-
1
-
-
80052233389
-
Endosome maturation
-
Huotari J, Helenius A. 2011. Endosome maturation. EMBO J. 30:3481-500
-
(2011)
EMBO J.
, vol.30
, pp. 3481-3500
-
-
Huotari, J.1
Helenius, A.2
-
3
-
-
25444443570
-
Principles of lysosomal membrane digestion: Stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids
-
Kolter T, Sandhoff K. 2005. Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids. Annu. Rev. Cell Dev. Biol. 21:81-103
-
(2005)
Annu. Rev. Cell Dev. Biol.
, vol.21
, pp. 81-103
-
-
Kolter, T.1
Sandhoff, K.2
-
4
-
-
62949241063
-
Molecular and cellular basis of lysosomal transmembrane protein dysfunction
-
Ruivo R, Anne C, Sagne C, Gasnier B. 2009. Molecular and cellular basis of lysosomal transmembrane protein dysfunction. Biochim. Biophys. Acta 1793:636-49
-
(2009)
Biochim. Biophys. Acta
, vol.1793
, pp. 636-649
-
-
Ruivo, R.1
Anne, C.2
Sagne, C.3
Gasnier, B.4
-
5
-
-
69249227502
-
Lysosome biogenesis and lysosomal membrane proteins: Trafficking meets function
-
Saftig P, Klumperman J. 2009. Lysosome biogenesis and lysosomal membrane proteins: Trafficking meets function. Nat. Rev. Mol. Cell Biol. 10:623-35
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 623-635
-
-
Saftig, P.1
Klumperman, J.2
-
6
-
-
84876812269
-
Signals from the lysosome: A control centre for cellular clearance and energy metabolism
-
Settembre C, Fraldi A, Medina DL, Ballabio A. 2013. Signals from the lysosome: a control centre for cellular clearance and energy metabolism. Nat. Rev. Mol. Cell Biol. 14:283-96
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, pp. 283-296
-
-
Settembre, C.1
Fraldi, A.2
Medina, D.L.3
Ballabio, A.4
-
7
-
-
77953699711
-
Termination of autophagy and reformation of lysosomes regulated by mTOR
-
Yu L, McPhee CK, Zheng L, Mardones GA, Rong Y, et al. 2010. Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature 465:942-46
-
(2010)
Nature
, vol.465
, pp. 942-946
-
-
Yu, L.1
McPhee, C.K.2
Zheng, L.3
Mardones, G.A.4
Rong, Y.5
-
8
-
-
79956346329
-
Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation
-
Rong Y, McPhee CK, Deng S, HuangL,ChenL, et al. 2011. Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation. Proc. Natl. Acad. Sci. USA 108:7826-31
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 7826-7831
-
-
Rong, Y.1
McPhee, C.K.2
Deng, S.3
Huang, L.4
Chen, L.5
-
9
-
-
80955177196
-
TFEB links autophagy to lysosomal biogenesis
-
Settembre C, Di Malta C, Polito VA, Garcia Arencibia M, Vetrini F, et al. 2011. TFEB links autophagy to lysosomal biogenesis. Science 332:1429-33
-
(2011)
Science
, vol.332
, pp. 1429-1433
-
-
Settembre, C.1
Di Malta, C.2
Polito, V.A.3
Garcia, A.M.4
Vetrini, F.5
-
10
-
-
80555143078
-
MTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolarH+-ATPase
-
Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y, Sabatini DM. 2011. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolarH+-ATPase. Science 334:678-83
-
(2011)
Science
, vol.334
, pp. 678-683
-
-
Zoncu, R.1
Bar-Peled, L.2
Efeyan, A.3
Wang, S.4
Sancak, Y.5
Sabatini, D.M.6
-
11
-
-
84876408458
-
Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion
-
Zhou J, Tan SH, Nicolas V, Bauvy C, Yang ND, et al. 2013. Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion. Cell Res. 23:508-23
-
(2013)
Cell Res.
, vol.23
, pp. 508-523
-
-
Zhou, J.1
Tan, S.H.2
Nicolas, V.3
Bauvy, C.4
Yang, N.D.5
-
12
-
-
79953316595
-
Lysosomal positioning coordinates cellular nutrient responses
-
Korolchuk VI, Saiki S, Lichtenberg M, Siddiqi FH, Roberts EA, et al. 2011. Lysosomal positioning coordinates cellular nutrient responses. Nat. Cell Biol. 13:453-60
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 453-460
-
-
Korolchuk, V.I.1
Saiki, S.2
Lichtenberg, M.3
Siddiqi, F.H.4
Roberts, E.A.5
-
13
-
-
84901688029
-
Organelles observed: Lysosomes
-
Mellman I. 1989. Organelles observed: lysosomes. Science 244:853-54
-
(1989)
Science
, vol.244
, pp. 853-854
-
-
Mellman, I.1
-
14
-
-
84900327199
-
Lysosome transport as a function of lysosome diameter
-
Bandyopadhyay D, Cyphersmith A, Zapata JA, Kim YJ, Payne CK. 2014. Lysosome transport as a function of lysosome diameter. PLOS ONE 9:e86847
-
(2014)
PLOS ONE
, vol.9
, pp. e86847
-
-
Bandyopadhyay, D.1
Cyphersmith, A.2
Zapata, J.A.3
Kim, Y.J.4
Payne, C.K.5
-
15
-
-
0020996054
-
Electrogenic nature of lysosomal proton pump as revealed with a cyanine dye
-
Ohkuma S, Moriyama Y, Takano T. 1983. Electrogenic nature of lysosomal proton pump as revealed with a cyanine dye. J. Biochem. 94:1935-43
-
(1983)
J. Biochem.
, vol.94
, pp. 1935-1943
-
-
Ohkuma, S.1
Moriyama, Y.2
Takano, T.3
-
16
-
-
77954412381
-
A cation counterflux supports lysosomal acidification
-
Steinberg BE, Huynh KK, Brodovitch A, Jabs S, Stauber T, et al. 2010. A cation counterflux supports lysosomal acidification. J. Cell Biol. 189:1171-86
-
(2010)
J. Cell Biol.
, vol.189
, pp. 1171-1186
-
-
Steinberg, B.E.1
Huynh, K.K.2
Brodovitch, A.3
Jabs, S.4
Stauber, T.5
-
18
-
-
80054015726
-
Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease
-
Morgan AJ, Platt FM, Lloyd-Evans E, Galione A. 2011. Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease. Biochem. J. 439:349-74
-
(2011)
Biochem. J.
