Circulating long noncoding RNAs as novel biomarkers of human diseases

Biomarkers in Medicine

Volumn 10, Issue 7, 2016, Pages 757-769

  Jiang, Xiaoying ^a   Lei, Ronghui ^a   Ning, Qilan ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

circulating lncRNAs; common diseases; diagnosis; long noncoding RNAs; prognosis

Indexed keywords

BIOLOGICAL MARKER; CYTOKERATIN 19 FRAGMENT; LONG UNTRANSLATED RNA; RNA H19; TUMOR MARKER;

ACUTE KIDNEY FAILURE; AORTA ANEURYSM; BREAST CANCER; CANCER PROGNOSIS; CANCER RISK; CANCER SURVIVAL; CARCINOGENESIS; CARDIOVASCULAR DISEASE; COLORECTAL CANCER; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DOWN REGULATION; ESOPHAGUS CARCINOMA; GENE EXPRESSION; H19 GENE; HASHIMOTO DISEASE; HEAD AND NECK CANCER; HEART FAILURE; HOTAIR GENE; HULC GENE; HUMAN; LIVER CELL CARCINOMA; LUNG CANCER; MAJOR DEPRESSION; MALAT1 GENE; NEOPLASM; NEUROLOGIC DISEASE; PCA3 GENE; PCAT18 GENE; POU3F3 GENE; PROSTATE CANCER; REVIEW; STOMACH CANCER; TUMOR GENE; TUMOR GROWTH; UPREGULATION; UTERINE CERVIX CANCER; ACUTE KIDNEY INJURY; BLOOD; CARDIOVASCULAR DISEASES; GENE EXPRESSION REGULATION; NEOPLASMS; NERVOUS SYSTEM DISEASES; PROGNOSIS;

ACUTE KIDNEY INJURY; BIOMARKERS; BIOMARKERS, TUMOR; CARDIOVASCULAR DISEASES; GENE EXPRESSION REGULATION; HUMANS; NEOPLASMS; NERVOUS SYSTEM DISEASES; PROGNOSIS; RNA, LONG NONCODING;

EID: 84977644638     PISSN: 17520363     EISSN: 17520371     Source Type: Journal    
DOI: 10.2217/bmm-2016-0039     Document Type: Review

References (96)

