메뉴 건너뛰기




Volumn 65, Issue 3, 2009, Pages 326-336

A KCNQ channel opener for experimental neonatal seizures and status epilepticus

Author keywords

[No Author keywords available]

Indexed keywords

DIAZEPAM; FLUPIRTINE MALEATE; FLUROTHYL; KAINIC ACID; PHENOBARBITAL; POTASSIUM CHANNEL KCNQ;

EID: 65249140516     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.21593     Document Type: Article
Times cited : (59)

References (55)
  • 2
    • 37349066228 scopus 로고    scopus 로고
    • Neonatal status epilepticus vs recurrent neonatal seizures: Clinical findings and outcome
    • Pisani F, Cerminara C, Fusco C, Sisti L. Neonatal status epilepticus vs recurrent neonatal seizures: clinical findings and outcome. Neurology 2007;69:2177-2185.
    • (2007) Neurology , vol.69 , pp. 2177-2185
    • Pisani, F.1    Cerminara, C.2    Fusco, C.3    Sisti, L.4
  • 3
    • 35948966025 scopus 로고    scopus 로고
    • Long-term prognosis in children with neonatal seizures: A population-based study
    • Ronen GM, Buckley D, Penney S, Streiner DL. Long-term prognosis in children with neonatal seizures: a population-based study. Neurology 2007;69:1816-1822.
    • (2007) Neurology , vol.69 , pp. 1816-1822
    • Ronen, G.M.1    Buckley, D.2    Penney, S.3    Streiner, D.L.4
  • 4
    • 0033549786 scopus 로고    scopus 로고
    • Phenobarbital compared with phenytoin for the treatment of neonatal seizures
    • Painter MJ, Scher MS, Stein AD, et al. Phenobarbital compared with phenytoin for the treatment of neonatal seizures. N Engl J Med 1999;341:485-489.
    • (1999) N Engl J Med , vol.341 , pp. 485-489
    • Painter, M.J.1    Scher, M.S.2    Stein, A.D.3
  • 5
    • 1342285589 scopus 로고    scopus 로고
    • Do pediatric drugs cause developing neurons to commit suicide?
    • Olney JW, Young C, Wozniak DF, et al. Do pediatric drugs cause developing neurons to commit suicide? Trends Pharmacol Sci 2004;25:135-139.
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 135-139
    • Olney, J.W.1    Young, C.2    Wozniak, D.F.3
  • 6
    • 0037069448 scopus 로고    scopus 로고
    • Antiepileptic drugs and apoptotic neurodegeneration in the developing brain
    • Bittigau P, Sifringer M, Genz K, et al. Antiepileptic drugs and apoptotic neurodegeneration in the developing brain. Proc Natl Acad Sci USA 2002;99:15089-15094.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 15089-15094
    • Bittigau, P.1    Sifringer, M.2    Genz, K.3
  • 7
    • 14644390865 scopus 로고    scopus 로고
    • Neonatal seizures: After all these years we still love what doesn't work
    • Sankar R, Painter MJ. Neonatal seizures: after all these years we still love what doesn't work. Neurology 2005;64:776-777.
    • (2005) Neurology , vol.64 , pp. 776-777
    • Sankar, R.1    Painter, M.J.2
  • 8
    • 47649086505 scopus 로고    scopus 로고
    • Improving the treatment of neonatal seizures: National Institute of Neurological Disorders and Stroke workshop report
    • Silverstein FS, Jensen FE, Inder T, et al. Improving the treatment of neonatal seizures: National Institute of Neurological Disorders and Stroke workshop report. J Pediatr 2008;153: 12-15.
    • (2008) J Pediatr , vol.153 , pp. 12-15
    • Silverstein, F.S.1    Jensen, F.E.2    Inder, T.3
  • 9
    • 0037386988 scopus 로고    scopus 로고
    • M-channels: Neurological diseases, neuromodulation, and drug development
    • Cooper EC, Jan LY. M-channels: neurological diseases, neuromodulation, and drug development. Arch Neurol 2003;60: 494-500.
