Circulating long noncoding RNA GAS5 levels are correlated to prevalence of type 2 diabetes mellitus

BBA Clinical

Volumn 4, Issue , 2015, Pages 102-107

  Carter, Gay ^a   Miladinovic, Branko ^b   Patel, Achintya A ^b   Deland, Lauren ^a   Mastorides, Stephen ^a   Patel, Niketa A ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Diabetes; GAS5; LncRNA; Serum; Veterans

Indexed keywords

COMPLEMENTARY DNA; LONG UNTRANSLATED RNA; LONG UNTRANSLATED RNA GAS5; UNCLASSIFIED DRUG;

ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; GENE EXPRESSION; GENETIC ASSOCIATION; HUMAN; NON INSULIN DEPENDENT DIABETES MELLITUS; PREVALENCE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RECEIVER OPERATING CHARACTERISTIC; RNA ISOLATION;

EID: 84943609763     PISSN: 22146474     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbacli.2015.09.001     Document Type: Article

References (30)

1. Colosia A.D., Palencia R., Khan S. Prevalence of hypertension and obesity in patients with type 2 diabetes mellitus in observational studies: a systematic literature review. Diabetes Metab. Syndr. Obes. Targets Ther. 2013, 6:327-338. Epub 2013/10/02, PubMed PMID: 24082791; PubMed Central PMCID: PMC3785394. 10.2147/DMSO.S51325.
2. Raj S.M., Halebeedu P., Kadandale J.S., Lahr M.M., Romero I.G., Yadhav J.R., Iliescu M., Rai N., Crivellaro F., Chaubey G., Villems R., Thangaraj K., Muniyappa K., Chandra H.S., Kivisild T. Variation at diabetes- and obesity-associated loci may mirror neutral patterns of human population diversity and diabetes prevalence in India. Ann. Hum. Genet. 2013, Epub 2013/07/03, PubMed PMID: 23808542. 10.1111/ahg.12028.
3. Sundborn G., Metcalf P.A., Gentles D., Scragg R., Dyall L., Black P., Jackson R. Overweight and obesity prevalence among adult Pacific peoples and Europeans in the Diabetes Heart and Health Study (DHAHS) 2002-2003, Auckland New Zealand. N. Z. Med. J. 2010, 123(1311):30-42. Epub 2010/04/03, PubMed PMID: 20360794.
4. Crawford A.G., Cote C., Couto J., Daskiran M., Gunnarsson C., Haas K., Haas S., Nigam S.C., Schuette R. Prevalence of obesity, type II diabetes mellitus, hyperlipidemia, and hypertension in the United States: findings from the GE Centricity Electronic Medical Record database. Popul. Health Manag. 2010, 13(3):151-161. Epub 2010/06/05, PubMed PMID: 20521902. 10.1089/pop.2009.0039.
5. Xu X.J., Pories W.J., Dohm L.G., Ruderman N.B. What distinguishes adipose tissue of severely obese humans who are insulin sensitive and resistant?. Curr. Opin. Lipidol. 2013, 24(1):49-56. Epub 2013/01/10, PubMed PMID: 23298959; PubMed Central PMCID: PMC3575680. 10.1097/MOL.0b013e32835b465b.
6. Chen X., Yan G.Y. Novel human lncRNA-disease association inference based on lncRNA expression profiles. Bioinformatics 2013, 29(20):2617-2624. PubMed PMID: 24002109. 10.1093/bioinformatics/btt426.
7. Arase M., Horiguchi K., Ehata S., Morikawa M., Tsutsumi S., Aburatani H., Miyazono K., Koinuma D. Transforming growth factor-beta-induced lncRNA-Smad7 inhibits apoptosis of mouse breast cancer JygMC(A) cells. Cancer Sci. 2014, 105(8):974-982. PubMed PMID: 24863656. 10.1111/cas.12454.
