Retigabine, a Kv7.2/Kv7.3-channel opener, attenuates drug-induced seizures in knock-in mice harboring Kcnq2 mutations

PLoS ONE

Volumn 11, Issue 2, 2016, Pages

  Ihara, Yukiko ^a   Tomonoh, Yuko ^a   Deshimaru, Masanobu ^a   Zhang, Bo ^a   Uchida, Taku ^a   Ishii, Atsushi ^a   Hirose, Shinichi ^a  

^a FUKUOKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

KAINIC ACID; PHENOBARBITAL; POTASSIUM CHANNEL KV7.2; POTASSIUM CHANNEL KV7.3; RETIGABINE; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL; CARBAMIC ACID DERIVATIVE; PHENYLENEDIAMINE DERIVATIVE; POTASSIUM CHANNEL KCNQ2; POTASSIUM CHANNEL KCNQ3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; ELECTROENCEPHALOGRAPHY; GENE; GENE MUTATION; GENETIC VARIABILITY; KCNQ2 GENE; MOLECULAR DOCKING; MOUSE; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NEWBORN; NONHUMAN; SEIZURE; SPIKE WAVE; TREATMENT RESPONSE; ANIMAL; CHANNEL GATING; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; GENE TARGETING; GENETICS; HUMAN; METABOLISM; MOLECULAR MODEL; MUTATION; PROTEIN TERTIARY STRUCTURE; SEIZURES;

ANIMALS; CARBAMATES; GENE KNOCK-IN TECHNIQUES; HUMANS; ION CHANNEL GATING; KAINIC ACID; KCNQ2 POTASSIUM CHANNEL; KCNQ3 POTASSIUM CHANNEL; MICE; MODELS, MOLECULAR; MUTATION; PHENYLENEDIAMINES; PROTEIN STRUCTURE, TERTIARY; SEIZURES;

EID: 84977664219     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0150095     Document Type: Article

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