    • (2003) Arch Neurol , vol.60 , pp. 494-500
    • Cooper, E.C.1    Jan, L.Y.2
  • 10
    • 0032542232 scopus 로고    scopus 로고
    • Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K channels causes epilepsy
    • Schroeder BC, Kubisch C, Stein V, Jentsch TJ. Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K channels causes epilepsy. Nature 1998;396:687-690.
    • (1998) Nature , vol.396 , pp. 687-690
    • Schroeder, B.C.1    Kubisch, C.2    Stein, V.3    Jentsch, T.J.4
  • 11
    • 0344012023 scopus 로고    scopus 로고
    • KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: Expansion of the functional and mutation spectrum
    • Singh NA, Westenskow P, Charlier C, et al. KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum. Brain 2003;126:2726-2737.
    • (2003) Brain , vol.126 , pp. 2726-2737
    • Singh, N.A.1    Westenskow, P.2    Charlier, C.3
  • 12
    • 33847216238 scopus 로고    scopus 로고
    • Benign familial neonatal convulsions: Always benign?
    • Steinlein OK, Conrad C, Weidner B. Benign familial neonatal convulsions: always benign? Epilepsy Res 2007;73:245-249.
    • (2007) Epilepsy Res , vol.73 , pp. 245-249
    • Steinlein, O.K.1    Conrad, C.2    Weidner, B.3
  • 13
    • 12244252214 scopus 로고    scopus 로고
    • Age-dependent modulation of hippocampal excitability by KCNQ-channels
    • Okada M, Zhu G, Hirose S, et al. Age-dependent modulation of hippocampal excitability by KCNQ-channels. Epilepsy Res 2003;53:81-94.
    • (2003) Epilepsy Res , vol.53 , pp. 81-94
    • Okada, M.1    Zhu, G.2    Hirose, S.3
  • 15
    • 33645020074 scopus 로고    scopus 로고
    • Epileptiform activity induced by pharmacologic reduction of M-current in the developing hippocampus in vitro
    • Pena F, Alavez-Perez N. Epileptiform activity induced by pharmacologic reduction of M-current in the developing hippocampus in vitro. Epilepsia 2006;47:47-54.
    • (2006) Epilepsia , vol.47 , pp. 47-54
    • Pena, F.1    Alavez-Perez, N.2
  • 16
    • 16644379267 scopus 로고    scopus 로고
    • Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior
    • Peters HC, Hu H, Pongs O, et al. Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior. Nat Neurosci 2005; 8:51-60.
    • (2005) Nat Neurosci , vol.8 , pp. 51-60
    • Peters, H.C.1    Hu, H.2    Pongs, O.3
  • 17
    • 33646378890 scopus 로고    scopus 로고
    • KCNQ channels mediate IKs, a slow K+ current regulating excitability in the rat node of Ranvier
    • Schwarz JR, Glassmeier G, Cooper EC, et al. KCNQ channels mediate IKs, a slow K+ current regulating excitability in the rat node of Ranvier. J Physiol 2006;573:17-34.
    • (2006) J Physiol , vol.573 , pp. 17-34
    • Schwarz, J.R.1    Glassmeier, G.2    Cooper, E.C.3
  • 18
    • 33644819526 scopus 로고    scopus 로고
    • A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon
    • Pan Z, Kao T, Horvath Z, et al. A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon. J Neurosci 2006;26:2599-2613.
    • (2006) J Neurosci , vol.26 , pp. 2599-2613
    • Pan, Z.1    Kao, T.2    Horvath, Z.3
  • 19
    • 34247372307 scopus 로고    scopus 로고
    • Requirement of subunit co-assembly and ankyrin-G for M-channel localization at the axon initial segment
    • Rasmussen HB, Frokjaer-Jensen C, Jensen CS, et al. Requirement of subunit co-assembly and ankyrin-G for M-channel localization at the axon initial segment. J Cell Sci 2007;120: 953-963.