1. Mallory AC, Shkumatava A. LncRNAs in vertebrates: advances and challenges. Biochimie 117, 3-14 (2015
2. Khorkova O, Hsiao J, Wahlestedt C. Basic biology and therapeutic implications of lncRNA. Adv. Drug. Deliv. Rev. 87, 15-24 (2015
3. Jiang X, Ning Q. The emerging roles of long noncoding RNAs in common cardiovascular diseases. Hypertens. Res. 38(6), 375-379 (2015
4. Gardini A, Shiekhattar R. The many faces of long noncoding RNAs. FEBS J. 282(9), 1647-1657 (2015
5. Mercer TR, Mattick JS. Structure and function of long noncoding RNAs in epigenetic regulation. Nat. Struct. Mol. Biol. 20(3), 300-307 (2013
6. Lam MT, Li W, Rosenfeld MG, Glass CK. Enhancer RNAs and regulated transcriptional programs. Trends. Biochem. Sci. 39(4), 170-182 (2014
7. Kallen AN, Zhou XB, Xu J, et al. The imprinted H19 lncRNA antagonizes let-7 microRNAs. Mol. Cell 52(1), 101-112 (2013
8. Tay Y, Rinn J, Pandolfi PP. The multilayered complexity of ceRNA crosstalk and competition. Nature 505(7483), 344-352 (2014
9. Yoon JH, Kim J, Gorospe M. Long noncoding RNA turnover. Biochimie 117, 15-21 (2015
10. Rossi MN, Antonangeli F. LncRNAs: new players in apoptosis control. Int. J. Cell. Biol. 2014, 473857 (2014
11. Chen X, Ba Y, Ma L, et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell. Res. 18(10), 997-1006 (2008
12. Weber JA, Baxter D, Zhang S, et al. The microRNA spectrum in 12 body fluids. Clin. Chem. 56(11), 1733-1741 (2010
13. Kondkar AA, Abu-Amero KK. Utility of circulating microRNAs as clinical biomarkers for cardiovascular diseases. Biomed. Res. Int. 2015, 821823 (2015
14. Keller A, Meese E. Can circulating miRNAs live up to the promise of being minimal invasive biomarkers in clinical settings? Wiley Interdiscip. Rev. RNA 7(2), 148-156 (2016
15. Zanutto S, Pizzamiglio S, Ghilotti M, et al. Circulating miR-378 in plasma: a reliable, haemolysis-independent biomarker for colorectal cancer. Br. J. Cancer 110(4), 1001-1007 (2014
16. Swarup V, Rajeswari MR. Circulating (cell-free) nucleic acids-A promising, non-invasive tool for early detection of several human diseases. FEBS Lett. 581(5), 795-799 (2007
17. He Y, Lin J, Kong D, et al. Current state of circulating microRNAs as cancer biomarkers. Clin. Chem. 61(9), 1138-1155 (2015
18. Yin C, Zhou X, Dang Y, Yan J, Zhang G. Potential role of circulating MiR-21 in the diagnosis and prognosis of digestive system cancer: a systematic review and metaanalysis. Medicine (Baltimore) 94(50), e2123 (2015
19. Li M, Zhang J. Circulating microRNAs: potential and emerging biomarkers for diagnosis of cardiovascular and cerebrovascular diseases. Biomed. Res. Int. 2015, 730535 (2015
20. Schulte C, Molz S, Appelbaum S, et al. miRNA-197 and miRNA-223 predict cardiovascular death in a cohort of patients with symptomatic coronary artery disease. PLoS ONE 10(12), e0145930 (2015
21. Su YJ, Yu J, Huang YQ, Yang J. Circulating long noncoding RNA as a potential target for prostate cancer. Int. J. Mol. Sci. 16(6), 13322-13338 (2015
22. Ren S, Wang F, Shen J, et al. Long non-coding RNA metastasis associated in lung adenocarcinoma transcript 1 derived miniRNA as a novel plasma-based biomarker for diagnosing prostate cancer. Eur. J. Cancer 49(13), 2949-2959 (2013
23. Crea F, Watahiki A, Quagliata L, et al. Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer. Oncotarget 5(3), 764-774 (2014
24. Arita T, Ichikawa D, Konishi H, et al. Circulating long non-coding RNAs in plasma of patients with gastric cancer. Anticancer Res. 33(8), 3185-3193 (2013
25. Zhou X, Yin C, Dang Y, Ye F, Zhang G. Identification of the long non-coding RNA H19 in plasma as a novel biomarker for diagnosis of gastric cancer. Sci. Rep. 5, 11516 (2015
26. Pang Q, Ge J, Shao Y, et al. Increased expression of long intergenic non-coding RNA LINC00152 in gastric cancer and its clinical significance. Tumour Biol. 35(6), 5441-5447 (2014
27. Li Q, Shao Y, Zhang X, et al. Plasma long noncoding RNA protected by exosomes as a potential stable biomarker for gastric cancer. Tumour Biol. 36(3), 2007-2012 (2015
