α-tocopherol attenuates the triglyceride- and cholesterol-lowering effects of rice bran tocotrienol in rats fed a western diet

Journal of Agricultural and Food Chemistry

Volumn 64, Issue 26, 2016, Pages 5361-5366

  Shibata, Akira ^a   Kawakami, Yuki ^b   Kimura, Toshiyuki ^c   Miyazawa, Teruo ^a   Nakagawa, Kiyotaka ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b OKAYAMA PREFECTURAL UNIVERSITY   (Japan)

^c FOOD RESEARCH INSTITUTE   (Japan)

Author keywords

cholesterol; F344 rat; tocopherol; tocotrienol; triglyceride

Indexed keywords

CHOLESTEROL; GENE EXPRESSION; GENES; METABOLISM; PHYSIOLOGY; RATS; TISSUE;

BENEFICIAL EFFECTS; CHOLESTEROL-LOWERING EFFECTS; HYPOCHOLESTEROLEMIC EFFECT; HYPOLIPIDEMIC EFFECT; TISSUE CONCENTRATIONS; TOCOPHEROL; TOCOTRIENOLS; TRIGLYCERIDE;

GENE EXPRESSION REGULATION;

ALPHA TOCOPHEROL; ALPHA TOCOTRIENOL; CARNITINE PALMITOYLTRANSFERASE; CARNITINE PALMITOYLTRANSFERASE-1A, RAT; CHOLESTEROL; PLANT EXTRACT; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ADVERSE EFFECTS; ANIMAL; CHEMISTRY; DYSLIPIDEMIAS; FISCHER 344 RAT; GENETICS; HUMAN; LIVER; MALE; METABOLISM; ORYZA; RAT; WESTERN DIET;

ADIPOSE TISSUE; ALPHA-TOCOPHEROL; ANIMALS; CARNITINE O-PALMITOYLTRANSFERASE; CHOLESTEROL; DIET, WESTERN; DYSLIPIDEMIAS; HUMANS; LIVER; MALE; ORYZA; PLANT EXTRACTS; RATS; RATS, INBRED F344; TOCOTRIENOLS; TRIGLYCERIDES;

EID: 84978069634     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/acs.jafc.6b02228     Document Type: Article

References (25)