8. Liu Q., Huang J., Zhou N., Zhang Z., Zhang A., Lu Z., Wu F., Mo Y.Y. LncRNA loc285194 is a p53-regulated tumor suppressor. Nucleic Acids Res. 2013, 41(9):4976-4987. PubMed PMID: 23558749; PubMed Central PMCID: PMC3643595. 10.1093/nar/gkt182.
9. Lander E.S., Linton L.M., Birren B., Nusbaum C., Zody M.C., Baldwin J., Devon K., Dewar K., Doyle M., FitzHugh W., Funke R., Gage D., Harris K., Heaford A., Howland J., Kann L., Lehoczky J., LeVine R., McEwan P., McKernan K., Meldrim J., Mesirov J.P., Miranda C., Morris W., Naylor J., Raymond C., Rosetti M., Santos R., Sheridan A., Sougnez C., Stange-Thomann N., Stojanovic N., Subramanian A., Wyman D., Rogers J., Sulston J., Ainscough R., Beck S., Bentley D., Burton J., Clee C., Carter N., Coulson A., Deadman R., Deloukas P., Dunham A., Dunham I., Durbin R., French L., Grafham D., Gregory S., Hubbard T., Humphray S., Hunt A., Jones M., Lloyd C., McMurray A., Matthews L., Mercer S., Milne S., Mullikin J.C., Mungall A., Plumb R., Ross M., Shownkeen R., Sims S., Waterston R.H., Wilson R.K., Hillier L.W., JD M.P., Marra M.A., Mardis E.R., Fulton L.A., Chinwalla A.T., Pepin K.H., Gish W.R., Chissoe S.L., Wendl M.C., Delehaunty K.D., Miner T.L., Delehaunty A., Kramer J.B., Cook L.L., Fulton R.S., Johnson D.L., Minx P.J., Clifton S.W., Hawkins T., Branscomb E., Predki P., Richardson P., Wenning S., Slezak T., Doggett N., Cheng J.F., Olsen A., Lucas S., Elkin C., Uberbacher E., Frazier M., Gibbs R.A., Muzny D.M., Scherer S.E., Bouck J.B., Sodergren E.J., Worley K.C., Rives C.M., Gorrell J.H., Metzker M.L., Naylor S.L., Kucherlapati R.S., Nelson D.L., Weinstock G.M., Sakaki Y., Fujiyama A., Hattori M., Yada T., Toyoda A., Itoh T., Kawagoe C., Watanabe H., Totoki Y., Taylor T., Weissenbach J., Heilig R., Saurin W., Artiguenave F., Brottier P., Bruls T., Pelletier E., Robert C., Wincker P., Smith D.R., Doucette-Stamm L., Rubenfield M., Weinstock K., Lee H.M., Dubois J., Rosenthal A., Platzer M., Nyakatura G., Taudien S., Rump A., Yang H., Yu J., Wang J., Huang G., Gu J., Hood L., Rowen L., Madan A., Qin S., Davis R.W., Federspiel N.A., Abola A.P., Proctor M.J., Myers R.M., Schmutz J., Dickson M., Grimwood J., Cox D.R., Olson M.V., Kaul R., Raymond C., Shimizu N., Kawasaki K., Minoshima S., Evans G.A., Athanasiou M., Schultz R., Roe B.A., Chen F., Pan H., Ramser J., Lehrach H., Reinhardt R., WR M.C., de la Bastide M., Dedhia N., Blocker H., Hornischer K., Nordsiek G., Agarwala R., Aravind L., Bailey J.A., Bateman A., Batzoglou S., Birney E., Bork P., Brown D.G., Burge C.B., Cerutti L., Chen H.C., Church D., Clamp M., Copley R.R., Doerks T., Eddy S.R., Eichler E.E., Furey T.S., Galagan J., Gilbert J.G., Harmon C., Hayashizaki Y., Haussler D., Hermjakob H., Hokamp K., Jang W., Johnson L.S., Jones T.A., Kasif S., Kaspryzk A., Kennedy S., Kent W.J., Kitts P., Koonin E.V., Korf I., Kulp D., Lancet D., Lowe T.M., McLysaght A., Mikkelsen T., Moran J.V., Mulder N., Pollara V.J., Ponting C.P., Schuler G., Schultz J., Slater G., Smit A.F., Stupka E., Szustakowski J., Thierry-Mieg D., Thierry-Mieg J., Wagner L., Wallis J., Wheeler R., Williams A., Wolf Y.I., Wolfe K.H., Yang S.P., Yeh R.F., Collins F., Guyer M.S., Peterson J., Felsenfeld A., Wetterstrand K.A., Patrinos A., Morgan M.J., de Jong P., Catanese J.J., Osoegawa K., Shizuya H., Choi S., Chen Y.J. International human genome sequencing C. Initial sequencing and analysis of the human genome. Nature 2001, 409(6822):860-921. PubMed PMID: 11237011. 10.1038/35057062.