    • (2007) J Cell Sci , vol.120 , pp. 953-963
    • Rasmussen, H.B.1    Frokjaer-Jensen, C.2    Jensen, C.S.3
  • 20
    • 15744362456 scopus 로고    scopus 로고
    • Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties
    • Peretz A, Degani N, Nachman R, et al. Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties. Mol Pharmacol 2005;67:1053-1066.
    • (2005) Mol Pharmacol , vol.67 , pp. 1053-1066
    • Peretz, A.1    Degani, N.2    Nachman, R.3
  • 21
    • 34247252905 scopus 로고    scopus 로고
    • Randomized, multicenter, dose-ranging trial of retigabine for partial-onset seizures
    • Porter RJ, Partiot A, Sachdeo R, et al. Randomized, multicenter, dose-ranging trial of retigabine for partial-onset seizures. Neurology 2007;68:1197-1204.
    • (2007) Neurology , vol.68 , pp. 1197-1204
    • Porter, R.J.1    Partiot, A.2    Sachdeo, R.3
  • 22
    • 0842305796 scopus 로고    scopus 로고
    • M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals
    • Martire M, Castaldo P, D'Amico M, et al. M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals. J Neurosci 2004;24:592-597.
    • (2004) J Neurosci , vol.24 , pp. 592-597
    • Martire, M.1    Castaldo, P.2    D'Amico, M.3
  • 23
    • 40849085408 scopus 로고    scopus 로고
    • N-(6-chloropyridin-3-yl)-3, 4-difluoro-benzamide (ICA-27243): A novel, selective KCNQ2/Q3 potassium channel activator
    • Wickenden AD, Krajewski JL, London B, et al. N-(6-chloropyridin-3-yl)-3, 4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. Mol Pharmacol 2008;73:977-986.
    • (2008) Mol Pharmacol , vol.73 , pp. 977-986
    • Wickenden, A.D.1    Krajewski, J.L.2    London, B.3
  • 25
    • 14544271983 scopus 로고    scopus 로고
    • Recent developments on KCNQ potassium channel openers
    • Wua YJ, Dworetzky SI. Recent developments on KCNQ potassium channel openers. Curr Med Chem 2005;12:453-460.
    • (2005) Curr Med Chem , vol.12 , pp. 453-460
    • Wua, Y.J.1    Dworetzky, S.I.2
  • 26
    • 0036194357 scopus 로고    scopus 로고
    • Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3- and CLN2-deficient neurons
    • Dhar S, Bitting RL, Rylova SN, et al. Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3- and CLN2-deficient neurons. Ann Neurol 2002;51: 448-466.
    • (2002) Ann Neurol , vol.51 , pp. 448-466
    • Dhar, S.1    Bitting, R.L.2    Rylova, S.N.3
  • 27
    • 0034698341 scopus 로고    scopus 로고
    • Flupirtine and retigabine prevent L-glutamate toxicity in rat pheochromocytoma PC 12 cells
    • Seyfried J, Evert BO, Rundfeldt C, et al. Flupirtine and retigabine prevent L-glutamate toxicity in rat pheochromocytoma PC 12 cells. Eur J Pharmacol 2000;400:155-166.
    • (2000) Eur J Pharmacol , vol.400 , pp. 155-166
    • Seyfried, J.1    Evert, B.O.2    Rundfeldt, C.3
  • 28
    • 10744219944 scopus 로고    scopus 로고
    • Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study
    • Otto M, Cepek L, Ratzka P, et al. Efficacy of flupirtine on cognitive function in patients with CJD: a double-blind study. Neurology 2004;62:714-718.
    • (2004) Neurology , vol.62 , pp. 714-718
    • Otto, M.1    Cepek, L.2    Ratzka, P.3
  • 29
    • 0345631278 scopus 로고
    • Effect of flupirtine on uncontrolled partial or absence seizures
    • Porter RJ, Gratz E, Narang PK, et al. Effect of flupirtine on uncontrolled partial or absence seizures. Epilepsia 1983;24: 253-254.