, vol.439
, pp. 349-374
-
-
Morgan, A.J.1
Platt, F.M.2
Lloyd-Evans, E.3
Galione, A.4
-
19
-
-
0025746712
-
The transport systems of mammalian lysosomes
-
Pisoni RL, Thoene JG. 1991. The transport systems of mammalian lysosomes. Biochim. Biophys. Acta 1071:351-73
-
(1991)
Biochim. Biophys. Acta
, vol.1071
, pp. 351-373
-
-
Pisoni, R.L.1
Thoene, J.G.2
-
20
-
-
84871386918
-
Orai-STIM-mediated Ca2+ release from secretory granules revealed by a targeted Ca2+ and pH probe
-
Dickson EJ, Duman JG, Moody MW, Chen L, Hille B. 2012. Orai-STIM-mediated Ca2+ release from secretory granules revealed by a targeted Ca2+ and pH probe. Proc. Natl. Acad. Sci. USA 109:E3539-48
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. E3539-E3548
-
-
Dickson, E.J.1
Duman, J.G.2
Moody, M.W.3
Chen, L.4
Hille, B.5
-
21
-
-
84870947500
-
Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy
-
Jezegou A, Llinares E, Anne C, Kieffer-Jaquinod S,O'Regan S, et al. 2012. Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy. Proc. Natl. Acad. Sci. USA 109:E3434-43
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. E3434-E3443
-
-
Jezegou, A.1
Llinares, E.2
Anne, C.3
Kieffer-Jaquinod, S.4
O'Regan, S.5
-
22
-
-
84873690749
-
Chloride in vesicular trafficking and function
-
Stauber T, Jentsch TJ. 2013. Chloride in vesicular trafficking and function. Annu. Rev. Physiol. 75:453-77
-
(2013)
Annu. Rev. Physiol.
, vol.75
, pp. 453-477
-
-
Stauber, T.1
Jentsch, T.J.2
-
23
-
-
84867565289
-
TPC proteins are phosphoinositide-Activated sodium-selective ion channels in endosomes and lysosomes
-
Wang X, Zhang X, Dong XP, Samie M, Li X, et al. 2012. TPC proteins are phosphoinositide-Activated sodium-selective ion channels in endosomes and lysosomes. Cell 151:372-83
-
(2012)
Cell
, vol.151
, pp. 372-383
-
-
Wang, X.1
Zhang, X.2
Dong, X.P.3
Samie, M.4
Li, X.5
-
24
-
-
84859175854
-
Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release
-
Shen D,Wang X, Li X, Zhang X, Yao Z, et al. 2012. Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release. Nat. Commun. 3:731
-
(2012)
Nat. Commun.
, vol.3
, pp. 731
-
-
Shen, D.1
Wang, X.2
Li, X.3
Zhang, X.4
Yao, Z.5
-
25
-
-
36749070036
-
The role of calcium and other ions in sorting and delivery in the late endocytic pathway
-
Luzio JP, Bright NA, Pryor PR. 2007. The role of calcium and other ions in sorting and delivery in the late endocytic pathway. Biochem. Soc. Trans. 35:1088-91
-
(2007)
Biochem. Soc. Trans.
, vol.35
, pp. 1088-1091
-
-
Luzio, J.P.1
Bright, N.A.2
Pryor, P.R.3
-
26
-
-
84884290253
-
Regulation of membrane trafficking by signalling on endosomal and lysosomal membranes
-
Li X, Garrity AG, Xu H. 2013. Regulation of membrane trafficking by signalling on endosomal and lysosomal membranes. J. Physiol. 591:4389-401
-
(2013)
J. Physiol.
, vol.591
, pp. 4389-4401
-
-
Li, X.1
Garrity, A.G.2
Xu, H.3
-
27
-
-
0035990976
-
The molecular basis of mucolipidosis type IV
-
Slaugenhaupt SA. 2002. The molecular basis of mucolipidosis type IV. Curr. Mol. Med. 2:445-50
-
(2002)
Curr. Mol. Med.
, vol.2
, pp. 445-450
-
-
Slaugenhaupt, S.A.1
-
28
-
-
84857260144
-
Lysosomal acidification mechanisms
-
Mindell JA. 2012. Lysosomal acidification mechanisms. Annu. Rev. Physiol. 74:69-86
-
(2012)
Annu. Rev. Physiol.
, vol.74
, pp. 69-86
-
-
Mindell, J.A.1
-
29
-
-
84874105202
-
MTOR regulates lysosomal ATP-sensitive two-pore Na+ channels to adapt to metabolic state
-
Cang C, Zhou Y, Navarro B, Seo YJ, Aranda K, et al. 2013. mTOR regulates lysosomal ATP-sensitive two-pore Na+ channels to adapt to metabolic state. Cell 152:778-90
-
(2013)
Cell
, vol.152
, pp. 778-790
-
-
Cang, C.1
Zhou, Y.2
Navarro, B.3
Seo, Y.J.4
Aranda, K.5
-
30
-
-
77949695459
-
TRP channels of intracellular membranes
-
Dong XP,Wang X, Xu H. 2010. TRP channels of intracellular membranes. J. Neurochem. 113:313-28
-
(2010)
J. Neurochem.
, vol.113
, pp. 313-328
-
-
Dong, X.P.1
Wang, X.2
Xu, H.3
-
31
-
-
55549134611
-
Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium
-
Lloyd-Evans E, Morgan AJ, He X, Smith DA, Elliot-Smith E, et al. 2008. Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium. Nat. Med. 14:1247-55
-
(2008)
Nat. Med.
, vol.14
, pp. 1247-1255
-
-
Lloyd-Evans, E.1
Morgan, A.J.2
He, X.3
Smith, D.A.4
Elliot-Smith, E.5
-
32
-
-
0036472494
-
PH-dependent regulation of lysosomal calcium in macrophages
-
Christensen KA, Myers JT, Swanson JA. 2002. pH-dependent regulation of lysosomal calcium in macrophages. J. Cell Sci. 115:599-607
-
(2002)
J. Cell Sci.
, vol.115
, pp. 599-607
-
-
Christensen, K.A.1
Myers, J.T.2
Swanson, J.A.3
-
33
-
-
0034729167
-
The role of intraorganellar Ca2+ in late endosome-lysosome heterotypic fusion and in the reformation of lysosomes from hybrid organelles
-
Pryor PR, Mullock BM, Bright NA, Gray SR, Luzio JP. 2000. The role of intraorganellar Ca2+ in late endosome-lysosome heterotypic fusion and in the reformation of lysosomes from hybrid organelles. J. Cell Biol. 149:1053-62
-
(2000)
J. Cell Biol.
, vol.149
, pp. 1053-1062
-
-
Pryor, P.R.1
Mullock, B.M.2
Bright, N.A.3
Gray, S.R.4
Luzio, J.P.5
-
34
-
-
84884154195
-
A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis
-
Samie M, Wang X, Zhang X, Goschka A, Li X, et al. 2013. A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis. Dev. Cell 26:511-24
-
(2013)
Dev. Cell
, vol.26
, pp. 511-524
-
-
Samie, M.1
Wang, X.2
Zhang, X.3
Goschka, A.4
Li, X.5
-
35
-
-
33748989031
-
Ca2+ and synaptotagmin VII-dependent delivery of lysosomal membrane to nascent phagosomes
-
Czibener C, Sherer NM, Becker SM, Pypaert M, Hui E, et al. 2006. Ca2+ and synaptotagmin VII-dependent delivery of lysosomal membrane to nascent phagosomes. J. Cell Biol. 174:997-1007
-
(2006)
J. Cell Biol.
, vol.174
, pp. 997-1007
-
-
Czibener, C.1
Sherer, N.M.2
Becker, S.M.3
Pypaert, M.4
Hui, E.5
-
36
-
-
73649127260
-
Identification of the penta-EF-hand protein ALG-2 as a Ca2+-dependent interactor of mucolipin-1
-
Vergarajauregui S, Martina JA, Puertollano R. 2009. Identification of the penta-EF-hand protein ALG-2 as a Ca2+-dependent interactor of mucolipin-1. J. Biol. Chem. 284:36357-66
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 36357-36366
-
-
Vergarajauregui, S.1
Martina, J.A.2
Puertollano, R.3
-
37
-
-
46449093538
-
How does synaptotagmin trigger neurotransmitter release?
