BRG1 expression is increased in thoracic aortic aneurysms and regulates proliferation and apoptosis of vascular smooth muscle cells through the long non-coding RNA HIF1A-AS1 in vitro

European Journal of Cardio-thoracic Surgery

Volumn 47, Issue 3, 2015, Pages 439-446

  Wang, Shuwei ^a,b   Zhang, Xiwu ^a   Yuan, Yang ^a   Tan, Mengwei ^a   Zhang, Le ^a   Xue, Xiang ^a   Yan, Yan ^a   Han, Lin ^a   Xu, Zhiyun ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b The 153 Central Hospital of Chinese PLA   (China)

Author keywords

Apoptosis; Brahma related gene 1; Long non coding RNA; Proliferation; Thoracic aortic aneurysm; Vascular smooth muscle cells

Indexed keywords

BRG1 PROTEIN; CASPASE 3; DNA NUCLEOTIDYLEXOTRANSFERASE; HIF 1 ALPHA ANTISENSE RNA 1; LENTIVIRUS VECTOR; LONG UNTRANSLATED RNA; PROTEIN BCL 2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; DNA HELICASE; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; NUCLEAR PROTEIN; SMARCA4 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

AORTA MEDIA; APOPTOSIS; ARTICLE; CELL COUNTING; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; THORACIC AORTA ANEURYSM; UPREGULATION; VASCULAR SMOOTH MUSCLE CELL; WESTERN BLOTTING; CELL LINE; CHEMISTRY; CYTOLOGY; GENETICS; METABOLISM; THORACIC AORTA; VASCULAR SMOOTH MUSCLE;

AORTA, THORACIC; AORTIC ANEURYSM, THORACIC; APOPTOSIS; CELL LINE; CELL PROLIFERATION; DNA HELICASES; GENE SILENCING; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MUSCLE, SMOOTH, VASCULAR; NUCLEAR PROTEINS; RNA, LONG NONCODING; TRANSCRIPTION FACTORS;

EID: 84928175519     PISSN: 10107940     EISSN: 1873734X     Source Type: Journal    
DOI: 10.1093/ejcts/ezu215     Document Type: Article

References (25)

