Potent KCNQ2/3-specific channel activator suppresses in vivo epileptic activity and prevents the development of tinnitus

Journal of Neuroscience

Volumn 35, Issue 23, 2015, Pages 8829-8842

  Kalappa, Bopanna I ^a   Soh, Heun ^b   Duignan, Kevin M ^b   Furuya, Takeru ^c   Edwards, Scott ^c   Tzingounis, Anastasios V ^b   Tzounopoulos, Thanos ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

^c SciFluor Life Sciences Inc   (United States)

Author keywords

Epilepsy; KCNQ channels; Tinnitus

Indexed keywords

POTASSIUM CHANNEL KCNQ2; POTASSIUM CHANNEL KCNQ3; POTASSIUM CHANNEL KCNQ4; POTASSIUM CHANNEL KCNQ5; RETIGABINE; VOLTAGE GATED POTASSIUM CHANNEL; ANTICONVULSIVE AGENT; CARBAMIC ACID DERIVATIVE; EMPTY SPIRACLES HOMEOBOX PROTEINS; HOMEODOMAIN PROTEIN; KCNQ4 PROTEIN, HUMAN; KCNQ5 PROTEIN, HUMAN; PHENYLENEDIAMINE DERIVATIVE; POTASSIUM CHANNEL KCNQ; TRANSCRIPTION FACTOR;

ACOUSTIC STRESS; ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CHEMICAL MODIFICATION; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG SYNTHESIS; ELECTRIC SHOCK; EPILEPSY; EVOKED BRAIN STEM AUDITORY RESPONSE; FEMALE; GAIT; HIPPOCAMPAL CA1 REGION; HUMAN; HUMAN CELL; MALE; MOUSE; NERVE EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; ROTAROD TEST; SCORING SYSTEM; TD50; THIN LAYER CHROMATOGRAPHY; TINNITUS; VOLTAGE CLAMP TECHNIQUE; AGONISTS; ANIMAL; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; IN VITRO STUDY; INSTITUTE FOR CANCER RESEARCH MOUSE; KNOCKOUT MOUSE; MEMBRANE POTENTIAL; METABOLISM; MUTATION; NEWBORN; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; ANTICONVULSANTS; CARBAMATES; DISEASE MODELS, ANIMAL; EPILEPSY; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; FEMALE; HEK293 CELLS; HOMEODOMAIN PROTEINS; HUMANS; IN VITRO TECHNIQUES; KCNQ POTASSIUM CHANNELS; KCNQ2 POTASSIUM CHANNEL; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED ICR; MICE, KNOCKOUT; MUTATION; PHENYLENEDIAMINES; RATS; RATS, SPRAGUE-DAWLEY; TINNITUS; TRANSCRIPTION FACTORS;

EID: 84930888395     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5176-14.2015     Document Type: Article

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