The role of the methionines and histidines in the transmembrane domain of mammalian copper transporter 1 in the cellular accumulation of cisplatin

Molecular Pharmacology

Volumn 78, Issue 3, 2010, Pages 333-339

  Larson, Christopher A ^a   Adams, Preston L ^a   Blair, Brian G ^a,b   Safaei, Roohangiz ^a   Howell, Stephen B ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CARRIER PROTEIN; CISPLATIN; COPPER TRANSPORTER 1; HISTIDINE; ISOLEUCINE; METHIONINE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CATION TRANSPORT PROTEIN; COPPER; PLATINUM;

ALLELE; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CYTOTOXICITY; DOWN REGULATION; DRUG ACCUMULATION; DRUG EFFECT; DRUG UPTAKE; FIBROBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANIMAL; CELLS; DRUG EFFECTS; DRUG INTERACTION; KNOCKOUT MOUSE; MAMMAL; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; CATION TRANSPORT PROTEINS; CELLS; CISPLATIN; COPPER; DRUG INTERACTIONS; HISTIDINE; MAMMALS; METHIONINE; MICE; MICE, KNOCKOUT; PLATINUM;

EID: 77956251788     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.110.064766     Document Type: Article

References (18)

1. Blair BG, Larson CA, Safaei R, and Howell SB (2009) Copper transporter 2 regulates the cellular accumulation and cytotoxicity of cisplatin and carboplatin. Clin Cancer Res 15:4312-4321.
2. De Feo CJ, Aller SG, Siluvai GS, Blackburn NJ, and Unger VM (2009) Three-dimensional structure of the human copper transporter hCTR1. Proc Natl Acad Sci USA 106:4237-4242.
3. De Feo CJ, Aller SG, and Unger VM (2007) A structural perspective on copper uptake in eukaryotes. Biometals 20:705-716.
4. Eisses JF and Kaplan JH (2005) The mechanism of copper uptake mediated by human CTR1: a mutational analysis. J Biol Chem 280:37159-37168.
5. Holzer AK and Howell SB (2006) The internalization and degradation of human copper transporter 1 following cisplatin exposure. Cancer Res 66:10944-10952.
6. Holzer AK, Samimi G, Katano K, Naerdemann W, Lin X, Safaei R, and Howell SB (2004) The copper influx transporter human copper transport protein 1 regulates the uptake of cisplatin in human ovarian carcinoma cells. Mol Pharmacol 66:817-823.
7. Holzer AK, Varki NM, Le QT, Gibson MA, Naredi P, and Howell SB (2006) Expression of the human copper influx transporter 1 in normal and malignant human tissues. J Histochem Cytochem 54:1041-1049.
8. Howell SB, Safaei R, Larson CA, and Sailor MJ (2010) Copper transporters and the cellular pharmacology of the platinum-containing cancer drugs. Mol Pharmacol 77:887-894.
9. Jandial DD, Farshchi-Heydari S, Larson CA, Elliott GI, Wrasidlo WJ, and Howell SB (2009) Enhanced delivery of cisplatin to intraperitoneal ovarian carcinomas mediated by the effects of bortezomib on the human copper transporter 1. Clin Cancer Res 15:553-560.
10. Larson CA, Blair BG, Safaei R, and Howell SB (2009) The role of the mammalian copper transporter 1 in the cellular accumulation of platinum-based drugs. Mol Pharmacol 75:324-330.
11. Lee J, Petris MJ, and Thiele DJ (2002) Characterization of mouse embryonic cells deficient in the ctr1 high affinity copper transporter. Identification of a Ctr1- independent copper transport system. J Biol Chem 277:40253-40259.
12. Liang ZD, Stockton D, Savaraj N, and Tien Kuo M (2009) Mechanistic comparison of human high-affinity copper transporter 1-mediated transport between copper ion and cisplatin. Mol Pharmacol 76:843-853.
13. Madsen E and Gitlin JD (2007) Copper deficiency. Curr Opin Gastroenterol 23:187-192.
14. Monks A, Scudiero D, Skehan P, Shoemaker R, Paull K, Vistica D, Hose C, Langley J, Cronise P, and Vaigro-Wolff A (1991) Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J Natl Cancer Inst 83:757-766.
15. Puig S, Lee J, Lau M, and Thiele DJ (2002) Biochemical and genetic analyses of yeast and human high affinity copper transporters suggest a conserved mechanism for copper uptake. J Biol Chem 277:26021-26030.
16. Safaei R, Maktabi MH, Blair BG, Larson CA, and Howell SB (2009) Effects of the loss of Atox1 on the cellular pharmacology of cisplatin. J Inorg Biochem 103:333-341.
17. Samimi G, Katano K, Holzer AK, Safaei R, and Howell SB (2004) Modulation of the cellular pharmacology of cisplatin and its analogs by the copper exporters ATP7A and ATP7B. Mol Pharmacol 66:25-32.
18. Song IS, Savaraj N, Siddik ZH, Liu P, Wei Y, Wu CJ, and Kuo MT (2004) Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells. Mol Cancer Ther 3:1543-1549.