10. Amaral P.P., Clark M.B., Gascoigne D.K., Dinger M.E., Mattick J.S. lncRNAdb: a reference database for long noncoding RNAs. Nucleic Acids Res. 2011, 39. (Database issue):D146-51. Epub 2010/11/30, PubMed PMID: 21112873; PubMed Central PMCID: PMC3013714. 10.1093/nar/gkq1138.
11. Williams G.T., Mourtada-Maarabouni M., Farzaneh F. A critical role for non-coding RNA GAS5 in growth arrest and rapamycin inhibition in human T-lymphocytes. Biochem. Soc. Trans. 2011, 39(2):482-486. Epub 2011/03/25, PubMed PMID: 21428924. 10.1042/BST0390482.
12. Budczies J., Klauschen F., Sinn B.V., Gyorffy B., Schmitt W.D., Darb-Esfahani S., Denkert C. Cutoff finder: a comprehensive and straightforward Web application enabling rapid biomarker cutoff optimization. PLoS One 2012;, 7(12):e51862. PubMed PMID: 23251644; PubMed Central PMCID: PMC3522617. 10.1371/journal.pone.0051862.
13. Taneera J., Fadista J., Ahlqvist E., Atac D., Ottosson-Laakso E., Wollheim C.B., Groop L. Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia. Hum. Mol. Genet. 2015, 24(7):1945-1955. PubMed PMID: 25489054. 10.1093/hmg/ddu610.
14. Fadista J., Vikman P., Laakso E.O., Mollet I.G., Esguerra J.L., Taneera J., Storm P., Osmark P., Ladenvall C., Prasad R.B., Hansson K.B., Finotello F., Uvebrant K., Ofori J.K., Di Camillo B., Krus U., Cilio C.M., Hansson O., Eliasson L., Rosengren A.H., Renstrom E., Wollheim C.B., Groop L. Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism. Proc. Natl. Acad. Sci. U. S. A. 2014, 111(38):13924-13929. PubMed PMID: 25201977; PubMed Central PMCID: PMC4183326. 10.1073/pnas.1402665111.
15. Ding G.L., Wang F.F., Shu J., Tian S., Jiang Y., Zhang D., Wang N., Luo Q., Zhang Y., Jin F., Leung P.C., Sheng J.Z., Huang H.F. Transgenerational glucose intolerance with Igf2/H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia. Diabetes 2012, 61(5):1133-1142. PubMed PMID: 22447856; PubMed Central PMCID: PMC3331740. 10.2337/db11-1314.
16. Pasmant E., Sabbagh A., Vidaud M., Bieche I. ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS. FASEB J. 2011, 25(2):444-448. PubMed PMID: 20956613. 10.1096/fj.10-172452.
17. Divoux A., Karastergiou K., Xie H., Guo W., Perera R.J., Fried S.K., Smith S.R. Identification of a novel lncRNA in gluteal adipose tissue and evidence for its positive effect on preadipocyte differentiation. Obesity 2014, 22(8):1781-1785. PubMed PMID: 24862299; PubMed Central PMCID: PMC4228784. 10.1002/oby.20793.
18. Cooper D.R., Carter G., Li P., Patel R., Watson J.E., Patel N.A. Long non-coding RNA NEAT1 associates with SRp40 to temporally regulate PPARgamma2 splicing during adipogenesis in 3T3-L1 Cells. Genes 2014, 5(4):1050-1063. PubMed PMID: 25437750; PubMed Central PMCID: PMC4276926. 10.3390/genes5041050.
19. Yacqub-Usman K., Pickard M.R., Williams G.T. Reciprocal regulation of GAS5 lncRNA levels and mTOR inhibitor action in prostate cancer cells. Prostate 2015, 75(7):693-705. PubMed PMID: 25650269. 10.1002/pros.22952.
