Lnk regulates integrin αIIbβ3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo

Journal of Clinical Investigation

Volumn 120, Issue 1, 2010, Pages 179-190

  Takizawa, Hitoshi ^a   Nishimura, Satoshi ^b,c,d   Takayama, Naoya ^c   Oda, Atsushi ^e   Nishikii, Hidekazu ^c   Morita, Yohei ^c   Kakinuma, Sei ^c   Yamazaki, Satoshi ^c   Okamura, Satoshi ^c   Tamura, Noriko ^f   Goto, Shinya ^f   Sawaguchi, Akira ^g   Manabe, Ichiro ^b,c,d   Takatsu, Kiyoshi ^h   Nakauchi, Hiromitsu ^c   Takaki, Satoshi ^a   Eto, Koji ^c  

^a NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^g UNIVERSITY OF MIYAZAKI   (Japan)

^h Preferectural Institute for Pharmaceutical Research   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ADAPTOR PROTEIN LNK; ALPHA INTEGRIN; ALPHA2B BETA3 INTEGRIN; BETA3 INTEGRIN; FERRIC CHLORIDE; FIBRINOGEN; PROTEIN KINASE FYN; TYROSINE; UNCLASSIFIED DRUG; FIBRINOGEN RECEPTOR; FYN PROTEIN, MOUSE; LNK PROTEIN, MOUSE; PROTEIN; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE C SRC; PROTEIN-TYROSINE KINASE C-SRC;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY INJURY; ARTICLE; BINDING AFFINITY; BLOOD CLOT; BONE MARROW TRANSPLANTATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; IN VIVO STUDY; LASER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE COUNT; THROMBOGENESIS; THROMBOSIS; WILD TYPE; ANIMAL; C57BL MOUSE; CELL STRAIN COS1; CERCOPITHECUS; CHO CELL; CRICETULUS; HAMSTER; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALS; BLOOD PLATELETS; CERCOPITHECUS AETHIOPS; CHO CELLS; COS CELLS; CRICETINAE; CRICETULUS; MALE; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN-TYROSINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS C-FYN; SIGNAL TRANSDUCTION; THROMBOSIS;

EID: 74949127673     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI39503     Document Type: Article

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