ZOT-derived peptide and chitosan functionalized nanocarrier for oral delivery of protein drug

Biomaterials

Volumn 103, Issue , 2016, Pages 160-169

  Lee, Jong Hyun ^a   Sahu, Abhishek ^a   Choi, Won Il ^b   Lee, Jae Young ^a   Tae, Giyoong ^a,c  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b Korea Institute of Ceramic Engineering and Technology (KICET)   (South Korea)

^c Korea Institute of Science and Technology   (South Korea)

Author keywords

Chitosan; Insulin; Oral delivery; Pluronic; Tight junction

Indexed keywords

CHITIN; CHITOSAN; LIGANDS; MONOLAYERS; PEPTIDES; PROTEINS;

BLOOD GLUCOSE LEVEL; CELL MONOLAYERS; ORAL ADMINISTRATION; ORAL DELIVERY; PLASMA INSULIN LEVELS; PLURONICS; TIGHT JUNCTIONS; TRANSEPITHELIAL ELECTRICAL RESISTANCES;

INSULIN;

CHITOSAN; CLAUDIN 4; GLUCOSE; HUMAN INSULIN; INSULIN; NANOCARRIER; POLOXAMER; TOXIN; UNCLASSIFIED DRUG; ZONULA OCCLUDIN TOXIN; CHOLERA TOXIN; NANOCAPSULE; ZONULA OCCLUDENS TOXIN, VIBRIO CHOLERAE;

ADSORPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CACO 2 CELL LINE; COMPARATIVE STUDY; CONJUGATION; CONTROLLED STUDY; DIABETES MELLITUS; ELECTRIC RESISTANCE; ENCAPSULATION; FLUORESCENCE MICROSCOPY; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RELEASE; MICROSCOPY; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SURFACE CHARGE; TEMPERATURE SENSITIVITY; TIGHT JUNCTION; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL; ANIMAL; BLOOD; CACO-2 CELL LINE; CHEMISTRY; DIFFUSION; MALE; ORAL DRUG ADMINISTRATION; PARTICLE SIZE; SPRAGUE DAWLEY RAT; TREATMENT OUTCOME; ULTRASTRUCTURE;

ADMINISTRATION, ORAL; ANIMALS; CACO-2 CELLS; CHITOSAN; CHOLERA TOXIN; DIABETES MELLITUS; DIFFUSION; HUMANS; INSULIN; MALE; NANOCAPSULES; PARTICLE SIZE; POLOXAMER; RATS; RATS, SPRAGUE-DAWLEY; TREATMENT OUTCOME;

EID: 84977080776     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2016.06.059     Document Type: Article

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