Regulation of copper transporter 2 expression by copper and cisplatin in human ovarian carcinoma cells

Molecular Pharmacology

Volumn 77, Issue 6, 2010, Pages 912-921

  Blair, Brian G ^a   Larson, Christopher A ^a   Adams, Preston L ^a   Abada, Paolo B ^a   Safaei, Roohangiz ^a   Howell, Stephen B ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATOX PROTEIN; CARRIER PROTEIN; CISPLATIN; COPPER; COPPER TRANSPORTER 1; COPPER TRANSPORTER 2; MESSENGER RNA; PROTEIN; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARCINOMA CELL; CELL LEVEL; CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG UPTAKE; EMBRYO; FIBROBLAST; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MICROSCOPY; MOUSE; NONHUMAN; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CATION TRANSPORT PROTEINS; CELL LINE, TUMOR; CELLS, CULTURED; CISPLATIN; COPPER; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; MOLECULAR CHAPERONES; OVARIAN NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 77952416458     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.109.062836     Document Type: Article

References (27)

1. Bellemare DR, Shaner L, Morano KA, Beaudoin J, Langlois R, and Labbe S (2002) Ctr6, a vacuolar membrane copper transporter in Schizosaccharomyces pombe. J Biol Chem 277:46676-46686.
2. Bertinato J, Swist E, Plouffe LJ, Brooks SP, and L'abbé MR (2008) Ctr2 is partially localized to the plasma membrane and stimulates copper uptake in COS-7 cells. Biochem J 409:731-740.
3. Blair BG, Larson CA, Safaei R, and Howell SB (2009) Copper transporter 2 regulates the cellular accumulation and cytotoxicity of Cisplatin and Carboplatin. Clin Cancer Res 15:4312-4321.
4. DiSaia PJ, Sinkovics JG, Rutledge FN, and Smith JP (1972) Cell-mediated immunity to human malignant cells. A brief review and further studies with two gynecologic tumors. Am J Obstet Gynecol 114:979-989.
5. Hamza I, Prohaska J, and Gitlin JD (2003) Essential role for Atox1 in the copper-mediated intracellular trafficking of the Menkes ATPase. Proc Natl Acad Sci USA 100:1215-1220. (Pubitemid 36183982)
6. Holzer AK and Howell SB (2006) The internalization and degradation of human copper transporter 1 following cisplatin exposure. Cancer Res 66:10944-10952.
7. Holzer AK, Katano K, Klomp LW, and Howell SB (2004a) Cisplatin rapidly down-regulates its own influx transporter hCTR1 in cultured human ovarian carcinoma cells. Clin Cancer Res 10:6744-6749. (Pubitemid 39346572)
8. Holzer AK, Samimi G, Katano K, Naerdemann W, Lin X, Safaei R, and Howell SB (2004b) The copper influx transporter human copper transport protein 1 regulates the uptake of cisplatin in human ovarian carcinoma cells. Mol Pharmacol 66:817-823. (Pubitemid 39319453)
9. Ishida S, Lee J, Thiele DJ, and Herskowitz I (2002) Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals. Proc Natl Acad Sci USA 99:14298-14302. (Pubitemid 35257666)
10. Itoh S, Kim HW, Nakagawa O, Ozumi K, Lessner SM, Aoki H, Akram K, McKinney RD, Ushio-Fukai M, and Fukai T (2008) Novel role of antioxidant-1 (Atox1) as a copper-dependent transcription factor involved in cell proliferation. J Biol Chem 283:9157-9167.
11. Itoh S, Ozumi K, Kim HW, Nakagawa O, McKinney RD, Folz RJ, Zelko IN, Ushio-Fukai M, and Fukai T (2009) Novel mechanism for regulation of extracellular SOD transcription and activity by copper: role of antioxidant-1. Free Radic Biol Med 46:95-104.
12. Jandial DD, Farshchi-Heydari S, Larson CA, Elliott GI, Wrasidlo WJ, and Howell SB (2009) Enhanced delivery of cisplatin to intraperitoneal ovarian carcinomas mediated by the effects of bortezomib on the human copper transporter 1. Clinical Cancer Research 15:553-560.
13. Jeney V, Itoh S, Wendt M, Gradek Q, Ushio-Fukai M, Harrison DG, and Fukai T (2005) Role of antioxidant-1 in extracellular superoxide dismutase function and expression. Circ Res 96:723-729. (Pubitemid 40559511)
14. Kampfenkel K, Kushnir S, Babiychuk E, Inzé D, and Van Montagu M (1995) Molecular characterization of a putative Arabidopsis thaliana copper transporter and its yeast homologue. J Biol Chem 270:28479-28486.
15. Larson CA, Blair BG, Safaei R, and Howell SB (2009) The role of the mammalian copper transporter 1 in the cellular accumulation of platinum-based drugs. Mol Pharmacol 75:324-330.
16. Lee JL, Wang MJ, and Chen JY (2009) Acetylation and activation of STAT3 mediated by nuclear translocation of CD44. J Cell Biol 185:949-957.
17. Liao HJ and Carpenter G (2007) Role of the Sec61 translocon in EGF receptor trafficking to the nucleus and gene expression. Mol Biol Cell 18:1064-1072.
18. Lin X, Okuda T, Holzer A, and Howell SB (2002) The copper transporter CTR1 regulates cisplatin uptake in Saccharomyces cerevisiae. Mol Pharmacol 62:1154-1159. (Pubitemid 35222507)
19. Lutsenko S, Tsivkovskii R, and Walker JM (2003) Functional properties of the human copper-transporting ATPase ATP7B (the Wilson's disease protein) and regulation by metallochaperone Atox1. Ann NY Acad Sci 986:204-211. (Pubitemid 36584083)
20. Miyayama T, Suzuki KT, and Ogra Y (2009) Copper accumulation and compartmentalization in mouse fibroblast lacking metallothionein and copper chaperone, Atox1. Toxicol Appl Pharmacol 237:205-213.
21. Monks A, Scudiero D, Skehan P, Shoemaker R, Paull K, Vistica D, Hose C, Langley J, Cronise P, and Vaigro-Wolff A (1991) Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J Natl Cancer Inst 83:757-765.
22. Muller PA and Klomp LW (2008) ATOX1: a novel copper-responsive transcription factor in mammals? Int J Biochem Cell Biol 41:1233-1236.
23. Portnoy ME, Schmidt PJ, Rogers RS, and Culotta VC (2001) Metal transporters that contribute copper to metallochaperones in Saccharomyces cerevisiae. Mol Genet Genomics 265:873-882.
24. Rees EM, Lee J, and Thiele DJ (2004) Mobilization of intracellular copper stores by the ctr2 vacuolar copper transporter. J Biol Chem 279:54221-54229. (Pubitemid 40053159)
25. Safaei R, Maktabi MH, Blair BG, Larson CA, and Howell SB (2009) Effects of the loss of Atox1 on the cellular pharmacology of cisplatin. J Inorg Biochem 103:333-341.
26. van den Berghe PV, Folmer DE, Malingré HE, van Beurden E, Klomp AE, van de Sluis B, Merkx M, Berger R, and Klomp LW (2007) Human copper transporter 2 is localized in late endosomes and lysosomes and facilitates cellular copper uptake. Biochem J 407:49-59.
27. Xiao Z and Wedd AG (2002) A C-terminal domain of the membrane copper pump Ctr1 exchanges copper(I) with the copper chaperone Atx1. Chem Commun (Camb) 6:588-589.