-
Chapman ER. 2008. How does synaptotagmin trigger neurotransmitter release? Annu. Rev. Biochem. 77:615-41
-
(2008)
Annu. Rev. Biochem.
, vol.77
, pp. 615-641
-
-
Chapman, E.R.1
-
38
-
-
80052634348
-
TRPML: Transporters of metals in lysosomes essential for cell survival?
-
Kiselyov K, Colletti GA, Terwilliger A, Ketchum K, Lyons CW, et al. 2011. TRPML: transporters of metals in lysosomes essential for cell survival? Cell Calcium 50:288-94
-
(2011)
Cell Calcium
, vol.50
, pp. 288-294
-
-
Kiselyov, K.1
Colletti, G.A.2
Terwilliger, A.3
Ketchum, K.4
Lyons, C.W.5
-
39
-
-
77952672976
-
Mechanisms of brain iron transport: Insight into neurodegeneration and CNS disorders
-
Mills E, Dong XP,Wang F, Xu H. 2010. Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders. Future Med. Chem. 2:51
-
(2010)
Future Med. Chem.
, vol.2
, pp. 51
-
-
Mills, E.1
Dong, X.P.2
Wang, F.3
Xu, H.4
-
40
-
-
0032540959
-
The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene
-
Schissel SL, Keesler GA, Schuchman EH, Williams KJ, Tabas I. 1998. The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene. J. Biol. Chem. 273:18250-59
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 18250-18259
-
-
Schissel, S.L.1
Keesler, G.A.2
Schuchman, E.H.3
Williams, K.J.4
Tabas, I.5
-
41
-
-
84879564204
-
Lysosomal metal, redox and proton cycles influencing the CysHis cathepsin reaction
-
Lockwood TD. 2013. Lysosomal metal, redox and proton cycles influencing the CysHis cathepsin reaction. Metallomics 5:110-24
-
(2013)
Metallomics
, vol.5
, pp. 110-124
-
-
Lockwood, T.D.1
-
43
-
-
34848916433
-
Luminal chloride-dependent activation of endosome calcium channels: Patch clamp study of enlarged endosomes
-
SaitoM, Hanson PI, Schlesinger P. 2007. Luminal chloride-dependent activation of endosome calcium channels: patch clamp study of enlarged endosomes. J. Biol. Chem. 282:27327-33
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 27327-27333
-
-
Saito, M.1
Hanson, P.I.2
Schlesinger, P.3
-
44
-
-
84862602473
-
Autophagy in lysosomal storage disorders
-
Lieberman AP, Puertollano R, Raben N, Slaugenhaupt S, Walkley SU, Ballabio A. 2012. Autophagy in lysosomal storage disorders. Autophagy 8:719-30
-
(2012)
Autophagy
, vol.8
, pp. 719-730
-
-
Lieberman, A.P.1
Puertollano, R.2
Raben, N.3
Slaugenhaupt, S.4
Walkley, S.U.5
Ballabio, A.6
-
45
-
-
39849109338
-
Autophagy fights disease through cellular self-digestion
-
Mizushima N, Levine B, Cuervo AM, Klionsky DJ. 2008. Autophagy fights disease through cellular self-digestion. Nature 451:1069-75
-
(2008)
Nature
, vol.451
, pp. 1069-1075
-
-
Mizushima, N.1
Levine, B.2
Cuervo, A.M.3
Klionsky, D.J.4
-
46
-
-
0032555641
-
Isolation and characterization of rat liver amphisomes Evidence for fusion of autophagosomes with both early and late endosomes
-
Berg TO, Fengsrud M, Stromhaug PE, Berg T, Seglen PO. 1998. Isolation and characterization of rat liver amphisomes. Evidence for fusion of autophagosomes with both early and late endosomes. J. Biol. Chem. 273:21883-92
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 21883-21892
-
-
Berg, T.O.1
Fengsrud, M.2
Stromhaug, P.E.3
Berg, T.4
Seglen, P.O.5
-
47
-
-
84901670787
-
Lysosomal exocytosis and lipid storage disorders
-
Samie MA, Xu H. 2014. Lysosomal exocytosis and lipid storage disorders. J. Lipid Res. 55:995-1009
-
(2014)
J. Lipid Res.
, vol.55
, pp. 995-1009
-
-
Samie, M.A.1
Xu, H.2
-
48
-
-
0035958557
-
Plasma membrane repair is mediated by Ca2+-regulated exocytosis of lysosomes
-
Reddy A, Caler EV, Andrews NW. 2001. Plasma membrane repair is mediated by Ca2+-regulated exocytosis of lysosomes. Cell 106:157-69
-
(2001)
Cell
, vol.106
, pp. 157-169
-
-
Reddy, A.1
Caler, E.V.2
Andrews, N.W.3
-
49
-
-
80052729465
-
Transcriptional activation of lysosomal exocytosis promotes cellular clearance
-
Medina DL, Fraldi A, Bouche V, Annunziata F, Mansueto G, et al. 2011. Transcriptional activation of lysosomal exocytosis promotes cellular clearance. Dev. Cell 21:421-30
-
(2011)
Dev. Cell
, vol.21
, pp. 421-430
-
-
Medina, D.L.1
Fraldi, A.2
Bouche, V.3
Annunziata, F.4
Mansueto, G.5
-
50
-
-
2442584514
-
Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis
-
Rao SK, Huynh C, Proux-Gillardeaux V, Galli T, Andrews NW. 2004. Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis. J. Biol. Chem. 279:20471-79
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 20471-20479
-
-
Rao, S.K.1
Huynh, C.2
Proux-Gillardeaux, V.3
Galli, T.4
Andrews, N.W.5
-
51
-
-
43149104361
-
Molecular physiology and pathophysiology of lysosomal membrane transporters
-
Sagne C, Gasnier B. 2008. Molecular physiology and pathophysiology of lysosomal membrane transporters. J. Inherit. Metab. Dis. 31:258-66
-
(2008)
J. Inherit. Metab. Dis.
, vol.31
, pp. 258-266
-
-
Sagne, C.1
Gasnier, B.2
-
52
-
-
0035503565
-
Cystinosin, the protein defective in cystinosis, is a H+-driven lysosomal cystine transporter
-
Kalatzis V, Cherqui S, Antignac C, Gasnier B. 2001. Cystinosin, the protein defective in cystinosis, is a H+-driven lysosomal cystine transporter. EMBO J. 20:5940-49
-
(2001)
EMBO J.