    • (1983) Epilepsia , vol.24 , pp. 253-254
    • Porter, R.J.1    Gratz, E.2    Narang, P.K.3
  • 30
    • 0027043159 scopus 로고
    • Age-dependent changes in long-term seizure susceptibility and behavior after hypoxia in rats
    • Jensen FE, Holmes GL, Lombroso CT, et al. Age-dependent changes in long-term seizure susceptibility and behavior after hypoxia in rats. Epilepsia 1992;33:971-980.
    • (1992) Epilepsia , vol.33 , pp. 971-980
    • Jensen, F.E.1    Holmes, G.L.2    Lombroso, C.T.3
  • 31
    • 10844254736 scopus 로고    scopus 로고
    • Cognitive impairment following status epilepticus and recurrent seizures during early development: Support for the two-hit hypothesis
    • Hoffmann AF, Zhao Q, Holmes GL. Cognitive impairment following status epilepticus and recurrent seizures during early development: support for the "two-hit hypothesis." Epilepsy Behav 2004;5:873-877.
    • (2004) Epilepsy Behav , vol.5 , pp. 873-877
    • Hoffmann, A.F.1    Zhao, Q.2    Holmes, G.L.3
  • 32
    • 0037380708 scopus 로고    scopus 로고
    • Epilepsy after earlylife seizures can be independent of hippocampal injury
    • Raol YS, Budreck EC, Brooks-Kayal AR. Epilepsy after earlylife seizures can be independent of hippocampal injury. Ann Neurol 2003;53:503-511.
    • (2003) Ann Neurol , vol.53 , pp. 503-511
    • Raol, Y.S.1    Budreck, E.C.2    Brooks-Kayal, A.R.3
  • 34
    • 0033669296 scopus 로고    scopus 로고
    • Developmental seizures induced by common early-life insults: Short- and long-term effects on seizure susceptibility
    • Jensen FE, Baram TZ. Developmental seizures induced by common early-life insults: short- and long-term effects on seizure susceptibility. Ment Retard Dev Disabil Res Rev 2000;6: 253-257.
    • (2000) Ment Retard Dev Disabil Res Rev , vol.6 , pp. 253-257
    • Jensen, F.E.1    Baram, T.Z.2
  • 35
    • 0032213144 scopus 로고    scopus 로고
    • The in vivo proconvulsant effects of corticotropin releasing hormone in the developing rat are independent of ionotropic glutamate receptor activation
    • Brunson KL, Schultz L, Baram TZ. The in vivo proconvulsant effects of corticotropin releasing hormone in the developing rat are independent of ionotropic glutamate receptor activation. Brain Res Dev Brain Res 1998;111:119-128.
    • (1998) Brain Res Dev Brain Res , vol.111 , pp. 119-128
    • Brunson, K.L.1    Schultz, L.2    Baram, T.Z.3
  • 36
    • 0029164633 scopus 로고
    • NBQX blocks acute and late epileptogenic effects of perinatal hypoxia
    • Jensen FE, Blume H, Alvarado S, et al. NBQX blocks acute and late epileptogenic effects of perinatal hypoxia. Epilepsia 1995;36:966-972.
    • (1995) Epilepsia , vol.36 , pp. 966-972
    • Jensen, F.E.1    Blume, H.2    Alvarado, S.3
  • 37
    • 0035869347 scopus 로고    scopus 로고
    • Reduced neurogenesis after neonatal seizures
    • McCabe BK, Silveira DC, Cilio MR, et al. Reduced neurogenesis after neonatal seizures. J Neurosci 2001;21:2094-2103.
    • (2001) J Neurosci , vol.21 , pp. 2094-2103
    • McCabe, B.K.1    Silveira, D.C.2    Cilio, M.R.3
  • 38
    • 30744467689 scopus 로고    scopus 로고
    • NKCC1 transporter facilitates seizures in the developing brain
    • Dzhala VI, Talos DM, Sdrulla DA, et al. NKCC1 transporter facilitates seizures in the developing brain. Nat Med 2005;11: 1205-1213.
