A spontaneous mutation involving Kcnq2 (Kv7.2) reduces M-current density and spike frequency adaptation in mouse CA1 neurons

Journal of Neuroscience

Volumn 26, Issue 7, 2006, Pages 2053-2059

  Otto, James F ^a   Yang, Yan ^b   Frankel, Wayne N ^b   White, H Steve ^a   Wilcox, Karen S ^a  

^a UNIVERSITY OF UTAH   (United States)

^b JACKSON LABORATORY   (United States)

Author keywords

BFNC; C terminal deletion; KCNQ2; M current; Retigabine; Spike frequency adaptation

Indexed keywords

ANTICONVULSIVE AGENT; GTPASE ACTIVATING PROTEIN THAT INACTIVATES ADP RIBOSYLATION FACTOR 1; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; LINOPIRDINE; NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA4; NICOTINIC RECEPTOR; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KCNQ2; POTASSIUM CHANNEL KCNQ3; RETIGABINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BENIGN CHILDHOOD EPILEPSY; BRAIN NERVE CELL; BRAIN SLICE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG SENSITIVITY; ELECTROPHYSIOLOGY; GENE DELETION; GENE MUTATION; HIPPOCAMPUS; MALE; MOUSE; MOUSE STRAIN; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE POTENTIAL; NEWBORN; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SEIZURE THRESHOLD; SPECIES COMPARISON; SPONTANEOUS MUTATION; XENOPUS;

ANIMALS; FEMALE; HIPPOCAMPUS; KCNQ2 POTASSIUM CHANNEL; MICE; MICE, INBRED C57BL; MUTATION; NEURONS; OOCYTES; PYRAMIDAL CELLS; SEIZURES; TRANSFECTION; XENOPUS;

EID: 33644518449     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1575-05.2006     Document Type: Article

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