, vol.20
, pp. 5940-5949
-
-
Kalatzis, V.1
Cherqui, S.2
Antignac, C.3
Gasnier, B.4
-
53
-
-
84863997137
-
LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis
-
Liu B, Du H, Rutkowski R, Gartner A,Wang X. 2012. LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis. Science 337:351-54
-
(2012)
Science
, vol.337
, pp. 351-354
-
-
Liu, B.1
Du, H.2
Rutkowski, R.3
Gartner, A.4
Wang, X.5
-
54
-
-
84871260456
-
Proton-Assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes
-
Ogmundsdottir MH, Heublein S, Kazi S, Reynolds B, Visvalingam SM, et al. 2012. Proton-Assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes. PLOS ONE 7:e36616
-
(2012)
PLOS ONE
, vol.7
, pp. e36616
-
-
Ogmundsdottir, M.H.1
Heublein, S.2
Kazi, S.3
Reynolds, B.4
Visvalingam, S.M.5
-
55
-
-
54049156405
-
The type IV mucolipidosis-Associated protein TRPML1 is an endolysosomal iron release channel
-
Dong XP, Cheng X, Mills E, Delling M, Wang F, et al. 2008. The type IV mucolipidosis-Associated protein TRPML1 is an endolysosomal iron release channel. Nature 455:992-96
-
(2008)
Nature
, vol.455
, pp. 992-996
-
-
Dong, X.P.1
Cheng, X.2
Mills, E.3
Delling, M.4
Wang, F.5
-
56
-
-
84875588858
-
Zinc-dependent lysosomal enlargement in TRPML1-deficient cells involves MTF-1 transcription factor and ZnT4 (Slc30a4) transporter
-
Kukic I, Lee JK, Coblentz J, Kelleher SL, Kiselyov K. 2013. Zinc-dependent lysosomal enlargement in TRPML1-deficient cells involves MTF-1 transcription factor and ZnT4 (Slc30a4) transporter. Biochem. J. 451:155-63
-
(2013)
Biochem. J.
, vol.451
, pp. 155-163
-
-
Kukic, I.1
Lee, J.K.2
Coblentz, J.3
Kelleher, S.L.4
Kiselyov, K.5
-
57
-
-
78049405392
-
Zinc dyshomeostasis is linked with the loss of mucolipidosis IV-Associated TRPML1 ion channel
-
Eichelsdoerfer JL, Evans JA, Slaugenhaupt SA, Cuajungco MP. 2010. Zinc dyshomeostasis is linked with the loss of mucolipidosis IV-Associated TRPML1 ion channel. J. Biol. Chem. 285:34304-8
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 34304-34308
-
-
Eichelsdoerfer, J.L.1
Evans, J.A.2
Slaugenhaupt, S.A.3
Cuajungco, M.P.4
-
58
-
-
55749083068
-
NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes
-
Infante RE, Wang ML, Radhakrishnan A, Kwon HJ, Brown MS, Goldstein JL. 2008. NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes. Proc. Natl. Acad. Sci. USA 105:15287-92
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 15287-15292
-
-
Infante, R.E.1
Wang, M.L.2
Radhakrishnan, A.3
Kwon, H.J.4
Brown, M.S.5
Goldstein, J.L.6
-
59
-
-
77954225471
-
Common and uncommon pathogenic cascades in lysosomal storage diseases
-
Vitner EB, Platt FM, Futerman AH. 2010. Common and uncommon pathogenic cascades in lysosomal storage diseases. J. Biol. Chem. 285:20423-27
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 20423-20427
-
-
Vitner, E.B.1
Platt, F.M.2
Futerman, A.H.3
-
61
-
-
77951945213
-
Lysosomal storage disease: Revealing lysosomal function and physiology
-
Parkinson-Lawrence EJ, Shandala T, Prodoehl M, Plew R, Borlace GN, Brooks DA. 2010. Lysosomal storage disease: revealing lysosomal function and physiology. Physiology 25:102-15
-
(2010)
Physiology
, vol.25
, pp. 102-115
-
-
Parkinson-Lawrence, E.J.1
Shandala, T.2
Prodoehl, M.3
Plew, R.4
Borlace, G.N.5
Brooks, D.A.6
-
62
-
-
62949156035
-
Secondary lipid accumulation in lysosomal disease
-
Walkley SU, VanierMT. 2009. Secondary lipid accumulation in lysosomal disease. Biochim. Biophys. Acta 1793:726-36
-
(2009)
Biochim. Biophys. Acta
, vol.1793
, pp. 726-736
-
-
Walkley, S.U.1
Vanier, M.T.2
-
63
-
-
62949116803
-
Lysosomal disorders: From storage to cellular damage
-
Ballabio A, Gieselmann V. 2009. Lysosomal disorders: from storage to cellular damage. Biochim. Biophys. Acta 1793:684-96
-
(2009)
Biochim. Biophys. Acta
, vol.1793
, pp. 684-696
-
-
Ballabio, A.1
Gieselmann, V.2
-
64
-
-
84901235419
-
The voltage-gated sodium channel TPC1 confers endolysosomal excitability
-
Cang C, Bekele B, Ren D. 2014. The voltage-gated sodium channel TPC1 confers endolysosomal excitability. Nat. Chem. Biol. 10:463-69
-
(2014)
Nat. Chem. Biol.
, vol.10
, pp. 463-469
-
-
Cang, C.1
Bekele, B.2
Ren, D.3
-
65
-
-
84894170193
-
MTORC1: Turning off is just as important as turning on
-
Benjamin D, Hall MN. 2014. mTORC1: Turning off is just as important as turning on. Cell 156:627-28
-
(2014)
Cell
, vol.156
, pp. 627-628
-
-
Benjamin, D.1
Hall, M.N.2
-
66
-
-
84866431363
-
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1
-
Bar-Peled L, Schweitzer LD, Zoncu R, Sabatini DM. 2012. Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell 150:1196-208
-
(2012)
Cell
, vol.150
, pp. 1196-1208
-
-
Bar-Peled, L.1
Schweitzer, L.D.2
Zoncu, R.3
Sabatini, D.M.4
-
67
-
-
35348829780
-
Neurologic, gastric, and opthalmologic pathologies in amurinemodel ofmucolipidosis type IV.Am
-
Venugopal B, Browning MF, Curcio-Morelli C, Varro A, Michaud N, et al. 2007. Neurologic, gastric, and opthalmologic pathologies in amurinemodel ofmucolipidosis type IV.Am. J. Hum. Genet. 81:1070-83
-
(2007)
J. Hum. Genet.
, vol.81
, pp. 1070-1083
-
-
Venugopal, B.1
Browning, M.F.2
Curcio-Morelli, C.3
Varro, A.4
Michaud, N.5
-
68
-
-
80051473235
-
PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome
-
Dong XP, Shen D, Wang X, Dawson T, Li X, et al. 2010. PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome. Nat. Commun. 1:38
-
(2010)
Nat. Commun.