20. Pickard M.R., Williams G.T. Regulation of apoptosis by long non-coding RNA GAS5 in breast cancer cells: implications for chemotherapy. Breast cancer research and treatment 2014, 145(2):359-370. PubMed PMID: 24789445. 10.1007/s10549-014-2974-y.
21. Pickard M.R., Mourtada-Maarabouni M., Williams G.T. Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines. Biochim. Biophys. Acta 2013, 1832(10):1613-1623. PubMed PMID: 23676682. 10.1016/j.bbadis.2013.05.005.
22. Mourtada-Maarabouni M., Pickard M.R., Hedge V.L., Farzaneh F., Williams G.T. GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer. Oncogene 2009, 28(2):195-208. PubMed PMID: 18836484. 10.1038/onc.2008.373.
23. Huang X., Yuan T., Tschannen M., Sun Z., Jacob H., Du M., Liang M., Dittmar R.L., Liu Y., Liang M., Kohli M., Thibodeau S.N., Boardman L., Wang L. Characterization of human plasma-derived exosomal RNAs by deep sequencing. BMC Genomics 2013, 14:319. PubMed PMID: 23663360; PubMed Central PMCID: PMC3653748. 10.1186/1471-2164-14-319.
24. Tsui N.B., Ng E.K., Lo Y.M. Molecular analysis of circulating RNA in plasma. Methods Mol. Biol. 2006, 336:123-134. Epub 2006/08/19, PubMed PMID: 16916258. 10.1385/1-59745-074-X:123.
25. Wang K., Yuan Y., Li H., Cho J.H., Huang D., Gray L., Qin S., Galas D.J. The spectrum of circulating RNA: a window into systems toxicology. Toxicol. Sci. 2013, 132(2):478-492. Epub 2013/01/30, PubMed PMID: 23358195. 10.1093/toxsci/kft014.
26. Baraniskin A., Nopel-Dunnebacke S., Ahrens M., Jensen S.G., Zollner H., Maghnouj A., Wos A., Mayerle J., Munding J., Kost D., Reinacher-Schick A., Liffers S., Schroers R., Chromik A.M., Meyer H.E., Uhl W., Klein-Scory S., Weiss F.U., Stephan C., Schwarte-Waldhoff I., Lerch M.M., Tannapfel A., Schmiegel W., Andersen C.L., Hahn S.A. Circulating U2 small nuclear RNA fragments as a novel diagnostic biomarker for pancreatic and colorectal adenocarcinoma. Int. J. Cancer 2013, 132(2):E48-E57. Epub 2012/08/22, PubMed PMID: 22907602. 10.1002/ijc.27791.
27. Payne R.E., Wang F., Su N., Krell J., Zebrowski A., Yague E., Ma X.J., Luo Y., Coombes R.C. Viable circulating tumour cell detection using multiplex RNA in situ hybridisation predicts progression-free survival in metastatic breast cancer patients. Br. J. Cancer 2012, 106(11):1790-1797. Epub 2012/04/28, PubMed PMID: 22538972; PubMed Central PMCID: PMC3364118. 10.1038/bjc.2012.137.
28. Xie J., Herbert T.P. The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic beta-cell mass: implications in the development of type-2 diabetes. Cell. Mol. Life Sci. 2012, 69(8):1289-1304. PubMed PMID: 22068611. 10.1007/s00018-011-0874-4.
29. Ost A., Svensson K., Ruishalme I., Brannmark C., Franck N., Krook H., Sandstrom P., Kjolhede P., Stralfors P. Attenuated mTOR signaling and enhanced autophagy in adipocytes from obese patients with type 2 diabetes. Mol. Med. 2010, 16(7-8):235-246. PubMed PMID: 20386866; PubMed Central PMCID: PMC2896460. 10.2119/molmed.2010.00023.
30. Fraenkel M., Ketzinel-Gilad M., Ariav Y., Pappo O., Karaca M., Castel J., Berthault M.F., Magnan C., Cerasi E., Kaiser N., Leibowitz G. mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes. Diabetes 2008, 57(4):945-957. PubMed PMID: 18174523. 10.2337/db07-0922.