1. Ghansah JN, Murphy JT. Complications of major aortic and lower extremity vascular surgery. Semin Cardiothorac Vasc Anesth 2004;8:335-61.
2. Durdu S, Deniz GC, Balci D, Zaim C, Dogan A, Can A et al. Apoptotic vascular smooth muscle cell depletion via BCL2 family of proteins in human ascending aortic aneurysm and dissection. Cardiovasc Ther 2012;30:308-16.
3. Zhou J, Zhang M, Fang H, El-Mounayri O, Rodenberg JM, Imbalzano AN et al. The SWI/SNF chromatin remodeling complex regulates myocardininduced smooth muscle-specific gene expression. Arterioscler Thromb Vasc Biol 2009;29:921-8.
4. Chen M, Herring BP. Regulation of microRNAs by Brahma-related gene 1 (BRG1) in smooth muscle cells. J Biol Chem 2013;288:6397-408.
5. Tsai MC, Manor O, Wan Y, Mosammaparast N, Wang JK, Lan F et al. Long noncoding RNA as modular scaffold of histone modification complexes. Science 2010;329:689-93.
6. Khalil AM, Guttman M, Huarte M, Garber M, Raj A, Rivea Morales D et al. Many human large intergenic noncoding RNAs associate with chromatinmodifying complexes and affect gene expression. Proc Natl Acad Sci USA 2009;106:11667-72.
7. Khaitan D, Dinger ME, Mazar J, Crawford J, Smith MA, Mattick JS et al. The melanoma-upregulated long noncoding RNA SPRY4-IT1 modulates apoptosis and invasion. Cancer Res 2011;71:3852-62.
8. Ren J, Li W, Yan L, Jiao W, Tian S, Li D et al. Expression of CIP2A in renal cell carcinomas correlates with tumour invasion, metastasis and patients' survival. Br J Cancer 2011;105:1905-11.
9. Zhu X, Li Y, Luo X, Fei J. Inhibition of small GTPase RalA regulates growth and arsenic-induced apoptosis in chronic myeloid leukemia (CML) cells. Cell Signal 2012;24:1134-40.
10. Hang CT, Yang J, Han P, Cheng HL, Shang C, Ashley E et al. Chromatin regulation by BRG1 underlies heart muscle development and disease. Nature 2010;466:62-7.
11. Sun A, Tawfik O, Gayed B, Thrasher JB, Hoestje S, Li C et al. Aberrant expression of SWI/SNF catalytic subunits BRG1/BRM is associated with tumor development and increased invasiveness in prostate cancers. Prostate 2007;67:203-13.
12. Chung AW, Au Yeung K, Sandor GG, Judge DP, Dietz HC, van Breemen C. Loss of elastic fiber integrity and reduction of vascular smooth muscle contraction resulting from the upregulated activities of matrix metalloproteinase-2 and -9 in the thoracic aortic aneurysm in Marfan syndrome. Circ Res 2007;101:512-22.
13. Zhang L, Liao MF, Tian L, Zou SL, Lu QS, Bao JM et al. Overexpression of interleukin-1beta and interferon-gamma in type I thoracic aortic dissections and ascending thoracic aortic aneurysms: possible correlation with matrix metalloproteinase-9 expression and apoptosis of aortic media cells. Eur J Cardiothorac Surg 2011;40:17-22.
14. Lesauskaite V, Tanganelli P, Sassi C, Neri E, Diciolla F, Ivanoviene L et al. Smooth muscle cells of the media in the dilatative pathology of ascending thoracic aorta: morphology, immunoreactivity for osteopontin, matrix metalloproteinases, and their inhibitors. Hum Pathol 2001;32:1003-11.
15. Saladi SV, Keenen B, Marathe HG, Qi H, Chin KV, de la Serna IL. Modulation of extracellular matrix/adhesion molecule expression by BRG1 is associated with increased melanoma invasiveness. Mol Cancer 2010;9:280.
16. Tai KY, Shieh YS, Lee CS, Shiah SG, Wu CW. Axl promotes cell invasion by inducing MMP-9 activity through activation of NF-kappaB and Brg-1. Oncogene 2008;27:4044-55.
17. Napolitano MA, Cipollaro M, Cascino A, Melone MA, Giordano A, Galderisi U. BRG1 chromatin remodeling factor is involved in cell growth arrest, apoptosis and senescence of rat mesenchymal stem cells. J Cell Sci 2007;120:2904-11.
18. Zhang QJ, Goddard M, Shanahan C, Shapiro L, Bennett M. Differential gene expression in vascular smooth muscle cells in primary atherosclerosis and in stent stenosis in humans. Arterioscler Thromb Vasc Biol 2002;22:2030-6.
19. Wu JI, Lessard J, Crabtree GR. Understanding the words of chromatin regulation. Cell 2009;136:200-6.
20. Rinn JL, Chang HY. Genome regulation by long noncoding RNAs. Annu Rev Biochem 2012;81:145-66.
21. Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA et al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell 2007;129:1311-23.
22. Chu C, Qu K, Zhong FL, Artandi SE, Chang HY. Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions. Mol Cell 2011;44:667-78.
23. Liu Q, Huang J, Zhou N, Zhang Z, Zhang A, Lu Z et al. LncRNA loc285194 is a p53-regulated tumor suppressor. Nucleic Acids Res 2013;41:4976-87.
24. Mercer TR, Qureshi IA, Gokhan S, Dinger ME, Li G, Mattick JS et al. Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation. BMC Neurosci 2010;11:14.
25. Hu W, Yuan B, Flygare J, Lodish HF. Long noncoding RNA-mediated antiapoptotic activity in murine erythroid terminal differentiation. Genes Dev 2011;25:2573-8.