, vol.1
, pp. 38
-
-
Dong, X.P.1
Shen, D.2
Wang, X.3
Dawson, T.4
Li, X.5
-
69
-
-
0021086597
-
The lysosomal proton pump is electrogenic
-
Harikumar P, Reeves JP. 1983. The lysosomal proton pump is electrogenic. J. Biol. Chem. 258:10403-10
-
(1983)
J. Biol. Chem.
, vol.258
, pp. 10403-10410
-
-
Harikumar, P.1
Reeves, J.P.2
-
70
-
-
33646229810
-
A voltage sensor-domain protein is a voltage-gated proton channel
-
Sasaki M, Takagi M, Okamura Y. 2006. A voltage sensor-domain protein is a voltage-gated proton channel. Science 312:589-92
-
(2006)
Science
, vol.312
, pp. 589-592
-
-
Sasaki, M.1
Takagi, M.2
Okamura, Y.3
-
72
-
-
44849107047
-
The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes
-
Graves AR, Curran PK, Smith CL, Mindell JA. 2008. The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes. Nature 453:788-92
-
(2008)
Nature
, vol.453
, pp. 788-792
-
-
Graves, A.R.1
Curran, P.K.2
Smith, C.L.3
Mindell, J.A.4
-
73
-
-
79957896458
-
ClC-7 is a slowly voltage-gated 2Cl-/1H+-exchanger and requires Ostm1 for transport activity
-
Leisle L, Ludwig CF, Wagner FA, Jentsch TJ, Stauber T. 2011. ClC-7 is a slowly voltage-gated 2Cl-/1H+-exchanger and requires Ostm1 for transport activity. EMBO J. 30:2140-52
-
(2011)
EMBO J.
, vol.30
, pp. 2140-2152
-
-
Leisle, L.1
Ludwig, C.F.2
Wagner, F.A.3
Jentsch, T.J.4
Stauber, T.5
-
74
-
-
9244254403
-
Ionic movements and electrical activity in giant nerve fibres
-
Hodgkin AL. 1958. Ionic movements and electrical activity in giant nerve fibres. Proc. R. Soc. B 148:1-37
-
(1958)
Proc. R. Soc. B
, vol.148
, pp. 1-37
-
-
Hodgkin, A.L.1
-
76
-
-
78649944879
-
Planar patch clamp approach to characterize ionic currents from intact lysosomes
-
Schieder M, Rotzer K, Bruggemann A, Biel M, Wahl-Schott C. 2010. Planar patch clamp approach to characterize ionic currents from intact lysosomes. Sci. Signal. 3:pl3
-
(2010)
Sci. Signal.
, vol.3
, pp. pl3
-
-
Schieder, M.1
Rotzer, K.2
Bruggemann, A.3
Biel, M.4
Wahl-Schott, C.5
-
77
-
-
84862007226
-
Membrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH-And Ca2+-sensitive organellar two-pore channel TPC1
-
Rybalchenko V, AhujaM, Coblentz J, Churamani D, Patel S, et al. 2012. Membrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH-And Ca2+-sensitive organellar two-pore channel TPC1. J. Biol. Chem. 287:20407-16
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 20407-20416
-
-
Rybalchenko, V.1
Ahuja, M.2
Coblentz, J.3
Churamani, D.4
Patel, S.5
-
78
-
-
84898630877
-
Convergent regulation of the lysosomal two-pore channel-2 by Mg2+, NAADP, PI(3,5)P2 and multiple protein kinases
-
Jha A, Ahuja M, Patel S, Brailoiu E, Muallem S. 2014. Convergent regulation of the lysosomal two-pore channel-2 by Mg2+, NAADP, PI(3,5)P2 and multiple protein kinases. EMBO J. 33:501-11
-
(2014)
EMBO J.
, vol.33
, pp. 501-511
-
-
Jha, A.1
Ahuja, M.2
Patel, S.3
Brailoiu, E.4
Muallem, S.5
-
79
-
-
77949696020
-
Mucolipins: Intracellular TRPML1-3 channels
-
Cheng X, Shen D, Samie M, Xu H. 2010. Mucolipins: intracellular TRPML1-3 channels. FEBS Lett. 584:2013-21
-
(2010)
FEBS Lett.
, vol.584
, pp. 2013-2021
-
-
Cheng, X.1
Shen, D.2
Samie, M.3
Xu, H.4
-
80
-
-
0035032399
-
Mucolipidosis type IV: Novel MCOLN1 mutations in Jewish and non-Jewish patients and the frequency of the disease in the Ashkenazi Jewish population
-
Bargal R, Avidan N, Olender T, Ben Asher E, Zeigler M, et al. 2001. Mucolipidosis type IV: novel MCOLN1 mutations in Jewish and non-Jewish patients and the frequency of the disease in the Ashkenazi Jewish population. Hum. Mutat. 17:397-402
-
(2001)
Hum. Mutat.
, vol.17
, pp. 397-402
-
-
Bargal, R.1
Avidan, N.2
Olender, T.3
Ben, A.E.4
Zeigler, M.5
-
81
-
-
0034641869
-
Mucolipidosis type IV is caused by mutations in a gene encoding a novel transient receptor potential channel
-
Sun M, Goldin E, Stahl S, Falardeau JL, Kennedy JC, et al. 2000. Mucolipidosis type IV is caused by mutations in a gene encoding a novel transient receptor potential channel. Hum. Mol. Genet. 9:2471-78
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 2471-2478
-
-
Sun, M.1
Goldin, E.2
Stahl, S.3
Falardeau, J.L.4
Kennedy, J.C.5
-
82
-
-
67749122634
-
A gene network regulating lysosomal biogenesis and function
-
Sardiello M, Palmieri M, di Ronza A, Medina DL, Valenza M, et al. 2009. A gene network regulating lysosomal biogenesis and function. Science 325:473-77
-
(2009)
Science
, vol.325
, pp. 473-477
-
-
Sardiello, M.1
Palmieri, M.2
Di Ronza, A.3
Medina, D.L.4
Valenza, M.5
-
84
-
-
33644655372
-
Two di-leucine motifs regulate trafficking of mucolipin-1 to lysosomes
-
Vergarajauregui S, Puertollano R. 2006. Two di-leucine motifs regulate trafficking of mucolipin-1 to lysosomes. Traffic 7:337-53
-
(2006)
Traffic
, vol.7
, pp. 337-353
-
-
Vergarajauregui, S.1
Puertollano, R.2
-
85
-
-
33748572921
-
Mucolipin-1 is a lysosomal membrane protein required for intracellular lactosylceramide traffic
-
Pryor PR, Reimann F, Gribble FM, Luzio JP. 2006. Mucolipin-1 is a lysosomal membrane protein required for intracellular lactosylceramide traffic. Traffic 7:1388-98
-
(2006)
Traffic
, vol.7
, pp. 1388-1398
-
-
Pryor, P.R.1
Reimann, F.2
Gribble, F.M.3
Luzio, J.P.4
-
86
-
-
79955052958
-
Role of TRP channels in the regulation of the endosomal pathway
-
AbeK, Puertollano R. 2011. Role of TRP channels in the regulation of the endosomal pathway. Physiology 26:14-22
-
(2011)
Physiology
, vol.26
, pp. 14-22
-
-
Abe, K.1
Puertollano, R.2
-
87
-
-
84863922724
-
Phosphoinositide isoforms determine compartment-specific ion channel activity
-
Zhang X, Li X, Xu H. 2012. Phosphoinositide isoforms determine compartment-specific ion channel activity. Proc. Natl. Acad. Sci. USA 109:11384-89
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 11384-11389
-
-
Zhang, X.1
Li, X.2
Xu, H.3
-
88
-
-
80051473235
-
PI(3,5)P2 controls membrane traffic by direct activation of mucolipin Ca release channels in the endolysosome
-
Dong XP, Shen D,Wang X, Dawson T, Li X, et al. 2010. PI(3,5)P2 controls membrane traffic by direct activation of mucolipin Ca release channels in the endolysosome. Nat. Commun. 1:38
-
(2010)
Nat. Commun.
