메뉴 건너뛰기




Volumn 33, Issue 5, 2012, Pages 246-256

Comparison of the intestinal absorption and bioavailability of γ-tocotrienol and α-tocopherol: In vitro, in situ and in vivo studies

Author keywords

tocopherol; tocotrienol; carrier mediated uptake; intestinal absorption; NPC1L1

Indexed keywords

ALPHA TOCOPHEROL; CORN OIL; DRUG CARRIER; EZETIMIBE; GAMMA TOCOTRIENOL;

EID: 84863716186     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.1790     Document Type: Article
Times cited : (39)

References (40)
  • 1
    • 34548786715 scopus 로고    scopus 로고
    • Comprehensive analysis of vitamin E constituents in human plasma by liquid chromatography-mass spectrometry
    • DOI 10.1021/ac0708689
    • Nagy K, Courtet-Compondu MC, Holst B, Kussmann M,. Comprehensive analysis of vitamin E constituents in human plasma by liquid chromatography-mass spectrometry. Anal Chem 2007; 79: 7087-7096. (Pubitemid 47438688)
    • (2007) Analytical Chemistry , vol.79 , Issue.18 , pp. 7087-7096
    • Nagy, K.1    Courtet-Compondu, M.-C.2    Holst, B.3    Kussmann, M.4
  • 2
    • 34347378847 scopus 로고    scopus 로고
    • Studies in vitamin E: Biochemistry and molecular biology of tocopherol quinones
    • Cornwell DG, Ma J,. Studies in vitamin E: biochemistry and molecular biology of tocopherol quinones. Vitam Horm 2007; 76: 99-134.
    • (2007) Vitam Horm , vol.76 , pp. 99-134
    • Cornwell, D.G.1    Ma, J.2
  • 3
    • 34548009166 scopus 로고    scopus 로고
    • Antioxidant effects of 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2- dipentylbenzofuran and α-tocopherol in hyperlipidemic mice as evaluated by hydroxyoctadecadienoic acid and 7-hydroxycholesterol
    • DOI 10.1016/j.bcp.2007.07.020, PII S0006295207004741
    • Yoshida Y, Hayakawa M, Itoh N, et al,. Antioxidant effects of 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran and alpha-tocopherol in hyperlipidemic mice as evaluated by hydroxyoctadecadienoic acid and 7-hydroxycholesterol. Biochem Pharmacol 2007; 74: 1010-1019. (Pubitemid 47284013)
    • (2007) Biochemical Pharmacology , vol.74 , Issue.7 , pp. 1010-1019
    • Yoshida, Y.1    Hayakawa, M.2    Itoh, N.3    Habuchi, Y.4    Inoue, R.5    Chen, Z.-H.6    Cao, J.7    Cynshi, O.8    Jishage, K.-I.9    Niki, E.10
  • 4
    • 40849133777 scopus 로고    scopus 로고
    • Mice lacking alpha-tocopherol transfer protein gene have severe alpha-tocopherol deficiency in multiple regions of the central nervous system
    • Gohil K, Oommen S, Quach HT, et al,. Mice lacking alpha-tocopherol transfer protein gene have severe alpha-tocopherol deficiency in multiple regions of the central nervous system. Brain Res 2008; 1201: 167-176.
    • (2008) Brain Res , vol.1201 , pp. 167-176
    • Gohil, K.1    Oommen, S.2    Quach, H.T.3
  • 5
    • 0030949103 scopus 로고    scopus 로고
    • Affinity for α-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs
    • DOI 10.1016/S0014-5793(97)00499-7, PII S0014579397004997
    • Hosomi A, Arita M, Sato Y, et al,. Affinity for alpha-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs. FEBS Lett 1997; 409: 105-108. (Pubitemid 27248576)
    • (1997) FEBS Letters , vol.409 , Issue.1 , pp. 105-108
    • Hosomi, A.1    Arita, M.2    Sato, Y.3    Kiyose, C.4    Ueda, T.5    Igarashi, O.6    Arai, H.7    Inoue, K.8
  • 6
    • 0042512196 scopus 로고    scopus 로고
    • Role of caspase-8 activation in mediating vitamin E-induced apoptosis in murine mammary cancer cells
    • Shah S, Gapor A, Sylvester PW,. Role of caspase-8 activation in mediating vitamin E-induced apoptosis in murine mammary cancer cells. Nutr Cancer 2003; 45: 236-246. (Pubitemid 37022798)
    • (2003) Nutrition and Cancer , vol.45 , Issue.2 , pp. 236-246
    • Shah, S.1    Gapor, A.2    Sylvester, P.W.3
  • 7
    • 33644891347 scopus 로고    scopus 로고
    • Tocotrienols: Vitamin e beyond tocopherols
    • Sen CK, Khanna S, Roy S,. Tocotrienols: vitamin E beyond tocopherols. Life Sci 2006; 78: 2088-2098.