28. Gao J, Cao R, Mu H. Long non-coding RNA UCA1 may be a novel diagnostic and predictive biomarker in plasma for early gastric cancer. Int. J. Clin. Exp. Pathol. 8(10), 12936-12942 (2015
29. Dong L, Qi P, Xu MD, et al. Circulating CUDR, LSINCT-5 and PTENP1 long noncoding RNAs in sera distinguish patients with gastric cancer from healthy controls. Int. J. Cancer 137(5), 1128-1235 (2015
30. Shao Y, Ye M, Jiang X, et al. Gastric juice long noncoding RNA used as a tumor marker for screening gastric cancer. Cancer 120(21), 3320-3328 (2014
31. Tong YS, Wang XW, et al. Identification of the long noncoding RNA POU3F3 in plasma as a novel biomarker for diagnosis of esophageal squamous cell carcinoma. Mol. Cancer 14, 3 (2015
32. Xie H, Ma H, Zhou D. Plasma HULC as a promising novel biomarker for the detection of hepatocellular carcinoma. Biomed. Res. Int. 2013, 136106 (2013
33. Li J, Wang X, Tang J, et al. HULC and Linc00152 Act as novel biomarkers in predicting diagnosis of hepatocellular carcinoma. Cell. Physiol. Biochem. 37(2), 687-696 (2015
34. Kogure T, Yan IK, Lin WL, Patel T. Extracellular vesicle-mediated transfer of a novel long noncoding RNA TUC339: a mechanism of intercellular signaling in human hepatocellular cancer. Genes Cancer 4(7), 261-272 (2013
35. Takahashi K, Yan IK, Wood J, Haga H, Patel T. Involvement of extracellular vesicle long noncoding RNA (linc-VLDLR) in tumor cell responses to chemotherapy. Mol. Cancer Res. 12(10), 1377-1387 (2014
36. Takahashi K, Yan IK, Haga H, Patel T. Modulation of hypoxia-signaling pathways by extracellular linc-RoR. J. Cell. Sci. 127(Pt7), 1585-1594 (2014
37. Takahashi K, Yan IK, Kogure T, Haga H, Patel T. Extracellular vesicle-mediated transfer of long noncoding RNA ROR modulates chemosensitivity in human hepatocellular cancer. FEBS Open. Bio 4, 458-467 (2014
38. Shi J, Li X, Zhang F, et al. Circulating lncRNAs associated with occurrence of colorectal cancer progression. Am. J. Cancer Res. 5(7), 2258-2265 (2015
39. Tang Q, Ni Z, Cheng Z, Xu J, Yu H, Yin P. Three circulating long non-coding RNAs act as biomarkers for predicting NSCLC. Cell Physiol. Biochem. 37(3), 1002-1009 (2015
40. Hu X, Bao J, Wang Z, et al. The plasma lncRNA acting as fingerprint in non-small-cell lung cancer. Tumour Biol. 37(3), 3497-3504 (2015
41. Hayes EL, Lewis-Wambi JS. Mechanisms of endocrine resistance in breast cancer: an overview of the proposed roles of noncoding RNA. Breast Cancer Res. 17, 40 (2015
42. Han L, Ma P, Liu SM, Zhou X. Circulating long noncoding RNA GAS5 as a potential biomarker in breast cancer for assessing the surgical effects. Tumour Biol. 37(5), 6847-6854 (2015
43. Xu N, Chen F, Wang F, et al. Clinical significance of high expression of circulating serum lncRNA RP11-445H22.4 in breast cancer patients: a Chinese population-based study. Tumour Biol. 36(10), 7659-7665 (2015
44. Li J, Wang Y, Yu J, Dong R, Qiu H. A high level of circulating HOTAIR is associated with progression and poor prognosis of cervical cancer. Tumour Biol. 36(3), 1661-1665 (2015
45. Isin M, Ozgur E, Cetin G, et al. Investigation of circulating lncRNAs in B-cell neoplasms. Clin. Chim. Acta 431, 255-259 (2014
46. Fayda M, Isin M, Tambas M, et al. Do circulating long noncoding RNAs (lncRNAs) (LincRNA-p21, GAS 5, HOTAIR) predict the treatment response in patients with head and neck cancer treated with chemoradiotherapy? Tumour Biol. 37(3), 3969-3978 (2015
47. Kumarswamy R, Bauters C, Volkmann I, et al. Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure. Circ. Res. 114(10), 1569-1575 (2014
48. Yang Y, Cai Y, Wu G, et al. Plasma long non-coding RNA, CoroMarker, a novel biomarker for diagnosis of coronary artery disease. Clin. Sci. 129(8), 675-685 (2015
49. Zhao Y, Feng G, Wang Y, Yue Y, Zhao W. Regulation of apoptosis by long non-coding RNA HIF1A-AS1 in VSMCs: implications for TAA pathogenesis. Int. J. Clin. Exp. Pathol. 7(11), 7643-7652 (2014
50. Yu B, Liu L, Sun H, Chen Y. Long noncoding RNA AK056155 involved in the development of Loeys-Dietz syndrome through AKT/PI3K signaling pathway. Int. J. Clin. Exp. Pathol. 8(9), 10768-10775 (2015