, vol.1
, pp. 38
-
-
Dong, X.P.1
Shen, D.2
Wang, X.3
Dawson, T.4
Li, X.5
-
89
-
-
33749836234
-
Phosphoinositides in cell regulation and membrane dynamics
-
Di Paolo G, De Camilli P. 2006. Phosphoinositides in cell regulation and membrane dynamics. Nature 443:651-57
-
(2006)
Nature
, vol.443
, pp. 651-657
-
-
Di Paolo, G.1
De Camilli, P.2
-
90
-
-
84889645553
-
Phosphatidylinositol 3,5-bisphosphate: Low abundance, high significance
-
McCartney AJ, Zhang Y, Weisman LS. 2014. Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance. BioEssays 36:52-64
-
(2014)
BioEssays
, vol.36
, pp. 52-64
-
-
McCartney, A.J.1
Zhang, Y.2
Weisman, L.S.3
-
91
-
-
77956272140
-
Phosphoinositides: Lipid regulators of membrane proteins
-
Falkenburger BH, Jensen JB, Dickson EJ, Suh BC, Hille B. 2010. Phosphoinositides: lipid regulators of membrane proteins. J. Physiol. 588:3179-85
-
(2010)
J. Physiol.
, vol.588
, pp. 3179-3185
-
-
Falkenburger, B.H.1
Jensen, J.B.2
Dickson, E.J.3
Suh, B.C.4
Hille, B.5
-
92
-
-
84891368628
-
Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics
-
Li X, Wang X, Zhang X, Zhao M, Tsang WL, et al. 2013. Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics. Proc. Natl. Acad. Sci. USA 110:21165-70
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 21165-21170
-
-
Li, X.1
Wang, X.2
Zhang, X.3
Zhao, M.4
Tsang, W.L.5
-
93
-
-
77049105199
-
Small molecule activators of TRPML3
-
Grimm C, Jors S, Saldanha SA,Obukhov AG, Pan B, et al. 2010. Small molecule activators of TRPML3. Chem. Biol. 17:135-48
-
(2010)
Chem. Biol.
, vol.17
, pp. 135-148
-
-
Grimm, C.1
Jors, S.2
Saldanha, S.A.3
Obukhov, A.G.4
Pan, B.5
-
94
-
-
79956070911
-
Pairing phosphoinositides with calcium ions in endolysosomal dynamics: Phosphoinositides control the direction and specificity ofmembrane trafficking by regulating the activity of calcium channels in the endolysosomes
-
Shen D,Wang X, Xu H. 2011. Pairing phosphoinositides with calcium ions in endolysosomal dynamics: Phosphoinositides control the direction and specificity ofmembrane trafficking by regulating the activity of calcium channels in the endolysosomes. BioEssays 33:448-57
-
(2011)
BioEssays
, vol.33
, pp. 448-457
-
-
Shen, D.1
Wang, X.2
Xu, H.3
-
95
-
-
43049139220
-
Lysosomal trafficking functions of mucolipin-1 in murine macrophages
-
Thompson EG, Schaheen L, Dang H, Fares H. 2007. Lysosomal trafficking functions of mucolipin-1 in murine macrophages. BMC Cell Biol. 8:54
-
(2007)
BMC Cell Biol.
, vol.8
, pp. 54
-
-
Thompson, E.G.1
Schaheen, L.2
Dang, H.3
Fares, H.4
-
97
-
-
79955075253
-
Macroautophagy is defective in mucolipin-1-deficient mouse neurons
-
Curcio-Morelli C, Charles FA, Micsenyi MC, Cao Y, Venugopal B, et al. 2010. Macroautophagy is defective in mucolipin-1-deficient mouse neurons. Neurobiol. Dis. 40:370-77
-
(2010)
Neurobiol. Dis.
, vol.40
, pp. 370-377
-
-
Curcio-Morelli, C.1
Charles, F.A.2
Micsenyi, M.C.3
Cao, Y.4
Venugopal, B.5
-
99
-
-
0032568565
-
Abnormal transport along the lysosomal pathway inmucolipidosis, type IV disease
-
Chen CS, Bach G, Pagano RE. 1998. Abnormal transport along the lysosomal pathway inmucolipidosis, type IV disease. Proc. Natl. Acad. Sci. USA 95:6373-78
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 6373-6378
-
-
Chen, C.S.1
Bach, G.2
Pagano, R.E.3
-
100
-
-
1842428593
-
Caenorhabditis elegans functional orthologue of human protein h-mucolipin-1 is required for lysosome biogenesis
-
Treusch S, Knuth S, Slaugenhaupt SA, Goldin E, Grant BD, Fares H. 2004. Caenorhabditis elegans functional orthologue of human protein h-mucolipin-1 is required for lysosome biogenesis. Proc. Natl. Acad. Sci. USA 101:4483-88
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 4483-4488
-
-
Treusch, S.1
Knuth, S.2
Slaugenhaupt, S.A.3
Goldin, E.4
Grant, B.D.5
Fares, H.6
-
101
-
-
70450236985
-
Activating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis
-
Dong XP,Wang X, Shen D, Chen S, Liu M, et al. 2009. Activating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis. J. Biol. Chem. 284:32040-52
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 32040-32052
-
-
Dong, X.P.1
Wang, X.2
Shen, D.3
Chen, S.4
Liu, M.5
-
102
-
-
33751120702
-
Lysosomal exocytosis is impaired in mucolipidosis type IV
-
LaPlante JM, Sun M, Falardeau J, Dai D, Brown EM, et al. 2006. Lysosomal exocytosis is impaired in mucolipidosis type IV. Mol. Genet. Metab. 89:339-48
-
(2006)
Mol. Genet. Metab.
, vol.89
, pp. 339-348
-
-
Laplante, J.M.1
Sun, M.2
Falardeau, J.3
Dai, D.4
Brown, E.M.5
-
103
-
-
0033046220
-
Mechanisms of phagocytosis in macrophages
-
Aderem A, Underhill DM. 1999. Mechanisms of phagocytosis in macrophages. Annu. Rev. Immunol. 17:593-623
-
(1999)
Annu. Rev. Immunol.