    • (2006) Life Sci , vol.78 , pp. 2088-2098
    • Sen, C.K.1    Khanna, S.2    Roy, S.3
  • 8
    • 77957909450 scopus 로고    scopus 로고
    • Tocotrienols, the vitamin e of the 21st century: Its potential against cancer and other chronic diseases
    • Aggarwal BB, Sundaram C, Prasad S, Kannappan R,. Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases. Biochem Pharmacol 2010; 80: 1613-1631.
    • (2010) Biochem Pharmacol , vol.80 , pp. 1613-1631
    • Aggarwal, B.B.1    Sundaram, C.2    Prasad, S.3    Kannappan, R.4
  • 10
    • 18344372608 scopus 로고    scopus 로고
    • Tocotrienol-induced cytotoxicity is unrelated to mitochondrial stress apoptotic signaling in neoplastic mammary epithelial cells
    • DOI 10.1139/o04-127
    • Shah SJ, Sylvester PW,. Tocotrienol-induced cytotoxicity is unrelated to mitochondrial stress apoptotic signaling in neoplastic mammary epithelial cells. Biochem Cell Biol 2005; 83: 86-95. (Pubitemid 40637970)
    • (2005) Biochemistry and Cell Biology , vol.83 , Issue.1 , pp. 86-95
    • Shah, S.J.1    Sylvester, P.W.2
  • 12
    • 0037249854 scopus 로고    scopus 로고
    • Influence of route of administration on the absorption and disposition of α-, γ- and δ-tocotrienols in rats
    • Yap SP, Yuen KH, Lim AB,. Influence of route of administration on the absorption and disposition of alpha-, gamma- and delta-tocotrienols in rats. J Pharm Pharmacol 2003; 55: 53-58. (Pubitemid 36142081)
    • (2003) Journal of Pharmacy and Pharmacology , vol.55 , Issue.1 , pp. 53-58
    • Yap, S.P.1    Yuen, K.H.2    Lim, A.B.3
  • 13
    • 3543106201 scopus 로고    scopus 로고
    • Influence of lipolysis and droplet size on tocotrienol absorption from self-emulsifying formulations
    • DOI 10.1016/j.ijpharm.2004.05.015, PII S0378517304003060
    • Yap SP, Yuen KH,. Influence of lipolysis and droplet size on tocotrienol absorption from self-emulsifying formulations. Int J Pharm 2004; 281: 67-78. (Pubitemid 39024264)
    • (2004) International Journal of Pharmaceutics , vol.281 , Issue.1-2 , pp. 67-78
    • Yap, S.P.1    Yuen, K.H.2
  • 14
    • 0022070123 scopus 로고
    • Absorption potential: Estimating the fraction absorbed for orally administered compounds
    • Dressman JB, Amidon GL, Fleisher D,. Absorption potential: estimating the fraction absorbed for orally administered compounds. J Pharm Sci 1985; 74: 588-589.