    • (2005) Nat Med , vol.11 , pp. 1205-1213
    • Dzhala, V.I.1    Talos, D.M.2    Sdrulla, D.A.3
  • 39
    • 0034854281 scopus 로고    scopus 로고
    • Topiramate blocks perinatal hypoxiainduced seizures in rat pups
    • Koh S, Jensen FE. Topiramate blocks perinatal hypoxiainduced seizures in rat pups. Ann Neurol 2001;50:366-372.
    • (2001) Ann Neurol , vol.50 , pp. 366-372
    • Koh, S.1    Jensen, F.E.2
  • 40
    • 65249172769 scopus 로고    scopus 로고
    • Developmental expression of KCNQ2 and KCNQ3 potassium channels at the axon initial segments of the mouse brain
    • San Diego, CA
    • Maljevic S, Kempfle J, Weber YG, et al. Developmental expression of KCNQ2 and KCNQ3 potassium channels at the axon initial segments of the mouse brain. Society for Neuroscience Annual Meeting; 2007; San Diego, CA.
    • (2007) Society for Neuroscience Annual Meeting
    • Maljevic, S.1    Kempfle, J.2    Weber, Y.G.3
  • 41
    • 0034712923 scopus 로고    scopus 로고
    • Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy
    • Cooper EC, Aldape KD, Abosch A, et al. Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy. Proc Natl Acad Sci USA 2000;97:4914-4919.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 4914-4919
    • Cooper, E.C.1    Aldape, K.D.2    Abosch, A.3
  • 42
    • 33646135533 scopus 로고    scopus 로고
    • Immunohistochemical analysis of KCNQ3 potassium channels in mouse brain
    • Geiger J, Weber YG, Landwehrmeyer B, et al. Immunohistochemical analysis of KCNQ3 potassium channels in mouse brain. Neurosci Lett 2006;400:101-104.
    • (2006) Neurosci Lett , vol.400 , pp. 101-104
    • Geiger, J.1    Weber, Y.G.2    Landwehrmeyer, B.3
  • 43
    • 36049036188 scopus 로고    scopus 로고
    • K+ M-current regulates the transition to seizures in immature and adult hippocampus
    • Qiu C, Johnson BN, Tallent MK. K+ M-current regulates the transition to seizures in immature and adult hippocampus. Epilepsia 2007;48:2047-2058.
    • (2007) Epilepsia , vol.48 , pp. 2047-2058
    • Qiu, C.1    Johnson, B.N.2    Tallent, M.K.3
  • 44
    • 0036210933 scopus 로고    scopus 로고
    • Effects of the anticonvulsant retigabine on cultured cortical neurons: Changes in electroresponsive properties and synaptic transmission
    • Otto JF, Kimball MM, Wilcox KS. Effects of the anticonvulsant retigabine on cultured cortical neurons: changes in electroresponsive properties and synaptic transmission. Mol Pharmacol 2002;61:921-927.
    • (2002) Mol Pharmacol , vol.61 , pp. 921-927
    • Otto, J.F.1    Kimball, M.M.2    Wilcox, K.S.3
  • 45
    • 33748709672 scopus 로고    scopus 로고
    • Andreas Rett and benign familial neonatal convulsions revisited
    • Zimprich F, Ronen GM, Stogmann W, et al. Andreas Rett and benign familial neonatal convulsions revisited. Neurology 2006; 67:864-866.
    • (2006) Neurology , vol.67 , pp. 864-866
    • Zimprich, F.1    Ronen, G.M.2    Stogmann, W.3
  • 46
    • 0024502803 scopus 로고
    • Benign familial neonatal convulsions linked to genetic markers on chromosome 20
    • Leppert M, Anderson VE, Quattlebaum T, et al. Benign familial neonatal convulsions linked to genetic markers on chromosome 20. Nature 1989;337:647-648.
