The active Zot domain (aa 288-293) increases ZO-1 and myosin 1C serine/threonine phosphorylation, alters interaction between ZO-1 and its binding partners, and induces tight junction disassembly through proteinase activated receptor 2 activation

FASEB Journal

Volumn 25, Issue 1, 2011, Pages 144-158

  Goldblum, Simeon E ^a   Rai, Usha ^a   Tripathi, Amit ^a   Thakar, Manjusha ^a   De Leo, Luigina ^b,c   Di Toro, Nicola ^b,c   Not, Tarcisio ^b,c   Ramachandran, Rithwik ^d   Puche, Adam C ^a   Hollenberg, Morley D ^a   Fasano, Alessio ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TRIESTE   (Italy)

^c INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

^d UNIVERSITY OF CALGARY   (Canada)

Author keywords

Intestinal permeability; Protein protein interaction; Zonula occludens 1

Indexed keywords

CLAUDIN 1; MYOSIN; MYOSIN 1C; OCCLUDIN; PROTEIN ZO1; PROTEINASE ACTIVATED RECEPTOR 2; SERINE; THREONINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVATION; EX VIVO STUDY; HUMAN; HUMAN CELL; INTERCELLULAR SPACE; INTESTINE MUCOSA PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN INTERACTION; PROTEIN MODIFICATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; RAT;

AMINO ACID SEQUENCE; ANIMALS; CACO-2 CELLS; CELL LINE; CELLS, CULTURED; CHOLERA TOXIN; EPITHELIAL CELLS; HUMANS; IMMUNOBLOTTING; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; MYOSINS; OLIGOPEPTIDES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE C-ALPHA; RATS; RATS, WISTAR; RECEPTOR, PAR-2; RNA INTERFERENCE; SERINE; THREONINE; TIGHT JUNCTIONS;

RATTUS; VIBRIO CHOLERAE;

EID: 79251567978     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-158972     Document Type: Article

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