    • (1985) J Pharm Sci , vol.74 , pp. 588-589
    • Dressman, J.B.1    Amidon, G.L.2    Fleisher, D.3
  • 16
    • 33847394968 scopus 로고    scopus 로고
    • Lipids and lipid-based formulations: Optimizing the oral delivery of lipophilic drugs
    • DOI 10.1038/nrd2197, PII NRD2197
    • Porter CJ, Trevaskis NL, Charman WN,. Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nat Rev Drug Discov 2007; 6: 231-248. (Pubitemid 46344627)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.3 , pp. 231-248
    • Porter, C.J.H.1    Trevaskis, N.L.2    Charman, W.N.3
  • 17
    • 45749155204 scopus 로고    scopus 로고
    • Niemann-Pick C1-like 1 mediates α-tocopherol transport
    • DOI 10.1124/mol.107.043034
    • Narushima K, Takada T, Yamanashi Y, Suzuki H,. Niemann-pick C1-like 1 mediates alpha-tocopherol transport. Mol Pharmacol 2008; 74: 42-49. (Pubitemid 351872157)
    • (2008) Molecular Pharmacology , vol.74 , Issue.1 , pp. 42-49
    • Narushima, K.1    Takada, T.2    Yamanashi, Y.3    Suzuki, H.4
  • 18
    • 77952294329 scopus 로고    scopus 로고
    • Intestinal absorption of gamma-tocotrienol is mediated by Niemann-Pick C1-like 1: In situ rat intestinal perfusion studies
    • Abuasal B, Sylvester PW, Kaddoumi A,. Intestinal absorption of gamma-tocotrienol is mediated by Niemann-Pick C1-like 1: in situ rat intestinal perfusion studies. Drug Metab Dispos 2010; 38: 939-945.
    • (2010) Drug Metab Dispos , vol.38 , pp. 939-945
    • Abuasal, B.1    Sylvester, P.W.2    Kaddoumi, A.3
  • 19
    • 0028948839 scopus 로고
    • A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability
    • Amidon GL, Lennernas H, Shah VP, Crison JR,. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res 1995; 12: 413-420.
    • (1995) Pharm Res , vol.12 , pp. 413-420
    • Amidon, G.L.1    Lennernas, H.2    Shah, V.P.3    Crison, J.R.4
  • 20
    • 0016735960 scopus 로고
    • Mechanism and site of small intestinal absorption of alpha-tocopherol in the rat
    • Hollander D, Rim E, Muralidhara KS,. Mechanism and site of small intestinal absorption of alpha-tocopherol in the rat. Gastroenterology 1975; 68: 1492-1499.
    • (1975) Gastroenterology , vol.68 , pp. 1492-1499
    • Hollander, D.1    Rim, E.2    Muralidhara, K.S.3
  • 21
    • 0022844787 scopus 로고
    • Transport and distribution of α-tocopherol in lymph, serum and liver cells in rats
    • DOI 10.1016/0167-4889(86)90193-X
    • Bjorneboe A, Bjorneboe GE, Bodd E, Hagen BF, Kveseth N, Drevon CA,. Transport and distribution of alpha-tocopherol in lymph, serum and liver cells in rats. Biochim Biophys Acta 1986; 889: 310-315. (Pubitemid 17229824)
    • (1986) Biochimica et Biophysica Acta - Molecular Cell Research , vol.889 , Issue.3 , pp. 310-315
    • Bjorneboe, A.1    Bjorneboe Aa, G.-E.2    Bodd, E.3
  • 22
    • 39049129258 scopus 로고    scopus 로고
    • In vitro lipid digestion models in design of drug delivery systems for enhancing oral bioavailability
    • DOI 10.1517/17425255.4.1.65
    • Fatouros DG, Mullertz A,. In vitro lipid digestion models in design of drug delivery systems for enhancing oral bioavailability. Expert Opin Drug Metab Toxicol 2008; 4: 65-76. (Pubitemid 351234101)
    • (2008) Expert Opinion on Drug Metabolism and Toxicology , vol.4 , Issue.1 , pp. 65-76
    • Fatouros, D.G.1    Mullertz, A.2
  • 23
    • 80052265520 scopus 로고    scopus 로고
    • In vitro lipolysis models as a tool for the characterization of oral lipid and surfactant based drug delivery systems
    • Larsen AT, Sassene P, Mullertz A,. In vitro lipolysis models as a tool for the characterization of oral lipid and surfactant based drug delivery systems. Int J Pharm 2011; 417: 245-255.