51. Liu Z, Li X, Sun N, et al. Microarray profiling and coexpression network analysis of circulating lncRNAs and mRNAs associated with major depressive disorder. PLoS ONE 9(3), e93388 (2014
52. Lorenzen JM, Schauerte C, Kielstein JT, et al. Circulating long noncoding RNATapSaki is a predictor of mortality in critically ill patients with acute kidney injury. Clin. Chem. 61(1), 191-201 (2015
53. Carter G, Miladinovic B, Patel AA, Deland L, Mastorides S, Patel NA. Circulating long noncoding RNA GAS5 levels are correlated to prevalence of Type 2 diabetes mellitus. BBA Clin. 4, 102-107 (2015
54. Peng H, Liu Y, Tian J, et al. The long noncoding RNA IFNG-AS1 promotes T helper Type 1 cells response in patients with Hashimoto's thyroiditis. Sci. Rep. 5, 17702 (2015
55. Yarmishyn AA, Kurochkin IV. Long noncoding RNAs: a potential novel class of cancer biomarkers. Front. Genet. 6, 145 (2015
56. Botti G Marra L, Malzone MG, et al. LncRNA HOTAIR as prognostic circulating marker and potential therapeutic target in patients with tumor diseases. Curr. Drug Targets doi: 10.2174/1389450117666151209122950 2015) (Epub ahead of print
57. Schwarzenbach H, Hoon DS, Pantel K. Cell-free nucleic acids as biomarkers in cancer patients. Nat. Rev. Cancer 11(6), 426-437 (2011
58. Rönnau CG, Verhaegh GW, Luna-Velez MV, Schalken JA. Noncoding RNAs as novel biomarkers in prostate cancer. Biomed. Res. Int. 2014, 591703 (2014
59. Walsh AL, Tuzova AV, Bolton EM, Lynch TH, Perry AS. Long noncoding RNAs and prostate carcinogenesis: the missing 'linc'? Trends. Mol. Med. 20(8), 428-436 (2014
60. Wang F, Ren S, Chen R, et al. Development and prospective multicenter evaluation of the long noncoding RNA MALAT-1 as a diagnostic urinary biomarker for prostate cancer. Oncotarget 5(22), 11091-11102 (2014
61. Li T, Mo X, Fu L, Xiao B, Guo J. Molecular mechanisms of long noncoding RNAs on gastric cancer. Oncotarget 7(8), 8601-8612 (2016
62. Lv XB1, Lian GY, Wang HR, Song E, Yao H, Wang MH. Long noncoding RNA HOTAIR is a prognostic marker for esophageal squamous cell carcinoma progression and survival. PLoS ONE 8(5), e63516 (2013
63. Wu W, Bhagat TD, Yang X, et al. Hypomethylation of noncoding DNA regions and overexpression of the long noncoding RNA, AFAP1-AS1, in Barrett's esophagus and esophageal adenocarcinoma. Gastroenterology 144(5), 956-966 (2013
64. Yang X, Song JH, Cheng Y, et al. Long non-coding RNA HNF1A-AS1 regulates proliferation and migration in oesophageal adenocarcinoma cells. Gut 63(6), 881-890 (2014
65. Wang CM, Wu QQ, Li SQ, et al. Upregulation of the long non-coding RNA PlncRNA-1 promotes esophageal squamous carcinoma cell proliferation and correlates with advanced clinical stage. Dig. Dis. Sci. 59(3), 591-597 (2014
66. Li W, Zheng J, Deng J, et al. Increased levels of the long intergenic non-protein coding RNA POU3F3 promote DNA methylation in esophageal squamous cell carcinoma cells. Gastroenterology 146(7), 1714-1726 (2014
67. Yao W, Bai Y, Li Y, et al. Upregulation of MALAT-1 and its association with survival rate and the effect on cell cycle and migration in patients with esophageal squamous cell carcinoma. Tumour Biol. 37(4), 4305-4312 (2016
68. Chen X, Kong J, Ma Z, Gao S, Feng X. Up regulation of the long non-coding RNA NEAT1 promotes esophageal squamous cell carcinoma cell progression and correlates with poor prognosis. Am. J. Cancer Res. 5(9), 2808-2815 (2015
69. Zhao J, Greene CM, Gray SG, Lawless MW. Long noncoding RNAs in liver cancer: what we know in 2014. Expert Opin. Ther. Targets 18(10), 1207-1218 (2014
70. Mohankumar S, Patel T. Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer. Brief Funct. Genomics 15(3), 249-256 (2015
71. Ji J, Tang J, Deng L, et al. LINC00152 promotes proliferation in hepatocellular carcinoma by targeting EpCAM via the mTOR signaling pathway. Oncotarget 6(40), 42813-42824 (2015
72. Zhou CC, Yang F, Yuan SX, et al. Systemic genome screening identified the outcome associated focal loss of long noncoding RNA PRAL in hepatocellular carcinoma. Hepatology 63(3), 850-863 (2016
