Blocking TGF-β signaling pathway preserves mitochondrial proteostasis and reduces early activation of PDGFRβ+ pericytes in aristolochic acid induced acute kidney injury in wistar male rats

PLoS ONE

Volumn 11, Issue 7, 2016, Pages

  Pozdzik, Agnieszka A ^a,b   Giordano, Laetitia ^c   Li, Gang ^d   Antoine, Marie Hélène ^a   Quellard, Nathalie ^e,f   Godet, Julie ^e,f   De Prez, Eric ^a   Husson, Cécile ^a   Declèves, Anne Emilie ^c   Arlt, Volker M ^g   Goujon, Jean Michel ^e,f   Brochériou Spelle, Isabelle ^h   Ledbetter, Steven R ^d   Caron, Nathalie ^c   Nortier, Joëlle L ^a,b  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b ERASME HOSPITAL   (Belgium)

^c UNIVERSITY OF NAMUR   (Belgium)

^d GENZYME CORPORATION   (United States)

^e POITIERS UNIVERSITY HOSPITAL   (France)

^f INSERM   (France)

^g KING'S COLLEGE LONDON   (United Kingdom)

^h HÔPITAL TENON   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARISTOLOCHIC ACID; FIBRONECTIN; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; VASCULOTROPIN C; MITOCHONDRIAL PROTEIN; NEUTRALIZING ANTIBODY; SMAD PROTEIN;

ACUTE KIDNEY FAILURE; ACUTE KIDNEY TUBULE NECROSIS; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CAPILLARITIS; CASE REPORT; CONTROLLED STUDY; EDEMA; END STAGE RENAL DISEASE; ENDOPLASMIC RETICULUM; EPITHELIUM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; KIDNEY FIBROSIS; KIDNEY TUBULE BASEMENT MEMBRANE; KIDNEY TUBULE EPITHELIUM; MALE; MIDDLE AGED; MITOCHONDRION; MYOFIBROBLAST; NONHUMAN; PROTEIN HOMEOSTASIS; RAT; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; WISTAR RAT; ANIMAL; BIOLOGICAL MODEL; CELL CULTURE; CELL LINE; DRUG EFFECT; ENDOTHELIUM CELL; HOMEOSTASIS; IMMUNOLOGY; KIDNEY PROXIMAL TUBULE; METABOLISM; PERICYTE; TIME FACTOR; WESTERN BLOTTING;

ACUTE KIDNEY INJURY; ANIMALS; ANTIBODIES, NEUTRALIZING; ARISTOLOCHIC ACIDS; BLOTTING, WESTERN; CELL LINE; CELLS, CULTURED; ENDOTHELIAL CELLS; HOMEOSTASIS; HUMANS; KIDNEY TUBULES, PROXIMAL; MALE; MITOCHONDRIAL PROTEINS; MODELS, BIOLOGICAL; MYOFIBROBLASTS; PERICYTES; RATS, WISTAR; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD PROTEINS; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84978033540     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0157288     Document Type: Article

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