    • (2011) Int J Pharm , vol.417 , pp. 245-255
    • Larsen, A.T.1    Sassene, P.2    Mullertz, A.3
  • 24
    • 34250867442 scopus 로고    scopus 로고
    • The effect of different lipid based formulations on the oral absorption of lipophilic drugs: The ability of in vitro lipolysis and consecutive ex vivo intestinal permeability data to predict in vivo bioavailability in rats
    • DOI 10.1016/j.ejpb.2007.01.017, PII S0939641107000227
    • Dahan A, Hoffman A,. The effect of different lipid based formulations on the oral absorption of lipophilic drugs: the ability of in vitro lipolysis and consecutive ex vivo intestinal permeability data to predict in vivo bioavailability in rats. Eur J Pharm Biopharm 2007; 67: 96-105. (Pubitemid 46991342)
    • (2007) European Journal of Pharmaceutics and Biopharmaceutics , vol.67 , Issue.1 , pp. 96-105
    • Dahan, A.1    Hoffman, A.2
  • 25
    • 39549095134 scopus 로고    scopus 로고
    • Comparison between lipolysis and compendial dissolution as alternative techniques for the in vitro characterization of alpha-tocopherol self-emulsified drug delivery systems (SEDDS)
    • Ali H, Nazzal M, Zaghloul AA, Nazzal S,. Comparison between lipolysis and compendial dissolution as alternative techniques for the in vitro characterization of alpha-tocopherol self-emulsified drug delivery systems (SEDDS). Int J Pharm 2008; 352: 104-114.
    • (2008) Int J Pharm , vol.352 , pp. 104-114
    • Ali, H.1    Nazzal, M.2    Zaghloul, A.A.3    Nazzal, S.4
  • 26
    • 78049518013 scopus 로고    scopus 로고
    • Precipitation of a poorly soluble model drug during in vitro lipolysis: Characterization and dissolution of the precipitate
    • Sassene PJ, Knopp MM, Hesselkilde JZ, et al,. Precipitation of a poorly soluble model drug during in vitro lipolysis: characterization and dissolution of the precipitate. J Pharm Sci 2010; 99: 4982-4991.
    • (2010) J Pharm Sci , vol.99 , pp. 4982-4991
    • Sassene, P.J.1    Knopp, M.M.2    Hesselkilde, J.Z.3
  • 28
    • 34547857877 scopus 로고    scopus 로고
    • Zetia: Inhibition of Niemann-Pick C1 like 1 (NPC1L1) to reduce intestinal cholesterol absorption and treat hyperlipidemia
    • Davis HR, Veltri EP,. Zetia: inhibition of Niemann-Pick C1 like 1 (NPC1L1) to reduce intestinal cholesterol absorption and treat hyperlipidemia. J Atheroscler Thromb 2007; 14: 99-108.
    • (2007) J Atheroscler Thromb , vol.14 , pp. 99-108
    • Davis, H.R.1    Veltri, E.P.2
  • 29
    • 0032912781 scopus 로고    scopus 로고
    • High in situ rat intestinal permeability of artemisinin unaffected by multiple dosing and with no evidence of P-glycoprotein involvement
    • Svensson US, Sandstrom R, Carlborg O, Lennernas H, Ashton M,. High in situ rat intestinal permeability of artemisinin unaffected by multiple dosing and with no evidence of P-glycoprotein involvement. Drug Metab Dispos 1999; 27: 227-232. (Pubitemid 29072076)
    • (1999) Drug Metabolism and Disposition , vol.27 , Issue.2 , pp. 227-232
    • Svensson, U.S.H.1    Sandstrom, R.2    Carlborg, O.3    Lennernas, H.4    Ashton, M.5
  • 30
    • 43249085299 scopus 로고    scopus 로고
    • The structure and function of Niemann-Pick C1-like 1 protein
    • DOI 10.1097/MOL.0b013e3282f9b563, PII 0004143320080600000008
    • Yu L,. The structure and function of Niemann-Pick C1-like 1 protein. Curr Opin Lipidol 2008; 19: 263-269. (Pubitemid 351653564)
    • (2008) Current Opinion in Lipidology , vol.19 , Issue.3 , pp. 263-269
    • Yu, L.1
  • 32
    • 79953684284 scopus 로고    scopus 로고
    • Development and validation of a reversed-phase HPLC method for the determination of gamma-tocotrienol in rat and human plasma
    • Abuasal B, Thomas S, Sylvester PW, Kaddoumi A,. Development and validation of a reversed-phase HPLC method for the determination of gamma-tocotrienol in rat and human plasma. Biomed Chromatogr 2011; 25: 621-627.
