, L., Kyvik, K. O., Bødker, F. L., Hvidberg, L., Petersen, I., ⋯ Christensen, K. (2013). The danish twin registry: Linking surveys, national registers, and biological information. Twin Research and Human Genetics, 16, 104-111.
48. Smith, C. (1970). Heritability of liability and concordance in monozygous twins. Annals of Human Genetics, 34, 85-91.
49. Stubbe, J. H., Boomsma, D. I., Vink, J. M., Cornes, B. K., Martin, N. G., Skytthe, A., ⋯ de Geus, E. J. (2006). Genetic influences on exercise participation in 37,051 twin pairs from seven countries. PLoS One, 20, e22.
50. Surakka, I., Whitfield, J. B., Perola, M., Visscher, P. M., Montgomery, G.W., Falchi, M., ⋯ Genom EU twin Project. (2012). A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol. Twin Research and Human Genetics, 15, 691-699.
51. van Dongen, J., Slagboom, P. E., Draisma, H. H., Martin, N. G., & Boomsma, D. I. (2012). The continuing value of twin studies in the omics era. Nature Reviews Genetics, 13, 640-653.
52. Vink, J. M., Boomsma, D. I., Medland, S. E., de Moor, M. H., Stubbe, J. H., Cornes, B. K., ⋯ de Geus, E. J. (2011). Variance components models for physical activity with age as modifier:Acomparative twin study inseven countries. Twin Research and Human Genetics, 14, 25-34.
53. Willemsen, G., Vink, J.M., Abdellaoui, A., den Braber, A., van Beek, J. H., Draisma, H. H., ⋯ Boomsma, D. I. (2013). The adult Netherlands twin register: Twenty-five years of survey and biological data collection. Twin Research and Human Genetics, 16, 271-281.
54. World Health Organization (WHO). (2015). Diabetes Fact sheet No 312. Retrieved March 20, 2015, from http://www.who.int/mediacentre/factsheets/fs312/en/.
55. Zimmet, P., Alberti, K. G., & Shaw, J. (2001). Global and societal implications of the diabetes epidemic. Nature, 13, 782-787.