Cathepsin protease controls copper and cisplatin accumulation via cleavage of the Ctr1 Metal-binding ectodomain

Journal of Biological Chemistry

Volumn 291, Issue 27, 2016, Pages 13905-13916

  Öhrvik, Helena ^a,f   Logeman, Brandon ^a   Turk, Boris ^c,d   Reinheckel, Thomas ^e   Thiele, Dennis J ^a,b  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Biology ^*  (United States)

^c JO EF STEFAN INSTITUTE   (Slovenia)

^d UNIVERSITY OF LJUBLJANA   (Slovenia)

^e UNIVERSITY OF FREIBURG   (Germany)

^f UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINS; CELL MEMBRANES; COPPER; METAL IONS; PLATINUM COMPOUNDS;

CARDIAC FUNCTIONS; CHEMOTHERAPEUTIC DRUGS; EMBRYONIC DEVELOPMENT; FULL-LENGTH PROTEINS; IRON ACQUISITION; PHYSIOLOGICAL PROCESS; RATE-LIMITING STEPS; TRANSPORT ACTIVITY;

METALS;

CATHEPSIN B; CATHEPSIN L; CISPLATIN; COPPER; COPPER TRANSPORTER 1; CYSTEINE PROTEINASE INHIBITOR; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; CATHEPSIN; CATION TRANSPORT PROTEIN; CTR1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CELL KILLING; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; FIBROBLAST; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN PURIFICATION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; KNOCKOUT MOUSE; METABOLISM; PROTEIN DEGRADATION; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; CATHEPSINS; CATION TRANSPORT PROTEINS; CELL LINE; CISPLATIN; COPPER; HUMANS; MICE; MICE, KNOCKOUT; PROTEOLYSIS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84976877617     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.731281     Document Type: Article

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