, vol.17
, pp. 593-623
-
-
Aderem, A.1
Underhill, D.M.2
-
105
-
-
84921960605
-
An intracellular Ca2+ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy
-
Cheng X, Zhang X, Gao Q, Azar M, TsangWL, et al. 2014. An intracellular Ca2+ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy. Nature Med. 20:1187-92
-
(2014)
Nature Med.
, vol.20
, pp. 1187-1192
-
-
Cheng, X.1
Zhang, X.2
Gao, Q.3
Azar, M.4
Tsang, W.L.5
-
106
-
-
79960743373
-
MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in between
-
Babst M. 2011. MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in between. Curr. Opin. Cell Biol. 23:452-57
-
(2011)
Curr. Opin. Cell Biol.
, vol.23
, pp. 452-457
-
-
Babst, M.1
-
107
-
-
77957361860
-
An emerging role forNAADPmediated Ca2+ signaling in the pancreatic β-cell
-
Arredouani A, Evans AM, Ma J, Parrington J, Zhu MX,Galione A. 2010. An emerging role forNAADPmediated Ca2+ signaling in the pancreatic β-cell. Islets 2:323-30
-
(2010)
Islets
, vol.2
, pp. 323-330
-
-
Arredouani, A.1
Evans, A.M.2
Ma, J.3
Parrington, J.4
Zhu, M.X.5
Galione, A.6
-
108
-
-
0034643304
-
Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels
-
Ishibashi K, Suzuki M, ImaiM. 2000. Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels. Biochem. Biophys. Res. Commun. 270:370-76
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.270
, pp. 370-376
-
-
Ishibashi, K.1
Suzuki, M.2
Imai, M.3
-
109
-
-
77449093874
-
An ancestral deuterostome family of two-pore channels mediates nicotinic acid adenine dinucleotide phosphate-dependent calcium release from acidic organelles
-
Brailoiu E, Hooper R, Cai X, Brailoiu GC, KeeblerMV, et al. 2010. An ancestral deuterostome family of two-pore channels mediates nicotinic acid adenine dinucleotide phosphate-dependent calcium release from acidic organelles. J. Biol. Chem. 285:2897-901
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 2897-2901
-
-
Brailoiu, E.1
Hooper, R.2
Cai, X.3
Brailoiu, G.C.4
Keebler, M.V.5
-
110
-
-
67349287016
-
NAADP mobilizes calcium from acidic organelles through two-pore channels
-
Calcraft PJ, Ruas M, Pan Z, Cheng X, Arredouani A, et al. 2009. NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature 459:596-600
-
(2009)
Nature
, vol.459
, pp. 596-600
-
-
Calcraft, P.J.1
Ruas, M.2
Pan, Z.3
Cheng, X.4
Arredouani, A.5
-
111
-
-
84874105202
-
MTOR regulates lysosomal ATP-sensitive two-pore Na+ channels to adapt to metabolic state
-
Cang C, Zhou Y, Navarro B, Seo Y-J, Aranda K, et al. 2013. mTOR regulates lysosomal ATP-sensitive two-pore Na+ channels to adapt to metabolic state. Cell 152:778-90
-
(2013)
Cell
, vol.152
, pp. 778-790
-
-
Cang, C.1
Zhou, Y.2
Navarro, B.3
Seo, Y.-J.4
Aranda, K.5
-
112
-
-
84922025311
-
The phosphoinositide PI(3,5)P2 mediates activation of mammalian but not plant TPC proteins: Functional expression of endolysosomal channels in yeast and plant cells
-
Boccaccio A, Scholz-Starke J, Hamamoto S, Larisch N, Festa M, et al. 2014. The phosphoinositide PI(3,5)P2 mediates activation of mammalian but not plant TPC proteins: functional expression of endolysosomal channels in yeast and plant cells. Cell. Mol. Life Sci. 71:4275-83
-
(2014)
Cell. Mol. Life Sci.
, vol.71
, pp. 4275-4283
-
-
Boccaccio, A.1
Scholz-Starke, J.2
Hamamoto, S.3
Larisch, N.4
Festa, M.5
-
113
-
-
84864751451
-
Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin
-
BridgesD,Ma JT, Park S, InokiK,WeismanLS, SaltielAR. 2012. Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin Mol. Biol. Cell 23:2955-62
-
(2012)
Mol. Biol. Cell
, vol.23
, pp. 2955-2962
-
-
Bridges, D.1
Ma, J.T.2
Park, S.3
Inoki, K.4
Weisman, L.S.5
Saltiel, A.R.6
-
114
-
-
33645322386
-
KATP channels as molecular sensors of cellular metabolism
-
Nichols CG. 2006. KATP channels as molecular sensors of cellular metabolism. Nature 440:470-76
-
(2006)
Nature
, vol.440
, pp. 470-476
-
-
Nichols, C.G.1
-
115
-
-
84859778293
-
MTOR signaling in growth control and disease
-
Laplante M, Sabatini DM. 2012. mTOR signaling in growth control and disease. Cell 149:274-93
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
116
-
-
0035798097
-
Mammalian TOR: A homeostatic ATP sensor
-
Dennis PB, Jaeschke A, Saitoh M, Fowler B, Kozma SC, Thomas G. 2001. Mammalian TOR: a homeostatic ATP sensor. Science 294:1102-5
-
(2001)
Science
, vol.294
, pp. 1102-1105
-
-
Dennis, P.B.1
Jaeschke, A.2
Saitoh, M.3
Fowler, B.4
Kozma, S.C.5
Thomas, G.6
-
117
-
-
77951768486
-
Ragulator-Rag complex targetsmTORC1 to the lysosomal surface and is necessary for its activation by amino acids
-
Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM. 2010. Ragulator-Rag complex targetsmTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141:290-303
-
(2010)
Cell
, vol.141
, pp. 290-303
-
-
Sancak, Y.1
Bar-Peled, L.2
Zoncu, R.3
Markhard, A.L.4
Nada, S.5
Sabatini, D.M.6
-
118
-
-
78049396024
-
TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+
-
Pitt SJ, Funnell TM, SitsapesanM, Venturi E, RietdorfK, et al. 2010. TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+. J. Biol. Chem. 285:35039-46
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 35039-35046
-
-
Pitt, S.J.1
Funnell, T.M.2
Sitsapesan, M.3
Venturi, E.4
Rietdorf, K.5
-
119
-
-
84892441168
-
Two-pore channels (TPCs): Current controversies
-
Morgan AJ, Galione A. 2014. Two-pore channels (TPCs): current controversies. BioEssays 36:173-83
-
(2014)
BioEssays
, vol.36
, pp. 173-183
-
-
Morgan, A.J.1
Galione, A.2
-
120
-
-
84856068326
-
Photoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cells
-
Lin-Moshier Y,Walseth TF, Churamani D, Davidson SM, Slama JT, et al. 2012. Photoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cells. J. Biol. Chem. 287:2296-307
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 2296-2307
-
-
Lin-Moshier, Y.1
Walseth, T.F.2
Churamani, D.3
Davidson, S.M.4
Slama, J.T.5
-
121
-
-
0031587822
-
Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals
-
Ichas F, Jouaville LS, Mazat JP. 1997. Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals. Cell 89:1145-53
-
(1997)
Cell
, vol.89
, pp. 1145-1153
-
-
Ichas, F.1
Jouaville, L.S.2
Mazat, J.P.3
-
122
-
-
84871303001
-
NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing
-
Davis LC, Morgan AJ, Chen JL, Snead CM, Bloor-Young D, et al. 2012. NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing. Curr. Biol. 22:2331-37
-
(2012)
Curr. Biol.