    • (2011) Biomed Chromatogr , vol.25 , pp. 621-627
    • Abuasal, B.1    Thomas, S.2    Sylvester, P.W.3    Kaddoumi, A.4
  • 34
    • 34347368866 scopus 로고    scopus 로고
    • Structure and Function of α-Tocopherol Transfer Protein: Implications for Vitamin e Metabolism and AVED
    • Litwack G. (ed). Elsevier Inc: San Diego
    • Min CK,. Structure and Function of α-Tocopherol Transfer Protein: Implications for Vitamin E Metabolism and AVED. In Vitamin E: Vitamins and Hormones Advances in Research and Applications, Litwack G, (ed). Elsevier Inc: San Diego, 2007; 23-43.
    • (2007) Vitamin E: Vitamins and Hormones Advances in Research and Applications , pp. 23-43
    • Min, C.K.1
  • 35
    • 23944483499 scopus 로고    scopus 로고
    • Novel lipid-based formulations enhancing the in vitro dissolution and permeability characteristics of a poorly water-soluble model drug, piroxicam
    • DOI 10.1016/j.ijpharm.2005.05.032, PII S0378517305003467
    • Prabhu S, Ortega M, Ma C,. Novel lipid-based formulations enhancing the in vitro dissolution and permeability characteristics of a poorly water-soluble model drug, piroxicam. Int J Pharm 2005; 301: 209-216. (Pubitemid 41206605)
    • (2005) International Journal of Pharmaceutics , vol.301 , Issue.1-2 , pp. 209-216
    • Prabhu, S.1    Ortega, M.2    Ma, C.3
  • 36
    • 77955159974 scopus 로고    scopus 로고
    • Coexistence of passive and carrier-mediated processes in drug transport
    • Sugano K, Kansy M, Artursson P, et al,. Coexistence of passive and carrier-mediated processes in drug transport. Nat Rev Drug Discov 2010; 9: 597-614.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 597-614
    • Sugano, K.1    Kansy, M.2    Artursson, P.3
  • 37
    • 84858016380 scopus 로고    scopus 로고
    • In silico modeling for the nonlinear absorption kinetics of UK-343,664: A P-gp and CYP3A4 substrate
    • Abuasal BS, Bolger MB, Walker DK, Kaddoumi A,. In silico modeling for the nonlinear absorption kinetics of UK-343,664: A P-gp and CYP3A4 substrate. Mol Pharm 2012; 9: 492-504.
    • (2012) Mol Pharm , vol.9 , pp. 492-504
    • Abuasal, B.S.1    Bolger, M.B.2    Walker, D.K.3    Kaddoumi, A.4
  • 38
    • 0023940704 scopus 로고
    • Determination of intrinsic membrane transport parameters from perfused intestine experiments: A boundary layer approach to estimating the aqueous and unbiased membrane permeabilities
    • Johnson DA, Amidon GL,. Determination of intrinsic membrane transport parameters from perfused intestine experiments: a boundary layer approach to estimating the aqueous and unbiased membrane permeabilities. J Theor Biol 1988; 131: 93-106.
    • (1988) J Theor Biol , vol.131 , pp. 93-106
    • Johnson, D.A.1    Amidon, G.L.2
  • 39
    • 84863445857 scopus 로고    scopus 로고
    • Enhancement of intestinal permeability utilizing solid lipid nanoparticles increases gamma-tocotrienol oral bioavailability
    • Abuasal BS, Lucas C, Peyton B, Alayoubi A, Nazzal S, Sylvester PW, Kaddoumi A,. Enhancement of intestinal permeability utilizing solid lipid nanoparticles increases gamma-tocotrienol oral bioavailability. Lipids 2012; 47: 461-469.
    • (2012) Lipids , vol.47 , pp. 461-469
    • Abuasal, B.S.1    Lucas, C.2    Peyton, B.3    Alayoubi, A.4    Nazzal, S.5    Sylvester, P.W.6    Kaddoumi, A.7
  • 40
    • 34248198290 scopus 로고    scopus 로고
    • Influence of major structural features of tocopherols and tocotrienols on their ω-oxidation by tocopherol-ω-hydroxylase
    • DOI 10.1194/jlr.M600514-JLR200
    • Sontag TJ, Parker RS,. Influence of major structural features of tocopherols and tocotrienols on their omega-oxidation by tocopherol-omega- hydroxylase. J Lipid Res 2007; 48: 1090-1098. (Pubitemid 46708676)
    • (2007) Journal of Lipid Research , vol.48 , Issue.5 , pp. 1090-1098
    • Sontag, T.J.1    Parker, R.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.