73. Smolle M, Uranitsch S, Gerger A, Pichler M, Haybaeck J. Current status of long non-coding RNAs in human cancer with specific focus on colorectal cancer. Int. J. Mol. Sci. 15(8), 13993-14013 (2014
74. Pedersen SK, Mitchell SM, Graham LD, et al. CAHM, a long non-coding RNA gene hypermethylated in colorectal neoplasia. Epigenetics 9(8), 1071-1082 (2014
75. Chen J, Wang R, Zhang K, Chen LB. Long non-coding RNAs in non-small cell lung cancer as biomarkers and therapeutic targets. J. Cell. Mol. Med. 18(12), 2425-2436 (2014
76. Kim HJ, Lee DW, Yim GW, et al. Long non-coding RNA HOTAIR is associated with human cervical cancer progression. Int. J. Oncol. 46(2), 521-530 (2015
77. Naemura M, Murasaki C, Inoue Y, Okamoto H, Kotake Y. Long noncoding RNA ANRIL regulates proliferation of nonsmall cell lung cancer and cervical cancer cells. Anticancer Res. 35(10), 5377-5382 (2015
78. Zou AE, Ku J, Honda TK, et al. Transcriptome sequencing uncovers novel long noncoding and small nucleolar RNAs dysregulated in head and neck squamous cell carcinoma. RNA 21(6), 1122-1134 (2015
79. Jiang X, Ning Q. The emerging roles of long noncoding RNAs in common cardiovascular diseases. Hypertens. Res. 38(6), 375-379 (2015
80. Archer K, Broskova Z, Bayoumi AS, et al. Long non-coding RNAs as master regulators in cardiovascular diseases. Int. J. Mol. Sci. 16(10), 23651-23667 (2015
81. Shi Q Yang X. Circulating microRNA and long noncoding RNA as biomarkers of cardiovascular diseases. J. Cell Physiol. doi: 10.1002/jcp.25174 2015
82. Wu C, Arora P. Long noncoding Mhrt RNA: molecular crowbar unravel insights into heart failure treatment. Circ. Cardiovasc. Genet. 8(1), 213-215 (2015
83. Di Salvo TG, Guo Y, Su YR, et al. Right ventricular long noncoding RNA expression in human heart failure. Pulm. Circ. 5(1), 135-161 (2015
84. Gao W, Wang ZM, Zhu M, et al. Altered long noncoding RNA expression profiles in the myocardium of rats with ischemic heart failure. J. Cardiovasc. Med. 16(7), 473-479 (2015
85. Li D, Chen G, Yang J, et al. Transcriptome analysis reveals distinct patterns of long noncoding RNAs in heart and plasma of mice with heart failure. PLoS ONE 8(10), e77938 (2013
86. Turgeon PJ, Sukumar AN, Marsden PA. Epigenetics of cardiovascular disease-A new 'beat' in coronary artery disease. Med. Epigenet. 2(1), 37-52 (2014
87. Zhou X, Han X, Wittfeldt A, et al. Long non-coding RNA ANRIL regulates inflammatory responses as a novel component of NF-?B pathway. RNA Biol. 13(1), 98-108 (2016
88. Gao W, Zhu M, Wang H, et al. Association of polymorphisms in long non-coding RNA H19 with coronary artery disease risk in a Chinese population. Mutat. Res. 772, 15-22 (2015
89. Douvris A, Soubeyrand S, Naing T, et al. Functional analysis of the TRIB1 associated locus linked to plasma triglycerides and coronary artery disease. J. Am. Heart Assoc. 3(3), e000884 (2014
90. Wu G, Cai J, Han Y, et al. LincRNA-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis, and atherosclerosis by enhancing p53 activity. Circulation 130(17), 1452-1465 (2014
91. Wang S, Zhang X, Yuan Y, et al. BRG1 expression is increased in thoracic aortic aneurysms and regulates proliferation and apoptosis of vascular smooth muscle cells through the long non-coding RNA HIF1A-AS1 in vitro. Eur. J. Cardiothorac. Surg. 47(3), 439-446 (2015
92. Pastori C1, Wahlestedt C. Involvement of long noncoding RNAs in diseases affecting the central nervous system. RNA Biol. 9(6), 860-870 (2012
93. Dwivedi Y. Emerging role of microRNAs in major depressive disorder: diagnosis and therapeutic implications. Dialogues Clin. Neurosci. 16(1), 43-61 (2014
94. Morán I, Akerman ?, van de Bunt M, et al. Human cell transcriptome analysis uncovers lncRNAs that are tissuespecific, dynamically regulated, and abnormally expressed in type 2 diabetes. Cell. Metab. 16(4), 435-448 (2012
95. Liu JY, Yao J, Li XM, et al. Pathogenic role of lncRNAMALAT1 in endothelial cell dysfunction in diabetes mellitus. Cell. Death Dis. 5, e1506 (2014
96. Reddy MA, Chen Z, Park JT, et al. Regulation of inflammatory phenotype in macrophages by a diabetesinduced long noncoding RNA. Diabetes 63(12), 4249-4261 (2014