, vol.22
, pp. 2331-2337
-
-
Davis, L.C.1
Morgan, A.J.2
Chen, J.L.3
Snead, C.M.4
Bloor-Young, D.5
-
123
-
-
84867429634
-
Identification of two-pore channel 2 as a novel regulator of osteoclastogenesis
-
Notomi T, Ezura Y, Noda M. 2012. Identification of two-pore channel 2 as a novel regulator of osteoclastogenesis. J. Biol. Chem. 287:35057-64
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 35057-35064
-
-
Notomi, T.1
Ezura, Y.2
Noda, M.3
-
124
-
-
84922823328
-
The involvement of NAADP and two-pore Ca2+ channels in the cardiac β-Adrenergic response
-
Philadelphia, Feb. 2-6
-
Bolton E, Bayliss R, Kalungia CA, Bloor-Young D, Ruas da Silva M, et al. 2013. The involvement of NAADP and two-pore Ca2+ channels in the cardiac β-Adrenergic response. Presented at Biophys. Soc. Annu. Meet., 58th, Philadelphia, Feb. 2-6
-
(2013)
Presented at Biophys. Soc. Annu. Meet., 58th
-
-
Bolton, E.1
Bayliss, R.2
Kalungia, C.A.3
Bloor-Young, D.4
Da Silva, R.M.5
-
125
-
-
80051497127
-
Nicotinic acid adenine dinucleotide phosphate (NAADP) regulates autophagy in cultured astrocytes
-
Pereira GJ, Hirata H, Fimia GM, do Carmo LG, Bincoletto C, et al. 2011. Nicotinic acid adenine dinucleotide phosphate (NAADP) regulates autophagy in cultured astrocytes. J. Biol. Chem. 286:27875-81
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 27875-27881
-
-
Pereira, G.J.1
Hirata, H.2
Fimia, G.M.3
Do Carmo, L.G.4
Bincoletto, C.5
-
126
-
-
77955291039
-
TPC2 proteins mediate nicotinic acid adenine dinucleotide phosphate (NAADP)-And agonist-evoked contractions of smooth muscle
-
Durlu-Kandilci NT, Ruas M, Chuang KT, Brading A, Parrington J, Galione A. 2010. TPC2 proteins mediate nicotinic acid adenine dinucleotide phosphate (NAADP)-And agonist-evoked contractions of smooth muscle. J. Biol. Chem. 285:24925-32
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 24925-24932
-
-
Durlu-Kandilci, N.T.1
Ruas, M.2
Chuang, K.T.3
Brading, A.4
Parrington, J.5
Galione, A.6
-
127
-
-
84907329806
-
High susceptibility to fatty liver disease in two-pore channel 2 deficient mice
-
Grimm C,Holdt LM, Chen CC, Hassan S,Muller C, et al. 2014. High susceptibility to fatty liver disease in two-pore channel 2 deficient mice. Nat. Commun. 5:4699
-
(2014)
Nat. Commun.
, vol.5
, pp. 4699
-
-
Grimm, C.1
Holdt, L.M.2
Chen, C.C.3
Hassan, S.4
Muller, C.5
-
128
-
-
84896283203
-
NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa
-
Arndt L, Castonguay J, Arlt E, Meyer D, Hassan S, et al. 2014. NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa. Mol. Biol. Cell 25:948-64
-
(2014)
Mol. Biol. Cell
, vol.25
, pp. 948-964
-
-
Arndt, L.1
Castonguay, J.2
Arlt, E.3
Meyer, D.4
Hassan, S.5
-
129
-
-
45549095745
-
Two newly identified genetic determinants of pigmentation in Europeans
-
Sulem P, Gudbjartsson DF, Stacey SN, Helgason A, Rafnar T, et al. 2008. Two newly identified genetic determinants of pigmentation in Europeans. Nat. Genet. 40:835-37
-
(2008)
Nat. Genet.
, vol.40
, pp. 835-837
-
-
Sulem, P.1
Gudbjartsson, D.F.2
Stacey, S.N.3
Helgason, A.4
Rafnar, T.5
-
130
-
-
84899648974
-
Salt stress-induced Ca2+ waves are associated with rapid, long-distance root-to-shoot signaling in plants
-
ChoiWG,ToyotaM,Kim SH,Hilleary R,Gilroy S. 2014. Salt stress-induced Ca2+ waves are associated with rapid, long-distance root-to-shoot signaling in plants. Proc. Natl. Acad. Sci. USA 111:6497-502
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 6497-6502
-
-
Choi, W.G.1
Toyota, M.2
Kim, S.H.3
Hilleary, R.4
Gilroy, S.5
-
131
-
-
33847122121
-
A gain-of-function allele of TPC1 activates oxylipin biogenesis after leaf wounding in Arabidopsis
-
Bonaventure G, Gfeller A, ProebstingWM, Hortensteiner S, Chetelat A, et al. 2007. A gain-of-function allele of TPC1 activates oxylipin biogenesis after leaf wounding in Arabidopsis. Plant J. 49:889-98
-
(2007)
Plant J.
, vol.49
, pp. 889-898
-
-
Bonaventure, G.1
Gfeller, A.2
Proebsting, W.M.3
Hortensteiner, S.4
Chetelat, A.5
-
132
-
-
56349119573
-
Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cells
-
Venkatachalam K, Long AA, Elsaesser R, Nikolaeva D, Broadie K, Montell C. 2008. Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cells. Cell 135:838-51
-
(2008)
Cell
, vol.135
, pp. 838-851
-
-
Venkatachalam, K.1
Long, A.A.2
Elsaesser, R.3
Nikolaeva, D.4
Broadie, K.5
Montell, C.6
-
133
-
-
84877601173
-
Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease
-
Spampanato C, Feeney E, Li L, Cardone M, Lim JA, et al. 2013. Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease. EMBO Mol. Med. 5:691-706
-
(2013)
EMBO Mol. Med.
, vol.5
, pp. 691-706
-
-
Spampanato, C.1
Feeney, E.2
Li, L.3
Cardone, M.4
Lim, J.A.5
-
134
-
-
74849083093
-
Lysosomal enhancement: A CLEAR answer to cellular degradative needs
-
Sardiello M, Ballabio A. 2009. Lysosomal enhancement: a CLEAR answer to cellular degradative needs. Cell Cycle 8:4021-22
-
(2009)
Cell Cycle
, vol.8
, pp. 4021-4022
-
-
Sardiello, M.1
Ballabio, A.2
|