1. Miller, M.; Stone, N. J.; Ballantyne, C.; Bittner, V.; Criqui, M. H.; Ginsberg, H. N.; Goldberg, A. C.; Howard, W. J.; Jacobson, M. S.; Kris-Etherton, P. M.; Lennie, T. A.; Levi, M.; Mazzone, T.; Pennathur, S. American Heart Association Clinical Lipidology, Thrombosis, and Prevention Committee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular Nursing; Council on the Kidney in Cardiovascular Disease. Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association Circulation 2011, 123, 2292-2333 10.1161/CIR.0b013e3182160726
2. Chen, G.; Wang, H.; Zhang, X.; Yang, S. T. Nutraceuticals and functional foods in the management of hyperlipidemia Crit. Rev. Food Sci. Nutr. 2014, 54, 1180-1201 10.1080/10408398.2011.629354
3. Parker, R. A.; Pearce, B. C.; Clark, R. W.; Gordon, D. A.; Wright, J. J. Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase J. Biol. Chem. 1993, 268, 11230-11238
4. Zaiden, N.; Yap, W. N.; Ong, S.; Xu, C. H.; Teo, V. H.; Chang, C. P.; Zhang, X. W.; Nesaretnam, K.; Shiba, S.; Yap, Y. L. γ δ tocotrienols reduce hepatic triglyceride synthesis and VLDL secretion J. Atheroscler. Thromb. 2010, 17, 1019-1032 10.5551/jat.4911
5. Khanna, S.; Roy, S.; Ryu, H.; Bahadduri, P.; Swaan, P. W.; Ratan, R. R.; Sen, C. K. Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration J. Biol. Chem. 2003, 278, 43508-43515 10.1074/jbc.M307075200
6. Nakagawa, K.; Shibata, A.; Yamashita, S.; Tsuzuki, T.; Kariya, J.; Oikawa, S.; Miyazawa, T. In vivo angiogenesis is suppressed by unsaturated vitamin E, tocotrienol J. Nutr. 2007, 137, 1938-1943
7. Minhajuddin, M.; Beg, Z. H.; Iqbal, J. Hypolipidemic and antioxidant properties of tocotrienol rich fraction isolated from rice bran oil in experimentally induced hyperlipidemic rats Food Chem. Toxicol. 2005, 43, 747-753 10.1016/j.fct.2005.01.015
8. Sookwong, P.; Nakagawa, K.; Murata, K.; Kojima, Y.; Miyazawa, T. Quantitation of tocotrienol and tocopherol in various rice brans J. Agric. Food Chem. 2007, 55, 461-466 10.1021/jf0621572
9. Aggarwal, B. B.; Sundaram, C.; Prasad, S.; Kannappan, R. Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases Biochem. Pharmacol. 2010, 80, 1613-1631 10.1016/j.bcp.2010.07.043
10. Qureshi, A. A.; Pearce, B. C.; Nor, R. M.; Gapor, A.; Peterson, D. M.; Elson, C. E. Dietary α-tocopherol attenuates the impact of γ-tocotrienol on hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in chickens J. Nutr. 1996, 126, 389-394
11. Folch, J.; Lees, M.; Sloane; Stanley, G. H. A simple method for the isolation and purification of total lipids from animal tissues J. Biol. Chem. 1957, 226, 497-509
12. Kawakami, Y.; Tsuzuki, T.; Nakagawa, K.; Miyazawa, T. Distribution of tocotrienols in rats fed a rice bran tocotrienol concentrate Biosci., Biotechnol., Biochem. 2007, 71, 464-471 10.1271/bbb.60524
13. Wong, W. Y.; Poudyal, H.; Ward, L. C.; Brown, L. Tocotrienols reverse cardiovascular, metabolic and liver changes in high carbohydrate, high fat diet-fed rats Nutrients 2012, 4, 1527-1541 10.3390/nu4101527
14. Burdeos, G. C.; Nakagawa, K.; Kimura, F.; Miyazawa, T. Tocotrienol attenuates triglyceride accumulation in HepG2 cells and F344 rats Lipids 2012, 47, 471-481 10.1007/s11745-012-3659-0
15. Burdeos, G. C.; Nakagawa, K.; Abe, T.; Kimura, F.; Miyazawa, T. Tocotrienol modulates crucial lipid metabolism-related genes in differentiated 3T3-L1 preadipocytes Food Funct. 2014, 5, 2221-2227 10.1039/C4FO00463A
16. Degrace, P.; Demizieux, L.; Gresti, J.; Chardigny, J. M.; Sébédio, J. L.; Clouet, P. Hepatic steatosis is not due to impaired fatty acid oxidation capacities in C57BL/6J mice fed the conjugated trans-10,cis-12-isomer of linoleic acid J. Nutr. 2004, 134, 861-867
17. Alberdi, G.; Rodríguez, V. M.; Macarulla, M. T.; Miranda, J.; Churruca, I.; Portillo, M. P. Hepatic lipid metabolic pathways modified by resveratrol in rats fed an obesogenic diet Nutrition 2013, 29, 562-567 10.1016/j.nut.2012.09.011
18. Rozman, D.; Monostory, K. Perspectives of the non-statin hypolipidemic agents Pharmacol. Ther. 2010, 127, 19-40 10.1016/j.pharmthera.2010.03.007
19. Song, B. L.; DeBose-Boyd, R. A. Insig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by δ- and γ-tocotrienols J. Biol. Chem. 2006, 281, 25054-25061 10.1074/jbc.M605575200
20. Mandard, S.; Müller, M.; Kersten, S. Peroxisome proliferator-activated receptor α target genes Cell. Mol. Life Sci. 2004, 61, 393-416 Review. 10.1007/s00018-003-3216-3
21. Fang, F.; Kang, Z.; Wong, C. Vitamin E tocotrienols improve insulin sensitivity through activating peroxisome proliferator-activated receptors Mol. Nutr. Food Res. 2010, 54, 345-352 10.1002/mnfr.200900119
22. Uchida, T.; Abe, C.; Nomura, S.; Ichikawa, T.; Ikeda, S. Tissue distribution of α- and γ-tocotrienol and γ-tocopherol in rats and interference with their accumulation by α-tocopherol Lipids 2012, 47, 129-139 10.1007/s11745-011-3620-7
23. Abuasal, B. S.; Qosa, H.; Sylvester, P. W.; Kaddoumi, A. Comparison of the intestinal absorption and bioavailability of γ-tocotrienol and α-tocopherol: in vitro, in situ and in vivo studies Biopharm. Drug Dispos. 2012, 33, 246-256 10.1002/bdd.1790
24. Hosomi, A.; Arita, M.; Sato, Y.; Kiyose, C.; Ueda, T.; Igarashi, O.; Arai, H.; Inoue, K. Affinity for α-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs FEBS Lett. 1997, 409, 105-108 10.1016/S0014-5793(97)00499-7
25. Shibata, A.; Nakagawa, K.; Sookwong, P.; Tsuduki, T.; Asai, A.; Miyazawa, T. α-Tocopherol attenuates the cytotoxic effect of δ-tocotrienol in human colorectal adenocarcinoma cells Biochem. Biophys. Res. Commun. 2010, 397, 214-219 10.1016/j.bbrc.2010.05.087