Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 11, 2015, Pages E1373-E1381

  Wang, Wuyang ^a   Gao, Qiong ^a   Yang, Meimei ^a   Zhang, Xiaoli ^a   Yu, Lu ^a   Lawas, Maria ^a   Li, Xinran ^a   Bryant Genevier, Marthe ^b   Southall, Noel T ^b   Marugan, Juan ^b   Ferrer, Marc ^b   Xu, Haoxing ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Lysosome; mTOR; Starvation; TFEB; TRPML1

Indexed keywords

CALCIUM ION; MAMMALIAN TARGET OF RAPAMYCIN; MUCOLIPIN 1; SODIUM; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EB; TRANSIENT RECEPTOR POTENTIAL CHANNEL; UNCLASSIFIED DRUG; AMINO ACID; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; CALCIUM; CHOLESTEROL; MCOLN1 PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3,5-DIPHOSPHATE; POLYPHOSPHOINOSITIDE; TARGET OF RAPAMYCIN KINASE;

ADAPTATION; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; LYSOSOME; NIEMANN PICK DISEASE; NUTRIENT; PRIORITY JOURNAL; PROTEIN HOMEOSTASIS; QUALITY CONTROL; SODIUM TRANSPORT; STARVATION; UPREGULATION; ANIMAL; CELL LINE; CELL NUCLEUS; DEFICIENCY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MUTATION; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT;

MAMMALIA;

AMINO ACIDS; ANIMALS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CALCIUM; CELL LINE; CELL NUCLEUS; CHOLESTEROL; GENE EXPRESSION REGULATION; HUMANS; LYSOSOMES; MUTATION; NIEMANN-PICK DISEASES; PHOSPHATIDYLINOSITOL PHOSPHATES; PROTEIN BIOSYNTHESIS; PROTEIN TRANSPORT; PROTEOLYSIS; SODIUM; TOR SERINE-THREONINE KINASES; TRANSCRIPTION, GENETIC; TRANSIENT RECEPTOR POTENTIAL CHANNELS; UP-REGULATION;

EID: 84925324770     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1419669112     Document Type: Article

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