    • (1989) Nature , vol.337 , pp. 647-648
    • Leppert, M.1    Anderson, V.E.2    Quattlebaum, T.3
  • 47
    • 0027359350 scopus 로고
    • Genetic heterogeneity in benign familial neonatal convulsions: Identification of a new locus on chromosome 8q
    • Lewis TB, Leach RJ, Ward K, et al. Genetic heterogeneity in benign familial neonatal convulsions: identification of a new locus on chromosome 8q. Am J Hum Genet 1993;53:670-675.
    • (1993) Am J Hum Genet , vol.53 , pp. 670-675
    • Lewis, T.B.1    Leach, R.J.2    Ward, K.3
  • 48
    • 0034303612 scopus 로고    scopus 로고
    • Neuronal KCNQ potassium channels: Physiology and role in disease
    • Jentsch TJ. Neuronal KCNQ potassium channels: physiology and role in disease. Nat Rev Neurosci 2000;1:21-30.
    • (2000) Nat Rev Neurosci , vol.1 , pp. 21-30
    • Jentsch, T.J.1
  • 49
    • 0035894853 scopus 로고    scopus 로고
    • Cooper EC, Harrington E, Jan YN, Jan LY M-channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain. J Neurosci 2001;21:9529-9540.
    • Cooper EC, Harrington E, Jan YN, Jan LY M-channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain. J Neurosci 2001;21:9529-9540.
  • 50
    • 38749119750 scopus 로고    scopus 로고
    • Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds
    • Xiong Q, Gao Z, Wang W, Li M. Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds. Trends Pharmacol Sci 2008;29:99-107.
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 99-107
    • Xiong, Q.1    Gao, Z.2    Wang, W.3    Li, M.4
  • 51
    • 27644518764 scopus 로고    scopus 로고
    • Pathways modulating neural KCNQ/M (Kv7) potassium channels
    • Delmas P, Brown DA. Pathways modulating neural KCNQ/M (Kv7) potassium channels. Nat Rev Neurosci 2005;6:850-862.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 850-862
    • Delmas, P.1    Brown, D.A.2
  • 52
    • 19044386394 scopus 로고    scopus 로고
    • Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine
    • Schenzer A, Friedrich T, Pusch M, et al. Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine. J Neurosci 2005;25:5051-5060.
    • (2005) J Neurosci , vol.25 , pp. 5051-5060
    • Schenzer, A.1    Friedrich, T.2    Pusch, M.3
  • 53
    • 0034996934 scopus 로고    scopus 로고
    • gamma- Aminobutyric acid(A) receptor subunit expression predicts functional changes in hippocampal dentate granule cells during postnatal development
    • Brooks-Kayal AR, Shumate MD, Jin H, et al. gamma- Aminobutyric acid(A) receptor subunit expression predicts functional changes in hippocampal dentate granule cells during postnatal development. J Neurochem 2001;77:1266-1278.
    • (2001) J Neurochem , vol.77 , pp. 1266-1278
    • Brooks-Kayal, A.R.1    Shumate, M.D.2    Jin, H.3
  • 54
    • 40449086100 scopus 로고    scopus 로고
    • Bumetanide enhances phenobarbital efficacy in a neonatal seizure model
    • Dzhala VI, Brumback AC, Staley KJ. Bumetanide enhances phenobarbital efficacy in a neonatal seizure model. Ann Neurol 2008;63:222-235.
    • (2008) Ann Neurol , vol.63 , pp. 222-235
    • Dzhala, V.I.1    Brumback, A.C.2    Staley, K.J.3
  • 55
    • 2342548181 scopus 로고    scopus 로고
    • Therapeutic doses of topiramate are not toxic to the developing rat brain
    • Glier C, Dzietko M, Bittigau P, et al. Therapeutic doses of topiramate are not toxic to the developing rat brain. Exp Neurol 2004;187:403-409.
    • (2004) Exp Neurol , vol.187 , pp. 403-409
    • Glier, C.1    Dzietko, M.2    Bittigau, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.